A Phase Ib Dose-Escalation Study of the Safety, Tolerability, and Pharmacokinetics of Cobimetinib and Duligotuzumab in Patients with Previously Treated Locally Advanced or Metastatic Cancers with Mutant KRAS

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A Phase Ib Dose-Escalation Study of the Safety, Tolerability, and Pharmacokinetics of Cobimetinib and Duligotuzumab in Patients with Previously Treated Locally Advanced or Metastatic Cancers with Mutant KRAS is …
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scholarly articleQ13442814

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P356DOI10.1634/THEONCOLOGIST.2017-0175
P932PMC publication ID5599193
P698PubMed publication ID28592615

P50authorJosep Tabernero CaturlaQ37387600
P2093author name stringAndrew H Ko
S Gail Eckhardt
Andrea Pirzkall
Manuel Hidalgo
Patricia LoRusso
David E Gerber
Jordan D Berlin
Christopher H Lieu
Andres Cervantes
Bruce McCall
J Paul Eder
Amy V Kapp
Anne Uyei
Amy Tsuhako
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Oncogenic and wild-type Ras play divergent roles in the regulation of mitogen-activated protein kinase signalingQ39252593
MEK inhibition leads to PI3K/AKT activation by relieving a negative feedback on ERBB receptorsQ39355055
Somatic activation of the K-ras oncogene causes early onset lung cancer in miceQ40809826
ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylationQ24621754
Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3Q24633878
Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3Q27646596
Intrinsic resistance to MEK inhibition in KRAS mutant lung and colon cancer through transcriptional induction of ERBB3.Q27852991
The cellular response to neuregulins is governed by complex interactions of the erbB receptor familyQ28609130
Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactionsQ28609149
EGFR antagonists in cancer treatmentQ29616740
Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancerQ29618030
The HER family and cancer: emerging molecular mechanisms and therapeutic targetsQ34558080
Targeting the function of the HER2 oncogene in human cancer therapeuticsQ34766486
The ErbB receptors and their role in cancer progression.Q35089324
Oncogenic KRAS-induced epiregulin overexpression contributes to aggressive phenotype and is a promising therapeutic target in non-small-cell lung cancerQ35671281
Synergistic effect between erlotinib and MEK inhibitors in KRAS wild-type human pancreatic cancer cellsQ35691935
Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibitionQ37331610
P433issue9
P407language of work or nameEnglishQ1860
P304page(s)1024-e89
P577publication date2017-06-07
P1433published inOncologistQ2122327
P1476titleA Phase Ib Dose-Escalation Study of the Safety, Tolerability, and Pharmacokinetics of Cobimetinib and Duligotuzumab in Patients with Previously Treated Locally Advanced or Metastatic Cancers with Mutant KRAS
P478volume22

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Q97525750Anti-EGFR therapy in metastatic colorectal cancer: mechanisms and potential regimens of drug resistance
Q64899982HER3 signaling and targeted therapy in cancer.
Q47318847MEK inhibitors under development for treatment of non-small-cell lung cancer

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