Valproic acid (VPA) inhibits the epithelial-mesenchymal transition in prostate carcinoma via the dual suppression of SMAD4.

scientific article published on 24 July 2015

Valproic acid (VPA) inhibits the epithelial-mesenchymal transition in prostate carcinoma via the dual suppression of SMAD4. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S00432-015-2020-4
P698PubMed publication ID26206483

P2093author name stringWei Jiang
Xunbo Jin
Xiaopeng Lan
Yougen Chen
Qinghua Xia
Guoliang Lu
Shaowei Mao
Chuanwei Yuan
P2860cites workTrichostatin A induces mesenchymal-like morphological change and gene expression but inhibits migration and colony formation in human cancer cellsQ38951837
Acetylation regulates the stability of glutamate carboxypeptidase II protein in human astrocytesQ38983633
Role of SMAD4 in the mechanism of valproic acid's inhibitory effect on prostate cancer cell invasivenessQ39058636
MicroRNA-146a modulates TGF-beta1-induced hepatic stellate cell proliferation by targeting SMAD4.Q39324702
Low dosed interferon alpha augments the anti-tumor potential of histone deacetylase inhibition on prostate cancer cell growth and invasionQ39369865
Sodium valproate inhibits MDA-MB-231 breast cancer cell migration by upregulating NM23H1 expressionQ39404011
HDAC inhibitor vorinostat enhances the antitumor effect of gefitinib in squamous cell carcinoma of head and neck by modulating ErbB receptor expression and reverting EMT.Q39527047
MS-275 sensitizes TRAIL-resistant breast cancer cells, inhibits angiogenesis and metastasis, and reverses epithelial-mesenchymal transition in vivoQ39637308
Valproic acid causes dose- and time-dependent changes in nuclear structure in prostate cancer cells in vitro and in vivoQ39860046
Elevated FOSB-expression; a potential marker of valproate sensitivity in AML.Q39911930
Histone deacetylase inhibitors have a profound antigrowth activity in endometrial cancer cellsQ40590583
Chromatin-modifying agents reactivate embryonic renal stem/progenitor genes in human adult kidney epithelial cells but abrogate dedifferentiation and stemnessQ41826504
Valproic acid suppresses cervical cancer tumor progression possibly via activating Notch1 signaling and enhances receptor-targeted cancer chemotherapeutic via activating somatostatin receptor type II.Q45912062
Impact of combined HDAC and mTOR inhibition on adhesion, migration and invasion of prostate cancer cellsQ47589926
Neuroprotective effects of valproic acid against hemin toxicity: possible involvement of the down-regulation of heme oxygenase-1 by regulating ubiquitin-proteasomal pathwayQ48220909
TIF1γ requires sumoylation to exert its repressive activity on TGFβ signaling.Q50889873
Effects of valproic acid on proliferation, apoptosis, angiogenesis and metastasis of ovarian cancer in vitro and in vivoQ85272127
Transcription factors OVOL1 and OVOL2 induce the mesenchymal to epithelial transition in human cancerQ21132487
Antagonistic regulation of EMT by TIF1γ and Smad4 in mammary epithelial cellsQ24303962
FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitinationQ24315150
Therapeutic potential of mood stabilizers lithium and valproic acid: beyond bipolar disorderQ24626017
The basics of epithelial-mesenchymal transitionQ24652992
Regulation of TGF-β signal transduction by mono- and deubiquitylation of SmadsQ26827667
Regulation of TGF-β Superfamily Signaling by SMAD Mono-UbiquitinationQ26830449
Cancer statistics, 2015Q27860576
AACR centennial series: the biology of cancer metastasis: historical perspectiveQ33683443
Role of androgens and the androgen receptor in epithelial-mesenchymal transition and invasion of prostate cancer cellsQ33694557
New perspectives of valproic acid in clinical practice.Q34380256
Axl as a mediator of cellular growth and survivalQ34619118
New and emerging therapies for bone metastases in genitourinary cancersQ36866291
Epithelial-mesenchymal transition in breast cancer progression and metastasisQ36986452
SMAD4-dependent barrier constrains prostate cancer growth and metastatic progressionQ37120753
Contributions of epithelial-mesenchymal transition and cancer stem cells to the development of castration resistance of prostate cancerQ37683681
Transcriptional crosstalk between TGF-β and stem cell pathways in tumor cell invasion: role of EMT promoting Smad complexesQ37762393
Mechanism of the mesenchymal-epithelial transition and its relationship with metastatic tumor formationQ37917310
TGF-β signalling and its role in cancer progression and metastasisQ38020111
New insights into extracellular and post-translational regulation of TGF-β family signalling pathwaysQ38108683
Histone deacetylase inhibitors: an overview of the clinical studies in solid tumorsQ38159410
Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disordersQ38240733
Breast cancer stem cells, EMT and therapeutic targetsQ38254848
Cytoskeleton targeting value in prostate cancer treatmentQ38265569
Histone deacetylases as therapeutic targets--from cancer to cardiac diseaseQ38274751
Connective tissue growth factor activates pluripotency genes and mesenchymal-epithelial transition in head and neck cancer cells.Q38315365
P433issue1
P921main subjectprostate carcinomaQ18553829
P304page(s)177-185
P577publication date2015-07-24
P1433published inJournal of Cancer Research and Clinical OncologyQ2081599
P1476titleValproic acid (VPA) inhibits the epithelial-mesenchymal transition in prostate carcinoma via the dual suppression of SMAD4.
P478volume142

Reverse relations

cites work (P2860)
Q41593141A combination of valproic acid sodium salt, CHIR99021, E-616452, tranylcypromine, and 3-Deazaneplanocin A causes stem cell-like characteristics in cancer cells
Q47387460Combination of sorafenib and Valproic acid synergistically induces cell apoptosis and inhibits hepatocellular carcinoma growth via down-regulating Notch3 and pAkt
Q28071912Epigenetic modulators as therapeutic targets in prostate cancer
Q52674354Glyoxalase 1 sustains the metastatic phenotype of prostate cancer cells via EMT control.
Q64243953Histone Deacetylase Inhibitors and Phenotypical Transformation of Cancer Cells
Q36508613MiR-130a-3p regulates cell migration and invasion via inhibition of Smad4 in gemcitabine resistant hepatoma cells
Q39329818The EMT spectrum and therapeutic opportunities
Q50911264USP17 is upregulated in osteosarcoma and promotes cell proliferation, metastasis, and epithelial-mesenchymal transition through stabilizing SMAD4.
Q52718768Valproic acid sensitizes metformin-resistant human renal cell carcinoma cells by upregulating H3 acetylation and EMT reversal.

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