Mitochondrial DNA content in breast cancer: Impact on in vitro and in vivo phenotype and patient prognosis

scientific article published on 11 April 2016

Mitochondrial DNA content in breast cancer: Impact on in vitro and in vivo phenotype and patient prognosis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.18632/ONCOTARGET.8688
P932PMC publication ID5045386
P698PubMed publication ID27081694

P50authorStefan SleijferQ87649316
P2093author name stringMarcel Smid
Maxime P Look
Anieta M Sieuwerts
John A Foekens
John W M Martens
Marjolein J A Weerts
P2860cites workThe regulation of mitochondrial DNA copy number in glioblastoma cellsQ37299449
Tumorigenic transformation of human breast epithelial cells induced by mitochondrial DNA depletionQ37438494
Mutational patterns in the breast cancer mitochondrial genome, with clinical correlatesQ37731513
Generation, function and diagnostic value of mitochondrial DNA copy number alterations in human cancersQ37891335
Mitochondrial genome acquisition restores respiratory function and tumorigenic potential of cancer cells without mitochondrial DNA.Q38922496
Mitochondrial DNA content as a potential marker to predict response to anthracycline in breast cancer patients.Q39712369
Mitochondrial DNA depletion promotes impaired oxidative status and adaptive resistance to apoptosis in T47D breast cancer cellsQ39824435
Mitochondrial DNA depletion in prostate epithelial cells promotes anoikis resistance and invasion through activation of PI3K/Akt2.Q39905594
Epithelial-mesenchymal transition in breast cancer relates to the basal-like phenotypeQ40012189
Depletion of mitochondrial DNA by ethidium bromide treatment inhibits the proliferation and tumorigenesis of T47D human breast cancer cellsQ40153122
Inter-genomic cross talk between mitochondria and the nucleus plays an important role in tumorigenesisQ40404693
Tumor-forming ability in athymic nude mice of human cell lines devoid of mitochondrial DNA.Q41454678
Subtypes of breast cancer show preferential site of relapseQ42435505
Copy number alterations that predict metastatic capability of human breast cancerQ45417199
Mitochondrial DNA content in paired normal and cancerous breast tissue samples from patients with breast cancerQ46174157
Mitochondrial DNA replication during differentiation of murine embryonic stem cellsQ46923126
Diminished tumorigenic phenotype after depletion of mitochondrial DNA.Q48571916
Reporting recommendations for tumor marker prognostic studies (REMARK).Q53268902
Tumor-specific changes in mtDNA content in human cancer.Q53358631
Quantification of mitochondrial DNA in peripheral blood mononuclear cells and subcutaneous fat using real-time polymerase chain reactionQ57235634
An alcoholic binge causes massive degradation of hepatic mitochondrial DNA in miceQ77922003
Mitochondrial DNA copy number is regulated by cellular proliferation: a role for Ras and p66(Shc)Q79863273
Reduced mitochondrial DNA copy number is correlated with tumor progression and prognosis in Chinese breast cancer patientsQ80677190
Infection with HIV-1 induces a decrease in mtDNAQ81612608
Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancersQ25255387
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
Mitochondrial DNA depletion syndromes: review and updates of genetic basis, manifestations, and therapeutic optionsQ26865135
Epithelial-mesenchymal transitions in tumour progressionQ27860487
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implicationsQ27860709
Molecular portraits of human breast tumoursQ28032461
Relevance of breast cancer antiestrogen resistance genes in human breast cancer progression and tamoxifen resistanceQ28303717
Mitochondrial DNA mutations and mitochondrial DNA depletion in breast cancerQ28304162
Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementationQ29614475
Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancerQ29615523
Mitochondria and cancerQ29616610
Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancerQ29619481
Pathway analysis of gene signatures predicting metastasis of node-negative primary breast cancerQ33300287
mtDNA depletion confers specific gene expression profiles in human cells grown in culture and in xenograftQ33382286
Improvement of the clinical applicability of the Genomic Grade Index through a qRT-PCR test performed on frozen and formalin-fixed paraffin-embedded tissuesQ33501853
Methylation profile of TP53 regulatory pathway and mtDNA alterations in breast cancer patients lacking TP53 mutationsQ33577711
Loss of E-cadherin is not a necessity for epithelial to mesenchymal transition in human breast cancer.Q34556770
Precise determination of mitochondrial DNA copy number in human skeletal and cardiac muscle by a PCR-based assay: lack of change of copy number with age.Q35032317
mtDNA depletion with variable tissue expression: a novel genetic abnormality in mitochondrial diseasesQ35196481
Origins and functional consequences of somatic mitochondrial DNA mutations in human cancerQ35212322
Mitochondrial DNA content varies with pathological characteristics of breast cancerQ35418164
The awakening of an advanced malignant cancer: an insult to the mitochondrial genomeQ35718294
Simultaneous detection and quantification of mitochondrial DNA deletion(s), depletion, and over-replication in patients with mitochondrial diseaseQ35790038
Genomic profiling of CHEK2*1100delC-mutated breast carcinomasQ35836700
Detection of a specific mitochondrial DNA deletion in tissues of older humansQ35891834
Mitochondrial respiration defects in cancer cells cause activation of Akt survival pathway through a redox-mediated mechanismQ36119450
Induction of acquired resistance to antiestrogen by reversible mitochondrial DNA depletion in breast cancer cell lineQ36540703
Progressive tumor features accompany epithelial-mesenchymal transition induced in mitochondrial DNA-depleted cells.Q36874174
miRNA expression profiling of 51 human breast cancer cell lines reveals subtype and driver mutation-specific miRNAsQ36902949
Frequent truncating mutation of TFAM induces mitochondrial DNA depletion and apoptotic resistance in microsatellite-unstable colorectal cancerQ37010058
Mitochondrial retrograde signaling induces epithelial-mesenchymal transition and generates breast cancer stem cellsQ37038507
P433issue20
P407language of work or nameEnglishQ1860
P921main subjectmitochondrial DNAQ27075
P304page(s)29166-29176
P577publication date2016-04-11
P1433published inOncotargetQ1573155
P1476titleMitochondrial DNA content in breast cancer: Impact on in vitro and in vivo phenotype and patient prognosis
P478volume7

Reverse relations

cites work (P2860)
Q64945266Clinical application of plasma mitochondrial DNA content in patients with lung cancer.
Q42210329Elevated Mitochondrial DNA Copy Number in Peripheral Blood and Tissue Predict the Opposite Outcome of Cancer: A Meta-Analysis
Q49708541Mitochondrial Dysfunction: A Novel Potential Driver of Epithelial-to-Mesenchymal Transition in Cancer.
Q60907386Mitochondrial RNA Expression and Single Nucleotide Variants in Association with Clinical Parameters in Primary Breast Cancers
Q38703672MtDNA As a Cancer Marker: A Finally Closed Chapter?
Q47162272Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer
Q38756331Prevalence of somatic mitochondrial mutations and spatial distribution of mitochondria in non-small cell lung cancer
Q92301834Retinal Bioenergetics: New Insights for Therapeutics
Q48113220Sensitive detection of mitochondrial DNA variants for analysis of mitochondrial DNA-enriched extracts from frozen tumor tissue
Q55518477Tumor-Specific Mitochondrial DNA Variants Are Rarely Detected in Cell-Free DNA.