Human immunodeficiency virus type 1 Nef protein on the cell surface is cytocidal for human CD4+ T cells

scientific article published on September 1996

Human immunodeficiency virus type 1 Nef protein on the cell surface is cytocidal for human CD4+ T cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/0014-5793(96)00862-9
P698PubMed publication ID8804435
P5875ResearchGate publication ID14401158

P2093author name stringFujii Y
Adachi A
Tashiro M
Otake K
P2860cites workIsolation of a T-Lymphotropic Retrovirus from a Patient at Risk for Acquired Immune Deficiency Syndrome (AIDS)Q22242256
Lipofection: a highly efficient, lipid-mediated DNA-transfection procedureQ24634002
Complete nucleotide sequence of the AIDS virus, HTLV-IIIQ28259080
Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipientsQ28284190
Nucleotide sequence of the AIDS virus, LAVQ28286313
Frequent Detection and Isolation of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and at Risk for AIDSQ29614260
Importance of the nef gene for maintenance of high virus loads and for development of AIDSQ29618369
Human immunodeficiency virus type 1 negative factor is a transcriptional silencerQ33836630
Isolation of Lymphocytopathic Retroviruses from San Francisco Patients with AIDSQ34250436
Nef protein of human immunodeficiency virus type 1: evidence against its role as a transcriptional inhibitorQ34323995
Mutational analysis of the human immunodeficiency virus: the orf-B region down-regulates virus replicationQ34603122
Downregulation of cell-surface CD4 expression by simian immunodeficiency virus Nef prevents viral super infectionQ36361799
The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophagesQ36362652
HIV accessory proteins: leading roles for the supporting cast.Q40456339
The role of Nef in the replication cycle of the human and simian immunodeficiency virusesQ40640655
Expression of human immunodeficiency virus type 1 Nef antigen on the surface of acutely and persistently infected human T cells.Q41530887
The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes.Q41768724
Generation and characterization of the human immunodeficiency virus type 1 mutantsQ45859881
Natural HIV-1 NEF accelerates virus replication in primary human lymphocytesQ45866982
Nucleotide sequence and expression of an AIDS-associated retrovirus (ARV-2).Q48381924
Cell-mediated cytotoxicity. A highly sensitive and informative flow cytometric assay.Q50890019
Nef protein of HIV-1 is a transcriptional repressor of HIV-1 LTRQ68097623
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)105-108
P577publication date1996-09-01
P1433published inFEBS LettersQ1388051
P1476titleHuman immunodeficiency virus type 1 Nef protein on the cell surface is cytocidal for human CD4+ T cells
P478volume393

Reverse relations

cites work (P2860)
Q33987022Cells of the central nervous system as targets and reservoirs of the human immunodeficiency virus
Q40161550Characterization of Nef-CXCR4 interactions important for apoptosis induction
Q36980963Constitutive activation of phosphatidylinositol 3-kinase signaling pathway down-regulates TLR4-mediated tumor necrosis factor-alpha release in alveolar macrophages from asymptomatic HIV-positive persons in vitro
Q37347813Contribution of nonneutralizing vaccine-elicited antibody activities to improved protective efficacy in rhesus macaques immunized with Tat/Env compared with multigenic vaccines.
Q44149032Different mechanisms are utilized by HIV-1 Nef and staphylococcal enterotoxin A to control and regulate interleukin-10 production
Q33714550Genetic characterization of HIV type 1 Nef-induced vesicle secretion
Q41851046HIV-1 Nef perturbs artificial membranes: investigation of the contribution of the myristoyl anchor
Q43935121HIV-1 Nef protein-induced apoptotic cytolysis of a broad spectrum of uninfected human blood cells independently of CD95(Fas).
Q35009887HIV-1 envelope induces activation of caspase-3 and cleavage of focal adhesion kinase in primary human CD4(+) T cells
Q28211642HIV-1 protease processes procaspase 8 to cause mitochondrial release of cytochrome c, caspase cleavage and nuclear fragmentation
Q33707527Human Immunodeficiency virus type 1 Nef potently induces apoptosis in primary human brain microvascular endothelial cells via the activation of caspases
Q34664366Human immunodeficiency virus-1 (HIV-1)-mediated apoptosis: new therapeutic targets
Q41060040Inhibition of HIV-1 Nef-induced apoptosis of uninfected human blood cells by serine/threonine protein kinase inhibitors, fasudil hydrochloride and M3.
Q38814829Microglia-derived HIV Nef+ exosome impairment of the blood-brain barrier is treatable by nanomedicine-based delivery of Nef peptides
Q33753132Molecular Mechanisms of Neurodegenerative Diseases Induced by Human Retroviruses: A Review
Q30350882Molecular interactions of human immunodeficiency virus type 1 with primary human oral keratinocytes.
Q24524045Mutation of a conserved residue (D123) required for oligomerization of human immunodeficiency virus type 1 Nef protein abolishes interaction with human thioesterase and results in impairment of Nef biological functions
Q42808088Nef protein induces differential effects in CD8+ cells from HIV-1-infected patients
Q41077393Nef protein of HIV-1 induces apoptotic cytolysis of murine lymphoid cells independently of CD95 (Fas) and its suppression by serine/threonine protein kinase inhibitors
Q35177355Neuroimmunity and the blood-brain barrier: molecular regulation of leukocyte transmigration and viral entry into the nervous system with a focus on neuroAIDS.
Q35666063Secretion modification region-derived peptide disrupts HIV-1 Nef's interaction with mortalin and blocks virus and Nef exosome release
Q36313028Validation of a novel secretion modification region (SMR) of HIV-1 Nef using cohort sequence analysis and molecular modeling
Q34434767Viral escape mechanisms--escapology taught by viruses

Search more.