Tranilast ameliorates impaired hepatic functions in Schistosoma mansoni-infected mice

scientific article published on 26 January 2012

Tranilast ameliorates impaired hepatic functions in Schistosoma mansoni-infected mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S10787-011-0117-1
P698PubMed publication ID22278738

P2093author name stringElsayed M Ammar
Shehta A Said
Nariman M Gameil
Wagdi F Elkashef
Eman Said
P2860cites workImmunopathology of Schistosoma mansoni infectionQ24616903
Identification of thioredoxin-binding protein-2/vitamin D(3) up-regulated protein 1 as a negative regulator of thioredoxin function and expressionQ28140461
Adhesion receptors of the immune systemQ29616393
Histological grading and staging of chronic hepatitisQ29619625
Non-invasive index of liver fibrosis induced by alcohol, thioacetamide and Schistosomal infection in miceQ33591803
Tranilast inhibits protein kinase C-dependent signalling pathway linked to angiogenic activities and gene expression of retinal microcapillary endothelial cellsQ35028866
Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitroQ35610349
Morbidity in schistosomiasis: an updateQ35881149
Schistosomiasis and liver fibrosisQ37613772
The anti-allergic compound tranilast attenuates inflammation and inhibits bone destruction in collagen-induced arthritis in miceQ39253354
Treatment of autoimmune neuroinflammation with a synthetic tryptophan metaboliteQ40354381
Tranilast ameliorates renal tubular damage in unilateral ureteral obstructionQ40807267
Praziquantel, a new broad-spectrum antischistosomal agentQ41323043
Tranilast inhibits the proliferation, chemotaxis and tube formation of human microvascular endothelial cells in vitro and angiogenesis in vivoQ43178739
Tranilast inhibits interleukin-1beta-induced monocyte chemoattractant protein-1 expression in rat mesangial cellsQ43737657
Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesisQ44121998
Mediation of the schistosomicidal effect of praziquantel through nitric oxideQ44254071
Mechanism of inhibitory action of tranilast on the release of slow reacting substance of anaphylaxis (SRS-A) in vitro: effect of tranilast on the release of arachidonic acid and its metabolitesQ44758939
Tranilast and hypertensive heart disease: further insights into mechanisms of an anti-inflammatory and anti-fibrotic drugQ44851414
Tranilast attenuates cardiac matrix deposition in experimental diabetes: role of transforming growth factor-betaQ45233765
Tranilast prevents the progression of experimental diabetic nephropathy through suppression of enhanced extracellular matrix gene expression.Q46460998
Effect of tranilast on matrix metalloproteinase production from neutrophils in-vitroQ46879755
Tranilast attenuates connective tissue growth factor-induced extracellular matrix accumulation in renal cellsQ46983859
Inhibition by tranilast of vascular endothelial growth factor (VEGF)/vascular permeability factor (VPF)-induced increase in vascular permeability in ratsQ47712082
Inhibitory effects of tranilast on expression of transforming growth factor-beta isoforms and receptors in injured arteriesQ47987270
Tranilast attenuates the up-regulation of thioredoxin-interacting protein and oxidative stress in an experimental model of diabetic nephropathy.Q53316900
Dynamics of collagen, MMP and TIMP gene expression during the granulomatous, fibrotic process induced by Schistosoma mansoni eggs.Q54704920
The mechanism involved in the inhibitory action of tranilast on collagen biosynthesis of keloid fibroblastsQ67466724
Inhibition of PDGF- and TGF-beta 1-induced collagen synthesis, migration and proliferation by tranilast in vascular smooth muscle cells from spontaneously hypertensive ratsQ71436522
Inhibition by tranilast of collagen accumulation in hypersensitive granulomatous inflammation in vivo and of morphological changes anf functions of fibroblasts in vitroQ71652147
Tranilast, a selective inhibitor of collagen synthesis in human skin fibroblastsQ71679320
Inhibitory effect of tranilast on activation and transforming growth factor beta 1 expression in cultured rat stellate cellsQ71700649
Suppressive effects of tranilast on pulmonary fibrosis and activation of alveolar macrophages in mice treated with bleomycin: role of alveolar macrophages in the fibrosisQ71707179
Inhibitory effects of tranilast on proliferation, migration, and collagen synthesis of human vascular smooth muscle cellsQ71883627
Cell action mechanism of tranilast--effect on the expression of HLA-class II antigenQ72093967
Experimental schistosomiasis mansoni: characterization of connective tissue cells in hepatic periovular granulomasQ72677852
Modulation of human monocyte activities by tranilast, SB 252218, a compound demonstrating efficacy in restenosisQ73199921
Vascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective beta-isoform-selective inhibitorQ73674093
Liver granulomas in schistosomiasis: mast cell-dependent induction of SCF expression in hepatic stellate cells is mediated by TNF-alphaQ73721697
Suppression of atherosclerotic development in Watanabe heritable hyperlipidemic rabbits treated with an oral antiallergic drug, tranilastQ74459717
Intervention with tranilast attenuates renal pathology and albuminuria in advanced experimental diabetic nephropathyQ75206070
Tranilast slows the progression of advanced diabetic nephropathyQ78354463
Praziquantel: The enigmatic antiparasiticQ80819033
P433issue2
P921main subjectSchistosoma mansoniQ2324689
P304page(s)77-87
P577publication date2012-01-26
P1433published inInflammopharmacologyQ15751310
P1476titleTranilast ameliorates impaired hepatic functions in Schistosoma mansoni-infected mice
P478volume20