RIPK1-RIPK3-MLKL-dependent necrosis promotes the aging of mouse male reproductive system.

scientific article published on 15 August 2017

RIPK1-RIPK3-MLKL-dependent necrosis promotes the aging of mouse male reproductive system. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.7554/ELIFE.27692
P8608Fatcat IDrelease_mjzvwzsw5bdmbmdil7bbsqy3cy
P932PMC publication ID5557593
P698PubMed publication ID28807105

P50authorXiaodong WangQ908515
Dianrong LiQ68473065
P2093author name stringXiao Liu
Zhiyuan Zhang
Tao Xu
Lingjun Meng
Yaning Su
P2860cites workFas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector moleculeQ24290576
Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinaseQ24302381
Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosisQ24311815
Reduced numbers of Sertoli, germ, and spermatogonial stem cells in impaired spermatogenesisQ84391919
TNF-alpha induces two distinct caspase-8 activation pathwaysQ24313656
Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alphaQ24338113
Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammationQ24338129
Reduced expression of MYC increases longevity and enhances healthspanQ27323151
The pseudokinase MLKL mediates necroptosis via a molecular switch mechanismQ27685465
Type I interferon induces necroptosis in macrophages during infection with Salmonella enterica serovar TyphimuriumQ28508897
Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosisQ28588383
RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosisQ28594624
Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell deathQ28660873
Molecular mechanisms of necroptosis: an ordered cellular explosionQ29616004
Identification of RIP1 kinase as a specific cellular target of necrostatinsQ29616006
Necroptosis as an alternative form of programmed cell deathQ33788116
Function of seminal vesicles and their role on male fertility.Q34106271
Reduced sperm count and normal fertility in male mice with targeted disruption of the ADP-ribosylation factor-like 4 (Arl4) gene.Q34277799
UTF1, a putative marker for spermatogonial stem cells in stallionsQ34278312
Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell deathQ34409204
Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3.Q34413744
Necroptosis in health and diseasesQ34432108
Mouse models of male infertility.Q34932076
Differential effects of spermatogenesis and fertility in mice lacking androgen receptor in individual testis cellsQ35539729
Aging results in differential regulation of DNA repair pathways in pachytene spermatocytes in the Brown Norway ratQ35780416
RIP3-mediated necrotic cell death accelerates systematic inflammation and mortalityQ36055706
Practical pathology of aging miceQ36159848
Kinase RIP3 is dispensable for normal NF-kappa Bs, signaling by the B-cell and T-cell receptors, tumor necrosis factor receptor 1, and Toll-like receptors 2 and 4.Q36233089
Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosisQ36751262
Lifelong running reduces oxidative stress and degenerative changes in the testes of mice.Q37003183
Isolation of Sertoli, Leydig, and spermatogenic cells from the mouse testisQ37173882
Consistent age-dependent declines in human semen quality: a systematic review and meta-analysisQ38280895
Expression of the pluripotency marker UTF1 is restricted to a subpopulation of early A spermatogonia in rat testis.Q38292040
Virus inhibition of RIP3-dependent necrosisQ39711744
Intra-testicular injection of adenoviral constructs results in Sertoli cell-specific gene expression and disruption of the seminiferous epithelium.Q40032775
Discovery of a Highly Potent, Selective, and Metabolically Stable Inhibitor of Receptor-Interacting Protein 1 (RIP1) for the Treatment of Systemic Inflammatory Response Syndrome.Q48139721
Influence of some biological indexes on sex hormone-binding globulin and androgen levels in aging or obese malesQ49100770
Enlarged Seminal Vesicles of Senescent C57BL/6J MiceQ54329262
P407language of work or nameEnglishQ1860
P577publication date2017-08-15
P1433published ineLifeQ2000008
P1476titleRIPK1-RIPK3-MLKL-dependent necrosis promotes the aging of mouse male reproductive system
P478volume6

Reverse relations

cites work (P2860)
Q90028528Herpes simplex virus 1 ICP6 impedes TNF receptor 1-induced necrosome assembly during compartmentalization to detergent-resistant membrane vesicles
Q58581622I Spy in the Developing Fly a Multitude of Ways to Die
Q96303210Icariin Improves Age-Related Testicular Dysfunction by Alleviating Sertoli Cell Injury via Upregulation of the ERα/Nrf2-Signaling Pathway
Q94518190Molecular analysis of lipid uptake- and necroptosis-associated factor expression in vitrified-warmed mouse oocytes
Q98665172Myofiber necroptosis promotes muscle stem cell proliferation via releasing Tenascin-C during regeneration
Q61445996Necroptosis in stressed ovary
Q64967917Necroptosis increases with age and is reduced by dietary restriction.
Q58759838Necroptosis mediates myofibre death in dystrophin-deficient mice
Q90152760To the edge of cell death and back

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