Four human ras homologs differ in their abilities to activate Raf-1, induce transformation, and stimulate cell motility

scientific article published on June 1999

Four human ras homologs differ in their abilities to activate Raf-1, induce transformation, and stimulate cell motility is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.274.24.17164
P698PubMed publication ID10358073
P5875ResearchGate publication ID12941009

P2093author name stringJackson JH
Voice JK
Le A
Klemke RL
P2860cites workCAS/Crk coupling serves as a "molecular switch" for induction of cell migrationQ24311510
Phosphorylation-dependent activation of the Ras-GRF/CDC25Mm exchange factor by muscarinic receptors and G-protein beta gamma subunitsQ24313407
Regulation of cell motility by mitogen-activated protein kinaseQ24678874
Rho GTPases and the actin cytoskeletonQ27860579
Cell migration: a physically integrated molecular processQ27860682
Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activationQ28131755
14-3-3 zeta negatively regulates raf-1 activity by interactions with the Raf-1 cysteine-rich domainQ28246442
The complexity of Raf-1 regulationQ28305850
Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinasesQ28609156
ras genesQ29547799
14-3-3 facilitates Ras-dependent Raf-1 activation in vitro and in vivoQ33774875
Construction and applications of a highly transmissible murine retrovirus shuttle vectorQ34255941
Signal transduction from multiple Ras effectorsQ34415796
Structure of the Ki-ras gene of the human lung carcinoma cell line Calu-1.Q34708404
Polylysine domain of K-ras 4B protein is crucial for malignant transformationQ36000682
Signaling pathways in Ras-mediated tumorigenicity and metastasis.Q36219180
Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformationQ36561047
Differential expression of the ras gene family in miceQ36839048
Activation of the Raf-1/MAP kinase cascade is not sufficient for Ras transformation of RIE-1 epithelial cellsQ37475615
Complexes of polyoma virus medium T antigen and cellular proteinsQ37537980
Farnesol modification of Kirsten-ras exon 4B protein is essential for transformationQ37739922
Function and regulation of ras.Q40835314
Ras-GRF activates Ha-Ras, but not N-Ras or K-Ras 4B, protein in vivoQ41069980
Calcium activation of Ras mediated by neuronal exchange factor Ras-GRF.Q41312875
Rac and Cdc42 induce actin polymerization and G1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascadeQ42807716
Rap1 mediates sustained MAP kinase activation induced by nerve growth factorQ42830846
Increasing complexity of the Ras signaling pathwayQ47762067
Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutationsQ48396942
Developmentally-regulated expression of murine K-ras isoforms.Q52192161
Rho family proteins and Ras transformation: the RHOad less traveled gets congested.Q53429986
Increasing complexity of Ras signaling.Q53429989
P433issue24
P407language of work or nameEnglishQ1860
P304page(s)17164-17170
P577publication date1999-06-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleFour human ras homologs differ in their abilities to activate Raf-1, induce transformation, and stimulate cell motility
P478volume274

Reverse relations

cites work (P2860)
Q34174948A Ras by any other name
Q30416821A comprehensive survey of Ras mutations in cancer
Q93018032A model for RAS mutation patterns in cancers: finding the sweet spot
Q39180736A requirement for wild-type Ras isoforms in mutant KRas-driven signalling and transformation
Q36082699ASPP2 Is a Novel Pan-Ras Nanocluster Scaffold.
Q34044691Aberrant RNA splicing in cancer; expression changes and driver mutations of splicing factor genes
Q39999843Absence of K-Ras Reduces Proliferation and Migration But Increases Extracellular Matrix Synthesis in Fibroblasts
Q40014102Activated Kras, but not Hras or Nras, may initiate tumors of endodermal origin via stem cell expansion
Q41960466Aggregation of lipid-anchored full-length H-Ras in lipid bilayers: simulations with the MARTINI force field
Q38546927Chemistry and biology of the compounds that modulate cell migration
Q89727321Colorectal Cancer Modeling with Organoids: Discriminating between Oncogenic RAS and BRAF Variants
Q40259833Comparative proteomic analysis of compartmentalised Ras signalling
Q40113987Comparison of the Conformations of KRAS Isoforms, K-Ras4A and K-Ras4B, Points to Similarities and Significant Differences
Q79610587Conditional N-rasG12V expression promotes manifestations of neurofibromatosis in a mouse model
Q39739826DA-Raf1, a competent intrinsic dominant-negative antagonist of the Ras-ERK pathway, is required for myogenic differentiation
Q34994888Death pathways triggered by activated Ras in cancer cells
Q46264996Deciphering lipid codes: K-Ras as a paradigm
Q38238599Decoding RAS isoform and codon-specific signalling.
Q37834359Defining the cancer master switch
Q37583441Degradation of activated K-Ras orthologue via K-Ras-specific lysine residues is required for cytokinesis
Q42807754Differences on the inhibitory specificities of H-Ras, K-Ras, and N-Ras (N17) dominant negative mutants are related to their membrane microlocalization
Q40816808Differential activation of the Rac pathway by Ha-Ras and K-Ras
Q36697241Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon
Q39951891Differential interference of chlorpromazine with the membrane interactions of oncogenic K-Ras and its effects on cell growth
Q24321837Disruption of RAB40AL function leads to Martin--Probst syndrome, a rare X-linked multisystem neurodevelopmental human disorder
Q33230208Distinct functions for Ras GTPases in the control of proliferation and apoptosis in mouse and human mesangial cells
Q36223582Down-regulation of Cdx2 in colorectal carcinoma cells by the Raf-MEK-ERK 1/2 pathway
Q42818477Ecdysone-inducible expression of oncogenic Ha-Ras in NIH 3T3 cells leads to transient nuclear localization of activated extracellular signal-regulated kinase regulated by mitogen-activated protein kinase phosphatase-1
Q42161506Electron microscopic imaging of Ras signaling domains
Q24554279Elevated phospholipase D activity in H-Ras- but not K-Ras-transformed cells by the synergistic action of RalA and ARF6
Q39645041Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene
Q34293555Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: lessons from mechanism and bench-to-bedside translational studies
Q80510506Farnesyltransferase inhibitors
Q39339468Functional specific roles of H-ras and N-ras. A proteomic approach using knockout cell lines.
Q42784309Functional specificity of ras isoforms: so similar but so different
Q42122955Galectin-3 regulates RasGRP4-mediated activation of N-Ras and H-Ras
Q46633545H-Ras dynamically interacts with recycling endosomes in CHO-K1 cells: involvement of Rab5 and Rab11 in the trafficking of H-Ras to this pericentriolar endocytic compartment.
Q42497568H-Ras isoform modulates extracellular matrix synthesis, proliferation, and migration in fibroblasts
Q28564405H-Ras signaling and K-Ras signaling are differentially dependent on endocytosis
Q38515287H-Ras-specific activation of Rac-MKK3/6-p38 pathway: its critical role in invasion and migration of breast epithelial cells
Q40364754Identification of Differentially Expressed K-Ras Transcript Variants in Patients With Leiomyoma.
Q28203664Identification of a novel Ras-regulated proapoptotic pathway
Q33727657Inflammation to cancer: The molecular biology in the pancreas (Review).
Q34931245Insider information: how palmitoylation of Ras makes it a signaling double agent
Q36146950Integration of biochemical signalling in spines
Q91747785Isoform-specific Ras signaling is growth factor dependent
Q35131418Isoform-specific ras activation and oncogene dependence during MYC- and Wnt-induced mammary tumorigenesis
Q53654566K-Ras 4A Transcript variant is up-regulated in eutopic endometrium of endometriosis patients during proliferative phase of menstrual cycle.
Q35031435K-Ras4A splice variant is widely expressed in cancer and uses a hybrid membrane-targeting motif
Q37712302K-ras 4A and 4B mRNA levels correlate with superoxide in lung adenocarcinoma cells, while at the protein level, only mutant K-ras 4A protein correlates with superoxide
Q91892495KRAS4A directly regulates hexokinase 1
Q26751212Kirsten Ras* oncogene: Significance of its discovery in human cancer research
Q37126064Kras regulatory elements and exon 4A determine mutation specificity in lung cancer
Q36386755Label-free quantitative proteomics and N-glycoproteomics analysis of KRAS-activated human bronchial epithelial cells.
Q35729999Mammalian mRNA splice-isoform selection is tightly controlled.
Q37435513Mechanisms of Ras membrane organization and signalling: Ras on a rocker.
Q39455039MicroRNA-622 functions as a tumor suppressor by targeting K-Ras and enhancing the anticarcinogenic effect of resveratrol
Q42789242Molecular nevogenesis
Q27316056Mouse pulmonary adenoma susceptibility 1 locus is an expression QTL modulating Kras-4A
Q57371882Mutation of Ha-Ras C Terminus Changes Effector Pathway Utilization
Q38953667Mutation-specific RAS oncogenicity explains NRAS codon 61 selection in melanoma
Q46863515Mutationally activated K-ras 4A and 4B both mediate lung carcinogenesis
Q42795746NF1 modulates the effects of Ras oncogenes: evidence of other NF1 function besides its GAP activity
Q42805759Oncogenic K-Ras and basic fibroblast growth factor prevent Fas-mediated apoptosis in fibroblasts through activation of mitogen-activated protein kinase
Q37143762Oncogenic NRAS, KRAS, and HRAS exhibit different leukemogenic potentials in mice
Q47256433Oncogenic Ras Isoforms Signaling Specificity at the Membrane
Q36103287Oncogenic Ras in tumour progression and metastasis
Q75312802Opinion: Searching for the elusive targets of farnesyltransferase inhibitors
Q40601308Opposite effects of Ha-Ras and Ki-Ras on radiation-induced apoptosis via differential activation of PI3K/Akt and Rac/p38 mitogen-activated protein kinase signaling pathways
Q40790669P21(Cip1) induced by Raf is associated with increased Cdk4 activity in hematopoietic cells.
Q58577211Pharmacological targeting of RAS: Recent success with direct inhibitors
Q33921360Phosphoproteomics identifies oncogenic Ras signaling targets and their involvement in lung adenocarcinomas
Q39804200Plasma membrane nanoswitches generate high-fidelity Ras signal transduction
Q34010802Proteomic and phosphoproteomic alterations in benign, premalignant and tumor human breast epithelial cells and xenograft lesions: biomarkers of progression
Q57033842RAS variant signalling
Q24805649RETRACTED: Inactivation of MAP kinase signalling in Myc transformed cells and rescue by LiCl inhibition of GSK3.
Q43220010Rare codons regulate KRas oncogenesis
Q35564604Ras GTPases: integrins' friends or foes?
Q34467963Ras isoform-specific signaling: location, location, location
Q33667116Ras membrane orientation and nanodomain localization generate isoform diversity
Q36952890Ras nanoclusters: molecular structure and assembly
Q35120159Ras proteins: different signals from different locations
Q35062420Ras redux: rethinking how and where Ras acts.
Q33898992Ras regulation and function in lymphocytes.
Q42815732Ras signalling on the endoplasmic reticulum and the Golgi
Q33351823Ras, an actor on many stages: posttranslational modifications, localization, and site-specified events.
Q35064547Ras-effector interactions: after one decade
Q28138814Ras-induced cellular events (review)
Q89729002Ras2, the TC21/R-Ras2 Drosophila homologue, contributes to insulin signalling but is not required for organism viability
Q34598160Regulation of substrate adhesion dynamics during cell motility
Q55003080Role of epigenetic factors in the selection of the alternative splicing isoforms of human KRAS in colorectal cancer cell lines.
Q36098356SPRED1 Interferes with K-ras but Not H-ras Membrane Anchorage and Signaling
Q34964571Serum-dependent transcriptional networks identify distinct functional roles for H-Ras and N-Ras during initial stages of the cell cycle
Q33623159Signal integration by lipid-mediated spatial cross talk between Ras nanoclusters
Q35166852Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention.
Q38048779Signal transduction pathways in chronic inflammatory autoimmune disease: small GTPases
Q34358419Silencing the expression of Ras family GTPase homologues decreases inflammation and joint destruction in experimental arthritis
Q28587366Small GTPase Rah/Rab34 is associated with membrane ruffles and macropinosomes and promotes macropinosome formation
Q36808753Sos-mediated cross-activation of wild-type Ras by oncogenic Ras is essential for tumorigenesis
Q40015562Stem cell gene expression changes induced specifically by mutated K-ras.
Q28140980Structure and function of the C-terminal hypervariable region of K-Ras4B in plasma membrane targetting and transformation
Q35857145Synthesis and evaluation of antitumor activity of novel N-acyllavendamycin analogues and quinoline-5,8-diones
Q34110540Systems biology modeling reveals a possible mechanism of the tumor cell death upon oncogene inactivation in EGFR addicted cancers
Q47559665Targeted Therapies Against Growth Factor Signaling in Breast Cancer
Q42828406The P34G mutation reduces the transforming activity of K-Ras and N-Ras in NIH 3T3 cells but not of H-Ras.
Q34241295The Raf signal transduction cascade as a target for chemotherapeutic intervention in growth factor-responsive tumors
Q37312050The hypervariable region of K-Ras4B is responsible for its specific interactions with calmodulin
Q34034093The importance of being K-Ras
Q43786808The linker domain of the Ha-Ras hypervariable region regulates interactions with exchange factors, Raf-1 and phosphoinositide 3-kinase
Q35566863The polybasic region of Ras and Rho family small GTPases: a regulator of protein interactions and membrane association and a site of nuclear localization signal sequences
Q33343709The pro-apoptotic K-Ras 4A proto-oncoprotein does not affect tumorigenesis in the ApcMin/+ mouse small intestine.
Q38898397The role of wild type RAS isoforms in cancer
Q40243658Transcriptional networks of knockout cell lines identify functional specificities of H-Ras and N-Ras: significant involvement of N-Ras in biotic and defense responses
Q34360923When ubiquitination meets phosphorylation: a systems biology perspective of EGFR/MAPK signalling
Q34989253While K-ras is essential for mouse development, expression of the K-ras 4A splice variant is dispensable.
Q39554370c-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinoma
Q24618182cPLA2 regulates the expression of type I interferons and intracellular immunity to Chlamydia trachomatis

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