Eribulin alone or in combination with the PLK1 inhibitor BI 6727 triggers intrinsic apoptosis in Ewing sarcoma cell lines

scientific article published on 18 April 2017

Eribulin alone or in combination with the PLK1 inhibitor BI 6727 triggers intrinsic apoptosis in Ewing sarcoma cell lines is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.18632/ONCOTARGET.17190
P932PMC publication ID5581041
P698PubMed publication ID28881742

P50authorSimone FuldaQ21264686
P2093author name stringManuela Hugle
Lilly Magdalena WeiΔ
P2860cites workCyclin-dependent kinase 1-mediated Bcl-xL/Bcl-2 phosphorylation acts as a functional link coupling mitotic arrest and apoptosisQ24317740
Eribulin binds at microtubule ends to a single site on tubulin to suppress dynamic instabilityQ24610709
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Expression, purification, crystallization, and biochemical characterization of a recombinant protein phosphatase.Q54652530
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A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometryQ29617253
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Small interfering RNA library screen of human kinases and phosphatases identifies polo-like kinase 1 as a promising new target for the treatment of pediatric rhabdomyosarcomasQ33514778
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Eribulin mesilate suppresses experimental metastasis of breast cancer cells by reversing phenotype from epithelial-mesenchymal transition (EMT) to mesenchymal-epithelial transition (MET) statesQ34406761
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Interferon-gamma sensitizes resistant Ewing's sarcoma cells to tumor necrosis factor apoptosis-inducing ligand-induced apoptosis by up-regulation of caspase-8 without altering chemosensitivityQ35855534
Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapyQ36558024
Identification of synthetic lethality of PLK1 inhibition and microtubule-destabilizing drugsQ36751562
Critical role of anti-apoptotic Bcl-2 protein phosphorylation in mitotic deathQ37299645
ZEB2 Represses the Epithelial Phenotype and Facilitates Metastasis in Ewing SarcomaQ37424383
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Integrating mechanisms of response and resistance against the tubulin binding agent Eribulin in preclinical models of osteosarcoma.Q37699295
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Ewing Sarcoma: Current Management and Future Approaches Through CollaborationQ38573422
Synergistic induction of apoptosis by a polo-like kinase 1 inhibitor and microtubule-interfering drugs in Ewing sarcoma cellsQ38844740
Eribulin synergizes with Polo-like kinase 1 inhibitors to induce apoptosis in rhabdomyosarcomaQ38881789
Bortezomib antagonizes microtubule-interfering drug-induced apoptosis by inhibiting G2/M transition and MCL-1 degradationQ39058933
Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7.Q39582682
Polo-like kinase 1 is a therapeutic target in high-risk neuroblastomaQ39618381
Phosphorylation of Mcl-1 by CDK1-cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest.Q39696436
Identification of the major phosphorylation site in Bcl-xL induced by microtubule inhibitors and analysis of its functional significanceQ39923184
Comparison of the activities of the truncated halichondrin B analog NSC 707389 (E7389) with those of the parent compound and a proposed binding site on tubulin.Q40238368
Polo-like kinase 1 inhibition sensitizes neuroblastoma cells for vinca alkaloid-induced apoptosisQ41819580
P4510describes a project that usesImageJQ1659584
P433issue32
P407language of work or nameEnglishQ1860
P1104number of pages12
P304page(s)52445-52456
P577publication date2017-04-18
P1433published inOncotargetQ1573155
P1476titleEribulin alone or in combination with the PLK1 inhibitor BI 6727 triggers intrinsic apoptosis in Ewing sarcoma cell lines
P478volume8

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cites work (P2860)
Q64113336Emerging novel agents for patients with advanced Ewing sarcoma: a report from the Children's Oncology Group (COG) New Agents for Ewing Sarcoma Task Force
Q90396711Identification of PLK1 as a New Therapeutic Target in Mucinous Ovarian Carcinoma

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