Crystal structure of a low molecular weight activator Blm-pep with yeast 20S proteasome - insights into the enzyme activation mechanism

scientific article published on 21 July 2017

Crystal structure of a low molecular weight activator Blm-pep with yeast 20S proteasome - insights into the enzyme activation mechanism is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1090754894
P356DOI10.1038/S41598-017-05997-4
P932PMC publication ID5522460
P698PubMed publication ID28733623

P50authorPrzemyslaw GrudnikQ56863430
Julia WitkowskaQ59681993
Artur GieldonQ63388253
Elzbieta JankowskaQ64006727
Przemyslaw KarpowiczQ84315116
Grzegorz DubinQ40717413
P2093author name stringMałgorzata Giżyńska
Przemysław Golik
P2860cites workXDSAPP: a graphical user interface for the convenient processing of diffraction data usingXDSQ57973386
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Interactions of PAN's C-termini with archaeal 20S proteasome and implications for the eukaryotic proteasome–ATPase interactionsQ27646619
Structural Models for Interactions between the 20S Proteasome and Its PAN/19S ActivatorsQ27658058
Structure of a Blm10 Complex Reveals Common Mechanisms for Proteasome Binding and Gate OpeningQ27660222
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The Amber biomolecular simulation programsQ27860745
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Free R value: a novel statistical quantity for assessing the accuracy of crystal structuresQ27860894
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Proteasome activation is a mechanism for pyrazolone small molecules displaying therapeutic potential in amyotrophic lateral sclerosisQ34249469
The axial channel of the 20S proteasome opens upon binding of the PA200 activatorQ34555139
Interplay between Structure and Charge as a Key to Allosteric Modulation of Human 20S Proteasome by the Basic Fragment of HIV-1 Tat ProteinQ35843506
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Purification of large cytosolic proteases for in vitro assays: 20S and 26S proteasomesQ44249587
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)6177
P577publication date2017-07-21
P1433published inScientific ReportsQ2261792
P1476titleCrystal structure of a low molecular weight activator Blm-pep with yeast 20S proteasome - insights into the enzyme activation mechanism
P478volume7

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cites work (P2860)
Q64096816A Practical Review of Proteasome Pharmacology
Q91659959Aim for the core: suitability of the ubiquitin-independent 20S proteasome as a drug target in neurodegeneration
Q90700693All About the Core: A Therapeutic Strategy to Prevent Protein Accumulation with Proteasome Core Particle Stimulators
Q93273338Comparative Structural Analysis of 20S Proteasome Ortholog Protein Complexes by Native Mass Spectrometry
Q93210381Proline- and Arginine-Rich Peptides as Flexible Allosteric Modulators of Human Proteasome Activity
Q92923068Proteasomes and Several Aspects of Their Heterogeneity Relevant to Cancer
Q91663542Pyrazolones Activate the Proteasome by Gating Mechanisms and Protect Neuronal Cells from β-Amyloid Toxicity
Q95650650The proteasome as a druggable target with multiple therapeutic potentialities: Cutting and non-cutting edges

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