The death inhibitory molecules CED-9 and CED-4L use a common mechanism to inhibit the CED-3 death protease

scientific article published on July 1998

The death inhibitory molecules CED-9 and CED-4L use a common mechanism to inhibit the CED-3 death protease is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.273.28.17708
P8608Fatcat IDrelease_rsm2xhl7jbhoxdfye4fdxvilfe
P698PubMed publication ID9651369
P5875ResearchGate publication ID13634149

P2093author name stringChinnaiyan AM
Dixit VM
Chaudhary D
O'Rourke K
P2860cites workCytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascadeQ24311006
Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell deathQ24318779
Interaction and regulation of subcellular localization of CED-4 by CED-9Q24318813
Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3Q24324482
Apoptosis in the pathogenesis and treatment of diseaseQ28235731
Prevention of programmed cell death in Caenorhabditis elegans by human bcl-2Q28237519
The CARD domain: a new apoptotic signalling motifQ28239887
The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzymeQ28256420
Caspase-9, Bcl-XL, and Apaf-1 form a ternary complexQ28263687
The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell deathQ34306496
C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2.Q34322094
The molecular biology of apoptosisQ37688810
Protease activity of in vitro transcribed and translated Caenorhabditis elegans cell death gene (ced-3) productQ38361510
Epigenetic inheritance in the mouseQ40900201
Apoptosis and the maintenance of homoeostasis in the immune systemQ41049050
New members of the Bcl-2 family and their protein partnersQ41099855
Programmed cell death in invertebrates.Q41099862
Caenorhabditis elegans CED-4 stimulates CED-3 processing and CED-3-induced apoptosisQ41102675
The cell-death machineQ41110699
The role of programmed cell death as an emerging new concept for the pathogenesis of autoimmune diseasesQ41114658
Apoptosis: telling cells their time is up.Q41238272
The role of the Bcl-2 family of apoptosis regulatory proteins in the immune system.Q41433511
Double identity for proteins of the Bcl-2 familyQ41508318
CED-4--the third horseman of apoptosisQ41574380
Interaction between the C. elegans cell-death regulators CED-9 and CED-4.Q47068787
Role of CED-4 in the activation of CED-3.Q47068811
Caenorhabditis elegans CED-9 protein is a bifunctional cell-death inhibitorQ47068839
Direct physical interaction between the Caenorhabditis elegans 'death proteins' CED-3 and CED-4.Q47069167
Interaction and regulation of the Caenorhabditis elegans death protease CED-3 by CED-4 and CED-9.Q47069211
An alternatively spliced C. elegans ced-4 RNA encodes a novel cell death inhibitorQ47069461
CED-4 induces chromatin condensation in Schizosaccharomyces pombe and is inhibited by direct physical association with CED-9.Q52195652
Apoptosis CED-4 is a stranger no moreQ57939525
Programmed cell death in Caenorhabditis elegansQ57939597
P433issue28
P407language of work or nameEnglishQ1860
P921main subjectCell death protein 4 CELE_C35D10.9Q29798158
Cell death protein 3 subunit p17 CELE_C48D1.2Q29801550
P1104number of pages5
P304page(s)17708-17712
P577publication date1998-07-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe death inhibitory molecules CED-9 and CED-4L use a common mechanism to inhibit the CED-3 death protease
P478volume273

Reverse relations

cites work (P2860)
Q49149249A comparison of the expression and properties of Apaf-1 and Apaf-1L.
Q24290710A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif
Q41727106ATP-activated oligomerization as a mechanism for apoptosis regulation: fold and mechanism prediction for CED-4.
Q37166624Alternative Splicing Regulation of Cancer-Related Pathways in Caenorhabditis elegans: An In Vivo Model System with a Powerful Reverse Genetics Toolbox
Q34352949Apoptosis in amyotrophic lateral sclerosis: a review of the evidence.
Q33777704Apoptosis: definition, mechanisms, and relevance to disease
Q36368462Apoptotic protease activating factor 1 (Apaf-1)-independent cell death suppression by Bcl-2.
Q44817169Bcl-xES, a BH4- and BH2-containing antiapoptotic protein, delays Bax oligomer formation and binds Apaf-1, blocking procaspase-9 activation
Q58072502CED-4 forms a 2 : 2 heterotetrameric complex with CED-9 until specifically displaced by EGL-1 or CED-13
Q36078159Cell death throes
Q36385761Formation and structure of a NAIP5-NLRC4 inflammasome induced by direct interactions with conserved N- and C-terminal regions of flagellin.
Q40835187Genetics of programmed cell death in C. elegans: past, present and future.
Q89891233Highly-regulated, diversifying NTP-based biological conflict systems with implications for emergence of multicellularity
Q28274451Neuronal apoptosis-inhibitory protein does not interact with Smac and requires ATP to bind caspase-9
Q22010046Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB
Q77985326Purification, characterization, and role of nucleases and serine proteases in Streptomyces differentiation. Analogies with the biochemical processes described in late steps of eukaryotic apoptosis
Q40191060Regulation of Nod1-mediated signaling pathways
Q34405567The NOD: a signaling module that regulates apoptosis and host defense against pathogens
Q33997832The apoptosome: heart and soul of the cell death machine
Q30658082The domains of death: evolution of the apoptosis machinery
Q22003757Three new types of Apaf-1 in mammalian cells

Search more.