The role of Ets transcription factors in the development and function of the mammalian immune system

scientific article published on January 1997

The role of Ets transcription factors in the development and function of the mammalian immune system is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/S0065-2776(08)60887-1
P698PubMed publication ID9100980

P2093author name stringLeiden JM
Bassuk AG
P2860cites workCharacterization of Spi-B, a transcription factor related to the putative oncoprotein Spi-1/PU.1Q24293686
Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumoursQ24298221
A novel Ets-related transcription factor, Elf-1, binds to human immunodeficiency virus type 2 regulatory elements that are required for inducible trans activation in T cellsQ24300123
Structure and transcription of the human c-mpl gene (MPL)Q24313041
The high mobility group transcription factor, SOX4, transactivates the human CD2 enhancerQ24313046
ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulationQ24313680
Down's syndrome-like skeletal abnormalities in Ets2 transgenic miceQ24321587
cDNA cloning of transcription factor E4TF1 subunits with Ets and notch motifsQ24321852
Activation of the HIV-1 enhancer by the LEF-1 HMG protein on nucleosome-assembled DNA in vitroQ24336356
MafB is an interaction partner and repressor of Ets-1 that inhibits erythroid differentiationQ24336558
Net, a new ets transcription factor that is activated by RasQ24336684
Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response elementQ24337763
Spatial flexibility in ternary complexes between SRF and its accessory proteinsQ24555659
Identification and mapping of a common proviral integration site Fli-1 in erythroleukemia cells induced by Friend murine leukemia virusQ24559244
Characterization of the human interleukin-2 receptor beta-chain gene promoter: regulation of promoter activity by ets gene productsQ36823531
Identification of a killer cell-specific regulatory element of the mouse perforin gene: an Ets-binding site-homologous motif that interacts with Ets-related proteinsQ36824866
Ets proteins: new factors that regulate immunoglobulin heavy-chain gene expressionQ36826409
Transcriptional regulation of HLA-DRA geneQ36839439
A short-lived nuclear phosphoprotein encoded by the human ets-2 proto-oncogene is stabilized by activation of protein kinase C.Q36848613
The proto-oncogene c-ets is preferentially expressed in lymphoid cellsQ36951174
pokkuri, a Drosophila gene encoding an E-26-specific (Ets) domain protein, prevents overproduction of the R7 photoreceptorQ37124546
A phorbol ester response element within the human T-cell receptor beta-chain enhancerQ37258998
Molecular and functional characterization of the promoter of ETS2, the human c-ets-2 geneQ37685279
Identification of Essential GATA and Ets Binding Motifs within the Promoter of the Platelet Glycoprotein Ibα GeneQ38290326
Transactivation of the Moloney murine leukemia virus and T-cell receptor beta-chain enhancers by cbf and ets requires intact binding sites for both proteinsQ38293060
Myb and Ets proteins cooperate to transactivate an early myeloid geneQ38296597
A ternary complex factor-dependent mechanism mediates induction of egr-1 through selective serum response elements following antigen receptor cross-linking in B lymphocytesQ38299153
Involvement of the Ets family factor PU.1 in the activation of immunoglobulin promotersQ38299790
The Spi-1/PU.1 and Spi-B ets family transcription factors and the recombination signal binding protein RBP-J kappa interact with an Epstein-Barr virus nuclear antigen 2 responsive cis-element.Q38301679
The transcription factors Elk-1 and serum response factor interact by direct protein-protein contacts mediated by a short region of Elk-1.Q38308517
Identification and characterization of an Alu-containing, T-cell-specific enhancer located in the last intron of the human CD8 alpha geneQ38314503
Molecular regulation of the human IL-3 gene: inducible T cell-restricted expression requires intact AP-1 and Elf-1 nuclear protein binding sitesQ38314720
Characterization of the promoter region of the human c-kit proto-oncogeneQ38314991
C/EBP, NF-kappa B, and c-Ets family members and transcriptional regulation of the cell-specific and inducible macrophage inflammatory protein 1 alpha immediate-early geneQ38316488
Regulation of the Ets-related transcription factor Elf-1 by binding to the retinoblastoma proteinQ38319003
Both LyF-1 and an Ets protein interact with a critical promoter element in the murine terminal transferase gene.Q38319614
Effect of PU.1 phosphorylation on interaction with NF-EM5 and transcriptional activationQ38320946
Identification of Ets-like lymphoid specific elements within the immunoglobulin heavy chain 3' enhancerQ38326073
Ets-1 and Ets-2 protooncogene expression in theca cells of the adult mouse ovaryQ38326287
Identification of nucleotide preferences in DNA sequences recognised specifically by c-Ets-1 proteinQ38330363
Convergence of Ets- and notch-related structural motifs in a heteromeric DNA binding complexQ38333812
Sequence-specific binding of human Ets-1 to the T cell receptor alpha gene enhancerQ38338362
Molecular interactions within the ecdysone regulatory hierarchy: DNA binding properties of the Drosophila ecdysone-inducible E74A proteinQ38338810
Transcription factor PU.1 mediates induction of c-fms in vascular smooth muscle cells: a mechanism for phenotypic change to phagocytic cellsQ38358480
Pi 1 binding sites are negative regulators of bcl-2 expression in pre-B cellsQ40016702
PU.1 (Spi-1) and C/EBP alpha regulate expression of the granulocyte-macrophage colony-stimulating factor receptor alpha gene.Q40017440
Activation of transcription by PU.1 requires both acidic and glutamine domainsQ40018093
The myeloid-cell-specific c-fes promoter is regulated by Sp1, PU.1, and a novel transcription factorQ40018578
CpG methylation has differential effects on the binding of YY1 and ETS proteins to the bi-directional promoter of the Surf-1 and Surf-2 genesQ40393384
The activation domain of transcription factor PU.1 binds the retinoblastoma (RB) protein and the transcription factor TFIID in vitro: RB shows sequence similarity to TFIID and TFIIBQ24563487
Activation of ternary complex factor Elk-1 by MAP kinasesQ24564310
Human DNA polymerase alpha gene: sequences controlling expression in cycling and serum-stimulated cellsQ24603946
Human CD3-epsilon gene contains three miniexons and is transcribed from a non-TATA promoterQ24646441
Phosphorylation-dependent formation of a quaternary complex at the c-fos SREQ24650677
Regulation of cell-type-specific interleukin-2 receptor alpha-chain gene expression: potential role of physical interactions between Elf-1, HMG-I(Y), and NF-kappa B family proteinsQ24652745
Solution structure of the ets domain of Fli-1 when bound to DNAQ27730257
A new pattern for helix-turn-helix recognition revealed by the PU.1 ETS-domain-DNA complexQ27732614
The TBP-TFIIA Interaction in the Response to Acidic Activators in VivoQ27939451
The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogeneQ28116777
Ets-related protein Elk-1 is homologous to the c-fos regulatory factor p62TCFQ28283139
Functional analysis of the human interleukin 2 receptor gamma chain gene promoterQ28299407
Common sequence and structural features in the heat-shock factor and Ets families of DNA-binding domainsQ28509743
Repression of I-Aβ Gene Expression by the Transcription Factor PU.1Q28511025
Regulated expression of the ets-1 transcription factor in vascular smooth muscle cells in vivo and in vitroQ28569565
An inhibitory carboxyl-terminal domain in Ets-1 and Ets-2 mediates differential binding of ETS family factors to promoter sequences of the mb-1 geneQ28586875
Assembly and function of a TCR alpha enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactionsQ28593829
RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangementQ28594711
Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2Q28609817
Amino acid sequences common to rapidly degraded proteins: the PEST hypothesisQ29547538
The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domainQ29620270
NFβA, a factor required for maximal interleukin-1β gene expression is identical to the ets family member PU.1. Evidence for structural alteration following LPS activationQ30417405
Identification of the promoter of the myelomonocytic leukocyte integrin CD11bQ30985774
Interaction of murine ets-1 with GGA-binding sites establishes the ETS domain as a new DNA-binding motifQ30990862
cis-acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1.Q31117684
The c-ets proto-oncogenes encode transcription factors that cooperate with c-Fos and c-Jun for transcriptional activationQ33767307
Sequence-specific DNA binding of the proto-oncoprotein ets-1 defines a transcriptional activator sequence within the long terminal repeat of the Moloney murine sarcoma virusQ33919687
Erythroleukemia induction by Friend murine leukemia virus: insertional activation of a new member of the ets gene family, Fli-1, closely linked to c-ets-1.Q34114085
Pax5 (BSAP) regulates the murine immunoglobulin 3' alpha enhancer by suppressing binding of NF-alpha P, a protein that controls heavy chain transcriptionQ34212171
Scavenger receptor A gene regulatory elements target gene expression to macrophages and to foam cells of atherosclerotic lesionsQ34218612
Tripartite structure of the avian erythroblastosis virus E26 transforming geneQ34255156
A putative second cell-derived oncogene of the avian leukaemia retrovirus E26.Q34255162
Requirement of ets-2 expression for Xenopus oocyte maturationQ34257816
ERP, a new member of the ets transcription factor/oncoprotein family: cloning, characterization, and differential expression during B-lymphocyte developmentQ36652758
Cell-specific expression of the macrophage scavenger receptor gene is dependent on PU.1 and a composite AP-1/ets motifQ36656291
GATA and Ets cis-acting sequences mediate megakaryocyte-specific expressionQ36659956
Involvement of the transcription factor PU.1/Spi-1 in myeloid cell-restricted expression of an interferon-inducible gene encoding the human high-affinity Fc gamma receptorQ36662265
GSH1, which encodes gamma-glutamylcysteine synthetase, is a target gene for yAP-1 transcriptional regulationQ36664955
Elf-1 binds to a critical element in a second CD4 enhancerQ36666636
Identification of ETS domain proteins in murine T lymphocytes that interact with the Moloney murine leukemia virus enhancerQ36670051
The integrin αv gene: Identification and characterization of the promoter regionQ36676003
Promoter Structure and Transcriptional Activation of the Murine TSG-14 Gene Encoding a Tumor Necrosis Factor/Interleukin-1-inducible Pentraxin ProteinQ36685346
The Sfpi-1 proviral integration site of Friend erythroleukemia encodes the ets-related transcription factor Pu.1.Q36688154
Mitogenic signaling by colony-stimulating factor 1 and ras is suppressed by the ets-2 DNA-binding domain and restored by myc overexpressionQ36706125
Phosphorylation of the ETS-2 protein: regulation by the T-cell antigen receptor-CD3 complexQ36722432
Multiple motifs regulate the B-cell-specific promoter of the B29 geneQ36723592
Sequence-specific interaction of the Ets1 protein with the long terminal repeat of the human T-lymphotropic virus type I.Q36798336
PU.1 recruits a second nuclear factor to a site important for immunoglobulin kappa 3' enhancer activityQ36809426
Activation of the inducible orphan receptor gene nur77 by serum growth factors: dissociation of immediate-early and delayed-early responsesQ36823422
Transcription of the blk Gene in Human B Lymphocytes Is Controlled by Two PromotersQ34298249
Provirus insertion in Tpl-1, an Ets-1-related oncogene, is associated with tumor progression in Moloney murine leukemia virus-induced rat thymic lymphomasQ34307830
Cloning and expression analysis of the murine lymphotoxin beta gene.Q34317868
Phosphorylation of E2F-1 modulates its interaction with the retinoblastoma gene product and the adenoviral E4 19 kDa proteinQ34334020
Temporal and tissue-specific expression of mouse ets genesQ34622266
A single amino-acid substitution in the Ets domain alters core DNA binding specificity of Ets1 to that of the related transcription factors Elf1 and E74.Q35020209
Identification and preferential expression in thymic and bursal lymphocytes of a c-ets oncogene-encoded Mr 54,000 cytoplasmic proteinQ35594791
PU.1 and GATA: components of a mast cell-specific interleukin 4 intronic enhancerQ35661507
The ets gene familyQ35694093
The ets multigene family is conserved throughout the MetazoaQ35858162
Transcriptional regulation during T-cell development: the alpha TCR gene as a molecular modelQ35864576
The secondary structure of the ets domain of human Fli-1 resembles that of the helix-turn-helix DNA-binding motif of the Escherichia coli catabolite gene activator protein.Q35927957
Identification of cell-specific and developmentally regulated nuclear factors that direct myeloid and lymphoid expression of the CD11a geneQ36352024
Distinctive growth requirements and gene expression patterns distinguish progenitor B cells from pre-B cellsQ36361648
Opposing actions of c-ets/PU.1 and c-myb protooncogene products in regulating the macrophage-specific promoters of the human and mouse colony-stimulating factor-1 receptor (c-fms) genes.Q36364154
Anti-immunoglobulin M activates nuclear calcium/calmodulin-dependent protein kinase II in human B lymphocytes.Q36365586
Importance of low affinity Elf-1 sites in the regulation of lymphoid-specific inducible gene expressionQ36365913
The Ets protein Spi-B is expressed exclusively in B cells and T cells during developmentQ36366999
The Ets1 transcription factor is widely expressed during murine embryo development and is associated with mesodermal cells involved in morphogenetic processes such as organ formationQ36479295
Characterization of the human CD4 gene promoter: transcription from the CD4 gene core promoter is tissue-specific and is activated by Ets proteinsQ36487614
Mutations on the DNA-binding surface of TATA-binding protein can specifically impair the response to acidic activators in vivoQ36555209
Characterization of the cooperative function of inhibitory sequences in Ets-1.Q36559022
Spi-1/PU.1 transgenic mice develop multistep erythroleukemiasQ36559604
Generation of a novel Fli-1 protein by gene targeting leads to a defect in thymus development and a delay in Friend virus-induced erythroleukemiaQ36560011
ets-1 in astrocytes: expression and transmitter-evoked phosphorylationQ36566985
Identification of a ras-activated enhancer in the mouse osteopontin promoter and its interaction with a putative ETS-related transcription factor whose activity correlates with the metastatic potential of the cellQ36567151
Ets oncogene-related gene Elg functions in Drosophila oogenesisQ36632095
Functional analysis of the V gamma 3 promoter of the murine gamma delta T-cell receptorQ36644772
Cooperative binding of Ets-1 and core binding factor to DNAQ36644903
Activation of the granulocyte-macrophage colony-stimulating factor promoter in T cells requires cooperative binding of Elf-1 and AP-1 transcription factorsQ36646025
The human beta 2 integrin CD18 promoter consists of two inverted Ets cis elementsQ36650636
Differential regulation of the human immunodeficiency virus type 2 enhancer in monocytes at various stages of differentiationQ36650718
Activation of the human T-cell leukemia virus type I enhancer is mediated by binding sites for Elf-1 and the pets factor.Q36652164
DNA-binding and transcriptional activation properties of the EWS-FLI-1 fusion protein resulting from the t(11;22) translocation in Ewing sarcomaQ36652613
DNA bending in the ternary nucleoprotein complex at thec-fosprometerQ40394722
Elk-1 protein domains required for direct and SRF-assisted DNA-bindingQ40422931
Serum, AP-1 and Ets-1 stimulate the human ets-1 promoterQ40547731
Mouse DNA polymerase beta gene promoter: fine mapping and involvement of Sp1-like mouse transcription factor in its functionQ40555582
Transcriptional regulation of T-cell genes during T-cell developmentQ40623651
Pi, a pre-B-cell-specific enhancer element in the immunoglobulin heavy-chain enhancerQ40656002
PU.1 is a component of a multiprotein complex which binds an essential site in the murine immunoglobulin lambda 2-4 enhancerQ40656361
Ternary complex factors: growth factor regulated transcriptional activatorsQ40757584
IgM receptor-mediated transactivation of the IgH 3' enhancer couples a novel Elf-1-AP-1 protein complex to the developmental control of enhancer function.Q40789393
The Ets family of transcription factorsQ40871575
Combinatorial generation of variable fusion proteins in the Ewing family of tumours.Q40874946
Transcriptional regulation of T cell receptor genesQ40898227
Defective activation and survival of T cells lacking the Ets-1 transcription factorQ41281933
Increased T-cell apoptosis and terminal B-cell differentiation induced by inactivation of the Ets-1 proto-oncogeneQ41281946
GABP and PU.1 compete for binding, yet cooperate to increase CD18 (beta 2 leukocyte integrin) transcriptionQ41283980
Evidence of DNA: protein interactions that mediate HSV-1 immediate early gene activation by VP16.Q41336537
Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activatorQ41337122
Ets-1 activates the DRA promoter in B cellsQ41431603
Sequence specific binding of the transcription factor c-Ets1 to the human immunodeficiency virus type I long terminal repeatQ41507910
Regulatory elements involved in tax-mediated transactivation of the HTLV-I LTR.Q41522929
Regulation of lymphoid-specific immunoglobulin mu heavy chain gene enhancer by ETS-domain proteinsQ41542622
Identification of a novel interleukin-6 response element containing an Ets-binding site and a CRE-like site in the junB promoterQ41945472
ETS family proteins activate transcription from HIV-1 long terminal repeatQ42069520
Evolutionarily conserved Ets family members display distinct DNA binding specificitiesQ42125962
NF-kappa B-mediated chromatin reconfiguration and transcriptional activation of the HIV-1 enhancer in vitroQ42513846
The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathwayQ42598419
Negative control of photoreceptor development in Drosophila by the product of the yan gene, an ETS domain proteinQ42607539
Functional analysis of a growth factor-responsive transcription factor complexQ42810320
ets-2 regulates cdc2 kinase activity in mammalian cells: coordinated expression of cdc2 and cyclin A.Q42829509
Functional analysis of the human adenosine deaminase gene thymic regulatory region and its ability to generate position-independent transgene expressionQ43183220
The late promoter of the human papovavirus BK is contained within the early promoter enhancer regionQ44731475
The Drosophila 74EF early puff contains E74, a complex ecdysone-inducible gene that encodes two ets-related proteinsQ45196166
Synergistic transcriptional activation of the tissue inhibitor of metalloproteinases-1 promoter via functional interaction of AP-1 and Ets-1 transcription factorsQ45258911
Purification of a set of cellular polypeptides that bind to the purine-rich cis-regulatory element of herpes simplex virus immediate early genesQ45844904
The 3' enhancer region determines the B/T specificity and pro-B/pre-B specificity of immunoglobulin V kappa-J kappa joining.Q45960744
Evolution of the ets gene family.Q47268938
The Caenorhabditis elegans gene lin-1 encodes an ETS-domain protein and defines a branch of the vulval induction pathwayQ48068478
Structure of the murine VCAM1 gene.Q48096096
Cloning and Functional Analysis of the Mouse c-kit PromoterQ48128014
Identification of Ets- and notch-related subunits in GA binding proteinQ48214636
PU. 1 is not essential for early myeloid gene expression but is required for terminal myeloid differentiation.Q52204303
Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages.Q52214235
ERK2/p42 MAP kinase stimulates both autonomous and SRF-dependent DNA binding by Elk-1.Q54608590
The solution structure of the human ETS1-DNA complex reveals a novel mode of binding and true side chain intercalationQ57904773
Integration of MAP kinase signal transduction pathways at the serum response elementQ58415341
Cytosolic Phospholipase A2 Is Phosphorylated in Collagen- and Thrombin-stimulated Human Platelets Independent of Protein Kinase C and Mitogen-activated Protein KinaseQ63408094
The ETS-domain: a new DNA-binding motif that recognizes a purine-rich core DNA sequenceQ68624466
Ets-related protein PU.1 regulates expression of the immunoglobulin J-chain gene through a novel Ets-binding elementQ70495981
Modulation of transcription factor Ets-1 DNA binding: DNA-induced unfolding of an alpha helixQ71768221
CpG methylation and the binding of YY1 and ETS proteins to the Surf-1/Surf-2 bidirectional promoterQ71866532
A direct physical association between ETS and AP-1 transcription factors in normal human T cellsQ71992413
In vitro transcription of the TATAA-less mouse thymidylate synthase promoter: multiple transcription start points and evidence for bidirectionalityQ72164529
Conserved and nonconserved functions of the yeast and human TATA-binding proteinsQ72718769
Expression of the human ETS-2 oncogene in normal fetal tissues and in the brain of a fetus with trisomy 21Q93521826
P304page(s)65-104
P577publication date1997-01-01
P1433published inAdvances in ImmunologyQ15752932
P1476titleThe role of Ets transcription factors in the development and function of the mammalian immune system
P478volume64

Reverse relations

cites work (P2860)
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Q36454430The Ets transcription factor ERM is Th1-specific and induced by IL-12 through a Stat4-dependent pathway.
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Q77526138The Ets-1 transcription factor is required for the development of natural killer cells in mice
Q33980422The chromatin remodeling complex NoRC and TTF-I cooperate in the regulation of the mammalian rRNA genes in vivo
Q80598197The development of early and mature B cells is impaired in mice deficient for the Ets-1 transcription factor
Q34976886Tmevpg1, a candidate gene for the control of Theiler's virus persistence, could be implicated in the regulation of gamma interferon.

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