The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia

scientific article

The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/NM.4283
P932PMC publication ID5540325
P698PubMed publication ID28191887

P50authorYana PikmanQ44008671
Gabriela AlexeQ59440963
Kimberly StegmaierQ59441052
Nina FenouilleQ59441180
Frédéric LucianoQ30419950
P2093author name stringQing Li
Yi Zhang
Richard M Stone
Ilene Galinsky
Patrick Auberger
Michael T Hemann
Archibald S Perkins
Daniel J DeAngelo
Michael R Burgess
Kevin Shannon
Alexandre Puissant
Lina Benajiba
Issam Ben-Sahra
Christopher F Bassil
Azucena Ramos
Amy S Conway
P2860cites workTopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusionsQ21999527
SYK is a critical regulator of FLT3 in acute myeloid leukemiaQ24337247
Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the 'phosphocreatine circuit' for cellular energy homeostasisQ24527330
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profilesQ24536351
Hexokinase II: cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondriaQ24595940
The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarateQ24605258
RUNX1 mutations in acute myeloid leukemia: results from a comprehensive genetic and clinical analysis from the AML study groupQ27851623
Prognostic relevance of integrated genetic profiling in acute myeloid leukemiaQ27851726
Cancer cell metabolism: one hallmark, many faces.Q38046274
Oncogenic isocitrate dehydrogenase mutations: mechanisms, models, and clinical opportunitiesQ38116645
The role of EVI1 in myeloid malignanciesQ38185179
EBSeq: an empirical Bayes hierarchical model for inference in RNA-seq experimentsQ39190922
Activation of Evi1 inhibits cell cycle progression and differentiation of hematopoietic progenitor cells.Q39232300
Evi-1 is a critical regulator for hematopoietic stem cells and transformed leukemic cells.Q39953712
Arginine deprivation using pegylated arginine deiminase has activity against primary acute myeloid leukemia cells in vivo.Q41036166
Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1.Q41983843
Densely interconnected transcriptional circuits control cell states in human hematopoiesisQ42654933
Functional significance of mitochondrial bound hexokinase in tumor cell metabolism. Evidence for preferential phosphorylation of glucose by intramitochondrially generated ATP.Q44808698
Arginine addiction in AML.Q48165889
Creatine kinase: the reactive cysteine is required for synergism but is nonessential for catalysisQ72838514
Gene expression-based high-throughput screening(GE-HTS) and application to leukemia differentiationQ75447880
High EVI1 expression predicts outcome in younger adult patients with acute myeloid leukemia and is associated with distinct cytogenetic abnormalitiesQ83822325
Clinical, molecular, and prognostic significance of WHO type inv(3)(q21q26.2)/t(3;3)(q21;q26.2) and various other 3q abnormalities in acute myeloid leukemiaQ84596053
Visualizing gene-set enrichment results using the Cytoscape plug-in enrichment mapQ84855688
edgeR: a Bioconductor package for differential expression analysis of digital gene expression dataQ27860819
Creatine and creatinine metabolismQ28140735
Integrative Genomics Viewer (IGV): high-performance genomics data visualization and explorationQ28264933
IDH mutation impairs histone demethylation and results in a block to cell differentiationQ29305058
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetesQ29547229
RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genomeQ29547458
GenePattern 2.0Q29614171
Mutations in SDHD, a mitochondrial complex II gene, in hereditary paragangliomaQ29614552
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiationQ29615366
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemiaQ29617201
Identification of new genes associated with breast cancer progression by gene expression analysis of predefined sets of neoplastic tissuesQ33344596
Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.Q33716402
Enrichment map: a network-based method for gene-set enrichment visualization and interpretationQ33749961
The intersection of genetic and chemical genomic screens identifies GSK-3α as a target in human acute myeloid leukemiaQ34156754
Cell-state-specific metabolic dependency in hematopoiesis and leukemogenesisQ34338923
Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutationsQ34471702
Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locusQ34667782
Preclinical efficacy of MEK inhibition in Nras-mutant AML.Q34737521
Global Identification of EVI1 Target Genes in Acute Myeloid LeukemiaQ34796524
Germline SDHB mutations and familial renal cell carcinoma.Q34814012
Hexokinase II integrates energy metabolism and cellular protection: Akting on mitochondria and TORCing to autophagyQ34924245
Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcomeQ34930673
Arginine dependence of acute myeloid leukemia blast proliferation: a novel therapeutic target.Q35561304
Evi1 is essential for hematopoietic stem cell self-renewal, and its expression marks hematopoietic cells with long-term multilineage repopulating activityQ35669072
Ecotopic viral integration site 1 (EVI1) regulates multiple cellular processes important for cancer and is a synergistic partner for FOS protein in invasive tumorsQ35750824
MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.Q35898171
Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAiQ36088050
Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemiaQ36137651
Prediction of genomic functional elements.Q36528837
Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemiaQ36591394
Succinate dehydrogenase expression in breast cancer.Q37009756
Highly parallel identification of essential genes in cancer cellsQ37068513
Evi-1 as a critical regulator of leukemic cellsQ37763616
Therapeutic advances in acute myeloid leukemiaQ37827282
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)301-313
P577publication date2017-02-13
P1433published in???Q1633234
P1476titleThe creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia
P478volume23

Reverse relations

cites work (P2860)
Q58617350Creatine kinase pathway inhibition alters GSK3 and WNT signaling in EVI1-positive AML
Q96131649Creatine metabolism: energy homeostasis, immunity and cancer biology
Q96302631Detachment of cell sheets from clinically ubiquitous cell culture vessels by ultrasonic vibration
Q89509869EVI1 as a Prognostic and Predictive Biomarker of Clear Cell Renal Cell Carcinoma
Q64147072EVI1 carboxy-terminal phosphorylation is ATM-mediated and sustains transcriptional modulation and self-renewal via enhanced CtBP1 association
Q64109908Emerging Therapies for Acute Myelogenus Leukemia Patients Targeting Apoptosis and Mitochondrial Metabolism
Q91996647Exploiting metabolic vulnerabilities for personalized therapy in acute myeloid leukemia
Q46113055Mechanistic and Preclinical Insights from Mouse Models of Hematologic Cancer Characterized by Hyperactive Ras.
Q33758448Overexpression of ecotropic viral integration site-1 is a prognostic factor of lung squamous cell cancer
Q95279750Pathological processes in aqueous humor due to iris atrophy predispose to early corneal graft failure in humans and mice
Q89758359Sleeve Gastrectomy enhances glucose utilization and remodels adipose tissue independent of weight loss
Q58743792Suppression of GPR56 expression by pyrrole-imidazole polyamide represents a novel therapeutic drug for AML with high EVI1 expression
Q97643506The creatine-phosphagen system is mechanoresponsive in pancreatic adenocarcinoma and fuels invasion and metastasis

Search more.