The mechanism involved in the inhibitory action of tranilast on collagen biosynthesis of keloid fibroblasts

scientific article published on 01 October 1992

The mechanism involved in the inhibitory action of tranilast on collagen biosynthesis of keloid fibroblasts is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1254/JJP.60.91
P953full work available at URLhttps://www.jstage.jst.go.jp/article/jphs1951/60/2/60_2_91/_pdf
P698PubMed publication ID1282576

P2093author name stringN. Arai
S. Kikuchi
A. Koda
H. Suzawa
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)91-96
P577publication date1992-10-01
P1433published inThe Japanese Journal of PharmacologyQ45115274
P1476titleThe mechanism involved in the inhibitory action of tranilast on collagen biosynthesis of keloid fibroblasts
P478volume60

Reverse relations

cites work (P2860)
Q77585444Angiogenesis in pathological and surgical scars
Q45217870Antagonistic effects of tranilast on proliferation and collagen synthesis induced by TGF-beta2 in cultured human trabecular meshwork cells
Q42178648Antiproliferative and c-myc mRNA suppressive effect of tranilast on newborn human vascular smooth muscle cells in culture
Q55709554Assessing the response of morphea and limited scleroderma to tranilast: a small prospective study comparing topical corticosteroids to a combination of topical corticosteroids and tranilast.
Q36627103Attenuation of amiodarone induced lung fibrosis and phospholipidosis in hamsters, by treatment with the platelet activating factor receptor antagonist, WEB 2086
Q35439417Cancer-associated fibroblast-targeted strategy enhances antitumor immune responses in dendritic cell-based vaccine
Q64057927Cannabinoid Signaling in the Skin: Therapeutic Potential of the "C(ut)annabinoid" System
Q92728117Cardiac fibrosis: potential therapeutic targets
Q73219513Effect of Tranilast on chronic graft vascular disease and tracheal proliferation in a rat allograft model
Q41137969Effect of azelastine on PGE2 production in fibroblasts in normal skin. The possibility of inhibition of inducible cyclooxygenase by azelastine
Q36139952Effective treatment for prevention of post-operative adhesion after strabismus surgery in experimental rabbit model: 0.5 % tranilast ophthalmic solution
Q73833368Effectiveness of tranilast on restenosis after directional coronary atherectomy
Q44346218Effects of fibroblast growth inhibitor on proliferation and metastasis of oral squamous cell carcinoma
Q90282198Effects of tranilast on the epithelial-to-mesenchymal transition in peritoneal mesothelial cells
Q46406257Expression, localisation and function of ACE and chymase in normal and atherosclerotic human coronary arteries
Q40848340Hepatic fibrosis--current concepts of pathogenesis and therapy
Q57162899Immunomodulatory interventions in myocardial infarction and heart failure: a systematic review of clinical trials and meta-analysis of IL-1 inhibition
Q73128372Impact of tranilast on restenosis after coronary angioplasty: tranilast restenosis following angioplasty trial (TREAT)
Q47101405Importance of human peritoneal mesothelial cells in the progression, fibrosis, and control of gastric cancer: inhibition of growth and fibrosis by tranilast
Q32110855Inflammatory endobronchial stenosis
Q47712082Inhibition by tranilast of vascular endothelial growth factor (VEGF)/vascular permeability factor (VPF)-induced increase in vascular permeability in rats
Q73662537Inhibition of neointima formation by tranilast in pig coronary arteries after balloon angioplasty and stent implantation
Q73205042Inhibitory influences of tranilast on multinucleated giant cell formation from monocytes by supernatant of concanavalin A-stimulated mononuclear cells
Q41813563Innovative therapies in the treatment of keloids and hypertrophic scars
Q89687959Keloid pathophysiology: fibroblast or inflammatory disorders?
Q41882581Keloid-derived fibroblasts are refractory to Fas-mediated apoptosis and neutralization of autocrine transforming growth factor-beta1 can abrogate this resistance
Q34633683Kynurenine pathway metabolites in humans: disease and healthy States
Q77522059Medical therapies for the prevention of restenosis after percutaneous coronary interventions
Q34021948Nonsteroidal Anti-Inflammatory Drugs for Wounds: Pain Relief or Excessive Scar Formation?
Q41953103Overexpression of RACK1 inhibits collagen synthesis in keloid fibroblasts via inhibition of transforming growth factor-β1/Smad signaling pathway
Q36921222Pathobiology of transforming growth factor beta in cancer, fibrosis and immunologic disease, and therapeutic considerations
Q34265668Placement of self-expandable metallic stents for tracheal stenosis secondary to thyroid cancer
Q77644012Preventive effects of an antiallergic drug, pemirolast potassium, on restenosis after percutaneous transluminal coronary angioplasty
Q57483726Prior anti-CAFs break down the CAFs barrier and improve accumulation of docetaxel micelles in tumor
Q41944864Response of keloid fibroblasts to Vitamin D3 and quercetin treatment - in vitro study
Q38649653Scar management in burn injuries using drug delivery and molecular signaling: Current treatments and future directions
Q34393387Successful treatment of desmoid tumor of the chest wall with tranilast: a case report
Q73585262Suppressive effects of tranilast on the expression of inducible cyclooxygenase (COX2) in interleukin-1beta-stimulated fibroblasts
Q44126549Synthesis and structure-activity relationship of diarylamide derivatives as selective inhibitors of the proliferation of human endothelial cells
Q26863340Targeting mast cells tryptase in tumor microenvironment: a potential antiangiogenetic strategy
Q50159459Targeting nuclear receptors in cancer-associated fibroblasts as concurrent therapy to inhibit development of chemoresistant tumors
Q96304791The Keloid Disorder: Heterogeneity, Histopathology, Mechanisms and Models
Q39253354The anti-allergic compound tranilast attenuates inflammation and inhibits bone destruction in collagen-induced arthritis in mice
Q77739050The effect of the anti-allergic agent avil on abnormal scar fibroblasts
Q77958177The prevention of postoperative intraperitoneal adhesions by tranilast: N-(3',4'-dimethoxycinnamoyl)anthranilic acid
Q57281933Therapeutic potential of tranilast for the treatment of chronic graft-versus-host disease in mice
Q46470767Tranilast ameliorates impaired hepatic functions in Schistosoma mansoni-infected mice
Q46983859Tranilast attenuates connective tissue growth factor-induced extracellular matrix accumulation in renal cells
Q60472198Tranilast attenuates vascular hypertrophy, matrix accumulation and growth factor overexpression in experimental diabetes
Q37284410Tranilast enhances the anti-tumor effects of tamoxifen on human breast cancer cells in vitro.
Q64944714Tranilast enhances the effect of anticancer agents in osteosarcoma.
Q73501161Tranilast inhibits contraction of rat aortic smooth muscle
Q35028866Tranilast inhibits protein kinase C-dependent signalling pathway linked to angiogenic activities and gene expression of retinal microcapillary endothelial cells
Q52718681Tranilast inhibits the expression of genes related to epithelial-mesenchymal transition and angiogenesis in neurofibromin-deficient cells.
Q43178739Tranilast inhibits the proliferation, chemotaxis and tube formation of human microvascular endothelial cells in vitro and angiogenesis in vivo
Q73031635Tranilast suppresses the vascular intimal hyperplasia after balloon injury in rabbits fed on a high-cholesterol diet
Q77725736Tranilast, an anti-allergic drug, possesses antagonistic potency to angiotensin II
Q37743995Tranilast-induced stress alleviation in solid tumors improves the efficacy of chemo- and nanotherapeutics in a size-independent manner.

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