Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1

scientific article

Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1 is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1101/GAD.252103
P3181OpenCitations bibliographic resource ID4768995
P932PMC publication ID196026
P698PubMed publication ID12670868
P5875ResearchGate publication ID10825905

P50authorWinship HerrQ37382359
P2093author name stringMichael P Myers
Robert N Eisenman
Joanna Wysocka
Carol D Laherty
P2860cites workCloning and characterization of ASH2L and Ash2l, human and mouse homologs of the Drosophila ash2 geneQ22010215
Translating the Histone CodeQ22065840
The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription activation by GABPQ22253187
Regulation of chromatin structure by site-specific histone H3 methyltransferasesQ24290115
A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screeningQ24290201
ASH2L: alternative splicing and downregulation during induced megakaryocytic differentiation of multipotential leukemia cell linesQ24291473
Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complexQ24292515
Recruitment of O-GlcNAc transferase to promoters by corepressor mSin3A: coupling protein O-GlcNAcylation to transcriptional repressionQ24302865
The cellular C1 factor of the herpes simplex virus enhancer complex is a family of polypeptidesQ24315856
The VP16 accessory protein HCF is a family of polypeptides processed from a large precursor proteinQ24316442
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4aQ24324559
Luman, a new member of the CREB/ATF family, binds to herpes simplex virus VP16-associated host cellular factorQ24336173
The herpesvirus transactivator VP16 mimics a human basic domain leucine zipper protein, luman, in its interaction with HCFQ24523280
A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3Q24531253
An activation domain in the C-terminal subunit of HCF-1 is important for transactivation by VP16 and LZIP.Q24536035
The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4Q24536072
Viral mimicry: common mode of association with HCF by VP16 and the cellular protein LZIPQ24603763
VP16 targets an amino-terminal domain of HCF involved in cell cycle progressionQ24644447
Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste proteinQ24682617
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nucleiQ27860728
Mammalian Ras interacts directly with the serine/threonine kinase RafQ27860833
COMPASS: a complex of proteins associated with a trithorax-related SET domain proteinQ27931344
Cti6, a PHD domain protein, bridges the Cyc8-Tup1 corepressor and the SAGA coactivator to overcome repression at GAL1.Q27934762
COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expressionQ27938795
Hog1 kinase converts the Sko1-Cyc8-Tup1 repressor complex into an activator that recruits SAGA and SWI/SNF in response to osmotic stressQ27938913
Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tailsQ28216534
SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factorsQ28279441
The HCF repeat is an unusual proteolytic cleavage signalQ28291563
Histone H3 lysine 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiaeQ28343956
The mouse homologue of the human transcription factor C1 (host cell factor). Conservation of forms and functionQ28504647
Cloning and characterization of a novel WD-40 repeat protein that dramatically accelerates osteoblastic differentiationQ28508822
A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repressionQ28578229
Active genes are tri-methylated at K4 of histone H3Q29547668
Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylaseQ29547913
Methylation of histone H3 Lys 4 in coding regions of active genesQ29614680
Histone methylation in transcriptional controlQ29616553
Ethidium bromide provides a simple tool for identifying genuine DNA-independent protein associationsQ29620211
Identification of a new family of tissue-specific basic helix-loop-helix proteins with a two-hybrid systemQ29620436
Transitions in distinct histone H3 methylation patterns at the heterochromatin domain boundariesQ29622865
Methylation of histone H3 at lysine 4 is highly conserved and correlates with transcriptionally active nuclei in TetrahymenaQ30304568
ProFound: an expert system for protein identification using mass spectrometric peptide mapping informationQ30880899
The herpes simplex virus VP16-induced complex: mechanisms of combinatorial transcriptional regulationQ33671575
Sin meets NuRD and other tails of repression.Q33789548
Histone deacetylases: silencers for hire.Q33850039
Glycosylation of nucleocytoplasmic proteins: signal transduction and O-GlcNAcQ33939701
Recent advances in RNA-protein recognition.Q34141518
Histone H3 lysine 4 methylation is mediated by Set1 and promotes maintenance of active chromatin states in fission yeastQ34443938
Structural requirements in the herpes simplex virus type 1 transactivator Vmw65 for interaction with the cellular octamer-binding protein and target TAATGARAT sequences.Q38340581
Loss of HCF-1-chromatin association precedes temperature-induced growth arrest of tsBN67 cellsQ39459458
Inactivation of the retinoblastoma protein family can bypass the HCF-1 defect in tsBN67 cell proliferation and cytokinesisQ39675472
Concerted activity of host cell factor subregions in promoting stable VP16 complex assembly and preventing interference by the acidic activation domainQ40024083
Spontaneous reversion of tsBN67 cell proliferation and cytokinesis defects in the absence of HCF-1 functionQ40725742
A single-point mutation in HCF causes temperature-sensitive cell-cycle arrest and disrupts VP16 function.Q41120732
The Polycomb and trithorax group proteins of Drosophila: trans-regulators of homeotic gene functionQ41126293
Interactions of the Oct-1 POU subdomains with specific DNA sequences and with the HSV alpha-trans-activator proteinQ41713383
Correlation between histone lysine methylation and developmental changes at the chicken beta-globin locusQ43703042
Evidence that Set1, a factor required for methylation of histone H3, regulates rDNA silencing in S. cerevisiae by a Sir2-independent mechanismQ43871051
Combinatorial control of transcription: the herpes simplex virus VP16-induced complexQ44589073
Genome-wide binding map of the histone deacetylase Rpd3 in yeastQ45278552
The Structure of Herpes Simplex Virus Type 1 DNA as Probed by Micrococcal Nuclease DigestionQ45802614
Trans-regulation of thoracic homeotic selector genes of the Antennapedia and bithorax complexes by the trithorax group genes: absent, small, and homeotic discs 1 and 2.Q47070159
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectidentical protein bindingQ14762994
Host cell factor C1Q21130029
P304page(s)896-911
P577publication date2003-04-01
P1433published inGenes & DevelopmentQ1524533
P1476titleHuman Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1
P478volume17

Reverse relations

cites work (P2860)
Q536068245 Methylation and demethylation of his tone arg and lys residues in chromatin structure and function.
Q59127644A Novel Glycoproteomics Workflow Reveals Dynamic O-GlcNAcylation of COPγ1 as a Candidate Regulator of Protein Trafficking
Q28485041A combination of H2A.Z and H4 acetylation recruits Brd2 to chromatin during transcriptional activation
Q31025627A comparative analysis of an orthologous proteomic environment in the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe
Q33581427A conserved interaction between the SDI domain of Bre2 and the Dpy-30 domain of Sdc1 is required for histone methylation and gene expression
Q28080440A critical perspective of the diverse roles of O-GlcNAc transferase in chromatin
Q28505929A histone H3 methyltransferase controls epigenetic events required for meiotic prophase
Q24534923A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16
Q36154459A network of genes antagonistic to the LIN-35 retinoblastoma protein of Caenorhabditis elegans
Q34536856A novel non-SET domain multi-subunit methyltransferase required for sequential nucleosomal histone H3 methylation by the mixed lineage leukemia protein-1 (MLL1) core complex
Q36591414A novel selective LSD1/KDM1A inhibitor epigenetically blocks herpes simplex virus lytic replication and reactivation from latency
Q35765789A novel somatic mutation in ACD induces telomere lengthening and apoptosis resistance in leukemia cells
Q38340232A protein sequestering system reveals control of cellular programs by the transcriptional coactivator HCF-1.
Q27342739A role for Set1/MLL-related components in epigenetic regulation of the Caenorhabditis elegans germ line
Q38307367A role for WDR5 in integrating threonine 11 phosphorylation to lysine 4 methylation on histone H3 during androgen signaling and in prostate cancer
Q37631525A targeted RNA interference screen reveals novel epigenetic factors that regulate herpesviral gene expression
Q38327357A transcriptional regulatory role of the THAP11-HCF-1 complex in colon cancer cell function.
Q41677861AMPK blocks starvation-inducible transgenerational defects in Caenorhabditis elegans
Q36161239ASH1, a Drosophila trithorax group protein, is required for methylation of lysine 4 residues on histone H3
Q42689905ASXL gain-of-function truncation mutants: defective and dysregulated forms of a natural ribosomal frameshifting product?
Q37994551ATAC-king the complexity of SAGA during evolution
Q34235555Affinity purification of MLL3/MLL4 histone H3K4 methyltransferase complex
Q44385509Alterations of the CxxC domain preclude oncogenic activation of mixed-lineage leukemia 2.
Q33761102An Ash2L/RbBP5 heterodimer stimulates the MLL1 methyltransferase activity through coordinated substrate interactions with the MLL1 SET domain
Q28298001An X-linked cobalamin disorder caused by mutations in transcriptional coregulator HCFC1
Q24599005An emerging model for BAP1's role in regulating cell cycle progression
Q46925893Antagonistic functions of SET-2/SET1 and HPL/HP1 proteins in C. elegans development
Q35108215Application of ChIP-Seq and related techniques to the study of immune function
Q36590643Ash2 acts as an ecdysone receptor coactivator by stabilizing the histone methyltransferase Trr.
Q24329078Association of C-terminal ubiquitin hydrolase BRCA1-associated protein 1 with cell cycle regulator host cell factor 1
Q36898912Association of the cellular coactivator HCF-1 with the Golgi apparatus in sensory neurons
Q34280223BAP1 loss defines a new class of renal cell carcinoma
Q24309660BAT3 and SET1A form a complex with CTCFL/BORIS to modulate H3K4 histone dimethylation and gene expression
Q41752870BRCA1-associated protein 1 (BAP1) deubiquitinase antagonizes the ubiquitin-mediated activation of FoxK2 target genes
Q35660192Barrier-to-Autointegration Factor 1 (BAF/BANF1) Promotes Association of the SETD1A Histone Methyltransferase with Herpes Simplex Virus Immediate-Early Gene Promoters
Q35172965Biochemical reconstitution and phylogenetic comparison of human SET1 family core complexes involved in histone methylation
Q83951950Bittersweet memories: linking metabolism to epigenetics through O-GlcNAcylation
Q24297872CHD8 associates with human Staf and contributes to efficient U6 RNA polymerase III transcription
Q33590983CXXC finger protein 1 restricts the Setd1A histone H3K4 methyltransferase complex to euchromatin
Q21145855Caenorhabditis elegans HCF-1 functions in longevity maintenance as a DAF-16 regulator
Q35002660Caenorhabditis elegans chromatin-associated proteins SET-2 and ASH-2 are differentially required for histone H3 Lys 4 methylation in embryos and adult germ cells
Q39108521Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.
Q38122298Chromatin dynamics during lytic infection with herpes simplex virus 1.
Q40496550Combinatorial transcription of herpes simplex virus and varicella zoster virus immediate early genes is strictly determined by the cellular coactivator HCF-1.
Q27649358Conserved Themes in Target Recognition by the PAH1 and PAH2 Domains of the Sin3 Transcriptional Corepressor
Q33449310Construction and clarification of dynamic gene regulatory network of cancer cell cycle via microarray data.
Q57809415Context-specific interactions in literature-curated protein interaction databases
Q24300761Contribution of H3K4 methylation by SET-1A to interleukin-1-induced cyclooxygenase 2 and inducible nitric oxide synthase expression in human osteoarthritis chondrocytes
Q33729222Control of alpha-herpesvirus IE gene expression by HCF-1 coupled chromatin modification activities
Q50287029Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4)
Q39458959Core histones H2B and H4 are mobilized during infection with herpes simplex virus 1.
Q34463476CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex
Q58564337Critical observations that shaped our understanding of the function(s) of Intracellular Glycosylation (O-GlcNAc)
Q24338891Crosstalk between O-GlcNAcylation and proteolytic cleavage regulates the host cell factor-1 maturation pathway
Q36610180DNA damage promotes herpes simplex virus-1 protein expression in a neuroblastoma cell line
Q41449642Development and Use of Assay Conditions Suited to Screening for and Profiling of SET-Domain-Targeted Inhibitors of the MLL/SET1 Family of Lysine Methyltransferases
Q46936924Developmental timing in Dictyostelium is regulated by the Set1 histone methyltransferase.
Q80238624Differential subcellular localization and activity of kelch repeat proteins KLHDC1 and KLHDC2
Q90575977Dissenting degradation: Deubiquitinases in cell cycle and cancer
Q28547471Distinct OGT-Binding Sites Promote HCF-1 Cleavage
Q34400766Drosophila Myc interacts with host cell factor (dHCF) to activate transcription and control growth
Q37303993Drosophila O-GlcNAc transferase (OGT) is encoded by the Polycomb group (PcG) gene, super sex combs (sxc).
Q36876298Drosophila O-GlcNAcase Deletion Globally Perturbs Chromatin O-GlcNAcylation
Q35177234Drosophila Set1 is the major histone H3 lysine 4 trimethyltransferase with role in transcription.
Q28478317Drosophila melanogaster dHCF interacts with both PcG and TrxG epigenetic regulators
Q37492667During lytic infection herpes simplex virus type 1 is associated with histones bearing modifications that correlate with active transcription.
Q24814990Dynamic acetylation of all lysine 4-methylated histone H3 in the mouse nucleus: analysis at c-fos and c-jun
Q35582225Dynamic modulation of HSV chromatin drives initiation of infection and provides targets for epigenetic therapies
Q24646412E2F1 mediates DNA damage and apoptosis through HCF-1 and the MLL family of histone methyltransferases
Q37705337Electron transfer dissociation (ETD): the mass spectrometric breakthrough essential for O-GlcNAc protein site assignments-a study of the O-GlcNAcylated protein host cell factor C1
Q57026995Endoplasmic Reticulum Homeostasis Is Modulated by the Forkhead Transcription Factor FKH-9 During Infection of
Q38845518Epigenetic Changes in Diabetes and Cardiovascular Risk.
Q37742439Epigenetic regulation of development by histone lysine methylation.
Q27302346Epigenetic regulation of histone H3 serine 10 phosphorylation status by HCF-1 proteins in C. elegans and mammalian cells
Q64122242Ets1 suppresses atopic dermatitis by suppressing pathogenic T cell responses
Q36106246Evidence of a MOF histone acetyltransferase-containing NSL complex in C. elegans
Q24561943Exploring the O-GlcNAc proteome: direct identification of O-GlcNAc-modified proteins from the brain
Q35690493Expression of the epigenetic factor BORIS (CTCFL) in the human genome
Q44843426F-actin-dependent insolubility of chromatin-modifying components
Q33521703Fgfr3 is a transcriptional target of Ap2delta and Ash2l-containing histone methyltransferase complexes
Q55038783From chromatin to cancer: a new histone lysine methyltransferase enters the mix.
Q27009399Functional O-GlcNAc modifications: implications in molecular regulation and pathophysiology
Q35850361Functional dissection of the ash2 and ash1 transcriptomes provides insights into the transcriptional basis of wing phenotypes and reveals conserved protein interactions
Q64067921Genome-Wide Association Study Identifies Genomic Loci Affecting Filet Firmness and Protein Content in Rainbow Trout
Q35040925Genome-wide chromatin occupancy analysis reveals a role for ASH2 in transcriptional pausing.
Q42177531Genome-wide coactivation analysis of PGC-1alpha identifies BAF60a as a regulator of hepatic lipid metabolism
Q36289523Genomic Determinants of THAP11/ZNF143/HCFC1 Complex Recruitment to Chromatin
Q39859217GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis
Q28254074GlcNAcylation of histone H2B facilitates its monoubiquitination
Q24529562Global and Hox-specific roles for the MLL1 methyltransferase
Q38324759Global loss of Set1-mediated H3 Lys4 trimethylation is associated with silencing defects in Saccharomyces cerevisiae
Q37961731Grasping trimethylation of histone H3 at lysine 4.
Q24297198HCF-1 functions as a coactivator for the zinc finger protein Krox20
Q100958429HCF-1 promotes cell cycle progression by regulating the expression of CDC42
Q27674353HCF-1 self-association via an interdigitated Fn3 structure facilitates transcriptional regulatory complex formation
Q36889283HCFC1 is a common component of active human CpG-island promoters and coincides with ZNF143, THAP11, YY1, and GABP transcription factor occupancy.
Q42184608Herpes simplex virus-1 disarms the unfolded protein response in the early stages of infection.
Q33995588Histone H3 K36 methylation is associated with transcription elongation in Schizosaccharomyces pombe
Q38156524Histone H3 lysine 4 methyltransferases and demethylases in self-renewal and differentiation of stem cells
Q36732775Histone code modifications on pluripotential nuclei of reprogrammed somatic cells
Q38019133Histone deacetylases in viral infections
Q26777269Histone demethylases in chromatin biology and beyond
Q38060650Histone methylation in the nervous system: functions and dysfunctions
Q37780469Histone methyltransferases: regulation of transcription and contribution to human disease
Q24537631Host cell factor and an uncharacterized SANT domain protein are stable components of ATAC, a novel dAda2A/dGcn5-containing histone acetyltransferase complex in Drosophila
Q40288518Host cell factor-1 and E2F4 interact via multiple determinants in each protein
Q43048809Host cell factor-1 recruitment to E2F-bound and cell-cycle-control genes is mediated by THAP11 and ZNF143.
Q24320022Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein
Q24302754Identification and characterization of SAP25, a novel component of the mSin3 corepressor complex
Q37134376Identification and characterization of a novel nuclear protein complex involved in nuclear hormone receptor-mediated gene regulation.
Q24299989Identification and characterization of the human Set1B histone H3-Lys4 methyltransferase complex
Q37694408Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complex
Q37439584Inhibition of the histone demethylase LSD1 blocks alpha-herpesvirus lytic replication and reactivation from latency
Q24337427Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth
Q42229757Krox20 controls the transcription of its various targets in the developing hindbrain according to multiple modes.
Q28540872LANA binds to multiple active viral and cellular promoters and associates with the H3K4methyltransferase hSET1 complex
Q33281494Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity
Q24297027Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression
Q42407022Linker histones are mobilized during infection with herpes simplex virus type 1.
Q43134917MLL5 expression as a biomarker for DNA hypermethylation and sensitivity to epigenetic therapy
Q34208585Maximum growth and survival of estrogen receptor-alpha positive breast cancer cells requires the Sin3A transcriptional repressor
Q34784199Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans
Q24313196Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus
Q24295056Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive
Q37106839Minireview: the PGC-1 coactivator networks: chromatin-remodeling and mitochondrial energy metabolism
Q33943731Mixed lineage leukemia: a structure-function perspective of the MLL1 protein
Q33862548Mixed lineage leukemia: histone H3 lysine 4 methyltransferases from yeast to human
Q30419967Modification of RelA by O-linked N-acetylglucosamine links glucose metabolism to NF-κB acetylation and transcription
Q38161393Molecular and Epigenetic Mechanisms of MLL in Human Leukemogenesis
Q34546063Molecular recognition of histone H3 by the WD40 protein WDR5.
Q46650462Monomethyl histone H3 lysine 4 as an epigenetic mark for silenced euchromatin in Chlamydomonas.
Q24297025Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation
Q35897125Multi-omic measurement of mutually exclusive loss-of-function enriches for candidate synthetic lethal gene pairs
Q38816657Mutations in THAP11 cause an inborn error of cobalamin metabolism and developmental abnormalities
Q36082870Nucleosome and transcription activator antagonism at human beta-globin locus control region DNase I hypersensitive sites
Q47628534Nutrient-driven O-GlcNAc in proteostasis and neurodegeneration
Q24339060O-GlcNAc transferase catalyzes site-specific proteolysis of HCF-1
Q37727664O-GlcNAc transferase is critical for transducin-like enhancer of split (TLE)-mediated repression of canonical Wnt signaling
Q42076002O-GlcNAc transferase/host cell factor C1 complex regulates gluconeogenesis by modulating PGC-1α stability
Q58778244O-GlcNAcylation Signal Mediates Proteasome Inhibitor Resistance in Cancer Cells by Stabilizing NRF1
Q37536964O-linked N-acetylglucosamine transferase promotes cervical cancer tumorigenesis through human papillomaviruses E6 and E7 oncogenes
Q24339403On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex
Q38122565PBRM1 and BAP1 as novel targets for renal cell carcinoma
Q28510386PERIOD1-associated proteins modulate the negative limb of the mammalian circadian oscillator
Q24301870PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation
Q24338563PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression
Q24303480PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation
Q24305512PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex
Q33309162Pax7 activates myogenic genes by recruitment of a histone methyltransferase complex.
Q37161420Perichondrial expression of Wdr5 regulates chondrocyte proliferation and differentiation
Q90644667Physical and functional interaction between SET1/COMPASS complex component CFP-1 and a Sin3S HDAC complex in C. elegans
Q24305335Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF
Q48190662Pioneer factor Pax7 deploys a stable enhancer repertoire for specification of cell fate
Q37693066Pluripotency maintenance mechanism of embryonic stem cells and reprogramming
Q33920032Polycomb and trithorax opposition in development and disease
Q35035129Polycomb repressive complex 2 is necessary for the normal site-specific O-GlcNAc distribution in mouse embryonic stem cells
Q27936542Protein interactions within the Set1 complex and their roles in the regulation of histone 3 lysine 4 methylation
Q34752160Protein-arginine methyltransferase 1 (PRMT1) methylates Ash2L, a shared component of mammalian histone H3K4 methyltransferase complexes
Q27322397Proteolysis of HCF-1 by Ser/Thr glycosylation-incompetent O-GlcNAc transferase:UDP-GlcNAc complexes.
Q39756114Proteolytic processing is necessary to separate and ensure proper cell growth and cytokinesis functions of HCF-1
Q57293808Proteomic analysis of the OGT interactome: novel links to epithelial-mesenchymal transition and metastasis of cervical cancer
Q34416310Pygo2 associates with MLL2 histone methyltransferase and GCN5 histone acetyltransferase complexes to augment Wnt target gene expression and breast cancer stem-like cell expansion
Q40522106Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes
Q89136425ROS is the major player in regulating altered autophagy and lifespan in sin-3 mutants of C. elegans
Q34395567Rbm15-Mkl1 interacts with the Setd1b histone H3-Lys4 methyltransferase via a SPOC domain that is required for cytokine-independent proliferation
Q37333973Recruitment of the transcriptional coactivator HCF-1 to viral immediate-early promoters during initiation of reactivation from latency of herpes simplex virus type 1.
Q33836835Reduced genomic cytosine methylation and defective cellular differentiation in embryonic stem cells lacking CpG binding protein
Q35630571Regulation by polycomb and trithorax group proteins in Arabidopsis.
Q27316903Regulation of DCC localization by HTZ-1/H2A.Z and DPY-30 does not correlate with H3K4 methylation levels
Q24296408Regulation of HOXA2 gene expression by the ATP-dependent chromatin remodeling enzyme CHD8
Q29614518Regulation of MLL1 H3K4 methyltransferase activity by its core components
Q40261332Regulation of adeno-associated virus DNA replication by the cellular TAF-I/set complex
Q24594113Regulation of hepatic ApoC3 expression by PGC-1β mediates hypolipidemic effect of nicotinic acid
Q38028793Regulation of oncogene-induced cell cycle exit and senescence by chromatin modifiers
Q37334047Repression of ESR1 through actions of estrogen receptor alpha and Sin3A at the proximal promoter
Q24315991Repression of p53 activity by Smyd2-mediated methylation
Q33346968Role of chromatin during herpesvirus infections
Q38024616Role of host cell factor-1 in cell cycle regulation.
Q33528951Role of the HCF-1 basic region in sustaining cell proliferation
Q39019130Role of the histone H3 lysine 9 methyltransferase Suv39 h1 in maintaining Epsteinn-Barr virus latency in B95-8 cells
Q36138014Roles of a trithorax group gene, MLL, in hematopoiesis
Q35672331Roles of the nuclear lamina in stable nuclear association and assembly of a herpesviral transactivator complex on viral immediate-early genes
Q47096746Ronin Governs Early Heart Development by Controlling Core Gene Expression Programs
Q24336456Ronin is essential for embryogenesis and the pluripotency of mouse embryonic stem cells
Q24310032SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53
Q50287027SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4)
Q38306700SUMV-1 antagonizes the activity of synthetic multivulva genes in Caenorhabditis elegans
Q35964130Sin3: a flexible regulator of global gene expression and genome stability.
Q57050385Sin3A recruits Tet1 to the PAH1 domain via a highly conserved Sin3-Interaction Domain
Q34547044Site-specific proteolysis of the transcriptional coactivator HCF-1 can regulate its interaction with protein cofactors
Q34550834Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex
Q34315920Snapshots: chromatin control of viral infection
Q35543751Specific histone tail modification and not DNA methylation is a determinant of herpes simplex virus type 1 latent gene expression
Q27679498Structural Basis for WDR5 Interaction (Win) Motif Recognition in Human SET1 Family Histone Methyltransferases
Q40594716Survival motor neuron (SMN) protein interacts with transcription corepressor mSin3A.
Q34323801Systematic analysis of somatic mutations in phosphorylation signaling predicts novel cancer drivers
Q24312040TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS
Q36652895Targeting the JMJD2 histone demethylases to epigenetically control herpesvirus infection and reactivation from latency
Q24311695Tet proteins connect the O-linked N-acetylglucosamine transferase Ogt to chromatin in embryonic stem cells
Q34496129The BAP1/ASXL2 Histone H2A Deubiquitinase Complex Regulates Cell Proliferation and Is Disrupted in Cancer
Q38015891The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis
Q28757255The Drosophila cohesin subunit Rad21 is a trithorax group (trxG) protein
Q92538045The MLL1 trimeric catalytic complex is a dynamic conformational ensemble stabilized by multiple weak interactions
Q36745136The Proteomic Profile of Deleted in Breast Cancer 1 (DBC1) Interactions Points to a Multifaceted Regulation of Gene Expression
Q24301567The THAP-zinc finger protein THAP1 associates with coactivator HCF-1 and O-GlcNAc transferase: a link between DYT6 and DYT3 dystonias
Q24632245The Trithorax group protein Ash2l and Saf-A are recruited to the inactive X chromosome at the onset of stable X inactivation
Q35846187The coactivator host cell factor-1 mediates Set1 and MLL1 H3K4 trimethylation at herpesvirus immediate early promoters for initiation of infection
Q24323060The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1.
Q35018071The differential mobilization of histones H3.1 and H3.3 by herpes simplex virus 1 relates histone dynamics to the assembly of viral chromatin
Q34645506The direct interaction between ASH2, a Drosophila trithorax group protein, and SKTL, a nuclear phosphatidylinositol 4-phosphate 5-kinase, implies a role for phosphatidylinositol 4,5-bisphosphate in maintaining transcriptionally active chromatin
Q37015734The dynamics of HCF-1 modulation of herpes simplex virus chromatin during initiation of infection
Q28776149The essential WD repeat protein Swd2 has dual functions in RNA polymerase II transcription termination and lysine 4 methylation of histone H3
Q24337665The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO
Q34208918The herpes simplex virus VP16-induced complex: the makings of a regulatory switch
Q33625053The hexosamine signaling pathway: O-GlcNAc cycling in feast or famine
Q40549870The highly conserved region of the co-repressor Sin3A functionally interacts with the co-repressor Alien
Q41860564The latency-associated nuclear antigen interacts with MeCP2 and nucleosomes through separate domains
Q34683020The making of a sweet modification: structure and function of O-GlcNAc transferase.
Q43236176The metazoan ATAC and SAGA coactivator HAT complexes regulate different sets of inducible target genes
Q36579378The multiple faces of Set1.
Q34466767The neuronal host cell factor-binding protein Zhangfei inhibits herpes simplex virus replication
Q24557571The parafibromin tumor suppressor protein is part of a human Paf1 complex
Q24337692The polycomb group protein EZH2 is required for mammalian circadian clock function
Q38241688The potential role of O-GlcNAc modification in cancer epigenetics.
Q35046644The transcriptional co-regulator HCF-1 is required for INS-1 β-cell glucose-stimulated insulin secretion
Q24633127The ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY1 and HCF-1 and is a critical regulator of gene expression
Q35865320Transcription-coupled deposition of histone modifications during MHC class II gene activation
Q26996475Transcriptional co-repressors and memory storage
Q33603879Transcriptional coactivator HCF-1 couples the histone chaperone Asf1b to HSV-1 DNA replication components
Q28576674Transient reversal of episome silencing precedes VP16-dependent transcription during reactivation of latent HSV-1 in neurons
Q42063435Trimethylation of histone H3 lysine 4 by Set1 in the lytic infection of human herpes simplex virus 1.
Q36213044Undetectable histone O-GlcNAcylation in mammalian cells
Q36283485Unique Role of the WD-40 Repeat Protein 5 (WDR5) Subunit within the Mixed Lineage Leukemia 3 (MLL3) Histone Methyltransferase Complex
Q30426429WD repeat-containing protein 5, a ubiquitously expressed histone methyltransferase adaptor protein, regulates smooth muscle cell-selective gene activation through interaction with pituitary homeobox 2.
Q50287028WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4)
Q83859504Wdr5, a WD-40 protein, regulates osteoblast differentiation during embryonic bone development
Q24300306Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes
Q35884253Whole-genome sequencing reveals oncogenic mutations in mycosis fungoides
Q92099533Why are so many MLL lysine methyltransferases required for normal mammalian development?
Q34811661Zhangfei induces the expression of the nerve growth factor receptor, trkA, in medulloblastoma cells and causes their differentiation or apoptosis
Q24294669Zhangfei is a potent and specific inhibitor of the host cell factor-binding transcription factor Luman
Q36335746mSin3-associated protein, mSds3, is essential for pericentric heterochromatin formation and chromosome segregation in mammalian cells

Search more.