Constitutive androstane receptor activation promotes bilirubin clearance in a murine model of alcoholic liver disease

scientific article published on 4 April 2017

Constitutive androstane receptor activation promotes bilirubin clearance in a murine model of alcoholic liver disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3892/MMR.2017.6435
P932PMC publication ID5436297
P698PubMed publication ID28393244

P2093author name stringXiuyan Wang
Debin Zhu
Jinming Wu
Liyu Zheng
Mengqin Zhang
Xianfan Lin
Binbin Tang
P2860cites workInduction of bilirubin clearance by the constitutive androstane receptor (CAR)Q24683238
Alcoholic liver disease: pathogenesis, management, and novel targets for therapyQ26861620
Regulatory pathways for ATP-binding cassette transport proteins in kidney proximal tubulesQ28390004
Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugsQ28506256
Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CARQ34349336
Biochemical and haematological indicators of excessive alcohol consumptionQ34494420
Principles of hepatic organic anion transporter regulation during cholestasis, inflammation and liver regenerationQ36732805
Differential regulation of hepatic organic cation transporter 1, organic anion-transporting polypeptide 1a4, bile-salt export pump, and multidrug resistance-associated protein 2 transporter expression in lymphocyte-deficient mice associates with intQ37193232
Experimental non-alcoholic fatty liver disease results in decreased hepatic uptake transporter expression and function in rats.Q37337092
The constitutive androstane receptor is an anti-obesity nuclear receptor that improves insulin sensitivityQ37377724
Biochemical Evaluation of Patients of Alcoholic Liver Disease and Non-alcoholic Liver DiseaseQ37522015
Signaling control of the constitutive androstane receptor (CAR)Q37642162
Functions of OATP1A and 1B transporters in vivo: insights from mouse modelsQ37963157
The roles of MRP2, MRP3, OATP1B1, and OATP1B3 in conjugated hyperbilirubinemiaQ38181452
Inherited disorders of bilirubin transport and conjugation: new insights into molecular mechanisms and consequencesQ38202433
Phenobarbital induces cell cycle transcriptional responses in mouse liver humanized for constitutive androstane and pregnane x receptorsQ42706153
Ligand dependent hepatic gene expression profiles of nuclear receptors CAR and PXR.Q42717474
The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR.Q43601213
Interleukin 1beta inhibits CAR-induced expression of hepatic genes involved in drug and bilirubin clearanceQ45070050
Dual role of orphan nuclear receptor pregnane X receptor in bilirubin detoxification in miceQ45279418
Phenobarbital treatment enhances insulin-mediated glucose metabolism and improves lipid metabolism in the diabetic rat.Q45952388
CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in miceQ46573657
The nuclear receptor CAR modulates alcohol-induced liver injuryQ47588189
Importance of hepatic induction of constitutive androstane receptor and other transcription factors that regulate xenobiotic metabolism and transportQ50086288
Ethanol consumption alters expression and colocalization of bile salt export pump and multidrug resistance protein 2 in the rat.Q52577962
Hepatobiliary transporter expression in percutaneous liver biopsies of patients with cholestatic liver diseases.Q54017726
Activation of farnesoid X receptor attenuates hepatic injury in a murine model of alcoholic liver diseaseQ57154290
Inhibition of hepatic alcohol dehydrogenase by bilirubinQ72772003
Transcriptional induction of bilirubin UDP-glucuronosyltransrase by ethanol in rat liverQ73222718
Adaptive regulation of bile salt transporters in kidney and liver in obstructive cholestasis in the ratQ77308908
Inflammation mediated down-regulation of hepatobiliary transporters contributes to intrahepatic cholestasis and liver damage in murine biliary atresiaQ84185516
P433issue6
P921main subjectmurine modelQ122890741
P304page(s)3459-3466
P577publication date2017-04-04
P1433published inMolecular Medicine ReportsQ26842180
P1476titleConstitutive androstane receptor activation promotes bilirubin clearance in a murine model of alcoholic liver disease
P478volume15

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Q47419101Pregnane X receptor promotes ethanol-induced hepatosteatosis in micecites workP2860

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