PIKing the type and pattern of PI3K pathway mutations in endometrioid endometrial carcinomas

scientific article published on 18 February 2015

PIKing the type and pattern of PI3K pathway mutations in endometrioid endometrial carcinomas is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.YGYNO.2015.02.010
P698PubMed publication ID25701704
P5875ResearchGate publication ID272490427

P50authorJorge Reis-FilhoQ23892845
Robert A SoslowQ37839435
Salvatore PiscuoglioQ41195760
Britta WeigeltQ71780641
Caterina MarchiòQ88051049
P2093author name stringCharlotte K Y Ng
Maria R De Filippo
P2860cites workNaturally occurring neomorphic PIK3R1 mutations activate the MAPK pathway, dictating therapeutic response to MAPK pathway inhibitorsQ24305218
Deregulation of the PI3K and KRAS signaling pathways in human cancer cells determines their response to everolimusQ24600932
PIK3CA exon 20 mutations as a potential biomarker for resistance to anti-EGFR monoclonal antibodies in KRAS wild-type metastatic colorectal cancer: a systematic review and meta-analysisQ26992267
Predicting everolimus treatment efficacy in patients with advanced endometrial carcinoma: a GINECO group study.Q27851999
Molecular determinants of outcome with mammalian target of rapamycin inhibition in endometrial cancerQ27852608
High frequency of mutations of the PIK3CA gene in human cancersQ28131776
Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortalQ28288215
Integrated genomic characterization of endometrial carcinomaQ28289962
Mutational landscape and significance across 12 major cancer typesQ28300353
Signatures of mutational processes in human cancerQ29547191
Cancer statistics, 2009Q29547625
PI3K pathway alterations in cancer: variations on a themeQ29615530
Direct positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3-kinaseQ30156937
A phase I trial of liposomal doxorubicin, bevacizumab, and temsirolimus in patients with advanced gynecologic and breast malignanciesQ33397006
Theories of endometrial carcinogenesis: a multidisciplinary approachQ33886758
Mismatch repair deficiency endows tumors with a unique mutation signature and sensitivity to DNA double-strand breaksQ34077139
Microsatellite instability and ploidy status define three categories with distinctive prognostic impact in endometrioid endometrial cancerQ34227653
PTEN mutations and evolving concepts in endometrial neoplasiaQ34501209
A unique spectrum of somatic PIK3CA (p110alpha) mutations within primary endometrial carcinomasQ34694344
PIK3CA mutations in patients with advanced cancers treated with PI3K/AKT/mTOR axis inhibitorsQ34769343
AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancerQ34990362
PIK3R1 (p85α) is somatically mutated at high frequency in primary endometrial cancerQ35050913
Phase II study of temsirolimus in women with recurrent or metastatic endometrial cancer: a trial of the NCIC Clinical Trials GroupQ35172203
High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stabilityQ35275603
The phosphoinositide 3-kinase regulatory subunit p85alpha can exert tumor suppressor properties through negative regulation of growth factor signalingQ35479152
Rare cancer-specific mutations in PIK3CA show gain of functionQ35720258
The management of serous papillary uterine cancerQ36559234
EMu: probabilistic inference of mutational processes and their localization in the cancer genomeQ36872480
PI3K pathway dependencies in endometrioid endometrial cancer cell linesQ36980561
Genomic Determinants of PI3K Pathway Inhibitor Response in CancerQ38042638
Classification of endometrial carcinoma: more than two typesQ38215703
High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinomaQ40345165
Mutant PIK3CA promotes cell growth and invasion of human cancer cellsQ40410776
Hotspot mutations in PIK3CA associate with first-line treatment outcome for aromatase inhibitors but not for tamoxifenQ44850155
Detection of microsatellite instability in endometrial cancer: advantages of a panel of five mononucleotide repeats over the National Cancer Institute panel of markers.Q54616917
The frequency of p53, K-ras mutations, and microsatellite instability differs in uterine endometrioid and serous carcinoma: evidence of distinct molecular genetic pathwaysQ73459314
PIK3CA mutations in the kinase domain (exon 20) of uterine endometrial adenocarcinomas are associated with adverse prognostic parametersQ80209882
P433issue2
P407language of work or nameEnglishQ1860
P1104number of pages8
P304page(s)321-328
P577publication date2015-02-18
P1433published inGynecologic OncologyQ5625182
P1476titlePIKing the type and pattern of PI3K pathway mutations in endometrioid endometrial carcinomas
P478volume137

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cites work (P2860)
Q37466261Analysis of in vitro chemoresponse assays in endometrioid endometrial adenocarcinoma: an observational ancillary analysis
Q28078111HER2 aberrations and heterogeneity in cancers of the digestive system: Implications for pathologists and gastroenterologists
Q47240157Identification of somatic genetic alterations in ovarian clear cell carcinoma with next generation sequencing
Q64274212Molecular Insights into the Classification of Luminal Breast Cancers: The Genomic Heterogeneity of Progesterone-Negative Tumors
Q51032285Next-Generation Sequencing.
Q90654533Pilot investigation of the mutation profile of PIK3CA/PTEN genes (PI3K pathway) in grade 3 endometrial cancer
Q38820391The future therapy of endometrial cancer: microRNA's functionality, capability, and putative clinical application.

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