Legumain is activated in macrophages during pancreatitis

scientific article published on 11 August 2016

Legumain is activated in macrophages during pancreatitis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1152/AJPGI.00047.2016
P932PMC publication ID5075999
P698PubMed publication ID27514475

P50authorJohn B. FurnessQ42732057
Belinda S. ParkerQ53679448
Thomas ReinheckelQ56849298
Daniel Edgington-MitchellQ60151689
Matthew BogyoQ87128638
Laura E. EdgingtonQ41183551
P2093author name stringNigel W Bunnett
Bim Graham
Vasilena Gocheva
Peter Storz
Johanna A Joyce
TinaMarie Lieu
Martijn Verdoes
Wouter A van der Linden
Nimali P Withana
Thomas Wartmann
Walter Halangk
Luigi Aurelio
Alicia K Fleming
P2860cites workThe asparaginyl endopeptidase legumain after experimental strokeQ42575403
Distinct protease requirements for antigen presentation in vitro and in vivo.Q43158650
Legumain expression as a prognostic factor in breast cancer patients.Q44014299
Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer.Q44103830
Cathepsin B inhibition prevents trypsinogen activation and reduces pancreatitis severityQ44104053
Asparagine endopeptidase is not essential for class II MHC antigen presentation but is required for processing of cathepsin L in mice.Q46499913
Pancreatitis and the risk of pancreatic cancer. International Pancreatitis Study Group.Q51056982
Legumain: a biomarker for diagnosis and prognosis of human ovarian cancer.Q54317876
Acute pancreatitisQ55967029
Acute pancreatitisQ56094875
High expression of the cysteine proteinase legumain in colorectal cancer – Implications for therapeutic targetingQ56965662
Edema and intrapancreatic trypsinogen activation precede glutathione depletion during caerulein pancreatitisQ71404575
Intra-acinar cell activation of trypsinogen during caerulein-induced pancreatitis in ratsQ74831729
Cause-effect relationships between zymogen activation and other early events in secretagogue-induced acute pancreatitisQ79856720
Quantitative proteomics analysis reveals that proteins differentially expressed in chronic pancreatitis are also frequently involved in pancreatic cancerQ80317628
CCL2-induced migration and SOCS3-mediated activation of macrophages are involved in cerulein-induced pancreatitis in miceQ83252742
Structure and function of legumain in health and diseaseQ26781444
Mechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulationQ27678659
Biosynthetic processing of cathepsins and lysosomal degradation are abolished in asparaginyl endopeptidase-deficient miceQ28513876
Role of macrophages in the progression of acute pancreatitisQ33902198
Legumain expression in relation to clinicopathologic and biological variables in colorectal cancerQ34406043
Pancreatic cancer in chronic pancreatitis; aetiology, incidence, and early detectionQ34620078
Targeting tumor-associated macrophages as a novel strategy against breast cancerQ34803221
Expression of legumain correlates with prognosis and metastasis in gastric carcinomaQ34984213
Development of near-infrared fluorophore (NIRF)-labeled activity-based probes for in vivo imaging of legumainQ35567972
Functional imaging of legumain in cancer using a new quenched activity-based probeQ35600638
Active cathepsins B, L, and S in murine and human pancreatitisQ36312705
Cysteine cathepsin activity suppresses osteoclastogenesis of myeloid-derived suppressor cells in breast cancerQ36413686
Combined deletion of cathepsin protease family members reveals compensatory mechanisms in cancerQ36480910
Role of immune cells and immune-based therapies in pancreatitis and pancreatic ductal adenocarcinomaQ36810574
Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-κB and MMPs.Q37071752
Improved quenched fluorescent probe for imaging of cysteine cathepsin activityQ37304778
Functional role of asparaginyl endopeptidase ubiquitination by TRAF6 in tumor invasion and metastasisQ39017137
Activation of legumain involves proteolytic and conformational events, resulting in a context- and substrate-dependent activity profile.Q40247139
Development of activity-based probes for trypsin-family serine proteasesQ40301031
Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitisQ40735691
In vivo imaging and biochemical characterization of protease function using fluorescent activity-based probesQ41808773
Cathepsin L inactivates human trypsinogen, whereas cathepsin L-deletion reduces the severity of pancreatitis in mice.Q42273053
Essential role of monocytes and macrophages in the progression of acute pancreatitisQ42478797
P4510describes a project that usesImageJQ1659584
P433issue3
P304page(s)G548-60
P577publication date2016-08-11
P1433published inAmerican Journal of Physiology - Gastrointestinal and Liver PhysiologyQ15765756
P1476titleLegumain is activated in macrophages during pancreatitis
P478volume311

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cites work (P2860)
Q99712025Adipose Tissue Properties in Tumor-Bearing Breasts
Q64892923Legumain Promotes Atherosclerotic Vascular Remodeling.
Q92358245Legumain Promotes Gastric Cancer Progression Through Tumor-associated Macrophages In vitro and In vivo
Q40050488Transcriptome profiling of antiviral immune and dietary fatty acid dependent responses of Atlantic salmon macrophage-like cells

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