Expression of V642 APP mutant causes cellular apoptosis as Alzheimer trait-linked phenotype

scientific article

Expression of V642 APP mutant causes cellular apoptosis as Alzheimer trait-linked phenotype is …
instance of (P31):
scholarly articleQ13442814

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P932PMC publication ID449968
P698PubMed publication ID8599933

P2093author name stringMurayama Y
Takeda S
Okamoto T
Tanaka N
Nishimoto I
Yamatsuji T
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Reduced protein kinase C immunoreactivity and altered protein phosphorylation in Alzheimer's disease fibroblasts.Q53188448
An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.Q53207278
Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.Q53209417
Cell death in Alzheimer's disease evaluated by DNA fragmentation in situQ61709806
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Pertussis toxin suppresses long-term potentiation of hippocampal mossy fiber synapsesQ68493138
A pertussis toxin-sensitive G protein in hippocampal long-term potentiationQ69350059
Purification of the major GTP-binding proteins from human placental membranesQ70284484
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Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentationQ24642901
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beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activityQ28593175
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The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptorQ29618322
Localization of Alzheimer beta A4 amyloid precursor protein at central and peripheral synaptic sites.Q33298909
A Go-like protein in Drosophila melanogaster and its expression in memory mutantsQ33919591
Internal Ca2+ mobilization is altered in fibroblasts from patients with Alzheimer diseaseQ34982214
Molecular cloning and sequence determination of a cDNA coding for the alpha-subunit of a Go-type protein of Xenopus laevis oocytesQ35190251
Alterations in calcium content and biochemical processes in cultured skin fibroblasts from aged and Alzheimer donorsQ35601340
A simple and rapid method for detection of apoptosis in human cellsQ35931489
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Activating and inactivating mutations of the alpha subunit of Gi2 protein have opposite effects on proliferation of NIH 3T3 cellsQ37627890
Neuronal traits of clonal cell lines derived by fusion of dorsal root ganglia neurons with neuroblastoma cellsQ37689015
Activated mutants of the alpha subunit of G(o) promote an increased number of neurites per cell.Q38309402
A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowthQ38309410
Alzheimer amyloid protein precursor complexes with brain GTP-binding protein G(o)Q38321052
APP717 missense mutation affects the ratio of amyloid beta protein species (A beta 1-42/43 and a beta 1-40) in familial Alzheimer's disease brain.Q39507624
beta-Amyloid precursor protein metabolites and loss of neuronal Ca2+ homeostasis in Alzheimer's disease.Q40384274
G protein coupling to the thrombin receptor in Chinese hamster lung fibroblastsQ41480179
Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA.Q41577833
Alzheimer beta A4-amyloid protein precursor in immunocompetent cellsQ41593806
Protease inhibitors generate cytotoxic fragments from Alzheimer amyloid protein precursor in cDNA-transfected glioma cellsQ41602549
Cytosolic free calcium in lymphoblasts from young, aged and alzheimer subjectsQ41634523
Identification of the G-protein alpha-subunit encoded by alpha o2 cDNA as a 39 kDa pertussis toxin substrateQ41691087
Ligand-dependent G protein coupling function of amyloid transmembrane precursorQ42066774
Human 5-HT1A receptor expressed in insect cells activates endogenous G(o)-like G protein(s).Q42068600
Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185.Q42811529
Morphoregulatory activities of NCAM and N-cadherin can be accounted for by G protein-dependent activation of L- and N-type neuronal Ca2+ channelsQ42826381
Presence of three pertussis toxin substrates and Go alpha immunoreactivity in both plasma and granule membranes of chromaffin cellsQ44483294
The GTP-binding protein, Go, regulates neuronal calcium channelsQ44508440
Neural cell adhesion molecules influence second messenger systemsQ44943537
Decreased adhesiveness of Alzheimer's disease fibroblasts: is amyloid beta-protein precursor involved?Q45990148
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectAlzheimer's diseaseQ11081
phenotypeQ104053
P304page(s)498-509
P577publication date1996-02-01
P1433published inThe EMBO JournalQ1278554
P1476titleExpression of V642 APP mutant causes cellular apoptosis as Alzheimer trait-linked phenotype
P478volume15

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cites work (P2860)
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