Sorafenib targets dysregulated Rho kinase expression and portal hypertension in rats with secondary biliary cirrhosis

scientific article published on 26 March 2009

Sorafenib targets dysregulated Rho kinase expression and portal hypertension in rats with secondary biliary cirrhosis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/J.1476-5381.2009.00158.X
P932PMC publication ID2697813
P698PubMed publication ID19338580
P5875ResearchGate publication ID24250283

P50authorJonel TrebickaQ41068089
P2093author name stringT Sauerbruch
C Stark
J Heller
M Hennenberg
A Z Kohistani
P2860cites workBeta-arrestins and heterotrimeric G-proteins: collaborators and competitors in signal transductionQ24653656
Sorafenib in advanced hepatocellular carcinomaQ27861075
Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of RhoA/Rho-kinase and activation of endothelial nitric oxide synthaseQ28582593
Rho/Rho kinase is a key enzyme system involved in the angiotensin II signaling pathway of liver fibrosis and steatosisQ46967668
Defective RhoA/Rho-kinase signaling contributes to vascular hypocontractility and vasodilation in cirrhotic ratsQ46985848
Anesthetic influences on regional hemodynamics in normal and hemorrhaged rats.Q51836243
Sorafenib inhibits the angiogenesis and growth of orthotopic anaplastic thyroid carcinoma xenografts in nude mice.Q53545899
Measurement of organ blood flow with coloured microspheres in the ratQ72641928
A p160ROCK-specific inhibitor, Y-27632, attenuates rat hepatic stellate cell growthQ73876502
Both Ca2+ -dependent and -independent pathways are involved in rat hepatic stellate cell contraction and intrahepatic hyperresponsiveness to methoxamineQ79156898
Vascular dysfunction in human and rat cirrhosis: role of receptor-desensitizing and calcium-sensitizing proteinsQ79671118
Phase II study of sorafenib in patients with advanced hepatocellular carcinomaQ80112177
Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphataseQ29615195
Signal transduction by G-proteins, rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II.Q30304611
Post-transcriptional down-regulation of ROCKI/Rho-kinase through an MEK-dependent pathway leads to cytoskeleton disruption in Ras-transformed fibroblastsQ33953392
Characterisation of portal hypertension models by microspheres in anaesthetised rats: a comparison of liver flowQ34305850
Cytokine receptors and signaling in hepatic stellate cellsQ34391388
Vascular mediators in the injured liverQ35033793
When 6 is 9: 'uncoupled' AT1 receptors turn signalling on its head.Q35953152
Portal hypertension: from bedside to bench.Q36066757
Increased hepatic resistance: a new target in the pharmacologic therapy of portal hypertension.Q36066761
Rho kinases in cardiovascular physiology and pathophysiologyQ36399309
Signal switching, crosstalk, and arrestin scaffolds: novel G protein-coupled receptor signaling in cardiovascular disease.Q36526640
Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular systemQ36548154
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Splanchnic and systemic vasodilatation: the patientQ36988061
Splanchnic and systemic vasodilation: the experimental modelsQ36988066
Safety and anti-tumor activity of sorafenib (Nexavar) in combination with other anti-cancer agents: a review of clinical trialsQ37008436
Cardiovascular complications of cirrhosis.Q37056007
Incidence and risk of hypertension with sorafenib in patients with cancer: a systematic review and meta-analysisQ37067792
Mechanisms of extrahepatic vasodilation in portal hypertension.Q37150625
Antiangiogenic treatment with sunitinib ameliorates inflammatory infiltrate, fibrosis, and portal pressure in cirrhotic rats.Q40068184
Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5.Q40192837
Sorafenib (BAY 43-9006, Nexavar), a dual-action inhibitor that targets RAF/MEK/ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculatureQ40270911
Platelet-derived growth factor isoform expression in carbon tetrachloride-induced chronic liver injuryQ42439505
H-ras inhibits RhoA/ROCK leading to a decrease in the basal tone in the internal anal sphincter.Q42510616
Intrahepatic upregulation of RhoA and Rho-kinase signalling contributes to increased hepatic vascular resistance in rats with secondary biliary cirrhosisQ42667685
Guide to Receptors and Channels (GRAC), 3rd editionQ43088119
A selective ROCK inhibitor, Y27632, prevents dimethylnitrosamine-induced hepatic fibrosis in ratsQ43631422
Differential expression of platelet-derived growth factor α- and β-receptors on fat-storing cells and endothelial cells of rat liverQ43736383
Inhibitory effect of Y-27632, a ROCK inhibitor, on progression of rat liver fibrosis in association with inactivation of hepatic stellate cellsQ43780882
MEK mediates v-Src-induced disruption of the actin cytoskeleton via inactivation of the Rho-ROCK-LIM kinase pathwayQ43993777
Involvement of Rho/Rho kinase pathway in regulation of apoptosis in rat hepatic stellate cellsQ44493287
Fasudil hydrochloride hydrate, a Rho-kinase (ROCK) inhibitor, suppresses collagen production and enhances collagenase activity in hepatic stellate cellsQ46584631
Hemodynamic effects of urotensin II and its specific receptor antagonist palosuran in cirrhotic ratsQ46719870
Defective endothelial nitric oxide synthase signaling is mediated by rho-kinase activation in rats with secondary biliary cirrhosisQ46826996
Mechanisms of hypertension associated with BAY 43-9006.Q46919074
Phase I study of sorafenib in Japanese patients with hepatocellular carcinomaQ46937457
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectportal hypertensionQ124604
P304page(s)258-270
P577publication date2009-03-26
P1433published inBritish Journal of PharmacologyQ919631
P1476titleSorafenib targets dysregulated Rho kinase expression and portal hypertension in rats with secondary biliary cirrhosis
P478volume157

Reverse relations

cites work (P2860)
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