Randomized trial of interferon- and ribavirin-free ombitasvir/paritaprevir/ritonavir in treatment-experienced hepatitis C virus-infected patients

scientific article published on 23 March 2015

Randomized trial of interferon- and ribavirin-free ombitasvir/paritaprevir/ritonavir in treatment-experienced hepatitis C virus-infected patients is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/HEP.27705
P932PMC publication ID5763364
P698PubMed publication ID25644279

P50authorTami Pilot-MatiasQ47412244
Carolyn SetzeQ47412541
Kazuaki ChayamaQ87781872
Hiromitsu KumadaQ114433568
P2093author name stringRegis A Vilchez
Ken Sato
Masayuki Kurosaki
Prajakta Badri
Kazuo Notsumata
Lino Rodrigues
P2860cites workBoceprevir for previously treated chronic HCV genotype 1 infectionQ24620576
Epidemiology of viral hepatitis and hepatocellular carcinomaQ29617918
Telaprevir for retreatment of HCV infectionQ29619799
Telaprevir for previously untreated chronic hepatitis C virus infectionQ29619800
Sofosbuvir for hepatitis C genotype 2 or 3 in patients without treatment optionsQ29620126
Boceprevir for untreated chronic HCV genotype 1 infectionQ29620617
Ledipasvir and sofosbuvir for previously treated HCV genotype 1 infectionQ29620620
Prevalence of hepatitis C virus subgenotypes 1a and 1b in Japanese patients: ultra-deep sequencing analysis of HCV NS5B genotype-specific regionQ34998753
Once-daily simeprevir (TMC435) with peginterferon/ribavirin for treatment-naïve hepatitis C genotype 1-infected patients in Japan: the DRAGON studyQ37491370
Changing trends in hepatitis C infection over the past 50 years in JapanQ37672875
In vitro and in vivo antiviral activity and resistance profile of ombitasvir, an inhibitor of hepatitis C virus NS5A.Q38934649
In vitro and in vivo antiviral activity and resistance profile of the hepatitis C virus NS3/4A protease inhibitor ABT-450.Q41633072
Exploratory trial of ombitasvir and ABT-450/r with or without ribavirin for HCV genotype 1, 2, and 3 infectionQ41729517
All-oral daclatasvir plus asunaprevir for hepatitis C virus genotype 1b: a multinational, phase 3, multicohort studyQ42202767
ABT-450, ritonavir, ombitasvir, and dasabuvir achieves 97% and 100% sustained virologic response with or without ribavirin in treatment-experienced patients with HCV genotype 1b infection.Q42219325
Hepatitis C disease burden and strategies to manage the burden (Guest Editors Mark Thursz, Gregory Dore and John Ward).Q42220208
Sofosbuvir and ribavirin in HCV genotypes 2 and 3.Q42220605
ABT-450/r-ombitasvir and dasabuvir with or without ribavirin for HCV.Q42220608
Simeprevir with peginterferon/ribavirin for treatment-naïve hepatitis C genotype 1 patients in Japan: CONCERTO-1, a phase III trialQ42224933
ABT-450/r-ombitasvir and dasabuvir with ribavirin for hepatitis C with cirrhosisQ42225140
Treatment of HCV with ABT-450/r-ombitasvir and dasabuvir with ribavirinQ42225540
Retreatment of HCV with ABT-450/r-ombitasvir and dasabuvir with ribavirinQ42225545
Phase 2b trial of interferon-free therapy for hepatitis C virus genotype 1.Q42243136
Association of IL28B genotype and viral response of hepatitis C virus genotype 2 to interferon plus ribavirin combination therapy.Q42983726
Development and evaluation of an automated hepatitis C virus NS5B sequence-based subtyping assayQ42998028
Predictive value of the IL28B polymorphism on the effect of interferon therapy in chronic hepatitis C patients with genotypes 2a and 2b.Q43001836
Telaprevir with peginterferon and ribavirin for treatment-naive patients chronically infected with HCV of genotype 1 in JapanQ43039581
Association of IL28B variants with response to pegylated-interferon alpha plus ribavirin combination therapy reveals intersubgenotypic differences between genotypes 2a and 2b.Q45009249
Epidemiology of hepatitis C virus in japanQ45746821
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectribavirinQ421862
ritonavirQ422618
Hepatitis C virusQ708693
paritaprevirQ16824572
ombitasvirQ19598175
ombitasvir/paritaprevir/ritonavirQ19858657
P304page(s)1523-1532
P577publication date2015-03-23
P1433published inHepatologyQ15724398
P1476titleRandomized trial of interferon- and ribavirin-free ombitasvir/paritaprevir/ritonavir in treatment-experienced hepatitis C virus-infected patients
P478volume61

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cites work (P2860)
Q49446996A Hepatitis C Virus-Associated Chronic Hepatitis Patient Developing Various Adverse Events Including Severe Gingivitis, Gingival Bleeding, and Inflammation of Genital Vulva during the Course of Antiviral Therapy with Elbasvir/Grazoprevir
Q40130081A Hepatitis C Virus-Associated Cirrhotic Patient Developing Interstitial Pneumonia during the Course of Antiviral Therapy with Ombitasvir/Paritaprevir/Ritonavir
Q42400012APASL consensus statements and recommendation on treatment of hepatitis C.
Q40071581Acute Graft Rejection and Formation of De Novo Donor-Specific Antibodies Triggered by Low Cyclosporine Levels and Interferon Therapy for Recurrent Hepatitis C Infection After Liver Transplantation: A Case Report.
Q40116908Add-on effects of fluvastatin in simeprevir/pegylated-interferon/ribavirin combination therapy for patients with genotype 1 hepatitis C virus infection: A randomized controlled study.
Q26773274Alcoholic liver disease and hepatitis C virus infection
Q38367590Analysis of Hepatitis C Virus Genotype 1b Resistance Variants in Japanese Patients Treated with Paritaprevir-Ritonavir and Ombitasvir
Q40548267Characterization of NS5A polymorphisms and their impact on response rates in patients with HCV genotype 2 treated with daclatasvir-based regimens
Q39147495Clinical Pharmacokinetics of Ombitasvir
Q39150134Clinical Pharmacokinetics of Paritaprevir
Q39151677Current therapy for chronic hepatitis C: The role of direct-acting antivirals
Q36438920Drug Interactions with the Direct-Acting Antiviral Combination of Ombitasvir and Paritaprevir-Ritonavir
Q40697687Drug-Drug Interaction of Omeprazole With the HCV Direct-Acting Antiviral Agents Paritaprevir/Ritonavir and Ombitasvir With and Without Dasabuvir
Q37067118Drug-Drug Interactions Between the Anti-Hepatitis C Virus 3D Regimen of Ombitasvir, Paritaprevir/Ritonavir, and Dasabuvir and Eight Commonly Used Medications in Healthy Volunteers
Q36571969Drug-Drug Interactions between Sofosbuvir and Ombitasvir-Paritaprevir-Ritonavir with or without Dasabuvir
Q50208930Efficacy and safety of ombitasvir/paritaprevir/ritonavir in dialysis patients with genotype 1b chronic hepatitis C.
Q47888797Efficacy and safety of telaprevir with natural human interferon-β and ribavirin in Japanese chronic hepatitis C patients with depression
Q40721350Efficacy and safety of telaprevir with pegylated interferon α-2a and ribavirin in Japanese patients
Q38837174Efficacy of Interferon-Free Therapies for Chronic Hepatitis C: A Systematic Review of All Randomized Clinical Trials.
Q26782405HCV Drug Resistance Challenges in Japan: The Role of Pre-Existing Variants and Emerging Resistant Strains in Direct Acting Antiviral Therapy
Q49238531Health-related quality of life on the clinical course of patients with chronic hepatitis C receiving daclatasvir/asunaprevir therapy: A prospective observational study comparing younger (<70) and elderly (≥70) patients.
Q36933403Hepatitis C Virus Genotype 1 to 6 Protease Inhibitor Escape Variants: In Vitro Selection, Fitness, and Resistance Patterns in the Context of the Infectious Viral Life Cycle.
Q55280981Host-targeting therapies for hepatitis C virus infection: current developments and future applications.
Q40827559IFNL4 polymorphism effects on outcome of simeprevir, peginterferon, and ribavirin therapy for older patients with genotype 1 chronic hepatitis C.
Q59354172Interferon at the cellular, individual, and population level in hepatitis C virus infection: Its role in the interferon-free treatment era
Q40791531JSH Guidelines for the Management of Hepatitis C Virus Infection: A 2016 update for genotype 1 and 2.
Q27469038Mouse Systems to Model Hepatitis C Virus Treatment and Associated Resistance
Q40621621Pharmacokinetics and Tolerability of Anti-Hepatitis C Virus Treatment with Ombitasvir, Paritaprevir, Ritonavir, with or Without Dasabuvir, in Subjects with Renal Impairment
Q39675766Population Pharmacokinetics of Paritaprevir, Ombitasvir, and Ritonavir in Japanese Patients with Hepatitis C Virus Genotype 1b Infection.
Q26775825Profile of paritaprevir/ritonavir/ombitasvir plus dasabuvir in the treatment of chronic hepatitis C virus genotype 1 infection
Q40533002Protease Inhibitor Resistance Remains Even After Mutant Strains Become Undetectable by Deep Sequencing
Q38376454Randomized Phase 3 Trial of Ombitasvir/Paritaprevir/Ritonavir and Ribavirin for Hepatitis C Virus Genotype 2-Infected Japanese Patients
Q37309080Randomized phase 3 trial of ombitasvir/paritaprevir/ritonavir for hepatitis C virus genotype 1b-infected Japanese patients with or without cirrhosis
Q26750476Recent Advances in Antiviral Therapy for Chronic Hepatitis C
Q40069650Resistance Characterization of Hepatitis C Virus Genotype 2 from Japanese Patients Treated with Ombitasvir and Paritaprevir/Ritonavir.
Q40058097Safety and Efficacy of Ombitasvir/Paritaprevir/Ritonavir and Dasabuvir with or without Ribavirin for Treatment of Hepatitis C Virus Genotype 1: A Systematic Review and Meta-analysis
Q40413390Safety and efficacy of daclatasvir and asunaprevir in hepatitis C virus-infected patients with renal impairment.
Q38903835Safety of interferon-free therapies for chronic hepatitis C: a network meta-analysis.
Q36290778Substitutions at NS3 Residue 155, 156, or 168 of Hepatitis C Virus Genotypes 2 to 6 Induce Complex Patterns of Protease Inhibitor Resistance
Q39483711Sustained virologic response by direct antiviral agents reduces the incidence of hepatocellular carcinoma in patients with HCV infection.
Q59360750The Real-world Efficacy and Safety of Ombitasvir/Paritaprevir/Ritonavir for Hepatitis C Genotype 1
Q58088666The complex association of virus- and host-related factors with HCC rate following HCV clearance
Q40340001The efficacy and safety of dual oral therapy with daclatasvir and asunaprevir for genotype 1b in Japanese real-life settings
Q90134965The reduction of miR146b-5p in monocytes and T cells could contribute to the immunopathogenesis of hepatitis C virus infection
Q40087272The risks of hepatocellular carcinoma development after HCV eradication are similar between patients treated with peg-interferon plus ribavirin and direct-acting antiviral therapy.
Q45078816Treatment of HCV patients on hemodialysis with daclatasvir and asunaprevir
Q38431523Treatment of hepatitis C in difficult-to-treat patients

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