Replication fork collapse and genome instability in a deoxycytidylate deaminase mutant

scientific article published on 27 August 2012

Replication fork collapse and genome instability in a deoxycytidylate deaminase mutant is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.01062-12
P932PMC publication ID3486156
P698PubMed publication ID22927644

P50authorNevan KroganQ28450952
Andrei ChabesQ41166314
P2093author name stringPaul Russell
Assen Roguev
Sophie Rozenzhak
Sushma Sharma
Arancha Sánchez
P2860cites workStructural basis of γH2AX recognition by human PTIP BRCT5-BRCT6 domains in the DNA damage response pathwayQ24296259
Damage tolerance protein Mus81 associates with the FHA1 domain of checkpoint kinase Cds1Q24551095
Activation of the DNA damage checkpoint in mutants defective in DNA replication initiationQ24643321
Structural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repairQ27651403
γH2A binds Brc1 to maintain genome integrity during S-phaseQ27659111
Structure of C-terminal Tandem BRCT Repeats of Rtt107 Protein Reveals Critical Role in Interaction with Phosphorylated Histone H2A during DNA Damage RepairQ27676802
Mrc1 transduces signals of DNA replication stress to activate Rad53.Q27935521
Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolismQ28245231
Molecular genetic analysis of fission yeast Schizosaccharomyces pombeQ29547703
GammaH2AX and cancerQ29614974
Mus81-Eme1 are essential components of a Holliday junction resolvaseQ29619843
Ribonucleotide reductasesQ29620027
Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombinationQ33302634
Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenanceQ33415261
Fluctuation analysis CalculatOR: a web tool for the determination of mutation rate using Luria-Delbruck fluctuation analysisQ33430666
Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.Q33579032
Critical functions of Rpa3/Ssb3 in S-phase DNA damage responses in fission yeast.Q33707399
Chk1 and Cds1: linchpins of the DNA damage and replication checkpoint pathways.Q33824746
Ribonucleotide reductase: regulation, regulation, regulationQ33971451
Release of Ku and MRN from DNA ends by Mre11 nuclease activity and Ctp1 is required for homologous recombination repair of double-strand breaks.Q34023042
Brc1-dependent recovery from replication stressQ34172453
Requirement for the Phospho-H2AX Binding Module of Crb2 in Double-Strand Break Targeting and Checkpoint ActivationQ34177982
Thymidine Kinase: Evidence for its Absence from Neurospora crassa and Some Other Micro-organisms, and the Relevance of This to the Specific Labelling of Deoxyribonucleic AcidQ34238557
In vivo labeling of fission yeast DNA with thymidine and thymidine analogsQ34322429
Brc1-mediated DNA repair and damage toleranceQ34589597
Mechanisms of mutagenesis in vivo due to imbalanced dNTP poolsQ34609166
High-throughput genetic interaction mapping in the fission yeast Schizosaccharomyces pombeQ34692755
Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks, maintains checkpoint arrest, and influences DNA repair in fission yeastQ35126538
Mutator phenotypes in mammalian cell mutants with distinct biochemical defects and abnormal deoxyribonucleoside triphosphate poolsQ35350889
Retention but not recruitment of Crb2 at double-strand breaks requires Rad1 and Rad3 complexes.Q35661557
Dial 9-1-1 for DNA damage: the Rad9-Hus1-Rad1 (9-1-1) clamp complexQ35848485
Nuclear factories for signalling and repairing DNA double strand breaks in living fission yeast.Q36247923
Basic methods for fission yeastQ36405219
DNA precursor metabolism and genomic stabilityQ36525542
The Schizosaccharomyces pombe rad11+ gene encodes the large subunit of replication protein A.Q36567884
Mus81 is essential for sister chromatid recombination at broken replication forksQ36642712
Involvement of deoxycytidylate deaminase in the response to S(n)1-type methylation DNA damage in budding yeastQ36688814
Review of recent studies on resistance to cytotoxic deoxynucleoside analoguesQ36946228
Ribonucleotide reductase: a critical enzyme for cancer chemotherapy and antiviral agentsQ37066981
Taking the time to make important decisions: the checkpoint effector kinases Chk1 and Chk2 and the DNA damage responseQ37497709
DNA replication as a target of the DNA damage checkpointQ37511322
Genetic factors influencing cytarabine therapyQ37618228
Deoxyuridine analog nucleotides in deoxycytidine analog treatment: secondary active metabolites?Q37701947
DNA building blocks: keeping control of manufactureQ37952292
A tale of two enzymes, deoxycytidylate deaminase and thymidylate synthase.Q37999994
Cloning the RAD51 homologue of Schizosaccharomyces pombe.Q38315836
Threonine-11, phosphorylated by Rad3 and atm in vitro, is required for activation of fission yeast checkpoint kinase Cds1Q39530422
Swi1 prevents replication fork collapse and controls checkpoint kinase Cds1.Q39940510
Efficient labeling of fission yeast Schizosaccharomyces pombe with thymidine and BUdR.Q40240578
Genetic effects of deoxyribonucleotide pool imbalancesQ40252182
Regulation of the fission yeast transcription factor Pap1 by oxidative stress: requirement for the nuclear export factor Crm1 (Exportin) and the stress-activated MAP kinase Sty1/Spc1Q40444338
Regulation of pyrimidine deoxyribonucleotide metabolism by substrate cycles in dCMP deaminase-deficient V79 hamster cellsQ40671782
Molecular analysis of mutations in the hprt gene of V79 hamster fibroblasts: effects of imbalances in the dCTP, dGTP and dTTP poolsQ41283808
Deoxycytidylate deaminase from Bacillus subtilis. Purification, characterization, and physiological functionQ41406713
During replication stress, non-SMC element 5 (NSE5) is required for Smc5/6 protein complex functionality at stalled forksQ41768252
The Nse5-Nse6 dimer mediates DNA repair roles of the Smc5-Smc6 complexQ41971877
Ddb1 controls genome stability and meiosis in fission yeastQ42036717
Histone modification-dependent and -independent pathways for recruitment of checkpoint protein Crb2 to double-strand breaks.Q42150641
BRCT domain interactions with phospho-histone H2A target Crb2 to chromatin at double-strand breaks and maintain the DNA damage checkpointQ42413619
Highly mutagenic and severely imbalanced dNTP pools can escape detection by the S-phase checkpointQ42738775
Mus81-Eme1 and Rqh1 involvement in processing stalled and collapsed replication forksQ44041879
Measuring DNA content by flow cytometry in fission yeast.Q45948224
Mrc1 channels the DNA replication arrest signal to checkpoint kinase Cds1.Q45991206
Methods for studying mutagenesis and checkpoints in Schizosaccharomyces pombeQ46445542
Mutational specificity of DNA precursor pool imbalances in yeast arising from deoxycytidylate deaminase deficiency or treatment with thymidylate.Q52481551
Imbalanced deoxyribonucleoside triphosphate pools and spontaneous mutation rates determined during dCMP deaminase-defective bacteriophage T4 infectionsQ68951295
Deoxyribonucleoside triphosphate metabolism and the mammalian cell cycle. Effects of thymidine on wild-type and dCMP deaminase-deficient mouse S49 T-lymphoma cellsQ70644798
Mutationtal specificity of thymine nucleotide depletion in yeastQ72091932
The endogenous Mus81-Eme1 complex resolves Holliday junctions by a nick and counternick mechanismQ79120277
P433issue21
P407language of work or nameEnglishQ1860
P921main subjectgenome stabilityQ98655700
P304page(s)4445-4454
P577publication date2012-08-27
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleReplication fork collapse and genome instability in a deoxycytidylate deaminase mutant
P478volume32

Reverse relations

cites work (P2860)
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