Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity

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Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity is …
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P6179Dimensions Publication ID1021225438
P356DOI10.1186/1471-213X-7-30
P8608Fatcat IDrelease_g2zvu5qxxzcp3mh4s3motplldi
P932PMC publication ID1863419
P698PubMed publication ID17417969

P50authorMarc VidalQ81911349
Sander van den HeuvelQ43955839
Denis DupuyQ55154381
Julián CerónQ59487908
P2093author name stringJean-François Rual
Abha Chandra
P2860cites workCloning and characterization of a novel Kruppel-associated box family transcriptional repressor that interacts with the retinoblastoma gene product, RBQ22253280
Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1Q24299067
The retinoblastoma protein binds to RIZ, a zinc-finger protein that shares an epitope with the adenovirus E1A proteinQ24307350
Negative regulation of nuclear divisions in Caenorhabditis elegans by retinoblastoma and RNA interference-related genesQ24536288
The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic fociQ24540163
A role for the P-body component GW182 in microRNA functionQ24669847
KRAB-containing zinc-finger repressor proteinsQ24792646
Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functionsQ24803805
The retinoblastoma protein and cell cycle controlQ27860722
Systematic functional analysis of the Caenorhabditis elegans genome using RNAiQ27860839
Decapping and Decay of Messenger RNA Occur in Cytoplasmic Processing BodiesQ27931286
Protein interaction mapping in C. elegans using proteins involved in vulval developmentQ28141447
Functional genomic analysis of RNA interference in C. elegansQ28241721
Inhibition of translational initiation by Let-7 MicroRNA in human cellsQ28265842
Diverse chromatin remodeling genes antagonize the Rb-involved SynMuv pathways in C. elegansQ28469221
Chromatin and RNAi factors protect the C. elegans germline against repetitive sequencesQ28769875
Toward improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi libraryQ28770084
Cancer cell cyclesQ29547756
Epigenetic regulation of cellular memory by the Polycomb and Trithorax group proteinsQ29614507
A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcomaQ29618817
Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune responseQ33695936
A Toll-interleukin 1 repeat protein at the synapse specifies asymmetric odorant receptor expression via ASK1 MAPKKK signaling.Q33763795
Chromatin regulation and sumoylation in the inhibition of Ras-induced vulval development in Caenorhabditis elegansQ33899619
The retinoblastoma tumour suppressor in development and cancerQ34161991
The postembryonic cell lineages of the hermaphrodite and male gonads in Caenorhabditis elegansQ34218631
Retinoblastoma protein partnersQ34305195
Molecular mechanisms of E2F-dependent activation and pRB-mediated repressionQ34318740
The CDC-14 phosphatase controls developmental cell-cycle arrest in C. elegansQ34332788
The Sm proteins regulate germ cell specification during early C. elegans embryogenesisQ82264705
SynMuv genes redundantly inhibit lin-3/EGF expression to prevent inappropriate vulval induction in C. elegansQ83296442
Native E2F/RBF complexes contain Myb-interacting proteins and repress transcription of developmentally controlled E2F target genesQ34358237
gon-14 functions with class B and class C synthetic multivulva genes to control larval growth in Caenorhabditis elegansQ34411576
The tumor suppressor gene RIZ in cancer gene therapy (review).Q34465609
lin-8, which antagonizes Caenorhabditis elegans Ras-mediated vulval induction, encodes a novel nuclear protein that interacts with the LIN-35 Rb proteinQ34589802
lin-35/Rb cooperates with the SWI/SNF complex to control Caenorhabditis elegans larval developmentQ34645426
fzr-1 and lin-35/Rb function redundantly to control cell proliferation in C. elegans as revealed by a nonbiased synthetic screenQ35005474
Cell cycle-dependent and cell cycle-independent control of transcription by the Drosophila E2F/RB pathwayQ35971239
Claspin: timing the cell cycle arrest when the genome is damagedQ36685762
Soma-germ cell interactions in Caenorhabditis elegans: multiple events of hermaphrodite germline development require the somatic sheath and spermathecal lineagesQ36844317
A first version of the Caenorhabditis elegans PromoteromeQ37621437
Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complexQ37694408
A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans.Q39751086
Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathwaysQ39751785
Loss of LIN-35, the Caenorhabditis elegans ortholog of the tumor suppressor p105Rb, results in enhanced RNA interferenceQ40347079
lin-35/Rb and ubc-18, an E2 ubiquitin-conjugating enzyme, function redundantly to control pharyngeal morphogenesis in C. elegansQ40642793
lin-35 and lin-53, two genes that antagonize a C. elegans Ras pathway, encode proteins similar to Rb and its binding protein RbAp48.Q40983720
Ultrastructural features of the adult hermaphrodite gonad of Caenorhabditis elegans: relations between the germ line and somaQ42475326
dpl-1 DP and efl-1 E2F act with lin-35 Rb to antagonize Ras signaling in C. elegans vulval developmentQ43681650
C. elegans class B synthetic multivulva genes act in G(1) regulationQ44025674
A new class of C. elegans synMuv genes implicates a Tip60/NuA4-like HAT complex as a negative regulator of Ras signalingQ44833513
C. elegans HIM-17 links chromatin modification and competence for initiation of meiotic recombinationQ45021539
lin-35 Rb acts in the major hypodermis to oppose ras-mediated vulval induction in C. elegansQ45203829
The developmental timing regulator AIN-1 interacts with miRISCs and may target the argonaute protein ALG-1 to cytoplasmic P bodies in C. elegansQ47068671
A forkhead protein controls sexual identity of the C. elegans male somatic gonadQ47068674
Targeted mutations in the Caenorhabditis elegans POU homeo box gene ceh-18 cause defects in oocyte cell cycle arrest, gonad migration, and epidermal differentiationQ47068683
The coordinate regulation of pharyngeal development in C. elegans by lin-35/Rb, pha-1, and ubc-18.Q47068886
XNP-1/ATR-X acts with RB, HP1 and the NuRD complex during larval development in C. elegansQ47069240
A novel function for the Sm proteins in germ granule localization during C. elegans embryogenesisQ47069396
lin-35 Rb and cki-1 Cip/Kip cooperate in developmental regulation of G1 progression in C. elegansQ47069441
TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM.Q47069444
Loss of the putative RNA-directed RNA polymerase RRF-3 makes C. elegans hypersensitive to RNAiQ47884643
Multiple interactions between SRm160 and SR family proteins in enhancer-dependent splicing and development of C. elegans.Q48873078
lin-35/Rb and xnp-1/ATR-X function redundantly to control somatic gonad development in C. elegans.Q51938055
Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants.Q52043143
Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathwaysQ55554520
P921main subjectCaenorhabditis elegansQ91703
retinoblastomaQ500695
P304page(s)30
P577publication date2007-04-06
P1433published inBMC Developmental BiologyQ15761839
P1476titleLarge-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity
P478volume7

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