A comprehensive review on phytochemistry, pharmacology, and flavonoid biosynthesis of Scutellaria baicalensis

scientific article published on 01 December 2018

A comprehensive review on phytochemistry, pharmacology, and flavonoid biosynthesis of Scutellaria baicalensis is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1080/13880209.2018.1492620
P932PMC publication ID6292351
P698PubMed publication ID31070530

P2093author name stringShuang Wang
Min Ye
Yi Kuang
Xue Qiao
Zi-Long Wang
Zhi-Min Hu
P2860cites workEffect of Chinese and western antimicrobial agents on selected oral bacteriaQ72067313
Liquid chromatography/mass spectrometry analysis of PHY906, a Chinese medicine formulation for cancer therapyQ81456923
A simple isocratic HPLC method for the simultaneous determination of bioactive components of Scutellariae radix extractQ83391134
In vitro antifungal activity of the aqueous extract of Scutellaria baicalensis Georgi root against Candida albicansQ83656267
Investigation of flavonoid profile of Scutellaria bacalensis Georgi by high performance liquid chromatography with diode array detection and electrospray ion trap mass spectrometryQ83761806
Two new flavonoids from the roots of Scutellaria baicalensisQ86649411
Ameliorative effects of baicalein in MPTP-induced mouse model of Parkinson's disease: A microarray studyQ87155881
Studies on the Constituents of Scutellaria Species. II. On the Flavonoid Constituents of the Root of Scutellaria baicalensis GEORGI (2)Q104395978
Identification of flavonoids in the stems and leaves of Scutellaria baicalensis GeorgiQ44220191
Baicalin attenuates acute myocardial infarction of rats via mediating the mitogen-activated protein kinase pathwayQ44412420
Wogonoside induces cell cycle arrest and differentiation by affecting expression and subcellular localization of PLSCR1 in AML cellsQ44429899
Inhibition of cancer cell proliferation and prostaglandin E2 synthesis by Scutellaria baicalensis.Q44521080
Baicalein inhibits formation of α-synuclein oligomers within living cells and prevents Aβ peptide fibrillation and oligomerisationQ44582977
Anti-inflammatory effects of Scutellaria baicalensis extract via suppression of immune modulators and MAP kinase signaling moleculesQ28256017
The genus Scutellaria an ethnopharmacological and phytochemical reviewQ28269987
Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitorQ28288261
Scutellarin's Cardiovascular Endothelium Protective Mechanism: Important Role of PKG-IαQ28550064
Anticancer activity of extracts derived from the mature roots of Scutellaria baicalensis on human malignant brain tumor cellsQ28767955
Baicalein, Ethyl Acetate, and Chloroform Extracts of Scutellaria baicalensis Inhibit the Neuraminidase Activity of Pandemic 2009 H1N1 and Seasonal Influenza A Viruses.Q30352178
Antiviral activity of baicalin against influenza virus H1N1-pdm09 is due to modulation of NS1-mediated cellular innate immune responses.Q30358265
Cloning and expression of UDP-glucose: flavonoid 7-O-glucosyltransferase from hairy root cultures of Scutellaria baicalensisQ30882971
A targeted strategy to analyze untargeted mass spectral data: Rapid chemical profiling of Scutellaria baicalensis using ultra-high performance liquid chromatography coupled with hybrid quadrupole orbitrap mass spectrometry and key ion filteringQ31054229
Flavonoid baicalin inhibits HIV-1 infection at the level of viral entryQ31454756
Anti-hepatitis B virus effects of wogonin isolated from Scutellaria baicalensisQ31994556
Induction of apoptosis in prostate cancer cell lines by a flavonoid, baicalin.Q33181350
Targeting CDK9 by wogonin and related natural flavones potentiates the anti-cancer efficacy of the Bcl-2 family inhibitor ABT-263.Q33415723
A combination of Scutellaria baicalensis and Acacia catechu extracts for short-term symptomatic relief of joint discomfort associated with osteoarthritis of the kneeQ33767965
Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis GeorgiQ33880655
Purification and characterization of UDP-glucuronate: baicalein 7-O-glucuronosyltransferase from Scutellaria baicalensis Georgi. cell suspension culturesQ33895080
Antidepressant effects of a plant-derived flavonoid baicalein involving extracellular signal-regulated kinases cascadeQ34171601
The ethanol extract of Scutellaria baicalensis and the active compounds induce cell cycle arrest and apoptosis including upregulation of p53 and Bax in human lung cancer cellsQ34175051
Molecular mechanism of anti-prostate cancer activity of Scutellaria baicalensis extractQ34630490
Scutellaria baicalensis, the golden herb from the garden of Chinese medicinal plantsQ34679142
Extract of Scutellaria baicalensis inhibits dengue virus replicationQ34693815
PHY906(KD018), an adjuvant based on a 1800-year-old Chinese medicine, enhanced the anti-tumor activity of Sorafenib by changing the tumor microenvironmentQ35227285
Colon cancer chemopreventive effects of baicalein, an active enteric microbiome metabolite from baicalinQ35785294
The Traditional Chinese Medicine Baicalein Potently Inhibits Gastric Cancer CellsQ36567902
Anti-Bladder-Tumor Effect of Baicalein from Scutellaria baicalensis Georgi and Its Application In VivoQ36731046
A specialized flavone biosynthetic pathway has evolved in the medicinal plant, Scutellaria baicalensis.Q36839841
Baicalin inhibits IL-17-mediated joint inflammation in murine adjuvant-induced arthritisQ36959589
Effect of total flavonoids from Scutellaria baicalensis on dopaminergic neurons in the substantia nigraQ37108027
Scutellaria baicalensis and a constituent flavonoid, baicalein, attenuate ritonavir-induced gastrointestinal side-effectsQ37178633
New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and BaicalinQ37323907
Flavonoids Identified from Korean Scutellaria baicalensis Georgi Inhibit Inflammatory Signaling by Suppressing Activation of NF- κ B and MAPK in RAW 264.7 CellsQ37379898
Selective fraction of Scutellaria baicalensis and its chemopreventive effects on MCF-7 human breast cancer cellsQ37461123
Baicalin increases developmental competence of mouse embryos in vitro by inhibiting cellular apoptosis and modulating HSP70 and DNMT expressionQ37526286
Wogonin inhibits excitotoxic and oxidative neuronal damage in primary cultured rat cortical cellsQ44751866
Depletion of high-abundance flavonoids by metal complexation and identification of low-abundance flavonoids in Scutellaria baicalensis GeorgiQ44929658
Inhibition of microglial activation by the herbal flavonoid baicalein attenuates inflammation-mediated degeneration of dopaminergic neuronsQ45122878
Protective effect of baicalin on tert-butyl hydroperoxide-induced rat hepatotoxicityQ45220599
Identification and quantification of eight flavones in root and shoot tissues of the medicinal plant huang-qin (Scutellaria baicalensis Georgi) using high-performance liquid chromatography with diode array and mass spectrometric detectionQ45243310
Activations of GABAergic signaling, HSP70 and MAPK cascades are involved in baicalin's neuroprotection against gerbil global ischemia/reperfusion injuryQ45296872
Mode of action of the anti-influenza virus activity of plant flavonoid, 5,7,4'-trihydroxy-8-methoxyflavone, from the roots of Scutellaria baicalensisQ45785908
Baicalein, an antioxidant 12/15-lipoxygenase inhibitor improves clinical rating scores following multiple infarct embolic strokesQ46060228
Production of cytokines and stimulation of resistance to viral infection in human leukocytes by Scutellaria baicalensis flavones.Q46389893
Characterization of chemical constituents in Scutellaria baicalensis with antiandrogenic and growth-inhibitory activities toward prostate carcinomaQ46493726
Neuroprotective effect of baicalein against MPTP neurotoxicity: behavioral, biochemical and immunohistochemical profileQ46513468
Scutellaria baicalensis enhances the anti-diabetic activity of metformin in streptozotocin-induced diabetic Wistar rats.Q46548509
Prevention of oxidative injury by flavonoids from stems and leaves of Scutellaria baicalensis Georgi in PC12 cellsQ46883329
Anticancer effects of wogonin in both estrogen receptor-positive and -negative human breast cancer cell lines in vitro and in nude mice xenograftsQ46934281
Characterization of flavonoids in the traditional Chinese herbal medicine-Huangqin by liquid chromatography coupled with electrospray ionization mass spectrometryQ47176597
Biphasic effects of baicalin, an active constituent of Scutellaria baicalensis Georgi, in the spontaneous sleep-wake regulationQ47312646
Baicalin and its metabolites suppresses gluconeogenesis through activation of AMPK or AKT in insulin resistant HepG-2 cellsQ47657651
Osteoprotective Effect of Radix Scutellariae in Female Hindlimb-Suspended Sprague-Dawley Rats and the Osteogenic Differentiation Effect of Its Major ConstituentQ47711628
Neuroprotective Effects of Baicalein on Acrolein-induced Neurotoxicity in the Nigrostriatal Dopaminergic System of Rat BrainQ47779349
Baicalin improved the spatial learning ability of global ischemia/reperfusion rats by reducing hippocampal apoptosisQ48440111
Preventive effect of baicalein on methamphetamine-induced amnesia in the passive avoidance test in miceQ48576663
Baicalin protects mice from Staphylococcus aureus pneumonia via inhibition of the cytolytic activity of α-hemolysinQ48687023
Mediating macrophage immunity with wogonin in mice with vascular inflammationQ49568119
Scutellaria baicalensis and Cancer Treatment: Recent Progress and Perspectives in Biomedical and Clinical Studies.Q50115741
Baicalein enhances the osteogenic differentiation of human periodontal ligament cells by activating the Wnt/β-catenin signaling pathwayQ50215585
Two CYP82D Enzymes Function as Flavone Hydroxylases in the Biosynthesis of Root-Specific 4'-Deoxyflavones in Scutellaria baicalensisQ50330432
Baicalin administration attenuates hyperglycemia-induced malformation of cardiovascular systemQ50422611
A Scutellaria baicalensis radix water extract inhibits morphine-induced conditioned place preference.Q50645631
Baicalein exerts anti-neuroinflammatory effects to protect against rotenone-induced brain injury in rats.Q50939875
Anti-Inflammatory Effect of Baicalein on Polyinosinic⁻Polycytidylic Acid-Induced RAW 264.7 Mouse Macrophages.Q53071012
Scutellaria baicalensis, a herbal medicine: anti-proliferative and apoptotic activity against acute lymphocytic leukemia, lymphoma and myeloma cell lines.Q53596559
Extract from Scutellaria baicalensis Georgi attenuates oxidant stress in cardiomyocytes.Q54149855
Baicalein attenuates angiotensin II-induced cardiac remodeling via inhibition of AKT/mTOR, ERK1/2, NF-κB, and calcineurin signaling pathways in mice.Q54186670
Korean Scutellaria baicalensis Georgi methanol extracts inhibits metastasis via the Forkhead Box M1 activity in hepatocellular carcinoma cells.Q54204364
NMDA receptor-mediated neuroprotective effect of the Scutellaria baicalensis Georgi extract on the excitotoxic neuronal cell death in primary rat cortical cell culturesQ59100304
On the revised structure of skullcapflavone I, a flavone compound in the roots of Scutellaria baicalensis Georgi (Wogon) (author's transl)Q66927580
Studies on the constituents in the water extracts of crude drugs. II. On the leaves of scutellaria baicalensis Georgi (author's transl)Q67853106
Inhibition of mouse liver sialidase by plant flavonoidsQ69717429
[On the flavonoid constituents from the roots of Scutellaria baicalensis Georgi. I]Q70485643
[Studies on the constituents of Scutellaria species. III. On the flavonoid constituents of the root of Scutellaria baicalensis Georgi (3)]Q70651535
[Studies on the constituents of Scutellaria species. IV. On the flavonoid constituents of the root of Scutellaria baicalensis Georgi (4)]Q70651539
[Studies on the water-soluble constituents of the roots of Scutellaria baicalensis Georgi (Wogon) (author's transl)]Q70832833
Studies on Scutellariae radix. Part II: The antibacterial substanceQ71015412
[On the minor constituents of the roots of Scutellaria baicalensis Georgi (Wogon) (author's transl)]Q71098746
Two flavone 2'-glucosides from Scutellaria baicalensisQ71712002
A wogonin-rich-fraction of Scutellaria baicalensis root extract exerts chondroprotective effects by suppressing IL-1β-induced activation of AP-1 in human OA chondrocytes.Q37678771
Cytoprotective mechanism of baicalin against endothelial cell damage by peroxynitriteQ38511868
Baicalin Attenuates Alcoholic Liver Injury through Modulation of Hepatic Oxidative Stress, Inflammation and Sonic Hedgehog Pathway in RatsQ38748976
Total flavonoid aglycones extract in Radix scutellariae inhibits lung carcinoma and lung metastasis by affecting cell cycle and DNA synthesisQ38756554
Anti-H1N1 virus, cytotoxic and Nrf2 activation activities of chemical constituents from Scutellaria baicalensis.Q38818806
Baicalein upregulates DDIT4 expression which mediates mTOR inhibition and growth inhibition in cancer cellsQ38925099
Wogonoside displays anti-inflammatory effects through modulating inflammatory mediator expression using RAW264.7 cellsQ39161746
Baicalein induces G1 arrest in oral cancer cells by enhancing the degradation of cyclin D1 and activating AhR to decrease Rb phosphorylationQ39310487
Wogonin, an active ingredient of Chinese herb medicine Scutellaria baicalensis, inhibits the mobility and invasion of human gallbladder carcinoma GBC-SD cells by inducing the expression of maspinQ39487695
Synergistic activity of baicalein with ribavirin against influenza A (H1N1) virus infections in cell culture and in miceQ39502171
Baicalin prevents the production of hydrogen peroxide and oxidative stress induced by Aβ aggregation in SH-SY5Y cellsQ39601165
Korean Scutellaria baicalensis water extract inhibits cell cycle G1/S transition by suppressing cyclin D1 expression and matrix-metalloproteinase-2 activity in human lung cancer cellsQ39632383
Baicalein protects HT22 murine hippocampal neuronal cells against endoplasmic reticulum stress-induced apoptosis through inhibition of reactive oxygen species production and CHOP inductionQ39642134
Baicalin increases VEGF expression and angiogenesis by activating the ERR{alpha}/PGC-1{alpha} pathwayQ39654160
Baicalin induces human mucoepidermoid carcinoma Mc3 cells apoptosis in vitro and in vivoQ39732001
Inhibitory effects of baicalein on the influenza virus in vivo is determined by baicalin in the serumQ39745744
The effect of Scutellaria baicalensis on the signaling network in hepatocellular carcinoma cellsQ39786097
Wogonin, an active compound in Scutellaria baicalensis, induces apoptosis and reduces telomerase activity in the HL-60 leukemia cellsQ39829388
Baicalein exerts neuroprotective effects in 6-hydroxydopamine-induced experimental parkinsonism in vivo and in vitroQ39867380
An anti-sepsis monomer, 2',5,6',7-tetrahydroxyflavanonol (THF), identified from Scutellaria baicalensis Georgi neutralizes lipopolysaccharide in vitro and in vivoQ39946034
Wogonin, a bioactive flavonoid in herbal tea, inhibits inflammatory cyclooxygenase-2 gene expression in human lung epithelial cancer cellsQ39979721
Baicalein induces functional hypoxia-inducible factor-1alpha and angiogenesisQ39989928
Baicalin Alleviates Lipopolysaccharide-Induced Liver Inflammation in Chicken by Suppressing TLR4-Mediated NF-κB PathwayQ40068577
Efficacy of Scutellaria baicalensis for the Treatment of Hand, Foot, and Mouth Disease Associated with Encephalitis in Patients Infected with EV71: A Multicenter, Retrospective Analysis.Q40080206
Anti-hepatitis B virus activity of wogonin in vitro and in vivoQ40174404
Baicalin-induced apoptosis is mediated by Bcl-2-dependent, but not p53-dependent, pathway in human leukemia cell linesQ40301199
Effects of Scutellaria baicalensis on chronic cerebral hypoperfusion-induced memory impairments and chronic lipopolysaccharide infusion-induced memory impairmentsQ40319919
The antipyretic effects of baicalin in lipopolysaccharide-evoked fever in rabbits.Q40474487
Zinc coupling potentiates anti-HIV-1 activity of baicalinQ40506092
Flavones from Scutellaria baicalensis Georgi attenuate apoptosis and protein oxidation in neuronal cell linesQ40721535
The flavonoid baicalin exhibits anti-inflammatory activity by binding to chemokinesQ40854020
Bioactive Constituents of Glycyrrhiza uralensis (Licorice): Discovery of the Effective Components of a Traditional Herbal Medicine.Q40933400
Synergy between baicalein and penicillins against penicillinase-producing Staphylococcus aureusQ41193697
Baicalin attenuates chronic hypoxia-induced pulmonary hypertension via adenosine A2A receptor-induced SDF-1/CXCR4/PI3K/AKT signalingQ41250589
Therapeutic effects of baicalein on rotenone-induced Parkinson's disease through protecting mitochondrial function and biogenesisQ41565664
Baicalein reduces endometriosis by suppressing the viability of human endometrial stromal cells through the nuclear factor-κB pathway in vitroQ41623612
Inhibition of human T cell leukemia virus by the plant flavonoid baicalin (7-glucuronic acid, 5,6-dihydroxyflavone)Q41637928
The Chloroplast Genome Sequence of Scutellaria baicalensis Provides Insight into Intraspecific and Interspecific Chloroplast Genome Diversity in ScutellariaQ41673581
The effect of Scutellaria baicalensis stem-leaf flavonoids on spatial learning and memory in chronic cerebral ischemia-induced vascular dementia of ratsQ41884186
Inhibition of HIV infection by baicalin--a flavonoid compound purified from Chinese herbal medicineQ42278277
Baicalin, an inhibitor of HIV-1 production in vitroQ42542425
Baicalin attenuates global cerebral ischemia/reperfusion injury in gerbils via anti-oxidative and anti-apoptotic pathwaysQ42733714
The four-herb Chinese medicine PHY906 reduces chemotherapy-induced gastrointestinal toxicityQ42933552
Antiallergic herbal composition from Scutellaria baicalensis and Phyllostachys edulisQ43230072
Cytoprotective effect of Scutellaria baicalensis in CA1 hippocampal neurons of rats after global cerebral ischemiaQ43727757
Baicalein attenuates oxidant stress in cardiomyocytesQ43880525
Local differentiation of sugar donor specificity of flavonoid glycosyltransferase in LamialesQ43924201
Scutellaria baicalensis inhibits liver fibrosis induced by bile duct ligation or carbon tetrachloride in rats.Q43985281
Evaluation of variation of acteoside and three major flavonoids in wild and cultivated Scutellaria baicalensis roots by micellar electrokinetic chromatographyQ44072346
Inhibition of HIV replication by baicalin and S. baicalensis extracts in H9 cell cultureQ44097844
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P433issue1
P921main subjectpharmacologyQ128406
2-phenylchromane flavonoidQ222174
phytochemistryQ640068
Scutellaria baicalensisQ803769
Flavonoid biosynthesisQ5458172
drug discoveryQ1418791
phytochemicalsQ1639139
molecular medicineQ3523816
plant extractQ65618538
P304page(s)465-484
P577publication date2018-12-01
P1433published inPharmaceutical BiologyQ7180726
P1476titleA comprehensive review on phytochemistry, pharmacology, and flavonoid biosynthesis of Scutellaria baicalensis
P478volume56

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cites work (P2860)
Q89830117Baicalin ameliorates neuropathology in repeated cerebral ischemia-reperfusion injury model mice by remodeling the gut microbiota
Q94560936Chinese Herbal Medicine and Its Regulatory Effects on Tumor Related T Cells
Q99589543Complexity of active medicinal ingredients in radix scutellariae with sodium hydrosulfite exposure