EVI1 carboxy-terminal phosphorylation is ATM-mediated and sustains transcriptional modulation and self-renewal via enhanced CtBP1 association

scientific article published on 01 September 2018

EVI1 carboxy-terminal phosphorylation is ATM-mediated and sustains transcriptional modulation and self-renewal via enhanced CtBP1 association is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1093/NAR/GKY536
P932PMC publication ID6125627
P698PubMed publication ID29939287

P50authorAnthony D WhettonQ56421258
Tim C P SomervailleQ73267757
Andrew PierceQ38641924
Richard UnwinQ42908271
P2093author name stringHelen Smith
Stefan Meyer
Axel Schambach
Roberto Paredes
Henri J van de Vrugt
Andrew J K Williamson
Harald Löffler
Daniel J White
Joanne Muter
Marion Schneider
Adam Stevens
John A Chadwick
Stella Pearson
James R Kelly
Simon Lovell
Daniel H Wiseman
Olga Kustikova
Hsiang Ying Teng
Kathleen Connors
P2860cites workHigh EVI1 levels predict adverse outcome in acute myeloid leukemia: prevalence of EVI1 overexpression and chromosome 3q26 abnormalities underestimated.Q54546717
Fanconi anemia (FA)-associated 3q gains in leukemic transformation consistently target EVI1, but do not affect low TERC expression in FAQ57010929
Multiple Reaction Monitoring to Identify Sites of Protein Phosphorylation with High SensitivityQ57011006
The carboxyl domain of zinc fingers of the Evi-1 myeloid transforming gene binds a consensus sequence of GAAGATGAGQ72420809
Equal potency of gammaretroviral and lentiviral SIN vectors for expression of O6-methylguanine-DNA methyltransferase in hematopoietic cellsQ81353679
High EVI1 expression predicts outcome in younger adult patients with acute myeloid leukemia and is associated with distinct cytogenetic abnormalitiesQ83822325
EVI-1 interacts with histone methyltransferases SUV39H1 and G9a for transcriptional repression and bone marrow immortalizationQ84583338
EVI1 expression in childhood acute lymphoblastic leukaemia is not restricted to MLL and BCR/ABL rearrangements and is influenced by age.Q37555328
The Evi-1 proto-oncogene encodes a transcriptional repressor activity associated with transformationQ38348524
Prominent Oncogenic Roles of EVI1 in Breast CarcinomaQ38716103
Activation of Evi1 inhibits cell cycle progression and differentiation of hematopoietic progenitor cells.Q39232300
Ecotropic viral integration site 1, a novel oncogene in prostate cancerQ39401617
Cytotoxic potency of H2O2 in cell cultures: impact of cell concentration and exposure timeQ39673341
EVI1 induces myelodysplastic syndrome in miceQ39951095
Evi-1 is a critical regulator for hematopoietic stem cells and transformed leukemic cells.Q39953712
Amplification and translocation of 3q26 with overexpression of EVI1 in Fanconi anemia-derived childhood acute myeloid leukemia with biallelic FANCD1/BRCA2 disruptionQ40180071
The human promyelocytic leukemia zinc finger gene is regulated by the Evi-1 oncoprotein and a novel guanine-rich site binding proteinQ40708018
The leukemia-associated transcription repressor AML1/MDS1/EVI1 requires CtBP to induce abnormal growth and differentiation of murine hematopoietic cellsQ40722488
The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemiaQ41213085
Developmental-stage-dependent transcriptional response to leukaemic oncogene expression.Q42602670
Evi1 regulates Notch activation to induce zebrafish hematopoietic stem cell emergence.Q42727640
Phosphorylation of the leukemic oncoprotein EVI1 on serine 196 modulates DNA binding, transcriptional repression and transforming abilityQ21133010
Evi-1 transforming and repressor activities are mediated by CtBP co-repressor proteinsQ24291175
Oligomerization of Evi-1 regulated by the PR domain contributes to recruitment of corepressor CtBPQ24302267
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damageQ24306743
Global, in vivo, and site-specific phosphorylation dynamics in signaling networksQ27864128
EVI1 promotes cell proliferation by interacting with BRG1 and blocking the repression of BRG1 on E2F1 activityQ28209175
The corepressor CtBP interacts with Evi-1 to repress transforming growth factor beta signalingQ28213531
Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cellsQ28288970
Evi1 is a survival factor which conveys resistance to both TGFbeta- and taxol-mediated cell death via PI3K/AKTQ28296029
Ensembl 2017Q28584449
Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models of MLL-rearranged AML.Q30823304
The transcription factor evi-1 is overexpressed, promotes proliferation, and is prognostically unfavorable in infratentorial ependymomasQ33873238
Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous diseaseQ34094502
DNA damage regulates the mobility of Brca2 within the nucleoplasm of living cells.Q34410989
Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies.Q34536666
Genome-wide profiles of CtBP link metabolism with genome stability and epithelial reprogramming in breast cancer.Q34577891
A practical guide to evaluating colocalization in biological microscopyQ34782140
The transcriptional corepressor CtBP: a foe of multiple tumor suppressorsQ35200291
Evi1 is essential for hematopoietic stem cell self-renewal, and its expression marks hematopoietic cells with long-term multilineage repopulating activityQ35669072
Ecotopic viral integration site 1 (EVI1) regulates multiple cellular processes important for cancer and is a synergistic partner for FOS protein in invasive tumorsQ35750824
Lentiviral gene transfer into human and murine hematopoietic stem cells: size mattersQ36053424
Cell of origin determines clinically relevant subtypes of MLL-rearranged AMLQ36409664
Four of the seven zinc fingers of the Evi-1 myeloid-transforming gene are required for sequence-specific binding to GA(C/T)AAGA(T/C)AAGATAA.Q36690799
EVI1 oncoprotein interacts with a large and complex network of proteins and integrates signals through protein phosphorylationQ37068625
Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cellsQ37163021
EVI1 splice variants modulate functional responses in ovarian cancer cellsQ37246860
BRCA2 diffuses as oligomeric clusters with RAD51 and changes mobility after DNA damage in live cellsQ43189526
EVI-1 modulates leukemogenic potential and apoptosis sensitivity in human acute lymphoblastic leukemia.Q43486412
Evi1 represses PTEN expression and activates PI3K/AKT/mTOR via interactions with polycomb proteins.Q45345900
Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome, and DNA methylome analysis.Q46456469
The Identification of Potent, Selective, and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of AZD0156 (8-{6-[3-(Dimethylamino)propoxy]pyridin-3-yl}-3-methyl-1-(tetrahydro-2 H-pyran-4-yl)-1,3-dihydro-2 H-imiQ54114833
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue15
P407language of work or nameEnglishQ1860
P304page(s)7662-7674
P577publication date2018-09-01
P1433published inNucleic Acids ResearchQ135122
P1476titleEVI1 carboxy-terminal phosphorylation is ATM-mediated and sustains transcriptional modulation and self-renewal via enhanced CtBP1 association
P478volume46

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cites work (P2860)
Q91906032C-terminal of E1A binding protein 1 enhances the migration of gastric epithelial cells and has a clinicopathologic significance in human gastric carcinoma
Q89509869EVI1 as a Prognostic and Predictive Biomarker of Clear Cell Renal Cell Carcinoma
Q100750044EVI1 phosphorylation at S436 regulates interactions with CtBP1 and DNMT3A and promotes self-renewal

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