Alternative Splicing Regulation of Cancer-Related Pathways in Caenorhabditis elegans: An In Vivo Model System with a Powerful Reverse Genetics Toolbox

scientific article published on 28 August 2013

Alternative Splicing Regulation of Cancer-Related Pathways in Caenorhabditis elegans: An In Vivo Model System with a Powerful Reverse Genetics Toolbox is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1155/2013/636050
P932PMC publication ID3771449
P698PubMed publication ID24069034
P5875ResearchGate publication ID257075257

P2093author name stringJames Matthew Ragle
Sergio Barberán-Soler
P2860cites workCELF family RNA-binding protein UNC-75 regulates two sets of mutually exclusive exons of the unc-32 gene in neuron-specific manners in Caenorhabditis elegansQ21563362
The human U5 snRNP 52K protein (CD2BP2) interacts with U5-102K (hPrp6), a U4/U6.U5 tri-snRNP bridging protein, but dissociates upon tri-snRNP formationQ24300349
Proteomic analysis identifies a new complex required for nuclear pre-mRNA retention and splicingQ24317157
A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutantsQ24339624
The intronerator: exploring introns and alternative splicing in Caenorhabditis elegansQ24515292
Partial purification of the yeast U2 snRNP reveals a novel yeast pre-mRNA splicing factor required for pre-spliceosome assemblyQ24534180
Interaction between the N-terminal domain of human DNA topoisomerase I and the arginine-serine domain of its substrate determines phosphorylation of SF2/ASF splicing factorQ24548056
Formation, regulation and evolution of Caenorhabditis elegans 3'UTRsQ24598773
EGF signal propagation during C. elegans vulval development mediated by ROM-1 rhomboidQ24794899
Intronic alternative splicing regulators identified by comparative genomics in nematodesQ27339694
Genome sequence of the nematode C. elegans: a platform for investigating biologyQ27860527
Differential subcellular localization of DNA topoisomerase-1 isoforms and their roles during Caenorhabditis elegans development.Q51799146
Drosophila splicing factor SF2 knock-down mutant shows altered cell-cycle in vivo.Q52749358
High mutation rate and predominance of insertions in the Caenorhabditis elegans nuclear genome.Q52965913
Widespread Evolutionary Conservation of Alternatively Spliced Exons in CaenorhabditisQ58184156
siRNA-mediated knockdown of a splice variant of the PK-A catalytic subunit gene causes adult-onset paralysis in C. elegansQ60219652
Retinoblastoma: a prototypic hereditary neoplasmQ67312912
Molecular cloning of two types of GAP complementary DNA from human placentaQ67985384
Expression of multiple isoforms of the cAMP-dependent protein kinase (PK-A) catalytic subunit in the nematode, Caenorhabditis elegansQ79809418
Systematic functional analysis of the Caenorhabditis elegans genome using RNAiQ27860839
Caenorhabditis elegans gene ced-9 protects cells from programmed cell deathQ28299039
Integrative analysis of the Caenorhabditis elegans genome by the modENCODE projectQ28301622
Pattern formation during vulval development in C. elegansQ28304067
Muscle-specific splicing factors ASD-2 and SUP-12 cooperatively switch alternative pre-mRNA processing patterns of the ADF/cofilin gene in Caenorhabditis elegansQ28484356
Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell deathQ28507741
Post-embryonic cell lineages of the nematode, Caenorhabditis elegansQ29547748
Intron size, abundance, and distribution within untranslated regions of genesQ33257848
Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activityQ33281494
Alternative splicing regulation during C. elegans development: splicing factors as regulated targetsQ33331560
Large introns in relation to alternative splicing and gene evolution: a case study of Drosophila bruno-3Q33511369
A role for Caenorhabditis elegans in understanding the function and interactions of human disease genesQ33892608
A new kind of informational suppression in the nematode Caenorhabditis elegansQ33955803
Alternative splicing and genome complexityQ33956410
The Caenorhabditis elegans sex determination gene mog-1 encodes a member of the DEAH-Box protein familyQ33957514
WormBase 2012: more genomes, more data, new websiteQ34070082
An alternative splicing network links cell-cycle control to apoptosisQ34077168
Characterisation of the N'1 isoform of the cyclic AMP-dependent protein kinase (PK-A) catalytic subunit in the nematode, Caenorhabditis elegansQ34143880
Genetic control of programmed cell death in the nematode C. elegans.Q34196702
Co-regulation of alternative splicing by diverse splicing factors in Caenorhabditis elegansQ34513751
A global analysis of C. elegans trans-splicingQ34548280
Genome-wide analysis of alternative splicing in Caenorhabditis elegansQ34548324
SPK-1, an SR protein kinase, inhibits programmed cell death in Caenorhabditis elegansQ34550044
Genomics in C. elegans: so many genes, such a little wormQ34563189
The million mutation project: a new approach to genetics in Caenorhabditis elegansQ34783904
PRP-17 and the pre-mRNA splicing pathway are preferentially required for the proliferation versus meiotic development decision and germline sex determination in Caenorhabditis elegansQ34989684
Functional characterization of SR and SR-related genes in Caenorhabditis elegansQ35008078
The hermaphrodite sperm/oocyte switch requires the Caenorhabditis elegans homologs of PRP2 and PRP22.Q35108458
Sm protein down-regulation leads to defects in nuclear pore complex disassembly and distribution in C. elegans embryosQ35914647
The sperm-oocyte switch in the C. elegans hermaphrodite is controlled through steady-state levels of the fem-3 mRNA.Q36060824
Regulation of Ich-1 pre-mRNA alternative splicing and apoptosis by mammalian splicing factorsQ36252562
TEG-1 CD2BP2 regulates stem cell proliferation and sex determination in the C. elegans germ line and physically interacts with the UAF-1 U2AF65 splicing factorQ36304336
STAR family RNA-binding protein ASD-2 regulates developmental switching of mutually exclusive alternative splicing in vivoQ36411169
Chromosomal clustering and GATA transcriptional regulation of intestine-expressed genes in C. elegansQ36480375
smg mutants affect the expression of alternatively spliced SR protein mRNAs in Caenorhabditis elegansQ36574846
Alterations in cell lineage following laser ablation of cells in the somatic gonad of Caenorhabditis elegansQ36659504
RTK/Ras/MAPK signalingQ37020699
RasGAPs: a crucial regulator of extracellular stimuli for homeostasis of cellular functions.Q37147806
Alternative splicing and the steady-state ratios of mRNA isoforms generated by it are under strong stabilizing selection in Caenorhabditis elegansQ37306551
Global analysis of alternative splicing uncovers developmental regulation of nonsense-mediated decay in C. elegansQ37344523
NMD: a multifaceted response to premature translational terminationQ37675497
Roles of cAMP and cAMP-dependent protein kinase in the progression of prostate cancer: cross-talk with the androgen receptorQ37784867
Epidermal growth factor signaling induces behavioral quiescence in Caenorhabditis elegansQ39752359
Position-dependent and neuron-specific splicing regulation by the CELF family RNA-binding protein UNC-75 in Caenorhabditis elegansQ39876270
Splicing of a C. elegans myosin pre-mRNA in a human nuclear extractQ40513584
Meiotic recombination and DNA synthesis in a new cell cycle mutant of Saccharomyces cerevisiaeQ40944016
lin-35 and lin-53, two genes that antagonize a C. elegans Ras pathway, encode proteins similar to Rb and its binding protein RbAp48.Q40983720
The death inhibitory molecules CED-9 and CED-4L use a common mechanism to inhibit the CED-3 death proteaseQ41028558
Caenorhabditis elegans CED-4 stimulates CED-3 processing and CED-3-induced apoptosisQ41102675
Specific phosphorylation of SR proteins by mammalian DNA topoisomerase I.Q41199860
The Fox-1 family and SUP-12 coordinately regulate tissue-specific alternative splicing in vivoQ41788378
Evolution of exon-intron structure and alternative splicing in fruit flies and malarial mosquito genomes.Q41848375
High resolution transcriptome maps for wild-type and nonsense-mediated decay-defective Caenorhabditis elegansQ41864064
The multivulva phenotype of certain Caenorhabditis elegans mutants results from defects in two functionally redundant pathways.Q42961253
Organization and alternative splicing of the Caenorhabditis elegans cAMP-dependent protein kinase catalytic-subunit gene (kin-1).Q42993272
Regulation of gene expression, cellular localization, and in vivo function of Caenorhabditis elegans DNA topoisomerase I.Q43586089
dpl-1 DP and efl-1 E2F act with lin-35 Rb to antagonize Ras signaling in C. elegans vulval developmentQ43681650
A mutation in teg-4, which encodes a protein homologous to the SAP130 pre-mRNA splicing factor, disrupts the balance between proliferation and differentiation in the C. elegans germ lineQ44372316
Structural diversity of the cAMP-dependent protein kinase regulatory subunit in Caenorhabditis elegansQ46052553
Alternative splicing in the human, mouse and rat genomes is associated with an increased frequency of exon creation and/or lossQ46234594
Copulation in C. elegans males requires a nuclear hormone receptor.Q46464226
Role of CED-4 in the activation of CED-3.Q47068811
More mog genes that influence the switch from spermatogenesis to oogenesis in the hermaphrodite germ line of Caenorhabditis elegansQ47068881
SPK-1, a C. elegans SR protein kinase homologue, is essential for embryogenesis and required for germline developmentQ47068882
Interaction and regulation of the Caenorhabditis elegans death protease CED-3 by CED-4 and CED-9.Q47069211
Characterization of the C. elegans gap-2 gene encoding a novel Ras-GTPase activating protein and its possible role in larval developmentQ47069267
let-60, a gene that specifies cell fates during C. elegans vulval induction, encodes a ras proteinQ47069440
An alternatively spliced C. elegans ced-4 RNA encodes a novel cell death inhibitorQ47069461
Alternative splicing in the Caenorhabditis elegans DNA topoisomerase I geneQ48038913
Transgenic alternative-splicing reporters reveal tissue-specific expression profiles and regulation mechanisms in vivoQ48083916
Cloning, characterization, and expression of the gene for the catalytic subunit of cAMP-dependent protein kinase in Caenorhabditis elegans. Identification of highly conserved and unique isoforms generated by alternative splicingQ48269269
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P921main subjectCaenorhabditis elegansQ91703
alternative mRNA splicing, via spliceosomeQ21114084
P304page(s)636050
P577publication date2013-08-28
P1433published inInternational Journal of Cell BiologyQ26842205
P1476titleAlternative Splicing Regulation of Cancer-Related Pathways in Caenorhabditis elegans: An In Vivo Model System with a Powerful Reverse Genetics Toolbox
P478volume2013

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cites work (P2860)
Q35793524Coordinated tissue-specific regulation of adjacent alternative 3' splice sites in C. elegans
Q41682166The Annona muricata leaf ethanol extract affects mobility and reproduction in mutant strain NB327 Caenorhabditis elegans

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