Vascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective beta-isoform-selective inhibitor

scientific article published on 01 September 1997

Vascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective beta-isoform-selective inhibitor is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.2337/DIAB.46.9.1473
P698PubMed publication ID9287049

P50authorThomas A CiullaQ57159183
P2093author name stringH Ishii
L E Smith
L P Aiello
S E Bursell
F Mori
G L King
C Takagi
E Duh
K Ways
A Clermont
M Jirousek
P433issue9
P407language of work or nameEnglishQ1860
P304page(s)1473-1480
P577publication date1997-09-01
P1433published inDiabetesQ895262
P1476titleVascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective beta-isoform-selective inhibitor
P478volume46

Reverse relations

cites work (P2860)
Q35646181A Quantitative and Standardized Method for the Evaluation of Choroidal Neovascularization Using MICRON III Fluorescein Angiograms in Rats
Q33384375A phase I trial of enzastaurin in patients with recurrent gliomas
Q47890044A phase II trial of enzastaurin (LY317615) in combination with bevacizumab in adults with recurrent malignant gliomas
Q35027679A potential role for angiopoietin 2 in the regulation of the blood-retinal barrier in diabetic retinopathy
Q33355710A randomized trial comparing intravitreal triamcinolone acetonide and focal/grid photocoagulation for diabetic macular edema
Q84558890A randomized trial comparing the efficacy and safety of intravitreal triamcinolone with observation to treat vision loss associated with macular edema secondary to central retinal vein occlusion: the Standard Care vs Corticosteroid for Retinal Vein
Q24646760A randomized trial comparing the efficacy and safety of intravitreal triamcinolone with standard care to treat vision loss associated with macular Edema secondary to branch retinal vein occlusion: the Standard Care vs Corticosteroid for Retinal [...]
Q44070309Advanced glycation end products increase, through a protein kinase C-dependent pathway, vascular endothelial growth factor expression in retinal endothelial cells. Inhibitory effect of gliclazide
Q43095043Alternative therapies in exudative age related macular degeneration.
Q43946490Angiotensin II and vascular endothelial growth factor in the vitreous fluid of patients with diabetic macular edema and other retinal disorders
Q37369097Angiotensin blockade to reduce microvascular damage in diabetes mellitus
Q74682412Antiangiogenic and antitumor effects of a protein kinase Cbeta inhibitor in human breast cancer and ovarian cancer xenografts
Q34295974Antiangiogenic therapy for ischemic retinopathies
Q80350462Aqueous humor levels of cytokines are related to vitreous levels and progression of diabetic retinopathy in diabetic patients
Q33511170Aqueous vascular endothelial growth factor as a predictor of macular thickening following cataract surgery in patients with diabetes mellitus
Q37607650Beneficial effects of the nutritional supplements on the development of diabetic retinopathy
Q42123271Blockade of vascular endothelial growth factor receptor 1 prevents inflammation and vascular leakage in diabetic retinopathy.
Q48580864Bowman Lecture 1998. Diabetic retinopathy: some cellular, molecular and therapeutic considerations
Q36062252Cellular mechanisms and treatment of diabetes vascular complications converge on reactive oxygen species
Q37089750Cellular signaling and potential new treatment targets in diabetic retinopathy
Q31123332Changing times for the management of diabetic retinopathy
Q83008636Characteristics of diabetic retinopathy in SDT rats
Q28504628Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization
Q38260400Cinnamon extract inhibits angiogenesis in zebrafish and human endothelial cells by suppressing VEGFR1, VEGFR2, and PKC-mediated MAP kinase
Q34241921Combination therapy for diabetic macular edema.
Q37463972Comparison between intravitreal bevacizumab and triamcinolone for macular edema secondary to branch retinal vein occlusion
Q35086234Complex regulation of PKCβ2 and PDK-1/AKT by ROCK2 in diabetic heart
Q53766666Consumption of polyphenol-rich Morus alba leaves extract attenuates early diabetic retinopathy: the underlying mechanism.
Q37084522Contributions of inflammatory processes to the development of the early stages of diabetic retinopathy
Q31049802Cost-effectiveness of ranibizumab in treatment of diabetic macular oedema (DME) causing visual impairment: evidence from the RESTORE trial
Q36796899Cost-utility of ranibizumab versus aflibercept for treating Greek patients with visual impairment due to diabetic macular edema
Q43198819Counter regulatory effects of PKCbetaII and PKCdelta on coronary endothelial permeability
Q37221516Current and future approaches in the prevention and treatment of diabetic retinopathy.
Q37801912Current approaches to the management of diabetic retinopathy and diabetic macular oedema
Q37819879Current update on retinopathy of prematurity: screening and treatment
Q35768511Decreased K5 receptor expression in the retina, a potential pathogenic mechanism for diabetic retinopathy
Q37703235Delivery of celecoxib for treating diseases of the eye: influence of pigment and diabetes
Q42699559Diabetic Retinopathy and Laser Therapy in Rats: A Protein-Protein Interaction Network Analysis
Q37985854Diabetic macular edema: current and emerging therapies
Q34185374Diabetic macular edema: therapeutic options
Q30819244Diabetic macular oedema: a comparison of vitreous fluorometry, angiography, and retinopathy
Q36018006Diabetic macular oedema: pathophysiology, management challenges and treatment resistance
Q41012046Diabetic retinopathy and inflammation: novel therapeutic targets.
Q35545811Diabetic retinopathy, superoxide damage and antioxidants.
Q39451009Diabetic retinopathy: Breaking the barrier
Q39208422Diabetic retinopathy: new therapeutic perspectives based on pathogenic mechanisms.
Q34733351Diabetic vascular dysfunction: links to glucose-induced reductive stress and VEGF.
Q37733102Dietary hyperglycemia, glycemic index and metabolic retinal diseases
Q30631779Dramatic inhibition of retinal and choroidal neovascularization by oral administration of a kinase inhibitor
Q36431788Early diabetes-induced biochemical changes in the retina: comparison of rat and mouse models
Q31035344Effect of staurosporine on cycle of human gastric cancer cells.
Q89002608Effectiveness of the Dexamethasone Intravitreal Implant for Treatment of Patients with Diabetic Macular Oedema
Q54396384Effects of Trigonella foenum-graecum (L.) on retinal oxidative stress, and proinflammatory and angiogenic molecular biomarkers in streptozotocin-induced diabetic rats.
Q35057237Effects of arteriolar constriction on retinal gene expression and Müller cell responses in a rat model of branch retinal vein occlusion
Q46970219Effects of chronic renal failure on the pharmacokinetics of ruboxistaurin and its active metabolite 338522.
Q33871118Effects of intravitreal triamcinolone acetonide on retinal gene expression in a rat model of central retinal vein occlusion
Q90138907Efficacy of intravitreal dexamethasone implant in persistent diabetic macular edema after primary treatment with intravitreal ranibizumab
Q86867595Efficacy of single-dose dexamethasone implantation in patients with persistent diabetic macular edema
Q58907881Emerging pharmacotherapies for diabetic macular edema
Q38404246EphrinA1 inhibits vascular endothelial growth factor-induced intracellular signaling and suppresses retinal neovascularization and blood-retinal barrier breakdown
Q35171497Evaluation of the Response to Ranibizumab Therapy following Bevacizumab Treatment Failure in Eyes with Diabetic Macular Edema
Q35745334Expression of thrombospondin-1 in ischemia-induced retinal neovascularization
Q35765120Expression of vascular endothelial growth factor in the human retina and in nonproliferative diabetic retinopathy.
Q28285595Extracellular carbonic anhydrase mediates hemorrhagic retinal and cerebral vascular permeability through prekallikrein activation
Q34022792Free insulin-like growth factor binding protein-3 (IGFBP-3) reduces retinal vascular permeability in association with a reduction of acid sphingomyelinase (ASMase).
Q26824541Functions of Müller cell-derived vascular endothelial growth factor in diabetic retinopathy
Q38585087Genetic difference in susceptibility to the blood-retina barrier breakdown in diabetes and oxygen-induced retinopathy
Q28362039Glucose, VEGF-A, and diabetic complications
Q35648554Growth factors and protein kinase C inhibitors as novel therapies for the medical management diabetic retinopathy
Q34804249Haemodynamics in microvascular complications in type 1 diabetes
Q34415658Highly potent VEGF-A-antagonistic DARPins as anti-angiogenic agents for topical and intravitreal applications
Q28344038In vivo mechanisms of vascular endothelial growth factor-mediated increased hydraulic conductivity of Rana capillaries
Q52537902Increased H2O2, vascular endothelial growth factor and receptors in the retina of the BBZ/Wor diabetic rat.
Q40299296Inflammatory and angiogenic protein detection in the human vitreous: cytometric bead assay
Q35818087Inflammatory cytokines in aqueous humor of patients with choroidal neovascularization.
Q64112936Inhibition of Aberrant IGF-I Signaling in Diabetic Male Rat Retina Prevents and Reverses Changes of Diabetic Retinopathy
Q80178769Inhibition of PKC beta by ruboxistaurin does not enhance the acute blood pressure response to nitroglycerin
Q42767408Inhibition of advanced glycation and absence of galectin-3 prevent blood-retinal barrier dysfunction during short-term diabetes.
Q33703836Inhibition of protein kinase C delta attenuates blood-retinal barrier breakdown in diabetic retinopathy
Q35928442Inhibition of the adrenomedullin/nitric oxide signaling pathway in early diabetic retinopathy
Q78763438Inhibitory effects of bucillamine on increased blood-retinal barrier permeability in streptozotocin-induced diabetic rats
Q63241384Interaction of Endothelin-1 with Vasoactive Factors in Mediating Glucose-Induced Increased Permeability in Endothelial Cells
Q35993746Interleukin-1β-induced barrier dysfunction is signaled through PKC-θ in human brain microvascular endothelium
Q33771458Intraocular soluble intracellular adhesion molecule-1 correlates with subretinal fluid height of diabetic macular edema
Q51935620Intravitreal triamcinolone acetonide for macular oedema owing to retinal vein occlusion.
Q36082148Introduction of hyperglycemia and dyslipidemia in the pathogenesis of diabetic vascular complications
Q36977415Introduction, mechanism of action and rationale for anti-vascular endothelial growth factor drugs in age-related macular degeneration
Q62698433Is blockade of vascular endothelial growth factor beneficial for all types of diabetic retinopathy?
Q43299871Is neuronal dysfunction an early sign of diabetic retinopathy? Microperimetry and spectral domain optical coherence tomography (SD-OCT) study in individuals with diabetes, but no diabetic retinopathy
Q62066203Long-term global retinal microvascular changes in a transgenic vascular endothelial growth factor mouse model
Q45888226Loss of placental growth factor protects mice against vascular permeability in pathological conditions
Q41015495Many Faces of Renin-angiotensin System - Focus on Eye.
Q35175679Medical treatment of diabetic retinopathy
Q37139800Mice deficient in PKCbeta and apolipoprotein E display decreased atherosclerosis
Q34741796Modulation of VEGF-induced retinal vascular permeability by peroxisome proliferator-activated receptor-β/δ.
Q27014620Molecular mechanisms of diabetic retinopathy, general preventive strategies, and novel therapeutic targets
Q33558421Molecular mechanisms of diabetic vascular complications
Q37535022Molecular mechanisms of endothelial hyperpermeability: implications in inflammation
Q97882525Morin attenuates STZ-induced diabetic retinopathy in experimental animals
Q36511716Multiplex bead analysis of vitreous and serum concentrations of inflammatory and proangiogenic factors in diabetic patients
Q37076073Myosin light chain kinase signaling in endothelial barrier dysfunction
Q36706288Müller cells as players in retinal degeneration and edema
Q37267083Nanoparticle-mediated expression of an angiogenic inhibitor ameliorates ischemia-induced retinal neovascularization and diabetes-induced retinal vascular leakage
Q35071239Neurovascular interaction and the pathophysiology of diabetic retinopathy
Q34313113Novel atypical PKC inhibitors prevent vascular endothelial growth factor-induced blood-retinal barrier dysfunction
Q34688209Novel drugs and their targets in the potential treatment of diabetic retinopathy
Q27002622Novel pharmacotherapies in diabetic retinopathy
Q37217856Novel potential mechanisms for diabetic macular edema: leveraging new investigational approaches
Q41116544Occludin downregulation in high glucose is regulated by SSTR2 via the VEGF/NRP1/Akt signaling pathway in RF/6A cells.
Q37344103Occludin phosphorylation and ubiquitination regulate tight junction trafficking and vascular endothelial growth factor-induced permeability
Q35049903Ocular complications of diabetes mellitus
Q34565454Ocular manifestations of von Hippel-Lindau disease: clinical and genetic investigations.
Q34975866Ocular perfusion abnormalities in diabetes.
Q44635831Opposing effect of angiopoietin‐1 on VEGF‐mediated disruption of endothelial cell–cell interactions requires activation of PKCβ
Q35819297Oxidative stress and diabetic retinopathy
Q37226580Oxidative stress and diabetic retinopathy: pathophysiological mechanisms and treatment perspectives
Q38480783Oxidative stress and epigenetic modifications in the pathogenesis of diabetic retinopathy.
Q34498406Oxidative stress increases pulmonary vascular permeability in diabetic rats through activation of transient receptor potential melastatin 2 channels
Q33939170PEDF regulates vascular permeability by a γ-secretase-mediated pathway
Q34327850PKCbeta regulates ischemia/reperfusion injury in the lung
Q26865897Pathophysiology of diabetic retinopathy
Q44496983Perspectives on diabetic retinopathy
Q35827367Pharmacokinetics of ruboxistaurin are significantly altered by rifampicin-mediated CYP3A4 induction
Q33492340Pharmacologic therapies for diabetic retinopathy and diabetic macular edema
Q45183901Pharmacological treatment of diabetic retinopathy
Q33294882Pharmacotherapies for diabetic retinopathy: present and future
Q36294444Phosphorylation of pleckstrin increases proinflammatory cytokine secretion by mononuclear phagocytes in diabetes mellitus
Q43223636Pigment epithelium-derived factor inhibits vascular endothelial growth factor-and interleukin-1beta-induced vascular permeability and angiogenesis in retinal endothelial cells
Q35797036Plasma kallikrein mediates retinal vascular dysfunction and induces retinal thickening in diabetic rats
Q44686998Plasminogen kringle 5 reduces vascular leakage in the retina in rat models of oxygen-induced retinopathy and diabetes
Q35111433Population pharmacokinetics of pegaptanib sodium (Macugen(®)) in patients with diabetic macular edema
Q34626222Potential new medical therapies for diabetic retinopathy: protein kinase C inhibitors
Q35787073Pro-inflammatory cytokines induce expression of matrix-metabolizing enzymes in human cervical smooth muscle cells
Q35615435Protein kinase C inhibition and diabetic retinopathy: a shot in the dark at translational research
Q36187549Protein kinase C β inhibition by enzastaurin leads to mitotic missegregation and preferential cytotoxicity toward colorectal cancer cells with chromosomal instability (CIN)
Q35976653Protein kinase cβ phosphorylates occludin regulating tight junction trafficking in vascular endothelial growth factor-induced permeability in vivo
Q34440571Randomized clinical trial evaluating intravitreal ranibizumab or saline for vitreous hemorrhage from proliferative diabetic retinopathy
Q34410824Ranibizumab, verteporfin photodynamic therapy or observation for the treatment of myopic choroidal neovascularization: cost effectiveness in the UK.
Q28396273Reactive oxygen species in inflammation and tissue injury
Q49118822Recombinant human angiopoietin-1 ameliorates the expressions of ZO-1, occludin, VE-cadherin, and PKCα signaling after focal cerebral ischemia/reperfusion in rats
Q33969514Regulators of vascular permeability: potential sites for intervention in the treatment of macular edema
Q36035854Relationship between perifoveal capillaries and pathomorphology in macular oedema associated with branch retinal vein occlusion
Q58762933Remodeling of Retinal Architecture in Diabetic Retinopathy: Disruption of Ocular Physiology and Visual Functions by Inflammatory Gene Products and Pyroptosis
Q99561828Retinal Physiology and Circulation: Effect of Diabetes
Q40730311Retinal expression, regulation, and functional bioactivity of prostacyclin-stimulating factor
Q44108814Retinal metabolic abnormalities in diabetic mouse: comparison with diabetic rat.
Q37122850Retinal not systemic oxidative and inflammatory stress correlated with VEGF expression in rodent models of insulin resistance and diabetes
Q35210888Retracted: Nuclear Factor Kappa-B Signaling Is Integral to Ocular Neovascularization in Ischemia-Independent Microenvironment
Q34475449Review of therapeutic advances in diabetic retinopathy
Q35181953Role of VEGF in kidney development, microvascular maintenance and pathophysiology of renal disease
Q26775853Role of implants in the treatment of diabetic macular edema: focus on the dexamethasone intravitreal implant
Q34103169Role of vasoactive factors in the pathogenesis of early changes in diabetic retinopathy
Q33730079Safety and efficacy of ranibizumab in diabetic macular edema (RESOLVE Study): a 12-month, randomized, controlled, double-masked, multicenter phase II study
Q47879810Secretogranin III: a diabetic retinopathy-selective angiogenic factor.
Q34931190Selective PKC beta inhibition with ruboxistaurin and endothelial function in type-2 diabetes mellitus
Q44528945Serum-derived factors weaken the barrier properties of cultured porcine brain capillary endothelial cells in vitro
Q26774524Steroids in Central Retinal Vein Occlusion: Is There a Role in Current Treatment Practice?
Q38145185Structural changes in individual retinal layers in diabetic macular edema
Q33201162Surgery for macular edema
Q36287281Sustained pharmacological inhibition of deltaPKC protects against hypertensive encephalopathy through prevention of blood-brain barrier breakdown in rats
Q36894263Sustained-release ophthalmic drug delivery systems for treatment of macular disorders: present and future applications
Q34237700TNF-α signals through PKCζ/NF-κB to alter the tight junction complex and increase retinal endothelial cell permeability
Q34972210Targeting Neovascularization in Ischemic Retinopathy: Recent Advances
Q26852726Targeting inflammation in diabetes: Newer therapeutic options
Q42920003The Optic UK Lecture: bench-to-bedside adventures of a diabetes researcher: results past, results present
Q48308877The Role of Microglia in Diabetic Retinopathy: Inflammation, Microvasculature Defects and Neurodegeneration.
Q28353997The absence of diabetic retinopathy in patients with retinitis pigmentosa: implications for pathophysiology and possible treatment
Q30845192The angio-fibrotic switch of VEGF and CTGF in proliferative diabetic retinopathy
Q37098747The immunopharmacologic potential of Semaxanib and new generation directed therapeutic drugs: Receptor tyrosine kinase regulation with anti-tumorigenensis/angiogenesis properties
Q37811628The paradox of the neutrophil's role in tissue injury
Q38242801The role of inflammation in the pathogenesis of macular edema secondary to retinal vascular diseases.
Q34292435The role of oxidative stress in the onset and progression of diabetes and its complications: a summary of a Congress Series sponsored by UNESCO-MCBN, the American Diabetes Association and the German Diabetes Society
Q43051921The role of vascular endothelial growth factor in the progression of diabetic vascular complications
Q73406082The role of vitrectomy in the treatment of diabetic macular edema
Q64998563Therapeutic Effects of a Novel Phenylphthalimide Analog for Corneal Neovascularization and Retinal Vascular Leakage.
Q39214578Therapeutic targets of renin-angiotensin system in ocular disorders
Q46470767Tranilast ameliorates impaired hepatic functions in Schistosoma mansoni-infected mice
Q35028866Tranilast inhibits protein kinase C-dependent signalling pathway linked to angiogenic activities and gene expression of retinal microcapillary endothelial cells
Q83996781Transcriptional regulation of aquaporin-3 in human retinal pigment epithelial cells
Q35563022Treatment of central retinal vein occlusion with triamcinolone acetonide: an optical coherence tomography study.
Q36867626Using the past to inform the future: anti-VEGF therapy as a road map to develop novel therapies for diabetic retinopathy
Q36537262Vascular complications of diabetes: mechanisms of injury and protective factors
Q35810089Vascular endothelial growth factor (VEGF)-induced retinal vascular permeability is mediated by intercellular adhesion molecule-1 (ICAM-1).
Q28360225Vascular endothelial growth factor and the in vivo increase in plasma extravasation in the hamster cheek pouch
Q38572150Vasoinhibins prevent retinal vasopermeability associated with diabetic retinopathy in rats via protein phosphatase 2A-dependent eNOS inactivation
Q33542927Vitrectomy outcomes in eyes with diabetic macular edema and vitreomacular traction
Q36049918Zingiber officinale attenuates retinal microvascular changes in diabetic rats via anti-inflammatory and antiangiogenic mechanisms
Q83957028[Early antiexudative response--OCT monitoring after intravitreal bevacizumab injection]

Search more.