A combination of valproic acid sodium salt, CHIR99021, E-616452, tranylcypromine, and 3-Deazaneplanocin A causes stem cell-like characteristics in cancer cells

scientific article published on 7 June 2017

A combination of valproic acid sodium salt, CHIR99021, E-616452, tranylcypromine, and 3-Deazaneplanocin A causes stem cell-like characteristics in cancer cells is …
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scholarly articleQ13442814

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P356DOI10.18632/ONCOTARGET.18396
P932PMC publication ID5581111
P698PubMed publication ID28881812

P2093author name stringQing Chang
Chengzhao Lin
Shuang Song
Heyong Wang
Gentao Liu
Mingqiang Ren
Shuang Sha
Yuanfen Zhai
P2860cites workCancer Stem Cells and Epithelial-to-Mesenchymal Transition (EMT)-Phenotypic Cells: Are They Cousins or Twins?Q24628819
Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatmentQ24656967
Notch signaling: an emerging therapeutic target for cancer treatmentQ26784068
Induction of cancer stem cell properties in colon cancer cells by defined factorsQ27320228
Side population in human lung cancer cell lines and tumors is enriched with stem-like cancer cellsQ28302950
Drug-selected human lung cancer stem cells: cytokine network, tumorigenic and metastatic propertiesQ28473512
Glycogen synthase kinase 3 beta positively regulates Notch signaling in vascular smooth muscle cells: role in cell proliferation and survivalQ28583993
Pluripotent stem cells induced from mouse somatic cells by small-molecule compoundsQ29616608
Cisplatin and etoposide versus carboplatin and paclitaxel with concurrent radiotherapy for stage III non-small-cell lung cancer: an analysis of Veterans Health Administration dataQ30871677
A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanogQ33509682
Effect of Gsk3 inhibitor CHIR99021 on aneuploidy levels in rat embryonic stem cells.Q33775190
Evidence for self-renewing lung cancer stem cells and their implications in tumor initiation, progression, and targeted therapyQ33829820
CD133-positive cancer stem cells from Colo205 human colon adenocarcinoma cell line show resistance to chemotherapy and display a specific metabolomic profileQ34170564
The side population in human lung cancer cell line NCI-H460 is enriched in stem-like cancer cellsQ34200826
SOX2 regulates self-renewal and tumorigenicity of human melanoma-initiating cells.Q34269756
3-Deazaneplanocin A (DZNep), an inhibitor of S-adenosylmethionine-dependent methyltransferase, promotes erythroid differentiationQ34401976
Notch signaling and EMT in non-small cell lung cancer: biological significance and therapeutic applicationQ34712645
The roles of Notch3 on the cell proliferation and apoptosis induced by CHIR99021 in NSCLC cell lines: a functional link between Wnt and Notch signaling pathwaysQ35075849
EMT and acquisition of stem cell-like properties are involved in spontaneous formation of tumorigenic hybrids between lung cancer and bone marrow-derived mesenchymal stem cellsQ35091485
3-Deazaneplanocin A (DZNep), an inhibitor of the histone methyltransferase EZH2, induces apoptosis and reduces cell migration in chondrosarcoma cellsQ35172602
CD133+ ovarian cancer stem-like cells promote non-stem cancer cell metastasis via CCL5 induced epithelial-mesenchymal transitionQ35742418
Histone deacetylase inhibitor valproic acid (VPA) promotes the epithelial mesenchymal transition of colorectal cancer cells via up regulation of SnailQ37114711
Silencing NOTCH signaling causes growth arrest in both breast cancer stem cells and breast cancer cellsQ37323067
The Lnc RNA SPRY4-IT1 Modulates Trophoblast Cell Invasion and Migration by Affecting the Epithelial-Mesenchymal TransitionQ37419194
GSK-3 is a master regulator of neural progenitor homeostasisQ37670059
Cancer stem cells in lung cancer: Evidence and controversies.Q37709551
Therapy-induced enrichment of putative lung cancer stem-like cells.Q38150766
Cancer stem cells: progress and challenges in lung cancerQ38881450
Analysis of multiple markers for cancer stem-like cells in human thyroid carcinoma cell lines.Q39023422
CD133+ cancer stem-like cells in small cell lung cancer are highly tumorigenic and chemoresistant but sensitive to a novel neuropeptide antagonistQ39033543
NOTCH signaling is required for formation and self-renewal of tumor-initiating cells and for repression of secretory cell differentiation in colon cancerQ39227342
Cisplatin selects for multidrug-resistant CD133+ cells in lung adenocarcinoma by activating Notch signaling.Q39247985
Coexpression of Oct4 and Nanog enhances malignancy in lung adenocarcinoma by inducing cancer stem cell-like properties and epithelial-mesenchymal transdifferentiation.Q39619885
Valproic acid activates notch-1 signaling and regulates the neuroendocrine phenotype in carcinoid cancer cellsQ40086013
Valproic acid stimulates proliferation and self-renewal of hematopoietic stem cellsQ40433523
Effects of the histone deacetylase inhibitor valproic acid on Notch signalling in human neuroblastoma cells.Q40463075
Hes1 is involved in the self-renewal and tumourigenicity of stem-like cancer cells in colon cancerQ41846661
SOX2 expression associates with stem cell state in human ovarian carcinoma.Q46004424
Valproic acid (VPA) inhibits the epithelial-mesenchymal transition in prostate carcinoma via the dual suppression of SMAD4.Q53410584
The CD133 expression levels and its role as potential cancer stem cells marker in gastrointestinal stromal tumorQ59217176
P433issue32
P407language of work or nameEnglishQ1860
P304page(s)53302-53312
P577publication date2017-06-07
P1433published inOncotargetQ1573155
P1476titleA combination of valproic acid sodium salt, CHIR99021, E-616452, tranylcypromine, and 3-Deazaneplanocin A causes stem cell-like characteristics in cancer cells
P478volume8

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Q58616531Novel drug candidates for treating esophageal carcinoma: A study on differentially expressed genes, using connectivity mapping and molecular dockingcites workP2860

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