Plumbagin ameliorates diabetic nephropathy via interruption of pathways that include NOX4 signalling

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Plumbagin ameliorates diabetic nephropathy via interruption of pathways that include NOX4 signalling is …
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scholarly articleQ13442814

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P819ADS bibcode2013PLoSO...873428Y
P356DOI10.1371/JOURNAL.PONE.0073428
P8608Fatcat IDrelease_zuqweogkzzd45myjjrfw7ldzcq
P932PMC publication ID3753271
P698PubMed publication ID23991195
P5875ResearchGate publication ID256292088

P2093author name stringQing Ma
Sylvie Shen
Carol A Pollock
Rachel Yong
Sonia Saad
Xin-Ming Chen
Swarna Vijayaraj
P2860cites workPost-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegenerationQ27323209
The natural anticancer agent plumbagin induces potent cytotoxicity in MCF-7 human breast cancer cells by inhibiting a PI-5 kinase for ROS generationQ28483759
NAD(P)H oxidase mediates TGF-beta1-induced activation of kidney myofibroblastsQ33562191
A novel superoxide-producing NAD(P)H oxidase in kidneyQ33921569
Molecular basis of renal fibrosisQ34125332
NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis.Q34241578
Nox4 is a protective reactive oxygen species generating vascular NADPH oxidaseQ34264162
Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo.Q34276697
Inhibition of Nox-4 activity by plumbagin, a plant-derived bioactive naphthoquinoneQ34382679
NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblastsQ34453246
Nox4 is critical for hypoxia-inducible factor 2-alpha transcriptional activity in von Hippel-Lindau-deficient renal cell carcinomaQ34603364
Nox4 NAD(P)H oxidase mediates hypertrophy and fibronectin expression in the diabetic kidneyQ46681131
Transforming growth factor-beta1 induces Nox4 NAD(P)H oxidase and reactive oxygen species-dependent proliferation in human pulmonary artery smooth muscle cellsQ46755210
Tranilast attenuates connective tissue growth factor-induced extracellular matrix accumulation in renal cellsQ46983859
Role of Nox4 in murine models of kidney disease.Q47430771
Vascular Nox4Q56991375
No Superoxide—No Stress?Q60722890
The pathogenesis of chronic renal failure in diabetic nephropathy. Investigation of 488 cases of diabetic glomerulosclerosisQ70225378
Renal enlargement: comparative autoradiographic studies of 3H-thymidine uptake in diabetic and uninephrectomized ratsQ71100871
Novel sources of reactive oxygen species in the human bodyQ79906357
Integrated actions of transforming growth factor-beta1 and connective tissue growth factor in renal fibrosisQ80984741
Structural-functional relationships in diabetic nephropathyQ34616152
Diabetic nephropathy: mechanisms of renal disease progressionQ34729808
A key role for NOX4 in epithelial cell death during development of lung fibrosis.Q35185363
Tissue distribution and putative physiological function of NOX family NADPH oxidases.Q35928930
High glucose-induced thioredoxin-interacting protein in renal proximal tubule cells is independent of transforming growth factor-beta1.Q35963122
Progression in chronic kidney disease.Q36273914
Chronic hypoxia and tubulointerstitial injury: a final common pathway to end-stage renal failureQ36314459
NADPH-oxidase 4 protects against kidney fibrosis during chronic renal injuryQ36426109
Plumbagin, a plant derived natural agent inhibits the growth of pancreatic cancer cells in in vitro and in vivo via targeting EGFR, Stat3 and NF-κB signaling pathwaysQ36466176
Transforming growth factor-beta/connective tissue growth factor axis in the kidneyQ36735891
Oxygen regulates epithelial-to-mesenchymal transition: insights into molecular mechanisms and relevance to diseaseQ36757465
Angiotensin II-induced reactive oxygen species and the kidneyQ36905406
Adventitial fibroblast reactive oxygen species as autacrine and paracrine mediators of remodeling: bellwether for vascular disease?Q36906269
Role of Kruppel-like factor 6 in transforming growth factor-beta1-induced epithelial-mesenchymal transition of proximal tubule cellsQ36977366
Mechanisms of disease: the hypoxic tubular hypothesis of diabetic nephropathyQ37082467
Role of chronic hypoxia and hypoxia inducible factor in kidney diseaseQ37094114
Expression, localization, and function of the thioredoxin system in diabetic nephropathyQ37146420
New insights into the mechanisms of fibrosis and sclerosis in diabetic nephropathyQ37180781
Transcription factors Krüppel-like factor 6 and peroxisome proliferator-activated receptor-{gamma} mediate high glucose-induced thioredoxin-interacting proteinQ37413641
Therapies for hyperglycaemia-induced diabetic complications: from animal models to clinical trialsQ37464743
Diabetic nephropathy: a disorder of oxygen metabolism?Q37654732
New insights into hyperglycemia-induced molecular changes in microvascular cellsQ37665090
Myofibroblast differentiation during fibrosis: role of NAD(P)H oxidasesQ37838705
Plumbagin, a medicinal plant-derived naphthoquinone, is a novel inhibitor of the growth and invasion of hormone-refractory prostate cancerQ38359505
Increased renal gene transcription of protein kinase C-beta in human diabetic nephropathy: relationship to long-term glycaemic controlQ38427732
Plumbagin induces cell death through a copper-redox cycle mechanism in human cancer cellsQ39841222
Hypoxia-inducible factor-1alpha induces Twist expression in tubular epithelial cells subjected to hypoxia, leading to epithelial-to-mesenchymal transitionQ39874109
High glucose induces macrophage inflammatory protein-3 alpha in renal proximal tubule cells via a transforming growth factor-beta 1 dependent mechanismQ40100460
Transforming growth factor-beta1 differentially mediates fibronectin and inflammatory cytokine expression in kidney tubular cellsQ40276214
TGF-beta1 induces IL-8 and MCP-1 through a connective tissue growth factor-independent pathwayQ40365592
The transforming growth factor beta system in kidney disease and repair: recent progress and future directionsQ40827841
TGF-beta in kidney fibrosis: a target for gene therapyQ41469693
Polyunsaturated fatty acids modulate NOX 4 anion superoxide production in human fibroblastsQ42414902
The alpha8 integrin chain affords mechanical stability to the glomerular capillary tuft in hypertensive glomerular diseaseQ42794553
Partial attenuation of cytotoxicity and apoptosis by SOD1 in ischemic renal epithelial cellsQ42846730
Critical role of Nox4-based NADPH oxidase in glucose-induced oxidative stress in the kidney: implications in type 2 diabetic nephropathyQ42970293
The role of Sgk-1 in the upregulation of transport proteins by PPAR-{gamma} agonists in human proximal tubule cellsQ46255897
High glucose induced endothelial cell growth inhibition is associated with an increase in TGFbeta1 secretion and inhibition of Ras prenylation via suppression of the mevalonate pathway.Q46436440
PPARgamma agonists exert antifibrotic effects in renal tubular cells exposed to high glucoseQ46484275
High glucose transactivates the EGF receptor and up-regulates serum glucocorticoid kinase in the proximal tubuleQ46654151
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectdiabetic nephropathyQ1129105
P304page(s)e73428
P577publication date2013-08-26
P1433published inPLOS OneQ564954
P1476titlePlumbagin ameliorates diabetic nephropathy via interruption of pathways that include NOX4 signalling
P478volume8

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cites work (P2860)
Q46777093Alpha-Lipoic Acid Promotes Osteoblastic Formation in H2O2 -Treated MC3T3-E1 Cells and Prevents Bone Loss in Ovariectomized Rats
Q33710878Antioxidant Effect of Fructus Ligustri Lucidi Aqueous Extract in Ovariectomized Rats Is Mediated through Nox4-ROS-NF-κB Pathway
Q37349206Diabetes and Kidney Disease: Role of Oxidative Stress
Q33670665Flos Puerariae extract prevents myocardial apoptosis via attenuation oxidative stress in streptozotocin-induced diabetic mice
Q34109997Long-term low carbohydrate diet leads to deleterious metabolic manifestations in diabetic mice
Q40917613Plumbagin Ameliorates CCl 4 -Induced Hepatic Fibrosis in Rats via the Epidermal Growth Factor Receptor Signaling Pathway
Q37217028Plumbagin Protects Mice from Lethal Sepsis by Modulating Immunometabolism Upstream of PKM2
Q35088727Regulation of NADPH oxidase 5 by protein kinase C isoforms
Q36555973Toxicogenomics of Phenylhydrazine Induced Hematotoxicity and its Attenuation by Plumbagin from Plumbago zeylanica

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