scholarly article | Q13442814 |
P2093 | author name string | Murayama Y | |
Takeda S | |||
Okamoto T | |||
Tanaka N | |||
Nishimoto I | |||
Yamatsuji T | |||
P2860 | cites work | Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43). | Q48092766 |
Beta A4-amyloid protein precursor mRNA isoforms without exon 15 are ubiquitously expressed in rat tissues including brain, but not in neurons. | Q48189885 | ||
Mediation by G proteins of signals that cause collapse of growth cones | Q48365442 | ||
Degeneration in vitro of post-mitotic neurons overexpressing the Alzheimer amyloid protein precursor | Q48432892 | ||
Molecular and prospective phenotypic characterization of a pedigree with familial Alzheimer's disease and a missense mutation in codon 717 of the beta-amyloid precursor protein gene | Q48447843 | ||
Physical and immunological characterization of a guanine nucleotide-binding protein purified from bovine cerebral cortex. | Q48453829 | ||
The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth | Q48458288 | ||
Framing beta-amyloid | Q48464196 | ||
Developmental expression of Go in neuronal cultures from rat mesencephalon and hypothalamus | Q48964022 | ||
G0 is a major growth cone protein subject to regulation by GAP-43. | Q49017518 | ||
Reduced protein kinase C immunoreactivity and altered protein phosphorylation in Alzheimer's disease fibroblasts. | Q53188448 | ||
An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants. | Q53207278 | ||
Release of excess amyloid beta protein from a mutant amyloid beta protein precursor. | Q53209417 | ||
Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ | Q61709806 | ||
Expression of 'Alzheimer Antigens' in Cultured Skin Fibroblasts | Q67924870 | ||
Pertussis toxin suppresses long-term potentiation of hippocampal mossy fiber synapses | Q68493138 | ||
A pertussis toxin-sensitive G protein in hippocampal long-term potentiation | Q69350059 | ||
Purification of the major GTP-binding proteins from human placental membranes | Q70284484 | ||
Effects of chronic lithium treatment on platelet PKC isozymes in Alzheimer's and elderly control subjects | Q72277112 | ||
Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein | Q22251280 | ||
IL-8 induces the locomotion of human IL-2-activated natural killer cells. Involvement of a guanine nucleotide binding (Go) protein | Q24314320 | ||
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease | Q24316501 | ||
Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation | Q24642901 | ||
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease | Q28241772 | ||
Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene | Q28586800 | ||
beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity | Q28593175 | ||
Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3 | Q28645710 | ||
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor | Q29618322 | ||
Localization of Alzheimer beta A4 amyloid precursor protein at central and peripheral synaptic sites. | Q33298909 | ||
A Go-like protein in Drosophila melanogaster and its expression in memory mutants | Q33919591 | ||
Internal Ca2+ mobilization is altered in fibroblasts from patients with Alzheimer disease | Q34982214 | ||
Molecular cloning and sequence determination of a cDNA coding for the alpha-subunit of a Go-type protein of Xenopus laevis oocytes | Q35190251 | ||
Alterations in calcium content and biochemical processes in cultured skin fibroblasts from aged and Alzheimer donors | Q35601340 | ||
A simple and rapid method for detection of apoptosis in human cells | Q35931489 | ||
Mutational analysis of G protein alpha subunit G(o) alpha expressed in Escherichia coli | Q36774892 | ||
Activating and inactivating mutations of the alpha subunit of Gi2 protein have opposite effects on proliferation of NIH 3T3 cells | Q37627890 | ||
Neuronal traits of clonal cell lines derived by fusion of dorsal root ganglia neurons with neuroblastoma cells | Q37689015 | ||
Activated mutants of the alpha subunit of G(o) promote an increased number of neurites per cell. | Q38309402 | ||
A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth | Q38309410 | ||
Alzheimer amyloid protein precursor complexes with brain GTP-binding protein G(o) | Q38321052 | ||
APP717 missense mutation affects the ratio of amyloid beta protein species (A beta 1-42/43 and a beta 1-40) in familial Alzheimer's disease brain. | Q39507624 | ||
beta-Amyloid precursor protein metabolites and loss of neuronal Ca2+ homeostasis in Alzheimer's disease. | Q40384274 | ||
G protein coupling to the thrombin receptor in Chinese hamster lung fibroblasts | Q41480179 | ||
Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA. | Q41577833 | ||
Alzheimer beta A4-amyloid protein precursor in immunocompetent cells | Q41593806 | ||
Protease inhibitors generate cytotoxic fragments from Alzheimer amyloid protein precursor in cDNA-transfected glioma cells | Q41602549 | ||
Cytosolic free calcium in lymphoblasts from young, aged and alzheimer subjects | Q41634523 | ||
Identification of the G-protein alpha-subunit encoded by alpha o2 cDNA as a 39 kDa pertussis toxin substrate | Q41691087 | ||
Ligand-dependent G protein coupling function of amyloid transmembrane precursor | Q42066774 | ||
Human 5-HT1A receptor expressed in insect cells activates endogenous G(o)-like G protein(s). | Q42068600 | ||
Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185. | Q42811529 | ||
Morphoregulatory activities of NCAM and N-cadherin can be accounted for by G protein-dependent activation of L- and N-type neuronal Ca2+ channels | Q42826381 | ||
Presence of three pertussis toxin substrates and Go alpha immunoreactivity in both plasma and granule membranes of chromaffin cells | Q44483294 | ||
The GTP-binding protein, Go, regulates neuronal calcium channels | Q44508440 | ||
Neural cell adhesion molecules influence second messenger systems | Q44943537 | ||
Decreased adhesiveness of Alzheimer's disease fibroblasts: is amyloid beta-protein precursor involved? | Q45990148 | ||
P433 | issue | 3 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | Alzheimer's disease | Q11081 |
phenotype | Q104053 | ||
P304 | page(s) | 498-509 | |
P577 | publication date | 1996-02-01 | |
P1433 | published in | The EMBO Journal | Q1278554 |
P1476 | title | Expression of V642 APP mutant causes cellular apoptosis as Alzheimer trait-linked phenotype | |
P478 | volume | 15 |
Q26781496 | A Unified Hypothesis of Early- and Late-Onset Alzheimer's Disease Pathogenesis |
Q71786314 | Amyloid beta peptide of Alzheimer's disease downregulates Bcl-2 and upregulates bax expression in human neurons |
Q27012950 | Amyloid β precursor protein as a molecular target for amyloid β--induced neuronal degeneration in Alzheimer's disease |
Q33764574 | Coeloglossum viride var. bracteatum extract protects against amyloid toxicity in rat prefrontal cortex neurons |
Q41702482 | Detection of actin cleavage in Alzheimer's disease. |
Q37554874 | Establishment of a cell-free system of neuronal apoptosis: comparison of premitochondrial, mitochondrial, and postmitochondrial phases |
Q34545392 | Familial amyloid precursor protein mutants cause caspase-6-dependent but amyloid β-peptide-independent neuronal degeneration in primary human neuron cultures |
Q33887261 | G protein betagamma complex-mediated apoptosis by familial Alzheimer's disease mutant of APP. |
Q64092628 | G-Protein Coupled Receptors in the Aging Brain |
Q33588353 | Genetic risk factors in Alzheimer's disease |
Q36588392 | Humanin and colivelin: neuronal-death-suppressing peptides for Alzheimer's disease and amyotrophic lateral sclerosis |
Q40821287 | Insulin-like growth factor I (IGF-I) protects cells from apoptosis by Alzheimer's V642I mutant amyloid precursor protein through IGF-I receptor in an IGF-binding protein-sensitive manner. |
Q36110179 | Intracellular and secreted Alzheimer beta-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons |
Q35904068 | Intrinsic signaling function of APP as a novel target of three V642 mutations linked to familial Alzheimer's disease. |
Q33721127 | Molecular mechanisms of go signaling |
Q41065074 | Negative transactivation of cAMP response element by familial Alzheimer's mutants of APP. |
Q39248412 | Neuronal cell death in Alzheimer's disease and a neuroprotective factor, humanin |
Q48346669 | Overexpression in neurons of human presenilin-1 or a presenilin-1 familial Alzheimer disease mutant does not enhance apoptosis. |
Q44023815 | Reduction of trophic support enhances apoptosis in PC12 cells expressing Alzheimer's APP mutation and sensitizes cells to staurosporine-induced cell death |
Q39135552 | Role of APP Interactions with Heterotrimeric G Proteins: Physiological Functions and Pathological Consequences |
Q26799258 | The endocrine dyscrasia that accompanies menopause and andropause induces aberrant cell cycle signaling that triggers re-entry of post-mitotic neurons into the cell cycle, neurodysfunction, neurodegeneration and cognitive disease |
Q36202122 | The gonadotropin connection in Alzheimer's disease |
Q24338342 | Transforming growth factor beta2 is a neuronal death-inducing ligand for amyloid-beta precursor protein |
Q36400886 | Wild-type but not Alzheimer-mutant amyloid precursor protein confers resistance against p53-mediated apoptosis |
Q24291602 | c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK |