Host-targeting therapies for hepatitis C virus infection: current developments and future applications.

scientific article published on 21 March 2018

Host-targeting therapies for hepatitis C virus infection: current developments and future applications. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1177/1756284818759483
P932PMC publication ID5871046
P698PubMed publication ID29619090

P50authorFlorian WrenschQ55465237
Mirjam ZeiselQ73424648
Thomas F BaumertQ88786090
P2093author name stringCatherine Schuster
Emilie Crouchet
P2860cites workIdentification and targeting of an interaction between a tyrosine motif within hepatitis C virus core protein and AP2M1 essential for viral assemblyQ24297412
Identification of FBL2 as a geranylgeranylated cellular protein required for hepatitis C virus RNA replicationQ24302046
Regulation of hepatitis C virus translation and infectious virus production by the microRNA miR-122Q24609988
Review and management of drug interactions with boceprevir and telaprevirQ24628716
Unbiased probing of the entire hepatitis C virus life cycle identifies clinical compounds that target multiple aspects of the infectionQ24646403
microRNA-122 stimulates translation of hepatitis C virus RNAQ24654912
Inhibition of human immunodeficiency virus type 1 replication in human cells by Debio-025, a novel cyclophilin binding agentQ24656023
Host-Targeting Agents to Prevent and Cure Hepatitis C Virus InfectionQ26779128
New drugs for treating dyslipidemia: beyond statinsQ26821840
Effect of Quercetin on Hepatitis C Virus Life Cycle: From Viral to Host TargetsQ27468855
Characterization of Low- and Very-Low-Density Hepatitis C Virus RNA-Containing ParticlesQ27472884
Hepatitis C Virus Entry Depends on Clathrin-Mediated EndocytosisQ27473290
Hepatitis C virus production by human hepatocytes dependent on assembly and secretion of very low-density lipoproteinsQ27478188
Intravenous silibinin monotherapy shows significant antiviral activity in HCV-infected patients in the peri-transplantation periodQ87439606
Unexpected high incidence of hepatocellular carcinoma in cirrhotic patients with sustained virologic response following interferon-free direct-acting antiviral treatmentQ87700511
Effect of ezetimibe in HCV viral load after liver transplantationQ95492399
Cellular Determinants of Hepatitis C Virus Assembly, Maturation, Degradation, and SecretionQ27485447
Hepatitis C Virus NS5A Protein Is a Substrate for the Peptidyl-prolyl cis/trans Isomerase Activity of Cyclophilins A and BQ27488369
Critical Role of Cyclophilin A and Its Prolyl-Peptidyl Isomerase Activity in the Structure and Function of the Hepatitis C Virus Replication ComplexQ27488788
Essential Role of Cyclophilin A for Hepatitis C Virus Replication and Virus Production and Possible Link to Polyprotein Cleavage KineticsQ27489037
SCY-635, a Novel Nonimmunosuppressive Analog of Cyclosporine That Exhibits Potent Inhibition of Hepatitis C Virus RNA Replication In VitroQ27490844
Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNAQ27861124
Solute Carrier NTCP Regulates Innate Antiviral Immune Responses Targeting Hepatitis C Virus Infection of HepatocytesQ27928046
Lipid dysregulation in hepatitis C virus, and impact of statin therapy upon clinical outcomesQ28081216
The lipid droplet is an important organelle for hepatitis C virus productionQ28131709
Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemiaQ28282776
Treatment of HCV infection by targeting microRNAQ29547712
Ledipasvir and sofosbuvir for untreated HCV genotype 1 infectionQ29620318
Ledipasvir and sofosbuvir for 8 or 12 weeks for chronic HCV without cirrhosisQ29620612
Ledipasvir and sofosbuvir for previously treated HCV genotype 1 infectionQ29620620
Hepatitis C virus RNA replication is regulated by host geranylgeranylation and fatty acidsQ29620653
Hepatitis C virus infectionQ30235491
Access to treatment for hepatitis C virus infection: time to put patients firstQ30248987
A cell-based, high-throughput screen for small molecule regulators of hepatitis C virus replicationQ33269990
Direct-acting antivirals for the treatment of hepatitis C virus infection: optimizing current IFN-free treatment and future perspectivesQ34045760
Transcriptional regulation of human and rat hepatic lipid metabolism by the grapefruit flavonoid naringenin: role of PPARalpha, PPARgamma and LXRalphaQ34084372
Novel human SR-BI antibodies prevent infection and dissemination of HCV in vitro and in humanized mice.Q34194575
Identification of the Niemann-Pick C1-like 1 cholesterol absorption receptor as a new hepatitis C virus entry factorQ34245963
Profile of alisporivir and its potential in the treatment of hepatitis C.Q34329744
Hepatocyte nuclear factor 4α and downstream secreted phospholipase A2 GXIIB regulate production of infectious hepatitis C virusQ34381310
Successful anti-scavenger receptor class B type I (SR-BI) monoclonal antibody therapy in humanized mice after challenge with HCV variants with in vitro resistance to SR-BI-targeting agentsQ34416004
Global distribution and prevalence of hepatitis C virus genotypesQ34431175
Long-term safety and efficacy of microRNA-targeted therapy in chronic hepatitis C patientsQ34438448
The non-immunosuppressive cyclosporin DEBIO-025 is a potent inhibitor of hepatitis C virus replication in vitroQ34504825
Different anti-HCV profiles of statins and their potential for combination therapy with interferonQ34541863
Silibinin inhibits hepatitis C virus entry into hepatocytes by hindering clathrin-dependent traffickingQ34652154
MicroRNA-122 antagonism against hepatitis C virus genotypes 1-6 and reduced efficacy by host RNA insertion or mutations in the HCV 5' UTR.Q34721015
Apolipoprotein B-dependent hepatitis C virus secretion is inhibited by the grapefruit flavonoid naringeninQ34768265
Fluvastatin inhibits hepatitis C replication in humansQ34769764
Hepatitis C virus life cycle and lipid metabolismQ34792436
Disruption of hepatitis C virus RNA replication through inhibition of host protein geranylgeranylationQ34792600
Virion assembly and releaseQ38086754
New hepatitis C therapies: the toolbox, strategies, and challengesQ38196150
Cyclophilin inhibition as potential therapy for liver diseasesQ38232505
Hepatitis C virus RNA replication and assembly: living on the fat of the landQ38294573
The mechanism of HCV entry into host cellsQ38321419
Treatment of hepatitis C in difficult-to-treat patientsQ38431523
Hepatitis C Virus Resistance to Direct-Acting Antiviral Drugs in Interferon-Free RegimensQ38808740
Hepatitis C virus infection and chronic kidney disease: Time for reappraisalQ38819960
Prevention and management of treatment failure to new oral hepatitis C drugs.Q38826624
Patient-reported outcomes with sofosbuvir and velpatasvir with or without ribavirin for hepatitis C virus-related decompensated cirrhosis: an exploratory analysis from the randomised, open-label ASTRAL-4 phase 3 trialQ38839784
Update on Current Evidence for Hepatitis C Therapeutic Options in HCV Mono-infected PatientsQ38880996
Hepatitis C virus resistance to the new direct-acting antiviralsQ38887954
Selective Inhibitors of Cyclin G Associated Kinase (GAK) as Anti-Hepatitis C AgentsQ38893229
SKI-1/S1P inhibitor PF-429242 impairs the onset of HCV infectionQ38921779
Targeting Viral Entry for Treatment of Hepatitis B and C Virus InfectionsQ38951860
Safety and Efficacy of Elbasvir/Grazoprevir in Patients With Hepatitis C Virus Infection and Compensated Cirrhosis: An Integrated AnalysisQ38963481
miR-135a-5p-mediated downregulation of protein tyrosine phosphatase receptor delta is a candidate driver of HCV-associated hepatocarcinogenesisQ38979938
Alisporivir plus ribavirin, interferon free or in combination with pegylated interferon, for hepatitis C virus genotype 2 or 3 infectionQ38990715
Cyclophilin inhibitors reduce phosphorylation of RNA-dependent protein kinase to restore expression of IFN-stimulated genes in HCV-infected cellsQ38999757
Hepatitis C virus induced up-regulation of microRNA-27: a novel mechanism for hepatic steatosis.Q39118328
Current therapy for chronic hepatitis C: The role of direct-acting antiviralsQ39151677
Amiodarone inhibits the entry and assembly steps of hepatitis C virus life cycle.Q39154271
Inhibitors of endoplasmic reticulum alpha-glucosidases potently suppress hepatitis C virus virion assembly and releaseQ39617748
Small molecule scavenger receptor BI antagonists are potent HCV entry inhibitorsQ39646696
Inhibition of hepatitis C virus replication by chloroquine targeting virus-associated autophagy.Q39798599
Anti-CD81 antibodies can prevent a hepatitis C virus infection in vivoQ39912694
Humanisation of a claudin-1-specific monoclonal antibody for clinical prevention and cure of HCV infection without escapeQ40271516
Hepatitis C virus core protein modulates fatty acid metabolism and thereby causes lipid accumulation in the liverQ40392671
Impaired expression of the peroxisome proliferator-activated receptor alpha during hepatitis C virus infection.Q40463023
A Diacylglycerol Transferase 1 Inhibitor Is a Potent Hepatitis C Antiviral in Vitro but Not in Patients in a Randomized Clinical Trial.Q40479352
Cyclosporin A suppresses replication of hepatitis C virus genome in cultured hepatocytesQ40622941
New use of an old drug: chloroquine reduces viral and ALT levels in HCV non-responders (a randomized, triple-blind, placebo-controlled pilot trial).Q40747582
A Phase I Dose Escalation Study Demonstrates Quercetin Safety and Explores Potential for Bioflavonoid Antivirals in Patients with Chronic Hepatitis C.Q40888934
Sofosbuvir and Velpatasvir for HCV Genotype 2 and 3 InfectionQ40907444
Grazoprevir plus elbasvir in treatment-naive and treatment-experienced patients with hepatitis C virus genotype 1 infection and stage 4-5 chronic kidney disease (the C-SURFER study): a combination phase 3 studyQ40957442
Extreme bradycardia after first doses of sofosbuvir and daclatasvir in patients receiving amiodarone: 2 cases including a rechallenge.Q41064083
Randomized trial of interferon- and ribavirin-free ombitasvir/paritaprevir/ritonavir in treatment-experienced hepatitis C virus-infected patientsQ41508623
Bezafibrate maintenance therapy in patients with advanced chronic hepatitis C.Q41603967
The cyclophilin inhibitor SCY-635 disrupts hepatitis C virus NS5A-cyclophilin A complexesQ41843629
Statins potentiate the in vitro anti-hepatitis C virus activity of selective hepatitis C virus inhibitors and delay or prevent resistance developmentQ42168234
In vitro antiviral activity and preclinical and clinical resistance profile of miravirsen, a novel anti-hepatitis C virus therapeutic targeting the human factor miR-122.Q42181792
The impact of antihyperlipidemic drugs on the viral load of patients with chronic hepatitis C infection: a meta-analysis.Q42211503
ABT-450, ritonavir, ombitasvir, and dasabuvir achieves 97% and 100% sustained virologic response with or without ribavirin in treatment-experienced patients with HCV genotype 1b infection.Q42219325
Sofosbuvir and ribavirin in HCV genotypes 2 and 3.Q42220605
ABT-450/r-ombitasvir and dasabuvir with ribavirin for hepatitis C with cirrhosisQ42225140
Treatment of HCV with ABT-450/r-ombitasvir and dasabuvir with ribavirinQ42225540
Retreatment of HCV with ABT-450/r-ombitasvir and dasabuvir with ribavirinQ42225545
Curing chronic hepatitis C--the arc of a medical triumphQ42225548
Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1Q42321933
Resveratrol prevents hepatic steatosis induced by hepatitis C virus core proteinQ42983822
Safety and anti-HCV effect of prolonged intravenous silibinin in HCV genotype 1 subjects in the immediate liver transplant periodQ42985156
An open pilot study exploring the efficacy of fluvastatin, pegylated interferon and ribavirin in patients with hepatitis C virus genotype 1b in high viral loads.Q42986911
HRas signal transduction promotes hepatitis C virus cell entry by triggering assembly of the host tetraspanin receptor complex.Q42990165
Serum cholesterol and statin use predict virological response to peginterferon and ribavirin therapyQ42997897
Effects of bezafibrate in patients with chronic hepatitis C virus infection: combination with interferon and ribavirinQ43000770
Atorvastatin does not exhibit antiviral activity against HCV at conventional doses: a pilot clinical trialQ43036828
The cyclophilin inhibitor Debio-025 shows potent anti-hepatitis C effect in patients coinfected with hepatitis C and human immunodeficiency virus.Q43046668
Debio-025 inhibits HIV-1 by interfering with an early event in the replication cycleQ43254780
Statin Therapy Improves Sustained Virologic Response Among Diabetic Patients With Chronic Hepatitis CQ43991768
Triple therapy in treatment-experienced patients with HCV-cirrhosis in a multicentre cohort of the French Early Access Programme (ANRS CO20-CUPIC) - NCT01514890.Q44847210
Successful prevention of hepatitis C virus (HCV) liver graft reinfection by silibinin mono-therapyQ45376579
Inhibition of microsomal triglyceride transfer protein alone or with ezetimibe in patients with moderate hypercholesterolemiaQ46573174
Pitavastatin enhances antiviral efficacy of standard pegylated interferon plus ribavirin in patients with chronic hepatitis C: a prospective randomized pilot study.Q50555912
Association between sustained virological response and all-cause mortality among patients with chronic hepatitis C and advanced hepatic fibrosis.Q53118691
Position-dependent function for a tandem microRNA miR-122-binding site located in the hepatitis C virus RNA genomeQ34795106
Celgosivir, an alpha-glucosidase I inhibitor for the potential treatment of HCV infectionQ34995301
Effects of statins on the risk of hepatocellular carcinomaQ34997752
Synergy of entry inhibitors with direct-acting antivirals uncovers novel combinations for prevention and treatment of hepatitis C.Q35135565
Effect of the hepatitis C virus protease inhibitor telaprevir on the pharmacokinetics of amlodipine and atorvastatinQ35270890
Naringenin inhibits the assembly and long-term production of infectious hepatitis C virus particles through a PPAR-mediated mechanism.Q35399890
All-oral 12-week treatment with daclatasvir plus sofosbuvir in patients with hepatitis C virus genotype 3 infection: ALLY-3 phase III studyQ35538245
Clearance of persistent hepatitis C virus infection in humanized mice using a claudin-1-targeting monoclonal antibodyQ35602284
Pathogenesis and prevention of hepatitis C virus-induced hepatocellular carcinomaQ35619104
AP-2-associated protein kinase 1 and cyclin G-associated kinase regulate hepatitis C virus entry and are potential drug targetsQ35641039
Evaluation of ITX 5061, a scavenger receptor B1 antagonist: resistance selection and activity in combination with other hepatitis C virus antiviralsQ35694689
The Novel Cyclophilin Inhibitor CPI-431-32 Concurrently Blocks HCV and HIV-1 Infections via a Similar Mechanism of ActionQ35742761
Novel human anti-claudin 1 mAbs inhibit hepatitis C virus infection and may synergize with anti-SRB1 mAb.Q35828072
Safety and Efficacy of Simeprevir/Sofosbuvir in Hepatitis C-Infected Patients With Compensated and Decompensated CirrhosisQ35995534
MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesisQ36129123
Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver.Q36129129
Failure of Intravenous Silibinin Monotherapy to Prevent Hepatitis C Genotype 2A Liver Graft ReinfectionQ36142772
Apolipoprotein B100 is required for hepatitis C infectivity and Mipomersen inhibits hepatitis C.Q36233117
Hepatitis C-related hepatocellular carcinoma in the era of new generation antiviralsQ36306768
PPARalpha activation is essential for HCV core protein-induced hepatic steatosis and hepatocellular carcinoma in miceQ36330881
Statins and cancer preventionQ36337970
Effect of scavenger receptor class B type I antagonist ITX5061 in patients with hepatitis C virus infection undergoing liver transplantationQ36990362
New perspectives for preventing hepatitis C virus liver graft infectionQ37015805
Risk of hepatocellular carcinoma after sustained virological response in Veterans with hepatitis C virus infectionQ37029846
Efficient Suppression of Hepatitis C Virus Replication by Combination Treatment with miR-122 Antagonism and Direct-acting Antivirals in Cell Culture SystemsQ37148014
Open-label, ascending dose, prospective cohort study evaluating the antiviral efficacy of Rosuvastatin therapy in serum and lipid fractions in patients with chronic hepatitis CQ37304715
Daclatasvir, sofosbuvir, and ribavirin for hepatitis C virus genotype 3 and advanced liver disease: A randomized phase III study (ALLY-3+).Q37349005
Safety and antiviral activity of the HCV entry inhibitor ITX5061 in treatment-naive HCV-infected adults: a randomized, double-blind, phase 1b studyQ37582317
EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapyQ37609988
Host-targeting agents in the treatment of hepatitis C: a beginning and an end?Q37676364
Hepatitis C virus evasion mechanisms from neutralizing antibodiesQ37967737
SKI-1/S1P inhibition: a promising surrogate to statins to block hepatitis C virus replicationQ38012896
Statins are associated with a reduced risk of hepatocellular cancer: a systematic review and meta-analysisQ38051955
Hepatitis C virus entryQ38086750
Hepatitis C virus RNA translationQ38086752
P921main subjectHepatitis C virusQ708693
P304page(s)1756284818759483
P577publication date2018-03-21
P1433published inTherapeutic Advances in GastroenterologyQ21042423
P1476titleHost-targeting therapies for hepatitis C virus infection: current developments and future applications
P478volume11

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cites work (P2860)
Q96126330A genome-wide gain-of-function screen identifies CDKN2C as a HBV host factor
Q104486634Characterization of the erythrocyte GTPase Rac1 in relation to Plasmodium falciparum invasion
Q90825369Dengue drug discovery: Progress, challenges and outlook
Q90643079Effect of HCV treatment response on insulin resistance: A systematic review and meta-analysis
Q61805220Overview of HCV Life Cycle with a Special Focus on Current and Possible Future Antiviral Targets
Q57813384Status of Direct-acting Antiviral Therapy for HCV Infection and Remaining Challenges

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