Tranilast attenuates connective tissue growth factor-induced extracellular matrix accumulation in renal cells

scientific article published in March 2006

Tranilast attenuates connective tissue growth factor-induced extracellular matrix accumulation in renal cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/SJ.KI.5000189
P698PubMed publication ID16528248
P5875ResearchGate publication ID7250681

P2093author name stringChen X
Qi W
Gilbert RE
Pollock CA
Twigg S
Polhill TS
P2860cites workA new mathematical model for relative quantification in real-time RT-PCRQ27860781
The low density lipoprotein receptor-related protein/alpha2-macroglobulin receptor is a receptor for connective tissue growth factorQ28214235
Cyr61 and Fisp12 are both ECM-associated signaling molecules: activities, metabolism, and localization during developmentQ28508666
Nuclear expression of p53, p21 and cyclin D1 is increased in bronchioloalveolar carcinomaQ30682145
TGF-beta 1 induces proliferation in human renal fibroblasts via induction of basic fibroblast growth factor (FGF-2).Q31903554
Transforming growth factor beta contributes to progressive diabetic nephropathyQ36102963
Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-betaQ36663630
Cellular events in renal hypertrophyQ38201489
Increased expression of transforming growth factor-beta in renal diseaseQ40697165
Tranilast ameliorates renal tubular damage in unilateral ureteral obstructionQ40807267
The transforming growth factor beta system in kidney disease and repair: recent progress and future directionsQ40827841
TGF-beta in kidney fibrosis: a target for gene therapyQ41469693
Tranilast inhibits interleukin-1beta-induced monocyte chemoattractant protein-1 expression in rat mesangial cellsQ43737657
Tranilast prevents activation of transforming growth factor-beta system, leukocyte accumulation, and neointimal growth in porcine coronary arteries after stentingQ44030296
Inhibition by tranilast of vascular endothelial growth factor (VEGF)/vascular permeability factor (VPF)-induced increase in vascular permeability in ratsQ47712082
Inhibitory effects of tranilast on expression of transforming growth factor-beta isoforms and receptors in injured arteriesQ47987270
The mechanism involved in the inhibitory action of tranilast on collagen biosynthesis of keloid fibroblastsQ67466724
Treatment of linear localized scleroderma with the anti-allergic drug, tranilastQ71655515
Tranilast, a selective inhibitor of collagen synthesis in human skin fibroblastsQ71679320
Inhibitory effects of tranilast on proliferation, migration, and collagen synthesis of human vascular smooth muscle cellsQ71883627
Connective tissue growth factor: a potential stimulus for glomerulosclerosis and tubulointerstitial fibrosis in progressive renal diseaseQ73131683
Fibrogenic effects of cyclosporin A on the tubulointerstitium: role of cytokines and growth factorsQ73177086
High glucose increases growth and collagen synthesis in cultured human tubulointerstitial cellsQ73250910
Human renal fibroblasts modulate proximal tubule cell growth and transport via the IGF-I axisQ73961008
Role of connective tissue growth factor in profibrotic action of transforming growth factor-beta: a potential target for preventing renal fibrosisQ74568092
Intervention with tranilast attenuates renal pathology and albuminuria in advanced experimental diabetic nephropathyQ75206070
Paracrine stimulation of human renal fibroblasts by proximal tubule cellsQ77291518
Intermittent high glucose enhances cell growth and collagen synthesis in cultured human tubulointerstitial cellsQ78126462
Tranilast slows the progression of advanced diabetic nephropathyQ78354463
Integrated actions of transforming growth factor-beta1 and connective tissue growth factor in renal fibrosisQ80984741
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectconnective tissueQ25615
extracellular matrixQ193825
P304page(s)989-995
P577publication date2006-03-01
P1433published inKidney InternationalQ6404823
P1476titleTranilast attenuates connective tissue growth factor-induced extracellular matrix accumulation in renal cells
P478volume69

Reverse relations

cites work (P2860)
Q37306427Antitransforming growth factor-beta therapy in fibrosis: recent progress and implications for systemic sclerosis
Q39561570Cation-independent mannose 6-phosphate receptor inhibitor (PXS25) inhibits fibrosis in human proximal tubular cells by inhibiting conversion of latent to active TGF-beta1.
Q53478090Connective tissue growth factor stimulates renal cortical myofibroblast-like cell proliferation and matrix protein production.
Q36139952Effective treatment for prevention of post-operative adhesion after strabismus surgery in experimental rabbit model: 0.5 % tranilast ophthalmic solution
Q43244408Effects of tranilast and pentoxifylline in a mouse model of chronic asthma using house dust mite antigen
Q50534633Lupus miliaris disseminatus faciei successfully treated with tranilast: report of two cases.
Q36921222Pathobiology of transforming growth factor beta in cancer, fibrosis and immunologic disease, and therapeutic considerations
Q31133726Plumbagin ameliorates diabetic nephropathy via interruption of pathways that include NOX4 signalling
Q26784039Potential Renoprotective Agents through Inhibiting CTGF/CCN2 in Diabetic Nephropathy
Q28548700Precursor-Directed Combinatorial Biosynthesis of Cinnamoyl, Dihydrocinnamoyl, and Benzoyl Anthranilates in Saccharomyces cerevisiae
Q34583579Ramipril retards development of aortic valve stenosis in a rabbit model: mechanistic considerations.
Q37924999Targeting fibrosis for the treatment of heart failure: a role for transforming growth factor-β.
Q50051379The KCa3.1 blocker TRAM34 reverses renal damage in a mouse model of established diabetic nephropathy
Q36739752Therapeutic potential of TGF-beta inhibition in chronic renal failure
Q45919311Topical tranilast for treatment of the early stage of mild dry eye associated with chronic GVHD.
Q46470767Tranilast ameliorates impaired hepatic functions in Schistosoma mansoni-infected mice
Q53140506Tranilast inhibits the cell growth of normal human keratinocytes in vitro.
Q45559795Tranilast modulates fibrosis, epithelial-mesenchymal transition and peritubular capillary injury in unilateral ureteral obstruction rats
Q37743995Tranilast-induced stress alleviation in solid tumors improves the efficacy of chemo- and nanotherapeutics in a size-independent manner.
Q37413641Transcription factors Krüppel-like factor 6 and peroxisome proliferator-activated receptor-{gamma} mediate high glucose-induced thioredoxin-interacting protein

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