Arrestin development: emerging roles for beta-arrestins in developmental signaling pathways

scientific article published on October 2009

Arrestin development: emerging roles for beta-arrestins in developmental signaling pathways is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/J.DEVCEL.2009.09.011
P932PMC publication ID3221601
P698PubMed publication ID19853559
P5875ResearchGate publication ID38033023

P50authorRobert LefkowitzQ80910
P2093author name stringJeffrey J Kovacs
Makoto R Hara
Jihee Kim
Chandra L Davenport
P2860cites workArrestins: ubiquitous regulators of cellular signaling pathwaysQ21184142
Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexesQ22008730
beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2Q22253360
beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteinsQ24292014
A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcriptionQ24297869
Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signalingQ24299892
{beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligaseQ24301549
Mdm2 is involved in the ubiquitination and degradation of G-protein-coupled receptor kinase 2Q24305064
Beta-arrestin-dependent regulation of the cofilin pathway downstream of protease-activated receptor-2Q24305533
A beta-arrestin 2 signaling complex mediates lithium action on behaviorQ24306355
The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent mannerQ24308947
An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behaviorQ24310712
Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2Q24315023
Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5Q24316484
Functional specialization of beta-arrestin interactions revealed by proteomic analysisQ24318455
Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signalingQ24320156
Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptorQ24320318
The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitizationQ24323133
beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulationQ24324243
Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeatsQ24337414
Beta-arrestin 2-dependent angiotensin II type 1A receptor-mediated pathway of chemotaxisQ24337549
Activation of group III metabotropic glutamate receptors attenuates rotenone toxicity on dopaminergic neurons through a microtubule-dependent mechanism.Q48577723
Arrestin-mediated ERK activation by gonadotropin-releasing hormone receptors: receptor-specific activation mechanisms and compartmentalization.Q50746717
Wnt5a promotes adhesion of human dermal fibroblasts by triggering a phosphatidylinositol-3 kinase/Akt signal.Q51794895
The left-right determinant Inversin is a component of node monocilia and other 9+0 cilia.Q52107835
beta-Arrestin scaffolding of the ERK cascade enhances cytosolic ERK activity but inhibits ERK-mediated transcription following angiotensin AT1a receptor stimulationQ77452079
alpha-Thrombin induces rapid and sustained Akt phosphorylation by beta-arrestin1-dependent and -independent mechanisms, and only the sustained Akt phosphorylation is essential for G1 phase progressionQ77785692
Arrestin serves as a molecular switch, linking endogenous alpha2-adrenergic receptor to SRC-dependent, but not SRC-independent, ERK activationQ79815563
A phosphorylation cluster of five serine and threonine residues in the C-terminus of the follicle-stimulating hormone receptor is important for desensitization but not for beta-arrestin-mediated ERK activationQ80057802
Platelet-activating factor-induced clathrin-mediated endocytosis requires beta-arrestin-1 recruitment and activation of the p38 MAPK signalosome at the plasma membrane for actin bundle formationQ83367366
M3 muscarinic acetylcholine receptor-mediated signaling is regulated by distinct mechanismsQ34767650
Tgf-beta superfamily signaling in embryonic development and homeostasisQ34963093
Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney diseaseQ34982718
Regulation of G protein-coupled receptor kinases and arrestins during receptor desensitizationQ35028704
Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2Q35131741
IGF type 1 receptor: a cell cycle progression factor that regulates aging.Q35173474
Targeting of beta-arrestin2 to the centrosome and primary cilium: role in cell proliferation controlQ28571736
Independent beta-arrestin2 and Gq/protein kinase Czeta pathways for ERK stimulated by angiotensin type 1A receptors in vascular smooth muscle cells converge on transactivation of the epidermal growth factor receptorQ28572837
Sonic hedgehog guides axons through a noncanonical, Src-family-kinase-dependent signaling pathwayQ28575061
Insulin induces heterologous desensitization of G-protein-coupled receptor and insulin-like growth factor I signaling by downregulating beta-arrestin-1.Q28575441
{beta}-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD PhosphorylationQ28577649
Dopamine promotes striatal neuronal apoptotic death via ERK signaling cascadesQ28578325
Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestinsQ28578546
Cilia and Hedgehog responsiveness in the mouseQ28585101
Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conservedQ28585804
Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependenceQ28590279
A beta-arrestin-dependent scaffold is associated with prolonged MAPK activation in pseudopodia during protease-activated receptor-2-induced chemotaxisQ28592370
Hedgehog signalling in the mouse requires intraflagellar transport proteinsQ28593010
Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of GliQ28593401
The canonical Notch signaling pathway: unfolding the activation mechanismQ29547725
Kif3a constrains beta-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanismsQ29614613
WNT and beta-catenin signalling: diseases and therapiesQ29616159
Specificity and versatility in tgf-beta signaling through SmadsQ29616324
Beta-arrestins and cell signalingQ29616793
Transcriptional control by the TGF-beta/Smad signaling systemQ29618985
Non-Smad pathways in TGF-beta signalingQ29620040
Agonist-selective, receptor-specific interaction of human P2Y receptors with beta-arrestin-1 and -2Q30486708
The type III TGF-beta receptor regulates epithelial and cancer cell migration through beta-arrestin2-mediated activation of Cdc42.Q30487886
Dishevelled controls apical docking and planar polarization of basal bodies in ciliated epithelial cellsQ30491381
Primary cilia are not required for normal canonical Wnt signaling in the mouse embryo.Q33498502
Hedgehog signal transduction: from flies to vertebratesQ33783491
Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptorQ33819496
Role of TAK1 and TAB1 in BMP signaling in early Xenopus developmentQ33888315
Stirring up development with the heterotrimeric kinesin KIF3.Q34156482
Specificity in ligand binding and intracellular signalling by insulin and insulin-like growth factor receptorsQ34332448
Role of beta-arrestin 1 in the metastatic progression of colorectal cancerQ34335080
Molecular mechanisms of G protein-coupled receptor signaling: role of G protein-coupled receptor kinases and arrestins in receptor desensitization and resensitizationQ34470011
Differential kinetic and spatial patterns of beta-arrestin and G protein-mediated ERK activation by the angiotensin II receptorQ34548751
beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptorQ34562493
Cooperative regulation of extracellular signal-regulated kinase activation and cell shape change by filamin A and beta-arrestins.Q34564790
kurtz, a novel nonvisual arrestin, is an essential neural gene in DrosophilaQ34609991
beta-arrestins regulate mitogenic signaling and clathrin-mediated endocytosis of the insulin-like growth factor I receptorQ34754993
Notch signaling in development and diseaseQ35676772
Signaling in time and space: G protein-coupled receptors and mitogen-activated protein kinasesQ35748162
Beta-arrestin is a necessary component of Wnt/beta-catenin signaling in vitro and in vivo.Q35800324
beta-arrestins: traffic cops of cell signalingQ35804809
Seven-transmembrane receptors and ubiquitinationQ35951259
Mu opioid receptor activation of ERK1/2 is GRK3 and arrestin dependent in striatal neuronsQ36184325
Wnt and calcium signaling: beta-catenin-independent pathwaysQ36228742
A Drosophila nonvisual arrestin is required for the maintenance of olfactory sensitivity.Q36333860
Structure-function analysis of FrizzledsQ36397539
Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activationQ36411260
Beta-Arrestin-1 mediates glucagon-like peptide-1 signaling to insulin secretion in cultured pancreatic beta cellsQ36638807
New roles for beta-arrestins in cell signaling: not just for seven-transmembrane receptorsQ36678037
Physiological roles of G protein-coupled receptor kinases and arrestinsQ36737680
The IGF-I signaling pathwayQ36754655
Beta-blockers alprenolol and carvedilol stimulate beta-arrestin-mediated EGFR transactivation.Q36936400
Physical interaction of calmodulin with the 5-hydroxytryptamine2C receptor C-terminus is essential for G protein-independent, arrestin-dependent receptor signaling.Q36954117
Beta-arrestin-mediated localization of smoothened to the primary ciliumQ36983577
Smoothened signaling in vertebrates is facilitated by a G protein-coupled receptor kinaseQ36992971
TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-betaQ37052635
S-nitrosylation of beta-arrestin regulates beta-adrenergic receptor traffickingQ37070857
Identification of beta-arrestin2 as a G protein-coupled receptor-stimulated regulator of NF-kappaB pathwaysQ24338654
Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffoldsQ24605173
A molecular mechanism for the effect of lithium on developmentQ24629067
Kappa opioids promote the proliferation of astrocytes via Gbetagamma and beta-arrestin 2-dependent MAPK-mediated pathwaysQ24643003
Agonist-directed signaling of the serotonin 2A receptor depends on beta-arrestin-2 interactions in vivoQ24647416
Beta-arrestins and heterotrimeric G-proteins: collaborators and competitors in signal transductionQ24653656
beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in miceQ24654027
The retromer subunit Vps26 has an arrestin fold and binds Vps35 through its C-terminal domainQ24673655
Kappa opioid receptor activation of p38 MAPK is GRK3- and arrestin-dependent in neurons and astrocytesQ24685424
Structure of Vps26B and mapping of its interaction with the retromer protein complexQ27649357
The Wnt signaling pathway in development and diseaseQ27861019
Vertebrate Smoothened functions at the primary ciliumQ27919682
Arrestin-related ubiquitin-ligase adaptors regulate endocytosis and protein turnover at the cell surface.Q27939550
Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3Q28138462
Signal transduction by the JNK group of MAP kinasesQ28142592
The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activityQ28188156
Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestinQ28190513
Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4Q28205234
Hedgehog signaling in animal development: paradigms and principlesQ28208463
Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transductionQ28271470
Beta-arrestin signaling and regulation of transcriptionQ28282729
Proteasome-independent functions of ubiquitin in endocytosis and signalingQ28282959
Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebratesQ28285927
Divergence of hedgehog signal transduction mechanism between Drosophila and mammalsQ28295678
Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2Q28299947
Cilia and developmental signalingQ28302606
TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivoQ28504462
Enhanced morphine analgesia in mice lacking beta-arrestin 2Q28504554
Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebratesQ28506652
The TGF beta activated kinase TAK1 regulates vascular development in vivoQ28507785
Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 geneQ28507982
Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organizationQ28508928
beta-Arrestin1 knockout mice appear normal but demonstrate altered cardiac responses to beta-adrenergic stimulationQ28512807
Role of transforming growth factor-beta superfamily signaling pathways in human diseaseQ37099520
Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors.Q37105461
Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligandsQ37210835
Identification of betaArrestin2 as a corepressor of androgen receptor signaling in prostate cancerQ37224229
The type III transforming growth factor-beta receptor negatively regulates nuclear factor kappa B signaling through its interaction with beta-arrestin2.Q37281661
The type 1 insulin-like growth factor receptor pathwayQ37300867
Dampened Hedgehog signaling but normal Wnt signaling in zebrafish without ciliaQ37314322
G protein Galphai functions immediately downstream of Smoothened in Hedgehog signallingQ37348019
Hedgehog signaling in development and cancer.Q37350250
The primary cilium coordinates signaling pathways in cell cycle control and migration during development and tissue repairQ37369347
The transforming growth factor-beta type III receptor mediates distinct subcellular trafficking and downstream signaling of activin-like kinase (ALK)3 and ALK6 receptorsQ37387956
Wnt signaling pathways meet Rho GTPases.Q37388913
Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascadeQ37416273
Signal integration by JNK and p38 MAPK pathways in cancer developmentQ37560607
Ryk cooperates with Frizzled 7 to promote Wnt11-mediated endocytosis and is essential for Xenopus laevis convergent extension movementsQ38360630
Beta-arrestin-mediated signaling regulates protein synthesis.Q39782848
Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance.Q39898733
Beta-arrestin and casein kinase 1/2 define distinct branches of non-canonical WNT signalling pathwaysQ39924848
Functional characterization of kurtz, a Drosophila non-visual arrestin, reveals conservation of GPCR desensitization mechanisms.Q39927110
A novel protein kinase A-independent, beta-arrestin-1-dependent signaling pathway for p38 mitogen-activated protein kinase activation by beta2-adrenergic receptorsQ39954092
Beta-arrestin scaffolding of phosphatidylinositol 4-phosphate 5-kinase Ialpha promotes agonist-stimulated sequestration of the beta2-adrenergic receptorQ39974697
Arrestin-2 interacts with the ubiquitin-protein isopeptide ligase atrophin-interacting protein 4 and mediates endosomal sorting of the chemokine receptor CXCR4.Q40065770
The interaction of endoglin with beta-arrestin2 regulates transforming growth factor-beta-mediated ERK activation and migration in endothelial cellsQ40125606
Stimulation by ghrelin of p42/p44 mitogen-activated protein kinase through the GHS-R1a receptor: role of G-proteins and beta-arrestinsQ40127887
pVHL and GSK3beta are components of a primary cilium-maintenance signalling networkQ40142798
Beta-arrestin and Mdm2 mediate IGF-1 receptor-stimulated ERK activation and cell cycle progressionQ40170553
Targeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestinsQ40175757
The V2 vasopressin receptor stimulates ERK1/2 activity independently of heterotrimeric G protein signallingQ40253140
Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation.Q40313388
The sustainability of interactions between the orexin-1 receptor and beta-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of ERK MAPK regulation.Q40463546
Drosophila PI3 kinase and Akt involved in insulin-stimulated proliferation and ERK pathway activation in Schneider cellsQ40520944
Regulation of V2 vasopressin receptor degradation by agonist-promoted ubiquitinationQ40636866
G-protein-coupled receptor (GPCR) kinase phosphorylation and beta-arrestin recruitment regulate the constitutive signaling activity of the human cytomegalovirus US28 GPCR.Q40659675
Trafficking patterns of beta-arrestin and G protein-coupled receptors determined by the kinetics of beta-arrestin deubiquitinationQ40672031
Beta-arrestin2 is critically involved in CXCR4-mediated chemotaxis, and this is mediated by its enhancement of p38 MAPK activationQ40699131
Regulation of lysophosphatidic acid receptor-stimulated response by G-protein-coupled receptor kinase-2 and beta-arrestin1 in FRTL-5 rat thyroid cellsQ40720579
Insulin and insulin-like growth factor I receptors utilize different G protein signaling componentsQ40816727
Endocytosis of the type III transforming growth factor-beta (TGF-beta) receptor through the clathrin-independent/lipid raft pathway regulates TGF-beta signaling and receptor down-regulationQ41177526
Both ERK and Wnt/beta-catenin pathways are involved in Wnt3a-induced proliferationQ42472178
Essential role for beta-arrestin 2 in the regulation of Xenopus convergent extension movementsQ42791086
Protease-activated receptor-2 simultaneously directs beta-arrestin-1-dependent inhibition and Galphaq-dependent activation of phosphatidylinositol 3-kinaseQ42798396
Insulin-induced beta-arrestin1 Ser-412 phosphorylation is a mechanism for desensitization of ERK activation by Galphai-coupled receptorsQ45133871
Regulation of Notch signalling by non-visual beta-arrestinQ45345847
MT1 melatonin receptor internalization underlies melatonin-induced morphologic changes in Chinese hamster ovary cells and these processes are dependent on Gi proteins, MEK 1/2 and microtubule modulationQ46313463
Trimeric G protein-dependent frizzled signaling in DrosophilaQ47072581
Beta-arrestin 2 regulates zebrafish development through the hedgehog signaling pathwayQ47073322
The effect of pertussis toxin on zebrafish development: a possible role for inhibitory G-proteins in hedgehog signalingQ48512657
P433issue4
P407language of work or nameEnglishQ1860
P1104number of pages16
P304page(s)443-458
P577publication date2009-10-01
P1433published inDevelopmental CellQ1524277
P1476titleArrestin development: emerging roles for beta-arrestins in developmental signaling pathways
P478volume17

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cites work (P2860)
Q37065864A Significant Role of the Truncated Ghrelin Receptor GHS-R1b in Ghrelin-induced Signaling in Neurons.
Q35817527A negative allosteric modulator demonstrates biased antagonism of the follicle stimulating hormone receptor
Q28504855A novel KRAB domain-containing zinc finger transcription factor ZNF431 directly represses Patched1 transcription
Q39905040A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1.
Q50299929ARRB bind GPCRs
Q35647525Activated protein C promotes protease-activated receptor-1 cytoprotective signaling through β-arrestin and dishevelled-2 scaffolds
Q26849316Adaptive resistance to targeted therapies in cancer
Q35545433An emerging role for the lipid mediator sphingosine-1-phosphate in mast cell effector function and allergic disease
Q89454336Aptamers: Uptake mechanisms and intracellular applications
Q34537021Arrestin-2 Differentially Regulates PAR4 and ADP Receptor Signaling in Platelets
Q33992591Arrestin-2 interacts with the endosomal sorting complex required for transport machinery to modulate endosomal sorting of CXCR4
Q37321957Arrestins in host-pathogen interactions
Q36205804Astroglial β-Arrestin1-mediated Nuclear Signaling Regulates the Expansion of Neural Precursor Cells in Adult Hippocampus
Q33682193COX-1/PGE2/EP4 alleviates mucosal injury by upregulating β-arr1-mediated Akt signaling in colitis
Q34294578Caudal genes in blood development and leukemia
Q53682448Controversial Role of Kisspeptins/KiSS-1R Signaling System in Tumor Development.
Q36776746Cross-desensitization and cointernalization of H1 and H2 histamine receptors reveal new insights into histamine signal integration.
Q37807297Current perspectives on the selective regulation of dopamine D2 and D3 receptors
Q37259213Developmental and tumoral vascularization is regulated by G protein-coupled receptor kinase 2
Q33903905Distinct and shared roles of β-arrestin-1 and β-arrestin-2 on the regulation of C3a receptor signaling in human mast cells
Q50652866Downregulation of β-arrestin 1 suppresses glioblastoma cell malignant progression vis inhibition of Src signaling.
Q51321708Effect of troxerutin on insulin signaling molecules in the gastrocnemius muscle of high fat and sucrose-induced type-2 diabetic adult male rat.
Q36557104Effects of cocaine and withdrawal on the mouse nucleus accumbens transcriptome.
Q51872392Elevated β-arrestin1 expression correlated with risk stratification in acute lymphoblastic leukemia.
Q42565864Endoplasmic reticulum stress pathway required for immune homeostasis is neurally controlled by arrestin-1.
Q30415888Epigenetic coordination of signaling pathways during the epithelial-mesenchymal transition
Q37511632Epigenetic silencing of ARRDC3 expression in basal-like breast cancer cells
Q35779157Essential requirement for β-arrestin2 in mouse intestinal tumors with elevated Wnt signaling
Q34186022Functional selectivity of allosteric interactions within G protein-coupled receptor oligomers: the dopamine D1-D3 receptor heterotetramer.
Q49462148G Protein-Coupled Receptors As Regulators of Localized Translation: The Forgotten Pathway?
Q37880070G Protein-coupled receptor kinase 2 (GRK2): A novel modulator of insulin resistance
Q37970012G protein-coupled receptor signalling in the cardiac nuclear membrane: evidence and possible roles in physiological and pathophysiological function.
Q33707710GPR54 regulates ERK1/2 activity and hypothalamic gene expression in a Gα(q/11) and β-arrestin-dependent manner
Q35187043Glycogen synthase kinase-3 is essential for β-arrestin-2 complex formation and lithium-sensitive behaviors in mice
Q38028547Heterodimerisation of G protein-coupled receptors: implications for drug design and ligand screening
Q34256410Heterodimerization of serotonin receptors 5-HT1A and 5-HT7 differentially regulates receptor signalling and trafficking
Q35713259IQGAP1 and its binding proteins control diverse biological functions
Q37189430Identification of C-terminal phosphorylation sites of N-formyl peptide receptor-1 (FPR1) in human blood neutrophils
Q90762243Identification of beta-arrestin-1 as a diagnostic biomarker in lung cancer
Q35005851Interaction of Arrestin with Enolase1 in Photoreceptors
Q37809668International Union of Basic and Clinical Pharmacology. LXXX. The Class Frizzled Receptors
Q38053088Involvement of β-arrestins in cancer progression
Q52363961Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis.
Q37232939KIF3A binds to β-arrestin for suppressing Wnt/β-catenin signalling independently of primary cilia in lung cancer
Q35852118Long-Acting Beta Agonists Enhance Allergic Airway Disease
Q41721776Loss of β-arrestin-2 and Activation of CXCR2 Correlate with Lymph Node Metastasis in Non-small Cell Lung Cancer
Q40621763Loss of β-arrestin1 expression predicts unfavorable prognosis for non-small cell lung cancer patients
Q38086019Mitogen-Activated Protein (MAP) Kinase Scaffolding Proteins: A Recount.
Q34488901Multiple Scaffolding Functions of β-Arrestins in the Degradation of G Protein-coupled Receptor Kinase 2
Q27690729Nanobody stabilization of G protein-coupled receptor conformational states.
Q36505726Non-Hematopoietic β-Arrestin1 Confers Protection Against Experimental Colitis.
Q37869835Novel pathways in gonadotropin receptor signaling and biased agonism.
Q57192334Oligonucleotide Aptamer-Mediated Precision Therapy of Hematological Malignancies
Q35547856Orexin-corticotropin-releasing factor receptor heteromers in the ventral tegmental area as targets for cocaine
Q34581041Osteoblast regulation via ligand-activated nuclear trafficking of the oxytocin receptor
Q35078595P2Y(2) receptors and GRK2 are involved in oscillatory fluid flow induced ERK1/2 responses in chondrocytes
Q28569553PAF enhances MMP-2 production in rat aortic VSMCs via a β-arrestin2-dependent ERK signaling pathway
Q41563028PTEN controls glandular morphogenesis through a juxtamembrane β-Arrestin1/ARHGAP21 scaffolding complex
Q39316276Palmitate contributes to insulin resistance through downregulation of the Src-mediated phosphorylation of Akt in C2C12 myotubes
Q36618617Pharmacological blockade of a β(2)AR-β-arrestin-1 signaling cascade prevents the accumulation of DNA damage in a behavioral stress model
Q30400167Phosphorylation and Internalization of Lysophosphatidic Acid Receptors LPA1, LPA2, and LPA3.
Q51754961Phosphorylation regulates TRPV1 association with β-arrestin-2.
Q37761044Physiology of the (pro)renin receptor: Wnt of change?
Q27321217Pitchfork and Gprasp2 Target Smoothened to the Primary Cilium for Hedgehog Pathway Activation
Q35027563Regulation of Rho-GEF Rgf3 by the arrestin Art1 in fission yeast cytokinesis
Q37320596Regulation of Toll signaling and inflammation by β-arrestin and the SUMO protease Ulp1.
Q39131811Regulation of inflammation by β-arrestins: Not just receptor tales
Q28975781Regulation of the CUL3 Ubiquitin Ligase by a Calcium-Dependent Co-adaptor
Q53197894Role of Runx2 in IGF-1Rβ/Akt- and AMPK/Erk-dependent growth, survival and sensitivity towards metformin in breast cancer bone metastasis.
Q33969519Role of glycosylation of Notch in development
Q33855672Role of the Drosophila non-visual ß-arrestin kurtz in hedgehog signalling.
Q35002768SUMOylation attenuates human β-arrestin 2 inhibition of IL-1R/TRAF6 signaling
Q36647024Serotonin receptor signaling and regulation via β-arrestins
Q37954006Setting the clock for recirculating lymphocytes.
Q36470941Signaling organelles of the innate immune system
Q35972819Storage Temperature Alters the Expression of Differentiation-Related Genes in Cultured Oral Keratinocytes
Q92040403Structure-function analysis of β-arrestin Kurtz reveals a critical role of receptor interactions in downregulation of GPCR signaling in vivo
Q35148896Targeted disruption of β-arrestin 2-mediated signaling pathways by aptamer chimeras leads to inhibition of leukemic cell growth
Q39381430The Diverse Roles of Arrestin Scaffolds in G Protein-Coupled Receptor Signaling
Q38864897The SHP-1 protein tyrosine phosphatase negatively modulates Akt signaling in the ghrelin/GHSR1a system
Q26783047The emerging roles of β-arrestins in fibrotic diseases
Q26801420The mechanism of μ-opioid receptor (MOR)-TRPV1 crosstalk in TRPV1 activation involves morphine anti-nociception, tolerance and dependence
Q38188734The role of protein dynamics in GPCR function: insights from the β2AR and rhodopsin
Q36670706Ubiquitin-dependent regulation of G protein-coupled receptor trafficking and signaling
Q37309763Upregulation of neurovascular communication through filamin abrogation promotes ectopic periventricular neurogenesis
Q34044736β-Arrestin 2 negatively regulates Toll-like receptor 4 (TLR4)-triggered inflammatory signaling via targeting p38 MAPK and interleukin 10.
Q27325551β-Arrestin interacts with the beta/gamma subunits of trimeric G-proteins and dishevelled in the Wnt/Ca(2+) pathway in xenopus gastrulation
Q34718220β-Arrestin mediates oxytocin receptor signaling, which regulates uterine contractility and cellular migration
Q47425732β-Arrestin-1 deficiency ameliorates renal interstitial fibrosis by blocking Wnt1/β-catenin signaling in mice
Q33985855β-Arrestin-2 deficiency attenuates abdominal aortic aneurysm formation in mice
Q30448011β-Arrestin-2 desensitizes the transient receptor potential vanilloid 1 (TRPV1) channel
Q38863857β-Arrestin1 enhances hepatocellular carcinogenesis through inflammation-mediated Akt signalling.
Q33994385β-Arrestin1 promotes the progression of chronic myeloid leukaemia by regulating BCR/ABL H4 acetylation
Q38902143β-Arrestin2 Contributes to Cell Viability and Proliferation via the Down-Regulation of FOXO1 in Castration-Resistant Prostate Cancer
Q47268946β-Arrestin2 mediates progression of murine primary myelofibrosis
Q36140375β-Arrestin2 mediates the initiation and progression of myeloid leukemia.
Q61315205β-Arrestin2 plays a key role in the modulation of the pancreatic beta cell mass in mice
Q36755034β-Arrestins Negatively Regulate the Toll Pathway in Shrimp by Preventing Dorsal Translocation and Inhibiting Dorsal Transcriptional Activity
Q37810522β-Arrestins: multifunctional signaling adaptors in type 2 diabetes
Q64922148β-arrestin 1 Overexpression Increases Temozolomide Resistance in Human Malignant Glioma Cells.
Q35406094β-arrestin 2 is associated with multidrug resistance in breast cancer cells through regulating MDR1 gene expression
Q34540603β-arrestin 2-mediated immune suppression induced by chronic stress
Q24297887β-arrestin Kurtz inhibits MAPK and Toll signalling in Drosophila development
Q42734045β-arrestin deficiency protects against pulmonary fibrosis in mice and prevents fibroblast invasion of extracellular matrix
Q44686499β-arrestin-1 is a nuclear transcriptional regulator of endothelin-1-induced β-catenin signaling.
Q37630356β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions

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