Hypertrophic scars, keloids, and contractures. The cellular and molecular basis for therapy

scientific article published on June 1997

Hypertrophic scars, keloids, and contractures. The cellular and molecular basis for therapy is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/S0039-6109(05)70576-4
P698PubMed publication ID9194888

P2093author name stringTredget EE
Scott PG
Ghahary A
Nedelec B
P2860cites workImmunohistochemical localization of the proteoglycans decorin, biglycan and versican and transforming growth factor-beta in human post-burn hypertrophic and mature scarsQ71707970
Cultured epithelial autograft: five years of clinical experience with twenty-eight patientsQ72057781
Insulin-like growth factor I acts as an angiogenic agent in rabbit cornea and retina: comparative studies with basic fibroblast growth factorQ72077926
Silicone rubber substrata: a new wrinkle in the study of cell locomotionQ72128764
Regulation of collagen synthesis and mRNA expression in normal and hypertrophic scar fibroblasts in vitro by interferon-gammaQ72226215
A controlled clinical trial of topical silicone gel sheeting in the treatment of hypertrophic scars and keloidsQ72255215
Immunolocalization of TGF-beta 1 in human hypertrophic scar and normal dermal tissuesQ72309965
Effect of gamma-interferon on the clinical and biologic evolution of hypertrophic scars and Dupuytren's disease: an open pilot studyQ72392883
Keloids and hypertrophic scarsQ72414712
Skin wound healing: transforming growth factor beta antagonists decrease scarring and improve qualityQ72557412
The response of burn scars to intralesional verapamil. Report of five casesQ72703599
Malignant change in keloidsQ73217154
Transforming growth factor-beta: activity and efficacy in animal models of wound healingQ79407014
Interferons gamma and alpha-2b differentially regulate the expression of collagenase and tissue inhibitor of metalloproteinase-1 messenger RNA in human hypertrophic and normal dermal fibroblastsQ79437338
Non-pressure treatment of hypertrophic scarsQ93682577
Proteolytic activation of latent transforming growth factor-beta from fibroblast-conditioned mediumQ24679838
Transforming growth factor beta in tissue fibrosisQ28239292
Dependence of collagen remodelling on alpha-smooth muscle actin expression by fibroblastsQ28251091
Transforming growth factor beta stimulates collagen-matrix contraction by fibroblasts: implications for wound healingQ33586426
Human plasma epidermal growth factor/beta-urogastrone is associated with blood plateletsQ33821869
Growth factors in wound healing. Single and synergistic effects on partial thickness porcine skin woundsQ33848658
Dual control of cell growth by somatomedins and platelet-derived growth factorQ34166887
Transforming growth factor type beta induces monocyte chemotaxis and growth factor productionQ34339289
Expression and secretion of type beta transforming growth factor by activated human macrophagesQ34341606
An ordered sequence of events is required before BALB/c-3T3 cells become committed to DNA synthesisQ34539190
Evidence for a functional role of endogenously produced somatomedinlike peptides in the regulation of DNA synthesis in cultured human fibroblasts and porcine smooth muscle cellsQ34630317
Use of cryotherapy in the treatment of keloidsQ34731318
The metabolic effects of thermal injuryQ35193841
Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitroQ35610349
Platelet isoforms of platelet-derived growth factor stimulate fibroblasts to contract collagen matricesQ35815026
Relation between cell activity and the distribution of cytoplasmic actin and myosinQ36204969
Platelet-derived growth factor in chemotactic for fibroblastsQ36205866
A monoclonal antibody against alpha-smooth muscle actin: a new probe for smooth muscle differentiationQ36216808
Extracellular matrix contains insulin-like growth factor binding protein-5: potentiation of the effects of IGF-IQ36232491
Granulation tissue as a contractile organ. A study of structure and functionQ36271569
Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growthQ36351780
Stimulation of the chemotactic migration of human fibroblasts by transforming growth factor betaQ36352371
The effect of stretching on formation of myofibroblasts in mouse skinQ36653831
Treatment of keloid sternotomy scars with 585 nm flashlamp-pumped pulsed-dye laserQ36702717
Hormonal control of immunoreactive somatomedin production by cultured human fibroblastsQ37025320
Injury induces in vivo expression of platelet-derived growth factor (PDGF) and PDGF receptor mRNAs in skin epithelial cells and PDGF mRNA in connective tissue fibroblastsQ37376431
A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitroQ37438001
Cultured endothelial cells produce a platelet-derived growth factor-like proteinQ37607799
Eradication of established intracranial rat gliomas by transforming growth factor beta antisense gene therapyQ37680355
Interferons and collagen productionQ38010174
Suppression of in vitro proliferative scar fibroblast contraction by interferon alfa-2bQ39420449
Evaluation of various methods of treating keloids and hypertrophic scars: a 10-year follow-up studyQ39500821
Wound closure: evidence of cooperation between fibroblasts and collagen matrixQ39545120
The platelet-derived growth factorQ39739322
Postoperative irradiation in the prevention of keloidsQ40012402
The neutrophilic leukocyte in wound repair a study with antineutrophil serumQ40326337
Fibrogenic cytokines and connective tissue productionQ40391926
The role of extracellular matrix in postinflammatory wound healing and fibrosisQ40694808
Role of growth factors in cutaneous wound healing: a reviewQ40806891
Keloids Treated with Topical Injections of Triamcinolone Acetonide (Kenalog): Immediate and Long-term ResultsQ40872894
Angiogenesis and the skin: a primerQ40949301
An overview of the interferon system: signal transduction and mechanisms of actionQ40968135
Adhesive contact media--an update on graft fixation and burn scar managementQ41168358
In vitro paracrine regulation of human keratinocyte growth by fibroblast-derived insulin-like growth factorsQ41626903
Beta 1 integrin-mediated collagen gel contraction is stimulated by PDGF.Q41745333
A nuclear factor 1 binding site mediates the transcriptional activation of a type I collagen promoter by transforming growth factor-betaQ42804806
A significant part of macrophage-derived growth factor consists of at least two forms of PDGF.Q42814129
Smooth muscle alpha-action is a transformation-sensitive marker for mouse NIH 3T3 and Rat-2 cellsQ42814668
Modulation of collagen gel contraction by decorinQ42980949
Contraction of granulation tissue in vitro: similarity to smooth muscleQ43722441
Control of scarring in adult wounds by neutralising antibody to transforming growth factor betaQ43741134
The combined use of cryosurgery and intralesional injections of suspensions of fluorinated adrenocorticosteroids for reducing keloids and hypertrophic scarsQ43852900
Altered cytokine production in black patients with keloidsQ43926042
Serial casting as a technique to correct burn scar contractures. A case reportQ44018629
Presence of modified fibroblasts in granulation tissue and their possible role in wound contractionQ44160313
Alteration of Hypertrophic Scars Induced by Mechanical PressureQ44380769
Mast cell analyses in hypertrophic scars, hypertrophic scars treated with pressure and mature scarsQ44473680
Short-term keloid treatment in vivo with human interferon alfa-2b results in a selective and persistent normalization of keloidal fibroblast collagen, glycosaminoglycan, and collagenase production in vitroQ46058637
Wound macrophages express TGF-alpha and other growth factors in vivo: analysis by mRNA phenotypingQ46070830
Inhibition of collagen lattice contraction by pentoxifylline and interferon-alpha, -beta, and -gammaQ46694880
Expression of fibronectin messenger RNA in hypertrophic and normal dermal tissues and in vitro regulation by interferon alfa-2bQ47899903
Regulation of collagen synthesis and messenger RNA levels in normal and hypertrophic scar fibroblasts in vitro by interferon alfa-2bQ47899939
Characteristics of growth, morphology, contractility, and protein expression of fibroblasts derived from keloidQ47900011
Alteration in cell morphology triggers transforming growth factor-beta 1, collagenase, and tissue inhibitor of metalloproteinases-I expression in normal and hypertrophic scar fibroblasts.Q52507577
Platelets as a source of fibroblast growth-promoting activity.Q53597706
Assessment of cosmetic and functional results of conservative versus surgical management of facial burns.Q53632212
The Histiotypic Organization of the Hypertrophic Scar in HumansQ53937414
Covering by a flap induces apoptosis of granulation tissue myofibroblasts and vascular cells.Q53989083
Artificial Dermis for Major BurnsQ56621707
Fibroblast traction as a mechanism for collagen morphogenesisQ59063502
Gamma-interferon treatment inhibits collagen deposition in murine schistosomiasis.Q64932245
Tissue gases in human hypertrophic burn scarsQ67269016
The use of epidermis over a keloid as an autograft after resection of the keloidQ67497103
Silicone patches as a supplement for pressure therapy to control hypertrophic scarringQ68041287
Accelerated healing of incisional wounds in rats induced by transforming growth factor-betaQ69004035
Regulation of collagen gene expression in cutaneous diseases with dermal fibrosis: evidence for pretranslational controlQ69027956
Impairment, time out of school, and time off from work after burnsQ69039237
Collagen gene expression in keloids: analysis of collagen metabolism and type I, III, IV, and V procollagen mRNAs in keloid tissue and keloid fibroblast culturesQ69225828
Increased fibronectin production by cell lines from hypertrophic scar and keloidQ69456009
Silicone gel in scar treatmentQ69465775
Evidence that use of a silicone gel sheet increases range of motion over burn wound contracturesQ69832281
Biochemical composition of the connective tissue in keloids and analysis of collagen metabolism in keloid fibroblast culturesQ70112890
Activation of collagen gene expression in keloids: co-localization of type I and VI collagen and transforming growth factor-beta 1 mRNAQ70232613
Gas chromatography-mass spectrometry determination of 18O2 in 18O-labelled 4-hydroxyproline for measurement of collagen synthesis and intracellular degradationQ70614856
Transforming growth factor beta as a predictor of liver and lung fibrosis after autologous bone marrow transplantation for advanced breast cancerQ70700063
Epidermal growth factor and insulin-like growth factor I enhance keratinocyte migrationQ70711804
Prospective, randomized study of the efficacy of pressure garment therapy in patients with burnsQ70826017
Polypeptide transforming growth factors isolated from bovine sources and used for wound healing in vivoQ70898237
Treatment of keloids with excision and postoperative X-ray irradiationQ71067227
Human dermal fibroblasts produce nitric oxide and express both constitutive and inducible nitric oxide synthase isoformsQ71120708
Collagenase production is lower in post-burn hypertrophic scar fibroblasts than in normal fibroblasts and is reduced by insulin-like growth factor-1Q71120740
Chemical characterization and quantification of proteoglycans in human post-burn hypertrophic and mature scarsQ71149135
Increased androgen binding in keloids: a preliminary communicationQ71231193
Pressure therapy in the treatment of post-burn hypertrophic scar--a critical look into its usefulness and fallacies by pressure monitoringQ71349663
Enhanced expression of mRNA for insulin-like growth factor-1 in post-burn hypertrophic scar tissue and its fibrogenic role by dermal fibroblastsQ71522869
Nitric oxide activates metalloprotease enzymes in articular cartilageQ71667841
Pentoxifylline, pentifylline, and interferons decrease type I and III procollagen mRNA levels in dermal fibroblasts: evidence for mediation by nuclear factor 1 down-regulationQ71669820
P433issue3
P304page(s)701-730
P577publication date1997-06-01
P1433published inSurgical Clinics of North AmericaQ15765820
P1476titleHypertrophic scars, keloids, and contractures. The cellular and molecular basis for therapy
P478volume77

Reverse relations

cites work (P2860)
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