Molecular basis of polymorphic drug metabolism

scientific article published on November 1995

Molecular basis of polymorphic drug metabolism is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1007/BF00195139
P698PubMed publication ID8751138

P2093author name stringA K Daly
P2860cites workThe GSTM1 null genotype as a potential risk modifier for squamous cell carcinoma of the lungQ72828860
Cytochrome P450 enzymes involved in acetaminophen activation by rat and human liver microsomes and their kineticsQ72927887
Metabolism of isoniazid in man as related to the occurrence of peripheral neuritisQ73554499
Pharmacogenetics of alcohol metabolism and alcoholismQ22242782
Cloning and sequence determination of a complementary DNA related to human liver microsomal cytochrome P-450 S-mephenytoin 4-hydroxylaseQ22254865
Genetic polymorphism of human cytochrome P-450 (S)-mephenytoin 4-hydroxylase. Studies with human autoantibodies suggest a functionally altered cytochrome P-450 isozyme as cause of the genetic deficiencyQ24298532
Human liver dehydroepiandrosterone sulfotransferase: molecular cloning and expression of cDNAQ24301890
Human microsomal epoxide hydrolase: genetic polymorphism and functional expression in vitro of amino acid variantsQ24305540
Human liver estrogen sulfotransferase: identification by cDNA cloning and expressionQ24314381
Evidence that CYP2C19 is the major (S)-mephenytoin 4'-hydroxylase in humansQ24323988
Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylaminesQ24339615
Human cytochrome P-450 PB-1: a multigene family involved in mephenytoin and steroid oxidations that maps to chromosome 10Q24339638
A single point mutation leading to loss of catalytic activity in human thiopurine S-methyltransferaseQ24563229
cDNA and amino acid sequences of two members of the human P450IIC gene subfamilyQ24631075
A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 allelesQ24672583
Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activityQ24674721
Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of [...]Q28115162
Relationship between the GSTM1 genetic polymorphism and susceptibility to bladder, breast and colon cancerQ28118282
Denitrosation of 1,3-bis(2-chloroethyl)-1-nitrosourea by class mu glutathione transferases and its role in cellular resistance in rat brain tumor cellsQ41307358
Inheritance of human platelet thermolabile phenol sulfotransferase (TL PST) activityQ41395094
Genetic predisposition to bladder cancer: ability to hydroxylate debrisoquine and mephenytoin as risk factorsQ41463151
Site-directed mutation studies of human liver cytochrome P-450 isoenzymes in the CYP2C subfamilyQ41578273
Tolbutamide and mephenytoin hydroxylation by human cytochrome P450s in the CYP2C subfamilyQ41750193
Genotyping for polymorphisms in xenobiotic metabolism as a predictor of disease susceptibility.Q41828306
The human phenolsulphotransferase polymorphism is determined by the level of expression of the enzyme proteinQ41839923
Variability of acetaminophen metabolism in Caucasians and OrientalsQ42025095
Use of caffeine metabolite ratios to explore CYP1A2 and xanthine oxidase activitiesQ42052805
Dihydropyrimidine dehydrogenase deficiency leading to thymine-uraciluria. An inborn error of pyrimidine metabolismQ42250456
Simple and reliable CYP1A2 phenotyping by the paraxanthine/caffeine ratio in plasma and in saliva.Q42281878
Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation.Q42694246
Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphismQ42834608
Clozapine disposition covaries with CYP1A2 activity determined by a caffeine testQ43201721
Pharmacogenetics of acute azathioprine toxicity: relationship to thiopurine methyltransferase genetic polymorphismQ43531554
Association between Restriction Fragment Length Polymorphism of the Human Cytochrome P450IIE1 Gene and Susceptibility to Lung CancerQ43904565
Chlorzoxazone is metabolized by human CYP1A2 as well as by human CYP2E1.Q43927814
Debrisoquine/sparteine hydroxylation genotype and phenotype: analysis of common mutations and alleles of CYP2D6 in a European populationQ44115646
Cytochrome P450IIE1 genetic polymorphisms, racial variation, and lung cancer riskQ44293824
A glutathione transferase in human leukocytes as a marker for the susceptibility to lung cancerQ44629192
Ethnic distribution of the glutathione transferase Mu 1-1 (GSTM1) null genotype in 1473 individuals and application to bladder cancer susceptibilityQ44696853
Altered mercaptopurine metabolism, toxic effects, and dosage requirement in a thiopurine methyltransferase-deficient child with acute lymphocytic leukemiaQ44917795
Polymorphism of glutathione S-transferase M1 and lung cancer risk among African-Americans and Caucasians in Los Angeles County, California.Q46049355
Identification of the primary gene defect at the cytochrome P450 CYP2D locusQ48250898
The molecular basis of the human serum paraoxonase activity polymorphism.Q52542904
Glutathione S-transferase M1 and its variants A and B as host factors of bladder cancer susceptibility: a case-control study.Q53016262
Increase of cytochrome P450IA2 activity by omeprazole: evidence by the 13C-[N-3-methyl]-caffeine breath test in poor and extensive metabolizers of S-mephenytoinQ53025508
Human polymorphism in drug metabolism: mutation in the dihydropyrimidine dehydrogenase gene results in exon skipping and thymine uracilurea.Q53467377
Genetic susceptibility to lung cancer with special emphasis on CYP1A1 and GSTM1: a study on host factors in relation to age at onset, gender and histological cancer types.Q53470242
Lung cancer risk of GSTM1 null genotype is dependent on the extent of tobacco smoke exposure.Q53474186
Evidence for a new variant CYP2D6 allele CYP2D6J in a Japanese population associated with lower in vivo rates of sparteine metabolism.Q53477786
Human glutathione S-transferase mu (GST mu) deficiency as a marker for the susceptibility to bladder and larynx cancer among smokers.Q53482957
Relationship between the debrisoquine hydroxylase polymorphism and cancer susceptibility.Q53489724
Determination of CYP1A2 and NAT2 phenotypes in human populations by analysis of caffeine urinary metabolites.Q53490047
Glutathione S-transferase and epoxide hydrolase activity in human leukocytes in relation to risk of lung cancer and other smoking-related cancersQ53491507
Glutathione S-transferase mu locus: use of genotyping and phenotyping assays to assess association with lung cancer susceptibility.Q53496846
Aryl hydrocarbon hydroxylase inducibility and bronchogenic carcinoma.Q54216734
High susceptibility to lung cancer analyzed in terms of combined genotypes of P450IA1 and Mu-class glutathione S-transferase genesQ54985963
Urinary glucuronide excretion of fenofibric and clofibric acid glucuronides in man. Is it polymorphic?Q57997223
Metabolic oxidation phenotypes as markers for susceptibility to lung cancerQ59082319
Expression of Cytochrome-P450-3A5 in Escherichia Coli: Effects of 5′ Modification, Purification, Spectral Characterization, Reconstitution Conditions, and Catalytic ActivitiesQ59153257
A multifamily study on the relationship between CYP2C19 genotype and S-mephenytoin oxidation phenotypeQ60705920
An inactive cytochrome P450 CYP2D6 allele containing a deletion and a base substitutionQ63241981
Mutant debrisoquine hydroxylation genes in Parkinson's diseaseQ63241990
Correlation between dihydropyrimidine dehydrogenase activity in peripheral mononuclear cells and systemic clearance of fluorouracil in cancer patientsQ64916964
Pharmacogenetics of tolbutamide metabolism in humansQ67017361
Positive correlation between high aryl hydrocarbon hydroxylase activity and primary lung cancer as analyzed in cryopreserved lymphocytesQ67232854
Debrisoquine hydroxylase gene polymorphism and susceptibility to Parkinson's diseaseQ67516972
Racial and gender differences in N-acetyltransferase, xanthine oxidase, and CYP1A2 activitiesQ67599101
Genetic and metabolic criteria for the assignment of debrisoquine 4-hydroxylation (cytochrome P4502D6) phenotypesQ67652737
Identification of the “major” polymorphic carbocysteine metabolite as S-(carboxymethylthio)-l-cysteineQ67758541
Point-mutational MspI and Ile-Val polymorphisms closely linked in the CYP1A1 gene: lack of association with susceptibility to lung cancer in a Finnish study populationQ67809023
Interindividual variability of coumarin 7-hydroxylation in healthy volunteersQ67837226
Structure of human estrogen and aryl sulfotransferase gene. Two mRNA species issued from a single geneQ28240889
Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in JapaneseQ28241420
Selective expression of cytochrome P450 CYP3A mRNAs in embryonic and adult human liverQ28243581
The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humansQ28254348
Dihydropyrimidine dehydrogenase activity in human peripheral blood mononuclear cells and liver: population characteristics, newly identified deficient patients, and clinical implication in 5-fluorouracil chemotherapyQ28255501
Identification of an A-to-G missense mutation in exon 2 of the UGT1 gene complex that causes Crigler-Najjar syndrome type 2Q28258092
Identification of two human brain aryl sulfotransferase cDNAsQ28262159
Sequence analysis and expression of the cDNA for the phenol-sulfating form of human liver phenol sulfotransferaseQ28265524
Molecular characterisation of a human aryl sulfotransferase cDNAQ28268657
N-acetyltransferaseQ28270778
Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamilyQ28271091
The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomesQ28281124
Mechanisms of inherited deficiencies of multiple UDP‐glucuronosyltransferase isoforms in two patients with Crigler‐Najjar syndrome, type IQ28286095
Primary structures and properties of two related forms of aryl sulfotransferases in human liverQ28290822
Human Platelet Phenolsulfotransferases: cDNA Cloning, Stable Expression in V79 Cells, and Identification of a Novel Allelic Variant of the Phenol-Sulfating FormQ28298682
Polymerase chain reaction-directed identification, cloning, and quantification of human CYP2C18 mRNAQ28299067
Biochemistry and molecular biology of the human CYP2C subfamilyQ28299258
The molecular biology of the flavin-containing monooxygenases of manQ28300051
Nomenclature for N-acetyltransferasesQ28302652
Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspectsQ28322217
Decreased glucuronidation and increased bioactivation of acetaminophen in Gilbert's syndromeQ28324425
Genetic variants of human serum cholinesterase influence metabolism of the muscle relaxant succinylcholineQ28331073
Tolbutamide and phenytoin hydroxylations by cDNA-expressed human liver cytochrome P4502C9Q28335592
Impaired oxidation of debrisoquine in patients with perhexiline neuropathyQ28366143
Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquineQ28609999
Biochemistry and genetics of monoamine oxidaseQ30420505
Homozygous deletion of gene for glutathione S-transferase M1 in bladder cancer.Q30445553
Sequence of exons and the flanking regions of human bilirubin-UDP-glucuronosyltransferase gene complex and identification of a genetic mutation in a patient with Crigler-Najjar syndrome, type IQ31145683
Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphismQ33245041
Genetic Linkage of Lung Cancer-Associated MspI Polymorphisms with Amino Acid Replacement in the Heme Binding Region of the Human Cytochrome P450IA1 Gene1Q33269439
Heterologous expression of the allelic variant mu-class glutathione transferases mu and psi.Q33583775
Genetic basis for a lower prevalence of deficient CYP2D6 oxidative drug metabolism phenotypes in black AmericansQ33899650
Genetic polymorphism for human platelet thermostable phenol sulfotransferase (TS PST) activityQ33955645
Identification of a new variant CYP2D6 allele lacking the codon encoding Lys-281: possible association with the poor metabolizer phenotypeQ67911285
Paradoxical relationship between acetylator phenotype and amonafide toxicityQ68034189
Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemiaQ68092294
Comparison of a novel thin-layer chromatographic-fluorescence detection method with a spectrofluorometric method for the determination of 7-hydroxycoumarin in human urineQ68204605
Differences in metabolism of sulfonamides predisposing to idiosyncratic toxicityQ69562919
Polymorphism of propafenone metabolism and disposition in man: clinical and pharmacokinetic consequencesQ69783205
The human serum paraoxonase/arylesterase polymorphismQ69836522
Correlation of human cytochrome P4502C substrate specificities with primary structure: warfarin as a probeQ70552798
Genotype and phenotype of glutathione S-transferase class mu isoenzymes mu and psi in lung cancer patients and controlsQ70577046
Structural heterogeneity of Caucasian N-acetyltransferase at the NAT1 gene locusQ70583957
The glutathione S-transferase mu polymorphism as a marker for susceptibility to lung carcinomaQ70691847
Characterization of a common genetic defect of cytochrome P-450 function (debrisoquine-sparteine type polymorphism)--increased Michaelis is Constant (Km) and loss of stereoselectivity of bufuralol 1'-hydroxylation in poor metabolizersQ70702408
Major pathway of imipramine metabolism is catalyzed by cytochromes P-450 1A2 and P-450 3A4 in human liverQ70738005
Tolbutamide hydroxylation in humans: lack of bimodality in 106 healthy subjectsQ70780403
A novel CYP2D6 allele with an abolished splice recognition site associated with the poor metabolizer phenotypeQ70905284
Deficient metabolism of debrisoquine and sparteineQ71141001
Variation in human metabolism of S-carboxymethylcysteineQ71238173
An efficient strategy for detection of known and new mutations of the CYP2D6 gene using single strand conformation polymorphism analysisQ71365940
Both cytochromes P450 2E1 and 1A1 are involved in the metabolism of chlorzoxazoneQ71612339
Polymorphisms of human Ah receptor gene are not involved in lung cancerQ71721217
Methylation of mercaptopurine, thioguanine, and their nucleotide metabolites by heterologously expressed human thiopurine S-methyltransferaseQ71852856
Ultrarapid hydroxylation of debrisoquine in a Swedish population. Analysis of the molecular genetic basisQ71895813
Selectivity of cytochrome P4502E1 in chlorzoxazone 6-hydroxylationQ71940148
Impaired (S)-warfarin metabolism catalysed by the R144C allelic variant of CYP2C9Q71996232
Prevalence of CYP2D6 gene duplication and its repercussion on the oxidative phenotype in a white populationQ72113258
Genotyping of the CYP2D6 gene in Norwegian lung cancer patients and controlsQ72176950
Molecular basis for rational megaprescribing in ultrarapid hydroxylators of debrisoquineQ72207766
Azathioprine-induced myelosuppression in thiopurine methyltransferase deficient heart transplant recipientQ72209986
Molecular basis of genetic variation in debrisoquin hydroxylation in Chinese subjects: polymorphism in RFLP and DNA sequence of CYP2D6Q72216677
Detection of CYP2C9 polymorphism based on the polymerase chain reaction in ChineseQ72293605
Lack of a genetic polymorphism in the glucuronidation of fenofibric acidQ72293610
Studies on interindividual variations of CYP2E1 using chlorzoxazone as an in vivo probeQ72293614
Interindividual variability of chlorzoxazone 6-hydroxylation in men and women and its relationship to CYP2E1 genetic polymorphismsQ72313196
Characterization of the enzyme responsible for the metabolism of sumatriptan in human liverQ72371152
A missense mutation in exon 6 of the CYP2D6 gene leading to a histidine 324 to proline exchange is associated with the poor metabolizer phenotype of sparteineQ72519987
Isolation and characterization of human liver cytochrome P450 2C19: correlation between 2C19 and S-mephenytoin 4'-hydroxylationQ72545136
Individual variability in p-aminobenzoic acid N-acetylation by human N-acetyltransferase (NAT1) of peripheral bloodQ72556670
Human liver dehydroepiandrosterone sulfotransferase: nature and extent of individual variationQ72561475
A phenylalanine codon deletion at the UGT1 gene complex locus of a Crigler-Najjar type I patient generates a pH-sensitive bilirubin UDP-glucuronosyltransferaseQ72571462
Cloning and sequencing of a new non-functional CYP2D6 allele: deletion of T1795 in exon 3 generates a premature stop codonQ72640324
Beneficial effects of conversion from cyclosporin to azathioprine after kidney transplantationQ72648752
Phenotyping of CYP1A2 in Japanese population by analysis of caffeine urinary metabolites: absence of mutation prescribing the phenotype in the CYP1A2 geneQ72701476
Relationship in healthy subjects between CYP2E1 genetic polymorphisms and the 6-hydroxylation of chlorzoxazone: a putative measure of CYP2E1 activityQ72703173
Acetylator phenotyping: the urinary caffeine metabolite ratio in slow acetylators correlates with a marker of systemic NAT1 activityQ72703179
Identification of a new variant CYP2D6 allele with a single base deletion in exon 3 and its association with the poor metabolizer phenotypeQ72781679
Polymorphisms of the CYP1A1 and glutathione S-transferase genes associated with susceptibility to lung cancer in relation to cigarette dose in a Japanese populationQ72800543
Defective N-oxidation of sparteine in man: A new pharmacogenetic defectQ34053243
Polymorphic hydroxylation of Debrisoquine in man.Q34057031
Noninvasive tests of CYP3A enzymesQ34059919
Multiple mutations of the human cytochrome P450IID6 gene (CYP2D6) in poor metabolizers of debrisoquine. Study of the functional significance of individual mutations by expression of chimeric genesQ34083456
Identification of two single base substitutions in the UGT1 gene locus which abolish bilirubin uridine diphosphate glucuronosyltransferase activity in vitroQ34124730
Codeine increases pain thresholds to copper vapor laser stimuli in extensive but not poor metabolizers of sparteine.Q34228651
The clinical pharmacology of 6-mercaptopurineQ34265967
Existence of multiple forms of microsomal epoxide hydrolases with radically different substrate specificitiesQ34266391
Human dehydroepiandrosterone sulfotransferase gene: molecular cloning and structural characterizationQ34308132
Characterization of the microsomal epoxide hydrolase gene in patients with anticonvulsant adverse drug reactionsQ34323071
Patient-controlled analgesia (PCA) with codeine for postoperative pain relief in ten extensive metabolisers and one poor metaboliser of dextromethorphanQ34346859
Caffeine as a metabolic probe: a comparison of the metabolic ratios used to assess CYP1A2 activityQ34346940
A comparison of the pharmacokinetics of codeine and its metabolites in healthy Chinese and Caucasian extensive hydroxylators of debrisoquineQ34358854
The activation of the biguanide antimalarial proguanil co-segregates with the mephenytoin oxidation polymorphism--a panel studyQ34358893
Interindividual variability in the N-sulphation of desipramine in human liver and plateletsQ34402512
Genetic and environmental factors that regulate cytosolic epoxide hydrolase activity in normal human lymphocytesQ34580452
Genetic Polymorphisms in the 5′-Flanking Region Change Transcriptional Regulation of the Human Cytochrome P450IIE1 Gene1Q34677484
A Taq I polymorphism in the human P450IIE1 gene on chromosome 10 (CYP2E).Q34729809
Cosegregation of intragenic markers with a novel mutation that causes Crigler-Najjar syndrome type I: implication in carrier detection and prenatal diagnosisQ35195055
The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogeneQ35197475
The human CYP2D locus associated with a common genetic defect in drug oxidation: a G1934----A base change in intron 3 of a mutant CYP2D6 allele results in an aberrant 3' splice recognition siteQ35198610
The role of individual human cytochromes P450 in drug metabolism and clinical responseQ35206070
The novel bilirubin/phenol UDP-glucuronosyltransferase UGT1 gene locus: implications for multiple nonhemolytic familial hyperbilirubinemia phenotypesQ35223429
Identification of a genetic alteration in the code for bilirubin UDP-glucuronosyltransferase in the UGT1 gene complex of a Crigler-Najjar type I patientQ35603726
Expression of a human liver cytochrome P-450 protein with tolbutamide hydroxylase activity in Saccharomyces cerevisiaeQ35877286
Metabolic polymorphisms affecting activation of toxic and mutagenic arylaminesQ36327595
Nucleotide sequence of a human liver cytochrome P-450 related to the rat male specific formQ36420938
Altered coding for a strictly conserved di-glycine in the major bilirubin UDP-glucuronosyltransferase of a Crigler-Najjar type I patientQ36715577
Drug glucuronidation in humansQ36964610
Genetic heterogeneity of the human glutathione transferases: a complex of gene familiesQ37789537
Phenytoin: pharmacogenetic polymorphism of 4'-hydroxylationQ37924759
Sulfotransferase pharmacogeneticsQ38140212
Genetic polymorphism of trimethylamine N-oxidationQ38140229
UDP-glucuronosyltransferasesQ38234360
DNA haplotype-dependent differences in the amino acid sequence of debrisoquine 4-hydroxylase (CYP2D6): evidence for two major allozymes in extensive metabolisersQ38303763
Genetic polymorphism of S-mephenytoin hydroxylationQ38692055
Methyltransferase pharmacogeneticsQ38692057
An updated review of the clinical development of coumarin (1,2-benzopyrone) and 7-hydroxycoumarinQ39398936
Glutathione transferases--structure and catalytic activityQ39566893
Molybdenum hydroxylases as drug-metabolizing enzymesQ39834873
Polymorphic forms of the Ah receptor and induction of the CYP1A1 geneQ40426578
Potential importance of dihydropyrimidine dehydrogenase (DPD) in cancer chemotherapy.Q40498861
Mspl polymorphism of the human CYP2E geneQ40508074
An XmnI RFLP detected with a probe for the CYP2E gene locus on chromosome 10.Q40517031
GST1 gene deletion determined by polymerase chain reactionQ40517842
Genetically variable metabolism of antidepressants and neuroleptic drugs in man.Q40710734
Pharmacogenetic phenotyping and genotyping. Present status and future potential.Q40730354
Metabolic polymorphismsQ40840745
Biotransformation of caffeine and theophylline in mammalian cell lines genetically engineered for expression of single cytochrome P450 isoforms.Q41142887
Genetic risk and carcinogen exposure: a common inherited defect of the carcinogen-metabolism gene glutathione S-transferase M1 (GSTM1) that increases susceptibility to bladder cancerQ72804213
P433issue11
P304page(s)539-553
P577publication date1995-11-01
P1433published inJournal of Molecular MedicineQ6295593
P1476titleMolecular basis of polymorphic drug metabolism
P478volume73

Reverse relations

cites work (P2860)
Q343884721998 ASHG presidential address. Making genomic medicine a reality
Q573028083 The pharmacology of the cytochrome P450 enzyme system
Q38357424Biotransformation of xenobiotics in the human colon and rectum and its association with colorectal cancer
Q38496627CYP2D6 genetic polymorphisms and their relevance for poisoning due to amfetamines, opioid analgesics and antidepressants
Q47655039Cytochrome p450 1Al gene polymorphisms in patients with psoriatic arthritis
Q40504499Dapsone-induced agranulocytosis. The role of xenobiotic-metabolizing enzymes demonstrated by a case report
Q35876954Differences in drug pharmacokinetics between East Asians and Caucasians and the role of genetic polymorphisms
Q44600103Does the CYP3A5*3 polymorphism affect in vivo drug elimination?
Q34424230Enzymatic Mechanisms Involved in Phenanthrene Degradation by the White Rot Fungus Pleurotus ostreatus
Q37326678Expression of CYP2A6, CYP2D6 and CYP4A11 Polymorphisms in COS7 Mammalian Cell Line.
Q34207652Genetic clues to the molecular basis of tobacco addiction and progress towards personalized therapy
Q37775981Genetic polymorphism in metabolism and host defense enzymes: implications for human health risk assessment
Q81543852Genetic polymorphism of CYP2C19 in Maharashtrian population
Q43949916Genetic polymorphism of cytochrome P450 1A1 (Cyp1A1) and glutathione transferases (M1, T1 and P1) among Africans
Q44801583Genetic polymorphism of cytochrome P450 2C9 in diphenylhydantoin-induced cutaneous adverse drug reactions
Q74549948Genetic polymorphism of drug metabolizing enzymes: new mutations in CYP2D6 and CYP2A6 genes in Japanese
Q35753607Genetic polymorphisms of cytochrome P450 enzymes and the effect on interindividual, pharmacokinetic variability in extensive metabolizers
Q33538523Genetic polymorphisms of human N-acetyltransferase, cytochrome P450, glutathione-S-transferase, and epoxide hydrolase enzymes: relevance to xenobiotic metabolism and toxicity
Q34093093How to manage individualized drug therapy: application of pharmacogenetic knowledge of drug metabolism and transport.
Q34936720Immune-mediated drug-induced liver disease
Q33555327Investigating the Role of Plasma Glucose Concentration as a Phenotypic Marker for CYP2C9 Genetic Variants, in the Diabetic Population of Gujarat
Q57445890Making drug discovery a SN(i)P
Q43710026Manganese superoxide dismutase and cytochrome P450 1A1 genes polymorphisms in rheumatoid arthritis in Taiwan
Q33941950Pharmacogenetic screening for susceptibility to fetal malformations in women
Q73798847Pharmacogenetics and drug metabolism
Q33781271Pharmacogenetics of cytochromes P450.
Q28210286Pharmacogenomics: the promise of personalized medicine
Q34331552Polymorphic cytochrome P450 2D6: humanized mouse model and endogenous substrates.
Q33533986Recent advances in understanding the molecular basis of polymorphisms in genes encoding cytochrome P450 enzymes.
Q26781923Stem Cell Strategies to Evaluate Idiosyncratic Drug-induced Liver Injury
Q32103802Summary of information on human CYP enzymes: human P450 metabolism data
Q55474895The effect of anticonvulsant drugs on blood levels of methotrexate.
Q34232382The use of gene knockout mice to unravel the mechanisms of toxicity and chemical carcinogenesis
Q41877081Traditional Medicine to Modern Pharmacogenomics: Ayurveda Prakriti Type and CYP2C19 Gene Polymorphism Associated with the Metabolic Variability
Q34311096Understanding the interaction between environmental exposures and molecular events in colorectal carcinogenesis

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