Praziquantel, a new broad-spectrum antischistosomal agent

scientific article published on July 21, 1977

Praziquantel, a new broad-spectrum antischistosomal agent is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/BF00389899
P953full work available at URLhttp://link.springer.com/content/pdf/10.1007/BF00389899.pdf
http://link.springer.com/article/10.1007/BF00389899/fulltext.html
http://link.springer.com/content/pdf/10.1007/BF00389899
P698PubMed publication ID410178

P2093author name stringR. Gönnert
P. Andrews
P2860cites workJean-Baptiste François Pierre BulliardQ1246173
Studies with the schistosomicide oxamniquine (UK-4271) I. Activity in rodents and in vitroQ34052869
Influence of parasite strain on chemotherapy of murine infections with Schistosoma mansoniQ36720555
Protection against human schistosome cercariaeQ39969136
Experimental chemotherapy of schistosomiasis mansoni. XIII. Activity of praziquantel, an isoquinoline-pyrazino derivative, on mice, hamsters and Cebus monkeysQ41323055
The susceptibility to praziquantel of Schistosoma haematobium in the baboon (Papio anubis) and of S. japonicum in the vervet monkey (Cercopithecus aethiops)Q41323073
The structure-activity relationship in several schistosomicidal compoundsQ41883060
Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey, and man.Q43706400
The efficacy of praziquantel against cestodes in cats, dogs and sheepQ44388870
Susceptibility of Schistosoma mansoni from Liberia and Puerto Rico to antischistosomal drugsQ46720616
The efficacy of praziquantel against cestodes in animalsQ50968447
Experimental chemoprophylaxis against schistosomiasis. I. Introduction and rationale.Q52733401
An Improved Perfusion Technique for Recovering Adult Schistosomes from Laboratory AnimalsQ53755844
A new active metabolite of "Miracil D".Q53790645
The relative chemotherapeutic efficacy of a nitrovinylfuran (SQ 18,506) against immature and mature stages of Schistosoma mansoni.Q54046816
A comparison of the susceptibility to praziquantel of Schistosoma haematobium, S. japonicum, S. mansoni, S. intercalatum and S. mattheei im hamstersQ67682007
[Effect of hycanthone at different evolutive stages of experimental infection of the mouse by Schistosoma mansoni]Q68543672
Experimental chemoprophylaxis against schistosomiasis. II. Stage I comparison of lucanthone, hycanthone, niridazole and oxamniquine (UK 4271)Q69675861
Schistosoma mansoni: Early antimonial treatment of infected miceQ69750160
The control of immatureSchistosoma mansoniin mice by UK 3883, a novel 2-aminomethyltetrahydroquinoline derivativeQ70561571
Comparative studies of the action of mirasan, lucanthone, hycanthone and niridazole againstSchistosoma mansoniin miceQ71838835
Comparison of biological effects by programmed probit analysisQ72859007
[Dependence on host and parasite strain of the successful therapy of experimental schistosomiasis]Q73810786
Efficacy of a 2-Phenyl Quinoline against Experimental Schistosoma mansoni Infections in Mice and MonkeysQ76460473
CHEMOTHERAPY OF EXPERIMENTAL SCHISTOSOMIASIS MANSONI: PROPHYLACTIC AND PROTECTIVE ACTIVITY OF CLINICALLY ACTIVE COMPOUNDS IN MICE AND HAMSTERSQ76675059
CHEMOTHERAPY OF EXPERIMENTAL SCHISTOSOMIASIS MANSONI: PROPHYLACTIC, PROTECTIVE AND THERAPEUTIC ACTIVITY OF SODIUM ANTIMONY DIMERCAPTOSUCCINATE AND ANTIMONY DIMERCAPTOSUCCINIC ACID IN MICE AND HAMSTERSQ76966917
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectpraziquantelQ424145
P304page(s)129-150
P577publication date1977-07-01
1977-07-21
P1433published inZeitschrift für Parasitenkunde (Berlin, Germany)Q27713931
P1476titlePraziquantel, a new board-spectrum antischistosomal agent
Praziquantel, a new broad-spectrum antischistosomal agent
P478volume52

Reverse relations

cites work (P2860)
Q44983935A benzodiazepine derivative and praziquantel: effects on musculature of Schistosoma mansoni and Schistosoma japonicum
Q35801990A blood fluke serine protease inhibitor regulates an endogenous larval elastase
Q67682007A comparison of the susceptibility to praziquantel of Schistosoma haematobium, S. japonicum, S. mansoni, S. intercalatum and S. mattheei im hamsters
Q64243898A novel cell-free method to culture Schistosoma mansoni from cercariae to juvenile worm stages for in vitro drug testing
Q64947379A novel praziquantel solid lipid nanoparticle formulation shows enhanced bioavailability and antischistosomal efficacy against murine S. mansoni infection.
Q69038524Absorption, distribution and excretion of the anthelmintic praziquantel (Droncit) in rainbow trout (Salmo gairdneri R.).
Q34230702Activity of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine against Schistosomiasis mansoni in mice
Q39225562Adverse effects of praziquantel treatment of Schistosoma japonicum infection: involvement of host anaphylactic reactions induced by parasite antigen release
Q39392929An international initiative on praziquantel use.
Q28545088Anthelmintic activity in vivo of epiisopiloturine against juvenile and adult worms of Schistosoma mansoni
Q35663977Anti-Schistosomal Activity of Cinnamic Acid Esters: Eugenyl and Thymyl Cinnamate Induce Cytoplasmic Vacuoles and Death in Schistosomula of Schistosoma mansoni
Q42239154Anti-inflammatory/anti-fibrotic effects of the hepatoprotective silymarin and the schistosomicide praziquantel against Schistosoma mansoni-induced liver fibrosis
Q38975059Anti-schistosome chemotherapy enhanced by antibodies specific for a parasite esterase.
Q36394751Antioxidant and hepatoprotective role of gold nanoparticles against murine hepatic schistosomiasis
Q37674908Antischistosomal activity of a calcium channel antagonist on schistosomula and adult Schistosoma mansoni worms
Q37450784Antischistosomal activity of hexadecyloxypropyl cyclic 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine and other alkoxyalkyl esters of acyclic nucleoside phosphonates assessed by schistosome worm killing in vitro.
Q38077463Application of praziquantel in schistosomiasis japonica control strategies in China
Q60949181Artemether and Praziquantel: Origin, Mode of Action, Impact, and Suggested Application for Effective Control of Human Schistosomiasis
Q24615049Bioactivity of miltefosine against aquatic stages of Schistosoma mansoni, Schistosoma haematobium and their snail hosts, supported by scanning electron microscopy
Q83769924Bioavailability and in vivo efficacy of a praziquantel-polyvinylpyrrolidone solid dispersion in Schistosoma mansoni-infected mice
Q37557828Chapter 4. Peptidases of trematodes
Q28539314Chemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasis
Q57157512Chemotherapy for Fighting Schistosomiasis: Past, Present and Future
Q35841575Chemotherapy for major food-borne trematodes: a review
Q68732251Chemotherapy of experimental Echinococcus multilocularis in jirds
Q39729825Chemotherapy of parasitic infections
Q79239916Chemotherapy of schistosomiasis: an update
Q28328165Clinical pharmacology in normal volunteers of praziquantel, a new drug against schistosomes and cestodes. An example of a complex study covering both tolerance and pharmacokinetics
Q35536096Clinical study evaluating efficacy of praziquantel in clonorchiasis
Q34939414Combination chemotherapy of schistosomiasis in laboratory studies and clinical trials
Q46237917Comparative Analysis of Proteome-Wide Lysine Acetylation in Juvenile and Adult Schistosoma japonicum
Q37771992Controlling schistosomiasis in Southeast Asia: a tale of two countries
Q37726920Controlling schistosomiasis with praziquantel: How much longer without a viable alternative?
Q37405246Current chemotherapy arsenal for schistosomiasis mansoni: alternatives and challenges
Q36877133Current status of medicinal research in helminth diseases
Q40547961Cytokine patterns in experimental schistosomiasis mansoni infected mice treated with silymarin
Q33747366Design and synthesis of molecular probes for the determination of the target of the anthelmintic drug praziquantel
Q44211698Detection of circulating anodic antigen before and after specific chemotherapy in experimental murine schistosomiasis mansoni
Q28543164Development and validation of a luminescence-based, medium-throughput assay for drug screening in Schistosoma mansoni
Q39300204Discovery of New Anti-Schistosomal Hits by Integration of QSAR-Based Virtual Screening and High Content Screening
Q27306843Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screening
Q99719959Drug metabolism and pharmacokinetics of praziquantel: A review of variable drug exposure during schistosomiasis treatment in human hosts and experimental models
Q53605480Effect of adamantylamide dipeptide as adjuvant therapy to praziquantel in mice infected with different S. mansoni isolates.
Q35773009Effect of an integrated control strategy for schistosomiasis japonica in the lower reaches of the Yangtze River, China: an evaluation from 2005 to 2008
Q39544935Effect of combined treatment with praziquantel and artemether on Schistosoma japonicum and Schistosoma mansoni in experimentally infected animals
Q41763237Effect of praziquantel on certain immune responses of schistosomal Egyptian patients. I. Changes of specific immunoglobulins
Q46797403Effect of praziquantel on some aspects of carbohydrate metabolism in mice infected with Schistosoma mansoni
Q33884547Effect of praziquantel on the differential expression of mouse hepatic genes and parasite ATP binding cassette transporter gene family members during Schistosoma mansoni infection
Q44441883Effect of praziquantel on the distribution of interstitial collagen types I and III and basement membrane collagen types IV and V in murine hepatic schistosomiasis
Q67400835Effect of praziquantel on the free living stages of Schistosoma mansoni
Q44093477Effect of praziquantel prolonged administration on granuloma formation around Schistosoma japonicum eggs in lung of sensitized mice
Q73576307Effect of praziquantel together with artemether on Schistosoma japonicum parasites of different ages in rabbits
Q69091747Effect of praziquantel treatment on lung-stage larvae of Schistosoma mansoni in vivo
Q51400781Effect of the in vivo activity of dihydroartemisinin against Schistosoma mansoni infection in mice.
Q70790142Effects of free and liposomized praziquantel on worm burden and antibody response in mice infected with Mesocestoides corti tetrathyridia
Q69709333Effects of praziquantel on human intestinal flukes (Fasciolopsis buski and Heterophyes heterophyes)
Q38452685Efficacy and side-effects of two praziquantel treatments against Schistosoma haematobium infection, among schoolchildren from Côte d'Ivoire
Q37544555Evaluation of the anti-Schistosoma mansoni activity of thiosemicarbazones and thiazoles
Q44641141Evaluation of the safety of ivermectin-praziquantel administered orally to pregnant mares
Q35960717Evolutionary concepts in predicting and evaluating the impact of mass chemotherapy schistosomiasis control programmes on parasites and their hosts
Q49171947Experimental chemotherapy of Schistosoma curassoni in mice
Q67984511Experimental chemotherapy of Schistosoma mansoni with praziquantel and oxamniquine: differential effect of single or combined formulations of drugs on various strains and on both sexes of the parasite
Q41323055Experimental chemotherapy of schistosomiasis mansoni. XIII. Activity of praziquantel, an isoquinoline-pyrazino derivative, on mice, hamsters and Cebus monkeys
Q37373792Expression, immunolocalization and serodiagnostic value of a myophilin-like protein from Schistosoma japonicum.
Q71187170Factors affecting the acquisition of resistance against Schistosoma mansoni in the mouse. V. Reduction in the degree of resistance to reinfection after chemotherapeutic elimination of recently patent primary infections
Q69002001Fasciola hepatica: tegumental surface alterations following treatment in vitro with the deacetylated (amine) metabolite of diamphenethide
Q33642023Formulation, characterization and pharmacokinetics of praziquantel-loaded hydrogenated castor oil solid lipid nanoparticles
Q47988412Further studies on mefloquine and praziquantel alone or interaction of both drugs against Schistosoma japonicum in vitro
Q39786591Genetic activities of hycanthone and some other antischistosomal drugs
Q28552824Global Assessment of Schistosomiasis Control Over the Past Century Shows Targeting the Snail Intermediate Host Works Best
Q37280789Imaging schistosomes in vivo
Q39257435Immune dependence of schistosomicidal chemotherapy: an ultrastructural study of Schistosoma mansoni adult worms exposed to praziquantel and immune serum in vivo
Q35224451Immune-dependent chemotherapy of schistosomiasis
Q42859585Immunological and parasitological parameters after treatment with dexamethasone in murine Schistosoma mansoni
Q37292213In Vitro Schistosomicidal Activity of Phytol and Tegumental Alterations Induced in Juvenile and Adult Stages of Schistosoma haematobium
Q28542999In silico repositioning-chemogenomics strategy identifies new drugs with potential activity against multiple life stages of Schistosoma mansoni
Q64068974In vitro and in vivo activities of DW-3-15, a commercial praziquantel derivative, against Schistosoma japonicum
Q27339703In vitro and in vivo anti-schistosomal activity of the alkylphospholipid analog edelfosine
Q43713527In vitro responses of praziquantel-resistant and -susceptible Schistosoma mansoni to praziquantel
Q96816954Investigating the antifibrotic effect of the antiparasitic drug Praziquantel in in vitro and in vivo preclinical models
Q51741191Investigations on the interplays between Schistosoma mansoni, praziquantel and the gut microbiome.
Q51191319Is there a reduced sensitivity of dihydroartemisinin against praziquantel-resistant Schistosoma japonicum?
Q42920406Is there reduced susceptibility to praziquantel in Schistosoma japonicum? Evidence from China
Q52506843Light and electron microscopic studies on the effect of praziquantel on Schistosoma mansoni, Dicrocoelium dendriticum, and Fasciola hepatica (Trematoda) in vitro.
Q48578173London School of Hygiene and Tropical Medicine Meeting at Keppel Street, London, 12 April 2000. The Professor Gerald Webbe Memorial Lecture: global control of schistosomiasis
Q89967832MicroRNA-21 Mediates the Inhibiting Effect of Praziquantel on NLRP3 Inflammasome in Schistosoma japonicum Infection
Q36990847Microarray based analysis of temperature and oxidative stress induced messenger RNA in Schistosoma mansoni
Q38807251Modern approaches to accelerate discovery of new antischistosomal drugs.
Q39211542Morphological effects and tegumental alterations induced by mefloquine on schistosomula and adult flukes of Schistosoma mansoni
Q36675102Multicentre trials of praziquantel in human schistosomiasis: design and techniques
Q44042514Mutagenicity studies with Praziquantel, a new anthelmintic drug, in mammalian systems
Q40817009Mutagenicity studies with praziquantel, a new anthelmintic drug: Tissue-, host-, and urine-mediated mutagenicity assays
Q38334179Natural products as leads in schistosome drug discovery.
Q37177725New approaches for understanding mechanisms of drug resistance in schistosomes
Q37943763New insight into praziquantel against various developmental stages of schistosomes
Q34163477New praziquantel derivatives containing NO-donor furoxans and related furazans as active agents against Schistosoma mansoni
Q39386825Parasitological evaluation of Ro 15-9268, a 9-acridanone-hydrazone derivative against Schistosoma mansoni in mice, and observations on changes in serum enzyme levels
Q46921243Pharmacodynamics of mefloquine and praziquantel combination therapy in mice harbouring juvenile and adult Schistosoma mansoni
Q51034558Pharmacokinetics of new high-concentration and long-acting praziquantel oily suspensions after intramuscular administration in cattle.
Q35281233Polymorphism associated with the Schistosoma mansoni tetraspanin-2 gene
Q36099895Population Pharmacokinetics and Pharmacodynamics of Praziquantel in Ugandan Children with Intestinal Schistosomiasis: Higher Dosages Are Required for Maximal Efficacy.
Q52206275Population dynamics of Schistosoma mansoni in mice repeatedly exposed to infection.
Q44574643Potential antifibrotic effects of AT1 receptor antagonist, losartan, and/or praziquantel on acute and chronic experimental liver fibrosis induced by Schistosoma mansoni
Q70419881Praziquantel
Q48622699Praziquantel Targets M1 Macrophages and Ameliorates Splenomegaly in Chronic Schistosomiasis
Q80983687Praziquantel and the benzodiazepine Ro 11-3128 do not compete for the same binding sites in schistosomes
Q36441487Praziquantel for the treatment of schistosomiasis: its use for control in areas with endemic disease and prospects for drug resistance
Q73338045Praziquantel has no direct effect on (Na(+)+K+)-ATPases and (Ca2(+)-Mg2+)ATPases of Schistosoma mansoni
Q35607817Praziquantel in a clay nanoformulation shows more bioavailability and higher efficacy against murine Schistosoma mansoni infection
Q28484303Praziquantel synergistically enhances paclitaxel efficacy to inhibit cancer cell growth
Q46797056Praziquantel treatment of Biomphalaria glabrata infected with Schistosoma mansoni--influence on snail fecundity
Q67879080Praziquantel treatment of muscle Taenia solium cysticercosis. 4. Reversible in vitro effect
Q45065380Praziquantel-induced exposure of Schistosoma mansoni alkaline phosphatase: drug-antibody synergy which acts preferentially against female worms
Q24677485Praziquantel: a new schistosomicide against Schistosoma haematobium
Q28475935Reduced susceptibility to praziquantel among naturally occurring Kenyan isolates of Schistosoma mansoni
Q44026136Reduction in the prevalence and intensity of hookworm infections after praziquantel treatment for schistosomiasis infection
Q43778585Reinfection with Schistosoma haematobium following school-based chemotherapy with praziquantel in four highly endemic villages in Côte d'Ivoire
Q39544940Relative contribution of day-to-day and intra-specimen variation in faecal egg counts of Schistosoma mansoni before and after treatment with praziquantel
Q34125799Research and development of antischistosomal drugs in the People's Republic of China a 60-year review
Q33735929Revisiting glucose uptake and metabolism in schistosomes: new molecular insights for improved schistosomiasis therapies
Q36664391Scanning and transmission electron microscope studies on the efficacy of praziquantel on Hymenolepis nana (Cestoda) in vitro
Q46793864Schistosoma japonicum-infected hamsters (Mesocricetus auratus) used as a model in experimental chemotherapy with praziquantel, artemether, and OZ compounds
Q41527168Schistosoma mansoni: Activity responses in vitro to praziquantel
Q44093854Schistosoma mansoni: Angiotensin converting enzyme activity in mice under the influence of praziquantel and/or captopril
Q40147049Schistosoma mansoni: The effects of a subcurative dose of praziquantel on the ultrastructure of worms in vivo
Q71088008Schistosoma mansoni: dose-related tegumental surface changes after in vivo treatment with praziquantel
Q54350844Schistosoma mansoni: enhanced efficacy of praziquantel treatment in immune mice.
Q52242503Schistosoma mansoni: stage-dependent damage after in vivo treatment with praziquantel.
Q39381400Schistosomes: challenges in compound screening
Q34573786Schistosomiasis Drug Therapy and Treatment Considerations
Q36459174Schistosomiasis--a century searching for chemotherapeutic drugs.
Q34998245Schistosomiasis--a rich vein of research
Q38984212Schistosomicidal and molluscicidal activities of aminoalkylamino substituted neo- and norneocryptolepine derivatives
Q44567644Sequence and level of endogenous expression of calcium channel beta subunits in Schistosoma mansoni displaying different susceptibilities to praziquantel
Q35927520Sexual biology of schistosomes
Q41875321Significant intrapulmonary Schistosoma egg antigens are not present in schistosomiasis-associated pulmonary hypertension
Q54448067Stability of Schistosoma mansoni progeny to antischistosomal drugs.
Q33687475Structural insights into a 20.8-kDa tegumental-allergen-like (TAL) protein from Clonorchis sinensis
Q37409571Structure mechanism insights and the role of nitric oxide donation guide the development of oxadiazole-2-oxides as therapeutic agents against schistosomiasis
Q70399501Studies on chemotherapy of parasitic helminths (IX). Effects of praziquantel on the motility of various parasitic helminths and isolated host tissues
Q35593046Suppression of the Insulin Receptors in Adult Schistosoma japonicum Impacts on Parasite Growth and Development: Further Evidence of Vaccine Potential
Q38050973Susceptibility or resistance of praziquantel in human schistosomiasis: a review
Q33504927Susceptibility to praziquantel of male and female cercariae of praziquantel-resistant and susceptible isolates of Schistosoma mansoni
Q39607879Synthesis of fluorescent derivatives of praziquantel: cell-imaging and interaction with Schistosoma japonicum cercariae
Q60053808TPT sulfonate, a single, oral dose schistosomicidal prodrug: In vivo efficacy, disposition and metabolic profiling
Q43762877Tegumental alterations in juvenile Schistosoma haematobium harboured in hamsters following artemether treatment
Q37071406Telmisartan, an AT1 receptor blocker and a PPAR gamma activator, alleviates liver fibrosis induced experimentally by Schistosoma mansoni infection
Q28552173The Schistosomiasis Clinical Trials Landscape: A Systematic Review of Antischistosomal Treatment Efficacy Studies and a Case for Sharing Individual Participant-Level Data (IPD)
Q58070149The anti-schistosomal drug praziquantel is an adenosine antagonist
Q56514272The antidepressant drug paroxetine as a new lead candidate in schistosome drug discovery
Q43823575The effect of Nigella sativa oil against the liver damage induced by Schistosoma mansoni infection in mice
Q41688910The effect of Praziquantel on Schistosoma mansoni
Q42472011The effect of praziquantel on the ultrastructure of Schistosoma margrebowiei.
Q50968447The efficacy of praziquantel against cestodes in animals
Q44388870The efficacy of praziquantel against cestodes in cats, dogs and sheep
Q41395086The efficacy of praziquantel against experimental cysticercosis and hydatidosis (author's transl)
Q34455017The potential of artemether for the control of schistosomiasis
Q36850831The schistosome in the mammalian host: understanding the mechanisms of adaptation
Q35910564The sensitivity of Schistosoma japonicum to praziquantel: a field evaluation in areas with low endemicity of China
Q41323073The susceptibility to praziquantel of Schistosoma haematobium in the baboon (Papio anubis) and of S. japonicum in the vervet monkey (Cercopithecus aethiops)
Q33914691Towards an understanding of the mechanism of action of praziquantel
Q46470767Tranilast ameliorates impaired hepatic functions in Schistosoma mansoni-infected mice
Q36442593Transcriptional analysis of Schistosoma mansoni treated with praziquantel in vitro
Q43832848Transmission electron microscopic observations on ultrastructural damage in juvenile Schistosoma mansoni caused by artemether
Q53691679Treatment of fish parasites. 1. Praziquantel effective against Monogenea (Dactylogyrus vastator, Dactylogyrus extensus, Diplozoon paradoxum).
Q70871918Treatment of human fascioliasis with niclofolan
Q46497362Ultrastructural changes of adult Schistosoma mansoni worms recovered from C57BL/6 mice passively immunized with normal and vaccinated rabbit sera in vivo
Q70746971Ultrastructural investigations on the effect of praziquantel on the tegument of five species of cestodes
Q38264085Vaccines and diagnostics for zoonotic schistosomiasis japonica.
Q36579608Wharton's jelly-derived mesenchymal stem cells combined with praziquantel as a potential therapy for Schistosoma mansoni-induced liver fibrosis
Q71248355[New aspects in the field of parasitology and parasitic diseases of man]

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