Temporal increase in thymocyte negative selection parallels enhanced thymic SIRPα+ DC function

scientific article published on 8 August 2016

Temporal increase in thymocyte negative selection parallels enhanced thymic SIRPα+ DC function is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/EJI.201646354
P932PMC publication ID5138854
P698PubMed publication ID27501268

P50authorRoland TischQ97091835
Bo WangQ97093714
Charles J KrogerQ114526153
P2860cites workEssential role for cathepsin S in MHC class II-associated invariant chain processing and peptide loadingQ24328923
Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunityQ24643886
Projection of an immunological self shadow within the thymus by the aire proteinQ28207164
Aire regulates negative selection of organ-specific T cellsQ28213185
Cathepsin S required for normal MHC class II peptide loading and germinal center developmentQ28611850
Differential antigen processing by dendritic cell subsets in vivoQ29615177
Self-antigen presentation by thymic stromal cells: a subtle division of laborQ33860558
Cutting edge: Antigen-specific thymocyte feedback regulates homeostatic thymic conventional dendritic cell maturationQ33965318
Dendritic cells in the thymus contribute to T-regulatory cell inductionQ34601754
Distinct pathways of antigen uptake and intracellular routing in CD4 and CD8 T cell activation.Q34623431
Thymus-specific serine protease controls autoreactive CD4 T cell development and autoimmune diabetes in miceQ34876029
Plasmacytoid dendritic cells transport peripheral antigens to the thymus to promote central toleranceQ35861549
The NOD mouse: a model of immune dysregulationQ36072434
Heterogeneity of thymic dendritic cellsQ36157476
Cathepsin S controls the trafficking and maturation of MHC class II molecules in dendritic cells.Q36301521
Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentationQ36399298
Thymus-blood protein interactions are highly effective in negative selection and regulatory T cell inductionQ36426341
A central role for central toleranceQ36427372
Functional redundancy between thymic CD8α+ and Sirpα+ conventional dendritic cells in presentation of blood-derived lysozyme by MHC class II proteinsQ36433047
Thymus-homing peripheral dendritic cells constitute two of the three major subsets of dendritic cells in the steady-state thymusQ37234298
β-cell-specific IL-2 therapy increases islet Foxp3+Treg and suppresses type 1 diabetes in NOD miceQ37251067
Neonatal tolerance revisited: a perinatal window for Aire control of autoimmunityQ37273185
Targeting proteins to distinct subcellular compartments reveals unique requirements for MHC class I and II presentationQ37363754
Thymic development of autoreactive T cells in NOD mice is regulated in an age-dependent mannerQ37381434
Cathepsin S activity regulates antigen presentation and immunityQ37382422
Thymus transplantationQ37710840
Clonal deletion of thymocytes by circulating dendritic cells homing to the thymusQ38466522
The thymic medulla: a unique microenvironment for intercellular self-antigen transferQ42572856
Distinct kinetics and dynamics of cross-presentation in liver sinusoidal endothelial cells compared to dendritic cells.Q45927002
The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes.Q52196097
Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus.Q52196099
Central tolerance spares the private high-avidity CD4(+) T-cell repertoire specific for an islet antigen in NOD mice.Q53170853
Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance.Q53253030
The T Cell Repertoire-Diversifying Enzyme TSSP Contributes to Thymic Selection of Diabetogenic CD4 T Cell Specificities Reactive to ChgA and IAPP Autoantigens.Q53408834
Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self.Q55035366
Development of the dendritic cell system during mouse ontogenyQ57134242
T-cell apoptosis detected in situ during positive and negative selection in the thymusQ59087078
Dendritic Cell-Specific Ablation of the Protein Tyrosine Phosphatase Shp1 Promotes Th1 Cell Differentiation and Induces AutoimmunityQ63968540
Effect of transferrin on the degradation of glycoproteins bearing a hybrid or high-mannose glycan by alveolar macrophagesQ72798135
Age-dependent T cell tolerance and autoimmunity to myelin basic proteinQ73835283
Polyethylene glycol-modified GM-CSF expands CD11b(high)CD11c(high) but notCD11b(low)CD11c(high) murine dendritic cells in vivo: a comparative analysis with Flt3 ligandQ73910703
Impaired invariant chain degradation and antigen presentation and diminished collagen-induced arthritis in cathepsin S null miceQ74595052
A defect in central tolerance in NOD miceQ74825850
Percutaneous intravenous injection in neonatal miceQ77993909
Defective central tolerance induction in NOD mice: genomics and geneticsQ81552095
Autonomous versus dendritic cell-dependent contributions of medullary thymic epithelial cells to central toleranceQ83863991
Crucial contribution of thymic Sirp alpha+ conventional dendritic cells to central tolerance against blood-borne antigens in a CCR2-dependent mannerQ84394189
Thymic but not splenic CD8⁺ DCs can efficiently cross-prime T cells in the absence of licensing factorsQ84543868
Autoimmunity during thymectomy-induced lymphopenia: role of thymus ablation and initial effector T cell activation timing in nonobese diabetic miceQ84624940
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectthymocyteQ7799635
P304page(s)2352-2362
P577publication date2016-08-08
P1433published inEuropean Journal of ImmunologyQ5412727
P1476titleTemporal increase in thymocyte negative selection parallels enhanced thymic SIRPα+ DC function
P478volume46

Reverse relations

cites work (P2860)
Q48333963Aire controls the recirculation of murine Foxp3+ regulatory T-cells back to the thymus.
Q88758055Directing T cell fate: How thymic antigen presenting cells coordinate thymocyte selection
Q91904950Early childhood education is critical for Treg cells
Q64052753Live-cell imaging reveals the relative contributions of antigen-presenting cell subsets to thymic central tolerance
Q45376715Redefining thymus medulla specialization for central tolerance
Q49200196Type 1 Diabetes: A Chronic Anti-Self-Inflammatory Response

Search more.