New roles for beta-arrestins in cell signaling: not just for seven-transmembrane receptors

scientific article published on December 2006

New roles for beta-arrestins in cell signaling: not just for seven-transmembrane receptors is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/J.MOLCEL.2006.11.007
P698PubMed publication ID17157248
P5875ResearchGate publication ID6642808

P50authorRobert LefkowitzQ80910
P2093author name stringErin J Whalen
Keshava Rajagopal
P2860cites workBeta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexesQ22008730
A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcriptionQ24297869
Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signalingQ24299892
{beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligaseQ24301549
beta-Arrestin: a protein that regulates beta-adrenergic receptor functionQ24305145
An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behaviorQ24310712
Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signalingQ24320156
beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulationQ24324243
Identification of beta-arrestin2 as a G protein-coupled receptor-stimulated regulator of NF-kappaB pathwaysQ24338654
beta-Arrestins bind and decrease cell-surface abundance of the Na+/H+ exchanger NHE5 isoformQ24556620
Nicotine induces cell proliferation by beta-arrestin-mediated activation of Src and Rb-Raf-1 pathwaysQ34803242
The ins and outs of G protein-coupled receptor traffickingQ35183866
The new face of active receptor bound arrestin attracts new partnersQ35214608
Beta-arrestin-2 regulates the development of allergic asthmaQ35242857
Regulation of G protein-coupled receptor endocytosis by ARF6 GTP-binding proteinsQ36021503
Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptorsQ36160942
Visual and both non-visual arrestins in their "inactive" conformation bind JNK3 and Mdm2 and relocalize them from the nucleus to the cytoplasmQ36726881
The proliferative and antiapoptotic effects of substance P are facilitated by formation of a beta -arrestin-dependent scaffolding complexQ37273521
beta-arrestin-1 competitively inhibits insulin-induced ubiquitination and degradation of insulin receptor substrate 1.Q37527105
Receptor activity-independent recruitment of betaarrestin2 reveals specific signalling modesQ40251292
Opposing effects of beta-arrestin1 and beta-arrestin2 on activation and degradation of Src induced by protease-activated receptor 1.Q40297494
Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation.Q40313388
Receptor-specific ubiquitination of beta-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes.Q40460839
Constitutive protease-activated receptor-2-mediated migration of MDA MB-231 breast cancer cells requires both beta-arrestin-1 and -2.Q40503317
Differential desensitization, receptor phosphorylation, beta-arrestin recruitment, and ERK1/2 activation by the two endogenous ligands for the CC chemokine receptor 7.Q40571692
Reciprocal regulation of angiotensin receptor-activated extracellular signal-regulated kinases by beta-arrestins 1 and 2.Q40601346
Regulation of V2 vasopressin receptor degradation by agonist-promoted ubiquitinationQ40636866
Beta-arrestin2 is critically involved in CXCR4-mediated chemotaxis, and this is mediated by its enhancement of p38 MAPK activationQ40699131
Phosphorylation of beta-arrestin2 regulates its function in internalization of beta(2)-adrenergic receptorsQ40709874
Differential affinities of visual arrestin, beta arrestin1, and beta arrestin2 for G protein-coupled receptors delineate two major classes of receptorsQ40889383
beta-arrestins regulate interleukin-8-induced CXCR1 internalizationQ40951707
Differential nucleocytoplasmic shuttling of beta-arrestins. Characterization of a leucine-rich nuclear export signal in beta-arrestin2.Q44094517
β-Arrestin1 Mediates Insulin-like Growth Factor 1 (IGF-1) Activation of Phosphatidylinositol 3-Kinase (PI3K) and Anti-apoptosisQ44610984
Arrestins block G protein-coupled receptor-mediated apoptosisQ44820320
Insulin-induced beta-arrestin1 Ser-412 phosphorylation is a mechanism for desensitization of ERK activation by Galphai-coupled receptorsQ45133871
Regulation of Notch signalling by non-visual beta-arrestinQ45345847
Molecular switches involving the AP-2 beta2 appendage regulate endocytic cargo selection and clathrin coat assemblyQ45345954
Nonvisual arrestin oligomerization and cellular localization are regulated by inositol hexakisphosphate bindingQ46913508
Beta-arrestin 2 regulates zebrafish development through the hedgehog signaling pathwayQ47073322
The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activationQ50335944
Arrestin-mediated ERK activation by gonadotropin-releasing hormone receptors: receptor-specific activation mechanisms and compartmentalizationQ50746717
A molecular pathway for light-dependent photoreceptor apoptosis in Drosophila.Q52584174
Heart failureQ53998058
The role of receptor kinases and arrestins in G protein-coupled receptor regulationQ74578170
G protein-coupled receptor kinasesQ77366588
Arrestin serves as a molecular switch, linking endogenous alpha2-adrenergic receptor to SRC-dependent, but not SRC-independent, ERK activationQ79815563
Platelet-activating factor-induced clathrin-mediated endocytosis requires beta-arrestin-1 recruitment and activation of the p38 MAPK signalosome at the plasma membrane for actin bundle formationQ83367366
Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffoldsQ24605173
Crystal structure of beta-arrestin at 1.9 A: possible mechanism of receptor binding and membrane TranslocationQ27634946
X-ray crystal structure of arrestin from bovine rod outer segmentsQ27748911
Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3Q28138462
Feedback regulation of beta-arrestin1 function by extracellular signal-regulated kinasesQ28144769
Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestinQ28190513
Regulation of arrestin-3 phosphorylation by casein kinase IIQ28205089
Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4Q28205234
Beta-arrestin 2 functions as a G-protein-coupled receptor-activated regulator of oncoprotein Mdm2Q28218131
Transduction of receptor signals by beta-arrestinsQ28246395
The Hedgehog response network: sensors, switches, and routersQ28267648
Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2Q28299947
beta -Arrestin-mediated recruitment of the Src family kinase Yes mediates endothelin-1-stimulated glucose transportQ28512887
Insulin induces heterologous desensitization of G-protein-coupled receptor and insulin-like growth factor I signaling by downregulating beta-arrestin-1.Q28575441
Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestinsQ28578546
A beta-arrestin-dependent scaffold is associated with prolonged MAPK activation in pseudopodia during protease-activated receptor-2-induced chemotaxisQ28592370
G proteins: transducers of receptor-generated signalsQ29547519
Seven-transmembrane receptorsQ29619896
Activation-dependent conformational changes in {beta}-arrestin 2.Q33208189
Functional antagonism of different G protein-coupled receptor kinases for beta-arrestin-mediated angiotensin II receptor signalingQ33819399
Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptorQ33819496
Arrestin-related proteins mediate pH signaling in fungi.Q33922905
Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice.Q34064133
The neurobiology of slow synaptic transmissionQ34100272
Phosphoserine/threonine-binding domainsQ34180612
Membrane trafficking of G protein-coupled receptorsQ34292577
Role of beta-arrestin 1 in the metastatic progression of colorectal cancerQ34335080
Functional desensitization of the isolated beta-adrenergic receptor by the beta-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48-kDa protein)Q34376629
beta-Arrestin inhibits NF-kappaB activity by means of its interaction with the NF-kappaB inhibitor IkappaBalpha.Q34513767
Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2.Q34536660
Differential kinetic and spatial patterns of beta-arrestin and G protein-mediated ERK activation by the angiotensin II receptorQ34548751
beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptorQ34562493
Cooperative regulation of extracellular signal-regulated kinase activation and cell shape change by filamin A and beta-arrestins.Q34564790
beta-arrestins regulate mitogenic signaling and clathrin-mediated endocytosis of the insulin-like growth factor I receptorQ34754993
P433issue5
P921main subjecttransmembrane proteinQ424204
P304page(s)643-652
P577publication date2006-12-01
P1433published inMolecular CellQ3319468
P1476titleNew roles for beta-arrestins in cell signaling: not just for seven-transmembrane receptors
P478volume24

Reverse relations

cites work (P2860)
Q80657778A crystal clear view of the beta2-adrenergic receptor
Q36691842A functional role for Anopheles gambiae Arrestin1 in olfactory signal transduction
Q39069074A genome-wide linkage scan in Tunisian families identifies a novel locus for non-syndromic posterior microphthalmia to chromosome 2q37.1.
Q39622751A kinase-independent role for unoccupied insulin and IGF-1 receptors in the control of apoptosis.
Q39954092A novel protein kinase A-independent, beta-arrestin-1-dependent signaling pathway for p38 mitogen-activated protein kinase activation by beta2-adrenergic receptors
Q45741993A novel receptor cross-talk between the ATP receptor P2Y2 and formyl peptide receptors reactivates desensitized neutrophils to produce superoxide
Q38089182A perspective on more effective GPCR-targeted drug discovery efforts.
Q38240756A-kinase anchoring proteins: cAMP compartmentalization in neurodegenerative and obstructive pulmonary diseases
Q89860579AGAP2: Modulating TGFβ1-Signaling in the Regulation of Liver Fibrosis
Q34577233ARRB1-mediated regulation of E2F target genes in nicotine-induced growth of lung tumors
Q34388776ARRB1/β-arrestin-1 mediates neuroprotection through coordination of BECN1-dependent autophagy in cerebral ischemia.
Q28541771Activation of mu opioid receptors sensitizes transient receptor potential vanilloid type 1 (TRPV1) via β-arrestin-2-mediated cross-talk
Q41788382Alternative signaling: cardiomyocyte beta1-adrenergic receptors signal through EGFRs
Q28578913An adrenal beta-arrestin 1-mediated signaling pathway underlies angiotensin II-induced aldosterone production in vitro and in vivo
Q38004211An expanded family of arrestins regulate metabolism
Q90305559Angiotensin II Type 1 Receptor Autoantibodies in Primary Aldosteronism
Q42371966Angiotensin receptor blocker drugs and inhibition of adrenal beta-arrestin-1-dependent aldosterone production: Implications for heart failure therapy
Q48474978Antidepressant-induced differential ubiquitination of β-arrestins 1 and 2 in mononuclear leucocytes of patients with depression
Q33832471Arrestin and the multi-PDZ domain-containing protein MPZ-1 interact with phosphatase and tensin homolog (PTEN) and regulate Caenorhabditis elegans longevity
Q35565885Arrestin development: emerging roles for beta-arrestins in developmental signaling pathways
Q41865336Arrestin orchestrates crosstalk between G protein-coupled receptors to modulate the spatiotemporal activation of ERK MAPK.
Q43240938Arrestin-like proteins mediate ubiquitination and endocytosis of the yeast metal transporter Smf1.
Q24647492Arresting serotonin
Q37341630Arrestins as adaptors for ubiquitination in endocytosis and sorting
Q37321957Arrestins in host-pathogen interactions
Q28831166Autophagy-associated alpha-arrestin signaling is required for conidiogenous cell development in Magnaporthe oryzae
Q37166800Beta-Arrestin2 regulates RANKL and ephrins gene expression in response to bone remodeling in mice.
Q36964334Beta-arrestin 2 is required for lysophosphatidic acid-induced NF-kappaB activation
Q34654662Beta-arrestin-biased ligands at seven-transmembrane receptors
Q36983577Beta-arrestin-mediated localization of smoothened to the primary cilium
Q39782848Beta-arrestin-mediated signaling regulates protein synthesis.
Q30372475BiPS, a photocleavable, isotopically coded, fluorescent cross-linker for structural proteomics.
Q38440471Biased agonism: An emerging paradigm in GPCR drug discovery
Q34104805Both hematopoietic-derived and non-hematopoietic-derived {beta}-arrestin-2 regulates murine allergic airway disease
Q24321812CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice
Q58600712CXCR7/CXCR4 heterodimer-induced histone demethylation: a new mechanism of colorectal tumorigenesis
Q90593525Cofilin, a Master Node Regulating Cytoskeletal Pathogenesis in Alzheimer's Disease
Q37919731Control of striatal signaling by g protein regulators
Q37145670Controlled-release carvedilol in the management of systemic hypertension and myocardial dysfunction
Q34285721Cooperation Between the Septins and the Actomyosin Ring and Role of a Cell-Integrity Pathway During Cell Division in Fission Yeast
Q36820191Deficiency of β-arrestin1 ameliorates collagen-induced arthritis with impaired TH17 cell differentiation.
Q37299072Designing heart performance by gene transfer.
Q37349092Down-regulation of β-arrestin2 promotes tumour invasion and indicates poor prognosis of hepatocellular carcinoma
Q51265394Downregulation of a GPCR by β-Arrestin2-Mediated Switch from an Endosomal to a TGN Recycling Pathway.
Q50652866Downregulation of β-arrestin 1 suppresses glioblastoma cell malignant progression vis inhibition of Src signaling
Q41071174Effects of chronic alcohol exposure on ischemia-reperfusion-induced acute kidney injury in mice: the role of β-arrestin 2 and glycogen synthase kinase 3.
Q36260340Effects of small platform catheter-based left ventricular assist device support on regional myocardial signal transduction.
Q37118269Efficient coupling of transducin to monomeric rhodopsin in a phospholipid bilayer
Q33356416Endocytic regulation of alkali metal transport proteins in mammals, yeast and plants
Q27937774Endocytosis of the Aspartic Acid/Glutamic Acid Transporter Dip5 Is Triggered by Substrate-Dependent Recruitment of the Rsp5 Ubiquitin Ligase via the Arrestin-Like Protein Aly2
Q47113667Enhanced response of melanoma cells to MEK inhibitors following unbiased IGF-1R down-regulation
Q38847534Expression array analysis of the hepatocyte growth factor invasive program
Q37729297Fenoterol, a beta(2)-adrenoceptor agonist, inhibits LPS-induced membrane-bound CD14, TLR4/CD14 complex, and inflammatory cytokines production through beta-arrestin-2 in THP-1 cell line
Q33757282Fission yeast arrestin-related trafficking adaptor, Arn1/Any1, is ubiquitinated by Pub1 E3 ligase and regulates endocytosis of Cat1 amino acid transporter
Q42619195Functional antagonism of β-arrestin isoforms balance IGF-1R expression and signalling with distinct cancer-related biological outcomes.
Q24318455Functional specialization of beta-arrestin interactions revealed by proteomic analysis
Q26853233G Protein-Coupled Receptor Signaling in Stem Cells and Cancer
Q37881660G protein-coupled receptor kinases in normal and failing myocardium
Q36914223G protein-coupled receptor-promoted trafficking of Gbeta1gamma2 leads to AKT activation at endosomes via a mechanism mediated by Gbeta1gamma2-Rab11a interaction
Q64252945GRKs and β-Arrestins: "Gatekeepers" of Mitochondrial Function in the Failing Heart
Q36049271Genetic Deletion of β-Arrestin-2 and the Mitigation of Established Airway Hyperresponsiveness in a Murine Asthma Model
Q37277318HIV-1 gp120 primes lymphocytes for opioid-induced, beta-arrestin 2-dependent apoptosis
Q38186583Heart failure-specific changes in protein kinase signalling.
Q35693310In silico screening for agonists and blockers of the β(2) adrenergic receptor: implications of inactive and activated state structures
Q28571025In vitro hypoxia impairs beta2-adrenergic receptor signaling in primary rat alveolar epithelial cells
Q91778396In vivo flow cytometry combined with intravital microscopy to monitor kinetics of transplanted bone marrow mononuclear cells in peripheral blood and bone marrow
Q61796045Indispensable role of β-arrestin2 in the protection of remifentanil preconditioning against hepatic ischemic reperfusion injury
Q99629092Individual phosphorylation sites at the C-terminus of the apelin receptor play different roles in signal transduction
Q35609910Inhibition of EGF-induced ERK/MAP kinase-mediated astrocyte proliferation by mu opioids: integration of G protein and beta-arrestin 2-dependent pathways
Q37119883Internalization and desensitization of adenosine receptors
Q53503547Interrogating 7TM receptors: does texture in the question yield greater texture in the answer?
Q24643003Kappa opioids promote the proliferation of astrocytes via Gbetagamma and beta-arrestin 2-dependent MAPK-mediated pathways
Q35779987Ligand-induced internalization of the type 1 cholecystokinin receptor independent of recognized signaling activity
Q79888462Long-distance affair with adrenal GRK2 hangs up heart failure
Q34397201M3-muscarinic receptor promotes insulin release via receptor phosphorylation/arrestin-dependent activation of protein kinase D1.
Q35424798Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury
Q28540099Modulation of Anopheles stephensi gene expression by nitroquine, an antimalarial drug against Plasmodium yoelii infection in the mosquito
Q34126537Molecular basis of lysophosphatidic acid-induced NF-κB activation
Q40024079Multiple roles for the C-terminal tail of the chemokine scavenger D6.
Q37380865Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression.
Q24658250Neurokinin 1 receptors regulate morphine-induced endocytosis and desensitization of mu-opioid receptors in CNS neurons
Q37590093Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system
Q38190099Non-canonical signalling and roles of the vasoactive peptides angiotensins and kinins.
Q90291856Novel high molecular weight albumin-conjugated angiotensin II activates β-arrestin and G-protein pathways
Q42146853Occupancy of human EPCR by protein C induces β-arrestin-2 biased PAR1 signaling by both APC and thrombin
Q47273596Oncogenic RAS-Induced Perinuclear Signaling Complexes Requiring KSR1 Regulate Signal Transmission to Downstream Targets
Q34581041Osteoblast regulation via ligand-activated nuclear trafficking of the oxytocin receptor
Q36911200Pharmacological onomastics: what's in a name?
Q27331560Polarization of migrating monocytic cells is independent of PI 3-kinase activity
Q92154971Possible association of arrestin domain-containing protein 3 and progression of non-alcoholic fatty liver disease
Q88208247Protease-activated receptor signalling by coagulation proteases in endothelial cells
Q39142718Protein kinase D links Gq-coupled receptors to cAMP response element-binding protein (CREB)-Ser133 phosphorylation in the heart
Q40815046Receptor-independent Ambient pH signaling by ubiquitin attachment to fungal arrestin-like PalF.
Q30010478Regulation of GPCR activity, trafficking and localization by GPCR-interacting proteins
Q36506527Regulation of mitochondrial oxidative stress by β-arrestins in cultured human cardiac fibroblasts
Q35604521Regulation of α(2B)-adrenergic receptor-mediated extracellular signal-regulated kinase 1/2 (ERK1/2) activation by ADP-ribosylation factor 1.
Q33975010Role for β-arrestin in mediating paradoxical β2AR and PAR2 signaling in asthma
Q42148785Role of Phosphorylation in the Control of Clathrin-Mediated Internalization of GPCR.
Q37070857S-nitrosylation of beta-arrestin regulates beta-adrenergic receptor trafficking
Q34402623Serotonin, but not N-methyltryptamines, activates the serotonin 2A receptor via a ß-arrestin2/Src/Akt signaling complex in vivo
Q33890786Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery
Q42722797Signalosomes: delivering cardioprotective signals from GPCRs to mitochondria
Q41416491Sorafenib targets dysregulated Rho kinase expression and portal hypertension in rats with secondary biliary cirrhosis
Q36252363Spinophilin as a novel regulator of M3 muscarinic receptor-mediated insulin release in vitro and in vivo
Q89847369Structure and function of β-arrestins, their emerging role in breast cancer, and potential opportunities for therapeutic manipulation
Q90862887Targeting cell signaling in allergic asthma
Q39916587The C-terminal tail of CRTH2 is a key molecular determinant that constrains Galphai and downstream signaling cascade activation
Q33927277The M3-muscarinic receptor regulates learning and memory in a receptor phosphorylation/arrestin-dependent manner
Q41193774The Neutrophil Response Induced by an Agonist for Free Fatty Acid Receptor 2 (GPR43) Is Primed by Tumor Necrosis Factor Alpha and by Receptor Uncoupling from the Cytoskeleton but Attenuated by Tissue Recruitment
Q27865233The action and mode of binding of thiazolidinedione ligands at free fatty acid receptor 1
Q37236186The arrestin fold: variations on a theme
Q30561736The arrestin-domain containing protein AdcA is a response element to stress
Q40446331The beta-arrestin-2 scaffold protein promotes c-Jun N-terminal kinase-3 activation by binding to its nonconserved N terminus.
Q36539176The mechanism and function of mitogen-activated protein kinase activation by ARF1.
Q26801420The mechanism of μ-opioid receptor (MOR)-TRPV1 crosstalk in TRPV1 activation involves morphine anti-nociception, tolerance and dependence
Q35534233The somatostatin analog 188Re-P2045 inhibits the growth of AR42J pancreatic tumor xenografts
Q29614609The vertebrate primary cilium in development, homeostasis, and disease
Q59807304Therapeutic Targets for Treatment of Heart Failure: Focus on GRKs and β-Arrestins Affecting βAR Signaling
Q24628602Therapeutic potential for novel drugs targeting the type 1 cholecystokinin receptor
Q37375712Thioredoxin-independent regulation of metabolism by the alpha-arrestin proteins.
Q48129778Thyroid Hormone-Induced Differentiation of Astrocytes is Associated with Transcriptional Upregulation of β-arrestin-1 and β-adrenergic Receptor-Mediated Endosomal Signaling
Q34359955Tolerance to the Antinociceptive Effect of Morphine in the Absence of Short-Term Presynaptic Desensitization in Rat Periaqueductal Gray Neurons
Q59336003Tonic ATP-mediated growth suppression in peripheral nerve glia requires arrestin-PP2 and is evaded in NF1
Q36887422Trafficking of the Menkes copper transporter ATP7A is regulated by clathrin-, AP-2-, AP-1-, and Rab22-dependent steps
Q42826128Tumor necrosis factor receptor-1 can function through a G alpha q/11-beta-arrestin-1 signaling complex
Q36755025Ubiquitin-specific Protease 20 Regulates the Reciprocal Functions of β-Arrestin2 in Toll-like Receptor 4-promoted Nuclear Factor κB (NFκB) Activation
Q36411260Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation
Q33942342Vascular signaling through G protein-coupled receptors: new concepts
Q41917803beta-Arrestin-biased agonism of the angiotensin receptor induced by mechanical stress
Q33840022beta-Arrestin-dependent activation of Ca(2+)/calmodulin kinase II after beta(1)-adrenergic receptor stimulation
Q24654027beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice
Q36156773beta-arrestin 2 oligomerization controls the Mdm2-dependent inhibition of p53.
Q40034384beta-arrestin-biased agonism at the beta2-adrenergic receptor
Q37551918β-Adrenergic Receptor and Insulin Resistance in the Heart
Q95834242β-Adrenergic receptor structure and function: molecular insights guiding the development of novel therapeutic strategies to treat malignancy
Q38015368β-Adrenoceptor Signaling Networks in Adipocytes for Recruiting Stored Fat and Energy Expenditure
Q34044736β-Arrestin 2 negatively regulates Toll-like receptor 4 (TLR4)-triggered inflammatory signaling via targeting p38 MAPK and interleukin 10.
Q59805371β-Arrestin Based Receptor Signaling Paradigms: Potential Therapeutic Targets for Complex Age-Related Disorders
Q34619611β-Arrestin-1 links mitogenic sonic hedgehog signaling to the cell cycle exit machinery in neural precursors
Q33985855β-Arrestin-2 deficiency attenuates abdominal aortic aneurysm formation in mice
Q30448011β-Arrestin-2 desensitizes the transient receptor potential vanilloid 1 (TRPV1) channel
Q41453724β-Arrestin-2 inhibits preference for alcohol in mice and suppresses Akt signaling in the dorsal striatum
Q35426493β-Arrestin-dependent deactivation of mouse melanopsin.
Q35175384β-Arrestin-mediated receptor trafficking and signal transduction
Q33808587β-Arrestin1 mediates the endocytosis and functions of macrophage migration inhibitory factor
Q34716806β-Arrestin: A signaling molecule and potential therapeutic target for heart failure
Q34603394β-Arrestins regulate human cardiac fibroblast transformation and collagen synthesis in adverse ventricular remodeling
Q37810522β-Arrestins: multifunctional signaling adaptors in type 2 diabetes
Q64922148β-arrestin 1 Overexpression Increases Temozolomide Resistance in Human Malignant Glioma Cells.
Q60932658β-arrestin 1 regulates β2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility
Q24297887β-arrestin Kurtz inhibits MAPK and Toll signalling in Drosophila development
Q35214338β-arrestin regulates estradiol membrane-initiated signaling in hypothalamic neurons
Q90711266β-arrestin-2 enhances intestinal epithelial apoptosis in necrotizing enterocolitis
Q34039598β-arrestin-2-biased agonism of delta opioid receptors sensitizes transient receptor potential vanilloid type 1 (TRPV1) in primary sensory neurons
Q24306884β-arrestin1 mediates metastatic growth of breast cancer cells by facilitating HIF-1-dependent VEGF expression
Q35741012β-arrestin1 over-expression is associated with an unfavorable prognosis in lung adenocarcinomas and correlated with vascular endothelial growth factor
Q54117203β-arrestin2 Affects Cardiac Progenitor Cell Survival through Cell Mobility and Tube Formation in Severe Hypoxia.
Q36756664β2-adrenergic receptor activation prevents rodent dopaminergic neurotoxicity by inhibiting microglia via a novel signaling pathway

Search more.