Baicalin attenuates chronic hypoxia-induced pulmonary hypertension via adenosine A2A receptor-induced SDF-1/CXCR4/PI3K/AKT signaling

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Baicalin attenuates chronic hypoxia-induced pulmonary hypertension via adenosine A2A receptor-induced SDF-1/CXCR4/PI3K/AKT signaling is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1090954102
P356DOI10.1186/S12929-017-0359-3
P932PMC publication ID5543745
P698PubMed publication ID28774332

P2093author name stringMin Xu
Guo-Ping Li
Dan Yao
Xiaoying Huang
Feifei Huang
Liangxing Wang
Mayun Chen
Peiliang Wu
Kate Huang
Manhuan Xu
P2860cites workAdenosine A2A and A2B Receptors Differentially Modulate Keratinocyte Proliferation: Possible Deregulation in Psoriatic Epidermis.Q51588386
Inhibition of CXCL12/CXCR4 suppresses pulmonary arterial smooth muscle cell proliferation and cell cycle progression via PI3K/Akt pathway under hypoxia.Q51682111
Salidroside attenuates chronic hypoxia-induced pulmonary hypertension via adenosine A2a receptor related mitochondria-dependent apoptosis pathway.Q52958943
SDF-1/CXCR4 signaling up-regulates survivin to regulate human sacral chondrosarcoma cell cycle and epithelial-mesenchymal transition via ERK and PI3K/AKT pathway.Q53001077
Pulmonary Arterial HypertensionQ58485998
Adenosine plasma concentration in pulmonary hypertensionQ73120029
Effects of San-Huang-Xie-Xin-Tang on U46619-induced increase in pulmonary arterial blood pressureQ81013757
Diversity and Inter-Connections in the CXCR4 Chemokine Receptor/Ligand Family: Molecular PerspectivesQ26782778
Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damageQ28214799
Inhibition of the CXCL12/CXCR4-axis as preventive therapy for radiation-induced pulmonary fibrosisQ28534937
Inhibition of phosphatidylinositol 3-kinase/Akt signaling attenuates hypoxia-induced pulmonary artery remodeling and suppresses CREB depletion in arterial smooth muscle cellsQ28581058
Absence of the Adenosine A<sub>2A</sub> Receptor Confers Pulmonary Arterial Hypertension and Increased Pulmonary Vascular Remodeling in MiceQ33715343
Functional class and targeted therapy are related to the survival in patients with pulmonary arterial hypertension.Q34384302
Transfusion of CXCR4-primed endothelial progenitor cells reduces cerebral ischemic damage and promotes repair in db/db diabetic miceQ34491057
Effects of baicalin on collagen Ι and collagen ΙΙΙ expression in pulmonary arteries of rats with hypoxic pulmonary hypertensionQ35167905
Chemokines and their receptors as therapeutic targets: the role of the SDF-1/CXCR4 axisQ35743534
Adenosine A2a receptors induce heterologous desensitization of chemokine receptorsQ35849780
CXCR4-SDF-1 signalling, locomotion, chemotaxis and adhesionQ35875566
Baseline Characteristics of the Korean Registry of Pulmonary Arterial HypertensionQ36075442
Pulmonary vascular changes 22 years after single lung transplantation for pulmonary arterial hypertension: a case report with molecular and pathological analysisQ36352139
Mechanisms controlling vascular tone in pulmonary arterial hypertension: implications for vasodilator therapyQ36674960
Phosphatidylinositol 3-kinase (PI3K) inhibitors as cancer therapeutics.Q37350230
Nitric oxide, oxidative stress and inflammation in pulmonary arterial hypertensionQ37669139
Scutellaria baicalensis in stroke management: nature's blessing in traditional Eastern medicineQ38206119
The CXCL12/CXCR4 chemokine ligand/receptor axis in cardiovascular diseaseQ38223391
The role of adenosine and adenosine receptors in the immunopathogenesis of multiple sclerosis.Q38767477
Adenosine kinase inhibition protects the kidney against streptozotocin-induced diabetes through anti-inflammatory and anti-oxidant mechanismsQ38993712
Adenosine and adenosine receptors in the pathogenesis and treatment of rheumatic diseasesQ39004042
LRRC4 inhibits human glioblastoma cells proliferation, invasion, and proMMP-2 activation by reducing SDF-1 alpha/CXCR4-mediated ERK1/2 and Akt signaling pathwaysQ40123732
Inhibition of the SDF-1/CXCR4 axis attenuates neonatal hypoxia-induced pulmonary hypertension.Q42577581
Baicalin inhibits PDGF-BB-stimulated vascular smooth muscle cell proliferation through suppressing PDGFRβ-ERK signaling and increase in p27 accumulation and prevents injury-induced neointimal hyperplasiaQ42957166
SDF-1/CXCR4-mediated migration of transplanted bone marrow stromal cells toward areas of heart myocardial infarction through activation of PI3K/AktQ43152356
Effect of baicalin on inflammatory mediator levels and microcirculation disturbance in rats with severe acute pancreatitisQ43298066
Quercetin inhibited epithelial mesenchymal transition in diabetic rats, high-glucose-cultured lens, and SRA01/04 cells through transforming growth factor-β2/phosphoinositide 3-kinase/Akt pathwayQ47321511
P433issue1
P921main subjectbaicalinQ2879368
P304page(s)52
P577publication date2017-08-03
P1433published inJournal of Biomedical ScienceQ15759332
P1476titleBaicalin attenuates chronic hypoxia-induced pulmonary hypertension via adenosine A2A receptor-induced SDF-1/CXCR4/PI3K/AKT signaling
P478volume24

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cites work (P2860)
Q60046539A comprehensive review on phytochemistry, pharmacology, and flavonoid biosynthesis of Scutellaria baicalensis
Q91866877CXCR4 knockdown prevents inflammatory cytokine expression in macrophages by suppressing activation of MAPK and NF-κB signaling pathways
Q90175450Effect of stromal cell-derived factor-1/CXCR4 axis in neural stem cell transplantation for Parkinson's disease
Q54964312High expression of CXCR4 and stem cell markers in a monocrotaline and chronic hypoxia-induced rat model of pulmonary arterial hypertension.
Q64244878Involvement of CXCR4 in Normal and Abnormal Development
Q92868479SDF-1/CXCR4 signalling is involved in blood vessel growth and remodelling by intussusception
Q64090954Silibinin efficacy in a rat model of pulmonary arterial hypertension using monocrotaline and chronic hypoxia

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