Ribosomal transcription is regulated by PGC-1alpha and disturbed in Huntington's disease

scientific article published on 17 August 2017

Ribosomal transcription is regulated by PGC-1alpha and disturbed in Huntington's disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41598-017-09148-7
P932PMC publication ID5561056
P698PubMed publication ID28819135

P50authorSebastian IbenQ63133027
Karin Scharffetter-KochanekQ63133070
Marius Costel AlupeiQ63133722
Hanna BayerQ67390342
Anke WittingQ67390353
P. WeydtQ67390356
Albert C. LudolphQ67390363
P2093author name stringMartina Zügel
Uwe Schumann
Francesca Tuorto
Sarah Jesse
Karmveer Singh
Silke Malmsheimer
Medhanie Mulaw
Jürgen Steinacker
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Expression of the thermogenic nuclear hormone receptor coactivator PGC-1α is reduced in the adipose tissue of morbidly obese subjectsQ58035875
HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1αQ59066890
Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcriptionQ24545711
The nucleolus under stressQ24597470
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1Q24679555
Mitochondrial Quality Control and Muscle Mass MaintenanceQ26770420
A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesisQ27860471
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SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}Q28235481
Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolismQ28266830
The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcriptionQ28508771
Exercise-induced mitochondrial biogenesis begins before the increase in muscle PGC-1alpha expressionQ28584173
Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null miceQ29614547
Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivatorsQ29617353
Metabolic and hormonal signatures in pre-manifest and manifest Huntington's disease patientsQ33789754
Lipocalin 2 regulates brown fat activation via a nonadrenergic activation mechanismQ34070383
A greatly extended PPARGC1A genomic locus encodes several new brain-specific isoforms and influences Huntington disease age of onsetQ34275231
PGC-1α is a male-specific disease modifier of human and experimental amyotrophic lateral sclerosisQ34344450
The nucleolus—guardian of cellular homeostasis and genome integrityQ34370085
Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathwayQ34377396
Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1.Q35041054
The Ribosomal Protein-Mdm2-p53 Pathway and Energy Metabolism: Bridging the Gap between Feast and FamineQ35103161
Can endurance exercise preconditioning prevention disuse muscle atrophy?Q35167280
Molecular and metabolomic effects of voluntary running wheel activity on skeletal muscle in late middle-aged ratsQ35363772
Mitochondrial energy metabolism in heart failure: a question of balanceQ36070074
PGC-1 coactivators and skeletal muscle adaptations in health and diseaseQ37265277
CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumoursQ37660623
Hypoxic induction of vascular endothelial growth factor (VEGF) and angiogenesis in muscle by truncated peroxisome proliferator-activated receptor γ coactivator (PGC)-1α.Q37691665
Brown fat biology and thermogenesisQ37825203
Biogenesis of mitochondrial proteinsQ38021397
PPARs and ERRs: molecular mediators of mitochondrial metabolismQ38285171
The Wnt Target Protein Peter Pan Defines a Novel p53-independent Nucleolar Stress-Response PathwayQ39944723
Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration.Q45302702
Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegenerationQ45302924
Targeting RNA polymerase I with an oral small molecule CX-5461 inhibits ribosomal RNA synthesis and solid tumor growth.Q45995796
Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscleQ47755014
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectHuntington's diseaseQ190564
P304page(s)8513
P577publication date2017-08-17
P1433published inScientific ReportsQ2261792
P1476titleRibosomal transcription is regulated by PGC-1alpha and disturbed in Huntington's disease
P478volume7

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cites work (P2860)
Q97067783Candidate Genes Associated With Neurological Findings in a Patient With Trisomy 4p16.3 and Monosomy 5p15.2.
Q91709884Gene-based analysis in HRC imputed genome wide association data identifies three novel genes for Alzheimer's disease
Q64085065Integration of the Deacetylase SIRT1 in the Response to Nucleolar Stress: Metabolic Implications for Neurodegenerative Diseases
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Q90235478The peculiar genetics of the ribosomal DNA blurs the boundaries of transgenerational epigenetic inheritance

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