Mutation-induced loss of APP function causes GABAergic depletion in recessive familial Alzheimer's disease: analysis of Osaka mutation-knockin mice

scientific article published on 31 July 2017

Mutation-induced loss of APP function causes GABAergic depletion in recessive familial Alzheimer's disease: analysis of Osaka mutation-knockin mice is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1090937545
P356DOI10.1186/S40478-017-0461-5
P932PMC publication ID5537936
P698PubMed publication ID28760161

P50authorKeizō TakaoQ59453900
Takami TomiyamaQ88643233
P2093author name stringYuki Fujita
Hiroshi Mori
Tetsuya Kimura
Takashi Morita
Yuki Yamashita
Tsuyoshi Miyakawa
Hiroshi Takuma
Shogo Matsuyama
Kayo Yoshida
Tomohiro Umeda
Akihiko Takashima
Ayumi Sakai
Mamiko Suzuki
Kiyouhisa Ohnishi
Minato Yamashita
P2860cites workThe E693Delta mutation in amyloid precursor protein increases intracellular accumulation of amyloid beta oligomers and causes endoplasmic reticulum stress-induced apoptosis in cultured cellsQ37150804
A recessive mutation in the APP gene with dominant-negative effect on amyloidogenesis.Q37309370
Amyloid precursor protein processing and Alzheimer's diseaseQ37860317
The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothesQ37979641
GABAergic neurotransmission and new strategies of neuromodulation to compensate synaptic dysfunction in early stages of Alzheimer's diseaseQ38225536
Storm before the quiet: neuronal hyperactivity and Aβ in the presymptomatic stages of Alzheimer's diseaseQ38274705
Neuronal activity and amyloid plaque pathology: an updateQ38601447
Benzodiazepine Use Attenuates Cortical β-Amyloid and is Not Associated with Progressive Cognitive Decline in Nondemented Elderly Adults: A Pilot Study Using F(18)-Florbetapir Positron Emission TomographyQ38810525
Posterior cingulate γ-aminobutyric acid and glutamate/glutamine are reduced in amnestic mild cognitive impairment and are unrelated to amyloid deposition and apolipoprotein E genotypeQ41151004
Major amyloid-β-degrading enzymes, endothelin-converting enzyme-2 and neprilysin, are expressed by distinct populations of GABAergic interneurons in hippocampus and neocortexQ46152909
Intraneuronal Abeta accumulation precedes plaque formation in beta-amyloid precursor protein and presenilin-1 double-transgenic miceQ48846848
Clinical course of patients with familial early-onset Alzheimer's disease potentially lacking senile plaques bearing the E693Δ mutation in amyloid precursor proteinQ48946574
Rifampicin is a candidate preventive medicine against amyloid-β and tau oligomers.Q50525085
A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo.Q51059487
A second pedigree with amyloid-less familial Alzheimer's disease harboring an identical mutation in the amyloid precursor protein gene (E693delta).Q53362350
A new amyloid beta variant favoring oligomerization in Alzheimer's-type dementia.Q53391715
A mutation in APP protects against Alzheimer’s disease and age-related cognitive declineQ22251083
Molecular genetics of early-onset Alzheimer's disease revisitedQ26750717
GABA(A) receptor-mediated acceleration of aging-associated memory decline in APP/PS1 mice and its pharmacological treatment by picrotoxinQ27300708
Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunctionQ29547778
APP processing and synaptic functionQ29615873
Comprehensive behavioral analysis of cluster of differentiation 47 knockout miceQ30442674
Intracellular Abeta and cognitive deficits precede beta-amyloid deposition in transgenic arcAbeta miceQ33252237
Decreased γ-aminobutyric acid levels in the parietal region of patients with Alzheimer's diseaseQ33907438
The amyloid precursor protein controls adult hippocampal neurogenesis through GABAergic interneuronsQ34268936
Oligomeric Aβ-induced synaptic dysfunction in Alzheimer's diseaseQ34544243
A dynamic relationship between intracellular and extracellular pools of AbetaQ35070713
Promotion of liver and lung tumorigenesis in DEN-treated cytoglobin-deficient miceQ35168131
Amyloid β oligomers in Alzheimer's disease pathogenesis, treatment, and diagnosisQ35327172
Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathologyQ35747757
Intraneuronal Abeta42 accumulation in human brain.Q35793325
P4510describes a project that usesImageQuantQ112270642
P433issue1
P921main subjectAlzheimer's diseaseQ11081
P304page(s)59
P577publication date2017-07-31
P1433published inActa Neuropathologica CommunicationsQ27724912
P1476titleMutation-induced loss of APP function causes GABAergic depletion in recessive familial Alzheimer's disease: analysis of Osaka mutation-knockin mice
P478volume5

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cites work (P2860)
Q89861110APP Osaka Mutation in Familial Alzheimer's Disease-Its Discovery, Phenotypes, and Mechanism of Recessive Inheritance
Q97882884GABAergic Inhibitory Interneuron Deficits in Alzheimer's Disease: Implications for Treatment
Q64100324Glial Contribution to Excitatory and Inhibitory Synapse Loss in Neurodegeneration
Q64087524Processing of Mutant β-Amyloid Precursor Protein and the Clinicopathological Features of Familial Alzheimer's Disease

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