Therapeutic effects of baicalein on rotenone-induced Parkinson's disease through protecting mitochondrial function and biogenesis

scientific article published on 30 August 2017

Therapeutic effects of baicalein on rotenone-induced Parkinson's disease through protecting mitochondrial function and biogenesis is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1091344466
P356DOI10.1038/S41598-017-07442-Y
P932PMC publication ID5577282
P698PubMed publication ID28855526

P2093author name stringXue Zhang
Wen Zhang
Guanhua Du
Yulin Yang
Lida Du
Qimeng Zhou
P2860cites workBaicalein inhibits α-synuclein oligomer formation and prevents progression of α-synuclein accumulation in a rotenone mouse model of Parkinson's diseaseQ57104189
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Baicalein protects the brain against neuron impairments induced by MPTP in C57BL/6 miceQ83285673
Constitutive SIRT1 overexpression impairs mitochondria and reduces cardiac function in miceQ85028210
Neurobehavioral assessment of outcome following traumatic brain injury in rats: an evaluation of selected measuresQ44884816
ERK and p38 inhibitors attenuate memory deficits and increase CREB phosphorylation and PGC-1α levels in Aβ-injected ratsQ45702362
Acetyl-L-carnitine-mediated neuroprotection during hypoxia is attributed to ERK1/2-Nrf2-regulated mitochondrial biosynthesisQ46087901
Exercise with low glycogen increases PGC-1α gene expression in human skeletal muscleQ46311179
Neuroprotective effect of baicalein against MPTP neurotoxicity: behavioral, biochemical and immunohistochemical profileQ46513468
The Interaction of Mitochondrial Biogenesis and Fission/Fusion Mediated by PGC-1α Regulates Rotenone-Induced Dopaminergic NeurotoxicityQ46536429
Mitochondrial dynamics and mitophagy in Parkinson's disease: A fly point of viewQ46642004
Mitochondrial complex I, II/III, and IV activities in familial and sporadic Parkinson's diseaseQ47820662
Prevention of vascular smooth muscle cell proliferation and injury-induced neointimal hyperplasia by CREB-mediated p21 induction: An insight from a plant polyphenolQ47886710
Protective effects of baicalein against rotenone-induced neurotoxicity in PC12 cells and isolated rat brain mitochondriaQ48842987
Assessment of the treatment effect of baicalein on a model of Parkinsonian tremor and elucidation of the mechanismQ50259411
Carvedilol promotes mitochondrial biogenesis by regulating the PGC-1/TFAM pathway in human umbilical vein endothelial cells (HUVECs).Q50267197
Activation of AMP-activated protein kinase by metformin protects against global cerebral ischemia in male rats: interference of AMPK/PGC-1α pathway.Q54383877
Mitochondrial defect and PGC-1α dysfunction in parkin-associated familial Parkinson's disease.Q54393752
Baicalein protects against 6-OHDA-induced neurotoxicity through activation of Keap1/Nrf2/HO-1 and involving PKCα and PI3K/AKT signaling pathways.Q54494363
Mitochondria: A Therapeutic Target for Parkinson's Disease?Q26784216
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SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}Q28235481
CREB regulates hepatic gluconeogenesis through the coactivator PGC-1Q29615692
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alphaQ29620443
Disease and the brain's dark energyQ33522559
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Cognitive impairment and dementia in Parkinson's disease: clinical features, diagnosis, and management.Q35988441
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Structural characteristics of alpha-synuclein oligomers stabilized by the flavonoid baicaleinQ36950121
PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditureQ37412140
Mitochondrial quality control and neurological disease: an emerging connectionQ37732485
Mitochondrial dynamics and neuronal fate in Parkinson's disease.Q38011533
The interplay of neuronal mitochondrial dynamics and bioenergetics: implications for Parkinson's diseaseQ38016276
An update on the rotenone models of Parkinson's disease: their ability to reproduce the features of clinical disease and model gene-environment interactions.Q38290588
Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 Alpha: An Emerging Target for Neuroprotection in Parkinson's DiseaseQ38391039
SIRT5 is under the control of PGC-1α and AMPK and is involved in regulation of mitochondrial energy metabolismQ39009602
Mitochondrial Dysfunction and Biogenesis in Neurodegenerative diseases: Pathogenesis and Treatment.Q39016389
Baicalein prevents 6-hydroxydopamine-induced mitochondrial dysfunction in SH-SY5Y cells via inhibition of mitochondrial oxidation and up-regulation of DJ-1 protein expression.Q39052298
Mitochondrial biogenesis in neurodegenerationQ39181903
Differential effects of wild-type and A53T mutant isoform of alpha-synuclein on the mitochondrial proteome of differentiated SH-SY5Y cellsQ39723568
Baicalein exerts neuroprotective effects in 6-hydroxydopamine-induced experimental parkinsonism in vivo and in vitroQ39867380
p38 mitogen-activated protein kinase activates peroxisome proliferator-activated receptor alpha: a potential role in the cardiac metabolic stress responseQ40778028
Mitochondrial complex I deficiency in Parkinson's disease.Q40868964
The Protective Effects of Salidroside from Exhaustive Exercise-Induced Heart Injury by Enhancing the PGC-1 α -NRF1/NRF2 Pathway and Mitochondrial Respiratory Function in RatsQ41523477
Exercise-induced metabolic fluctuations influence AMPK, p38-MAPK and CaMKII phosphorylation in human skeletal muscleQ41881893
Excessive levels of nitric oxide in rat model of Parkinson's disease induced by rotenoneQ42083792
The rotenone-induced rat model of Parkinson's disease: behavioral and electrophysiological findingsQ42469262
Baicalein attenuates astroglial activation in the 1-methyl-4-phenyl-1,2,3,4-tetrahydropyridine-induced Parkinson's disease model by downregulating the activations of nuclear factor-κB, ERK, and JNK.Q43730264
The flavonoid baicalein inhibits fibrillation of alpha-synuclein and disaggregates existing fibrilsQ44851129
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)9968
P577publication date2017-08-30
P1433published inScientific ReportsQ2261792
P1476titleTherapeutic effects of baicalein on rotenone-induced Parkinson's disease through protecting mitochondrial function and biogenesis
P478volume7

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cites work (P2860)
Q60046539A comprehensive review on phytochemistry, pharmacology, and flavonoid biosynthesis of Scutellaria baicalensis
Q55405917Flavonoids as Therapeutic Agents in Alzheimer's and Parkinson's Diseases: A Systematic Review of Preclinical Evidences.
Q47251476Multi-Protection of DL0410 in Ameliorating Cognitive Defects in D-Galactose Induced Aging Mice
Q90361871Potential Antidepressant Effects of Scutellaria baicalensis, Hericium erinaceus and Rhodiola rosea
Q92991007The Potential of Flavonoids for the Treatment of Neurodegenerative Diseases

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