scholarly article | Q13442814 |
P2093 | author name string | Hongbing Wang | |
Antonia H. Tolson | |||
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Comparison of inducibility of CYP1A and CYP3A mRNAs by prototypical inducers in primary cultures of human, cynomolgus monkey, and rat hepatocytes | Q80550563 | ||
Methadone induces the expression of hepatic drug-metabolizing enzymes through the activation of pregnane X receptor and constitutive androstane receptor | Q37311631 | ||
The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism | Q37400616 | ||
The structural basis of pregnane X receptor binding promiscuity | Q37461507 | ||
Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive androstane receptor, pregnane X receptor, glucocorticoid receptor, and hepatic nuclear factor 4alpha | Q38325508 | ||
The human sulfotransferase SULT1A1 gene is regulated in a synergistic manner by Sp1 and GA binding protein | Q38336303 | ||
Ligand-activated pregnane X receptor interferes with HNF-4 signaling by targeting a common coactivator PGC-1alpha. Functional implications in hepatic cholesterol and glucose metabolism. | Q38337494 | ||
Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice | Q38343998 | ||
Constitutive androstane receptor transcriptionally activates human CYP1A1 and CYP1A2 genes through a common regulatory element in the 5'-flanking region | Q38351409 | ||
Dexamethasone suppresses the expression of multiple rat carboxylesterases through transcriptional repression: evidence for an involvement of the glucocorticoid receptor | Q39927144 | ||
Pregnane X receptor protects HepG2 cells from BaP-induced DNA damage | Q39996314 | ||
PPP1R16A, the membrane subunit of protein phosphatase 1beta, signals nuclear translocation of the nuclear receptor constitutive active/androstane receptor | Q40023868 | ||
Vincristine transcriptional regulation of efflux drug transporters in carcinoma cell lines | Q40291045 | ||
Differential regulation of hepatic CYP2B6 and CYP3A4 genes by constitutive androstane receptor but not pregnane X receptor | Q40309271 | ||
Role of CYP3A4 in the regulation of the aryl hydrocarbon receptor by omeprazole sulphide. | Q40383724 | ||
A role for constitutive androstane receptor in the regulation of human intestinal MDR1 expression | Q40399800 | ||
Identification of BCRP as transporter of benzo[a]pyrene conjugates metabolically formed in Caco-2 cells and its induction by Ah-receptor agonists | Q40417118 | ||
Disruption of cell-cell contact maximally but transiently activates AhR-mediated transcription in 10T1/2 fibroblasts | Q40516181 | ||
Nuclear receptors. Lonesome orphans | Q40521372 | ||
Development and refinement of pregnane X receptor (PXR) DNA binding site model using information theory: insights into PXR-mediated gene regulation. | Q40524591 | ||
Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers | Q40587140 | ||
Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor | Q40768989 | ||
Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450. | Q40785589 | ||
The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism | Q40845372 | ||
The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin | Q40851439 | ||
The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module | Q40916686 | ||
Orphan nuclear receptors--the first eight years | Q40922436 | ||
Nuclear uptake of the Ah (dioxin) receptor in response to omeprazole: transcriptional activation of the human CYP1A1 gene. | Q41563459 | ||
Transcriptional activation of cytochrome P450 genes by different classes of chemical inducers | Q41716962 | ||
Induction of mouse UDP-glucuronosyltransferase mRNA expression in liver and intestine by activators of aryl-hydrocarbon receptor, constitutive androstane receptor, pregnane X receptor, peroxisome proliferator-activated receptor alpha, and nuclear fa | Q42133496 | ||
Regulation of Drug Transporter Gene Expression by Nuclear Receptors | Q42439759 | ||
Stimulation of AMP-activated protein kinase is essential for the induction of drug metabolizing enzymes by phenobarbital in human and mouse liver | Q42501625 | ||
Regulation of sulfotransferase enzymes by prototypical microsomal enzyme inducers in mice | Q42521334 | ||
Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta | Q22003994 | ||
SXR, a novel steroid and xenobiotic-sensing nuclear receptor | Q22003995 | ||
Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR | Q24290621 | ||
2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin | Q24294476 | ||
The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions | Q24310512 | ||
A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements | Q24324246 | ||
The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR | Q24554260 | ||
Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene | Q24554439 | ||
Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor | Q24564124 | ||
The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity | Q24630723 | ||
Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction | Q24646162 | ||
Induction of bilirubin clearance by the constitutive androstane receptor (CAR) | Q24683238 | ||
Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor | Q24683260 | ||
Comparison of complete nuclear receptor sets from the human, Caenorhabditis elegans and Drosophila genomes | Q24803733 | ||
The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity | Q27632611 | ||
Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor | Q27641809 | ||
Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha | Q27730245 | ||
The nuclear receptor superfamily: the second decade | Q27860725 | ||
The steroid and thyroid hormone receptor superfamily | Q27861095 | ||
The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene | Q28137778 | ||
A unified nomenclature system for the nuclear receptor superfamily | Q28142509 | ||
Human UDP-glucuronosyltransferases: metabolism, expression, and disease | Q28145608 | ||
Identification of the nuclear receptor CAR:HSP90 complex in mouse liver and recruitment of protein phosphatase 2A in response to phenobarbital | Q28190299 | ||
Organ distribution of multidrug resistance proteins 1, 2, and 3 (Mrp1, 2, and 3) mRNA and hepatic induction of Mrp3 by constitutive androstane receptor activators in rats | Q28191907 | ||
The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism | Q28206406 | ||
Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR | Q28207193 | ||
Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin | Q28211706 | ||
Regulation of the rat glutathione S-transferase A2 gene by glucocorticoids: involvement of both the glucocorticoid and pregnane X receptors | Q28212640 | ||
Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital | Q28212942 | ||
Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes | Q28213013 | ||
Regulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding site | Q28218180 | ||
Differential transactivation by two isoforms of the orphan nuclear hormone receptor CAR | Q28248788 | ||
PXR and CAR in energy metabolism | Q28251686 | ||
An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway | Q28263744 | ||
Primary structure and expression of a functional human glucocorticoid receptor cDNA | Q28282278 | ||
Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation | Q28290595 | ||
Identification of a new class of steroid hormone receptors | Q28294293 | ||
AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line | Q28295835 | ||
Induction of CYP1A2 by phenobarbital in the livers of aryl hydrocarbon-responsive and -nonresponsive mice | Q28370736 | ||
Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands | Q28375193 | ||
Challenges predicting ligand-receptor interactions of promiscuous proteins: the nuclear receptor PXR | Q28472135 | ||
Induction of drug metabolism enzymes and transporters by oltipraz in rats | Q28570858 | ||
Xenobiotic responsive element-mediated transcriptional activation in the UDP-glucuronosyltransferase family 1 gene complex | Q28581823 | ||
Xenobiotic-induced transcriptional regulation of xenobiotic metabolizing enzymes of the cytochrome P450 superfamily in human extrahepatic tissues | Q28645832 | ||
Glutathione transferases | Q29616501 | ||
The PAS superfamily: sensors of environmental and developmental signals | Q29622907 | ||
Expression and induction of CYP1A1/1A2, CYP2A6 and CYP3A4 in primary cultures of human hepatocytes: a 10-year follow-up | Q31420859 | ||
Role reversal: new insights from new ligands for the xenobiotic receptor CAR. | Q31798023 | ||
The transcriptional regulation of the human CYP2C genes | Q33597311 | ||
Orphan nuclear receptors: shifting endocrinology into reverse | Q33604569 | ||
Induction of cytochrome P4501A1. | Q33636653 | ||
Activation of xenobiotic receptors: driving into the nucleus | Q33742134 | ||
Hepatocyte nuclear factor 4{alpha} regulates rifampicin-mediated induction of CYP2C genes in primary cultures of human hepatocytes | Q33754808 | ||
The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene | Q33779787 | ||
Use of the nuclear receptor PXR to predict drug interactions | Q34088796 | ||
Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR). | Q34161577 | ||
Phenobarbital response elements of cytochrome P450 genes and nuclear receptors | Q34192683 | ||
Pregnane X receptor: molecular basis for species differences in CYP3A induction by xenobiotics | Q34241276 | ||
Synergistically enhanced CYP2B6 inducibility between a polymorphic mutation in CYP2B6 promoter and pregnane X receptor activation | Q34310059 | ||
Orphan nuclear receptors: the exotics of xenobiotics. | Q34311554 | ||
Aryl-hydrocarbon receptor activation regulates constitutive androstane receptor levels in murine and human liver | Q42736383 | ||
The aldo-keto reductase Akr1b7 gene is a common transcriptional target of xenobiotic receptors pregnane X receptor and constitutive androstane receptor | Q43065859 | ||
The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR. | Q43601213 | ||
Regulation of the human CYP2B6 gene by the nuclear pregnane X receptor | Q43705734 | ||
Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor | Q43767882 | ||
Organic anion transporting polypeptides, cholestasis, and nuclear receptors | Q43899948 | ||
Induction of rat organic anion transporting polypeptide 2 by pregnenolone-16alpha-carbonitrile is via interaction with pregnane X receptor | Q43922034 | ||
Identification of a defect in the UGT1A1 gene promoter and its association with hyperbilirubinemia | Q43924893 | ||
Role of constitutive androstane receptor in the in vivo induction of Mrp3 and CYP2B1/2 by phenobarbital. | Q44068586 | ||
Effects of dexamethasone on aryl (SULT1A1)- and hydroxysteroid (SULT2A1)-sulfotransferase gene expression in primary cultured human hepatocytes | Q44094353 | ||
Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification | Q44104285 | ||
Involvement of the xenobiotic response element (XRE) in Ah receptor-mediated induction of human UDP-glucuronosyltransferase 1A1. | Q44302135 | ||
A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression | Q44305000 | ||
Tissue mRNA expression of the rat UDP-glucuronosyltransferase gene family | Q44313288 | ||
Genetic profiling defines the xenobiotic gene network controlled by the nuclear receptor pregnane X receptor | Q44381593 | ||
Nuclear receptor, pregname X receptor, is required for induction of UDP-glucuronosyltranferases in mouse liver by pregnenolone-16 alpha-carbonitrile | Q44483245 | ||
Identification of constitutive androstane receptor and glucocorticoid receptor binding sites in the CYP2C19 promoter | Q44517600 | ||
Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity | Q44552108 | ||
Contribution of the Ah receptor to the phenolic antioxidant-mediated expression of human and rat UDP-glucuronosyltransferase UGT1A6 in Caco-2 and rat hepatoma 5L cells | Q44569047 | ||
Activation of the Ah receptor signal transduction pathway by bilirubin and biliverdin | Q44570441 | ||
Hepatic CYP2B6 expression: gender and ethnic differences and relationship to CYP2B6 genotype and CAR (constitutive androstane receptor) expression | Q44613137 | ||
Cytoplasmic Accumulation of the Nuclear Receptor CAR by a Tetratricopeptide Repeat Protein in HepG2 Cells | Q44628543 | ||
Induction of Human CYP2C9 by Rifampicin, Hyperforin, and Phenobarbital Is Mediated by the Pregnane X Receptor | Q44644004 | ||
A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification | Q44741483 | ||
The nuclear receptor CAR is a regulator of thyroid hormone metabolism during caloric restriction | Q44788639 | ||
The constitutive active/androstane receptor regulates phenytoin induction of Cyp2c29. | Q44904904 | ||
Enhanced acetaminophen toxicity by activation of the pregnane X receptor | Q45085024 | ||
Role of the constitutive androstane receptor in xenobiotic-induced thyroid hormone metabolism | Q45162999 | ||
Regulation of human hepatic hydroxysteroid sulfotransferase gene expression by the peroxisome proliferator-activated receptor alpha transcription factor | Q45213487 | ||
Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin | Q45261165 | ||
Orphan nuclear receptors--new ligands and new possibilities. | Q46247763 | ||
Lipopolysaccharide treatment downregulates the expression of the pregnane X receptor, cyp3a11 and mdr1a genes in mouse placenta | Q46470937 | ||
CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice | Q46573657 | ||
[[Inflammation and drug metabolism: NF-kappB and the CAR and PXR xeno-receptors]. | Q46707658 | ||
Orphan nuclear receptor pregnane X receptor sensitizes oxidative stress responses in transgenic mice and cancerous cells | Q46728757 | ||
Multidrug resistance associated proteins as determining factors of pharmacokinetics and pharmacodynamics of drugs | Q46791084 | ||
Differential regulation of individual sulfotransferase isoforms by phenobarbital in male rat liver | Q47710611 | ||
Pyrene-induced CYP1A2 and SULT1A1 may be regulated by CAR and not by AhR. | Q50086354 | ||
Induction of human CYP2A6 is mediated by the pregnane X receptor with peroxisome proliferator-activated receptor-gamma coactivator 1alpha | Q50092212 | ||
Induction of rat UDP-glucuronosyltransferases in liver and duodenum by microsomal enzyme inducers that activate various transcriptional pathways | Q50092240 | ||
Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes | Q50092409 | ||
Ontogeny and hormonal basis of female-dominant rat hepatic sulfotransferases. | Q51001579 | ||
Characterization of a steroid hormone receptor gene and mRNA in wild-type and mutant cells | Q59071105 | ||
Positive and Negative Regulation of Human Hepatic Hydroxysteroid Sulfotransferase (SULT2A1) Gene Transcription by Rifampicin: Roles of Hepatocyte Nuclear Factor 4 and Pregnane X Receptor | Q62009086 | ||
Enhancement of glucuronide-conjugating capacity in a hyperbilirubinemic infant due to apparent enzyme induction by phenobarbital | Q72169069 | ||
Evidence for the ligand-independent activation of the AH receptor | Q72200627 | ||
Differential induction of rat hepatic cytochrome P-448 and glutathione S-transferase B messenger RNAs by 3-methylcholanthrene | Q72664542 | ||
An okadaic acid-sensitive pathway involved in the phenobarbital-mediated induction of CYP2B gene expression in primary rat hepatocyte cultures | Q73599278 | ||
Effect of phenobarbital on hepatic CYP1A1 and CYP1A2 in the Ahr-null mouse | Q74113890 | ||
Nuclear translocation of adenoviral-enhanced yellow fluorescent protein-tagged-human constitutive androstane receptor (hCAR): a novel tool for screening hCAR activators in human primary hepatocytes | Q37195534 | ||
Regulation of tissue-specific carboxylesterase expression by pregnane x receptor and constitutive androstane receptor. | Q37233837 | ||
Novel orphan nuclear receptors-coregulator interactions controlling anti-cancer drug metabolism | Q37264630 | ||
Pyrethroid insecticides: isoform-dependent hydrolysis, induction of cytochrome P450 3A4 and evidence on the involvement of the pregnane X receptor | Q37308959 | ||
The mycoestrogen zearalenone induces CYP3A through activation of the pregnane X receptor | Q34312427 | ||
Ketoconazole and miconazole are antagonists of the human glucocorticoid receptor: consequences on the expression and function of the constitutive androstane receptor and the pregnane X receptor. | Q34512866 | ||
Regulation of xenobiotic and bile acid metabolism by the nuclear pregnane X receptor | Q34563453 | ||
Reactions and significance of cytochrome P-450 enzymes | Q34659868 | ||
Broad but distinct role of pregnane x receptor on the expression of individual cytochrome p450s in human hepatocytes | Q34683339 | ||
PXR, CAR and drug metabolism | Q34743280 | ||
Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes | Q34946568 | ||
Regulation of UDP glucuronosyltransferase genes. | Q35137540 | ||
Drug-activated nuclear receptors CAR and PXR. | Q35160978 | ||
Phenytoin induction of the cyp2c37 gene is mediated by the constitutive androstane receptor | Q35185572 | ||
Induction of drug metabolism: the role of nuclear receptors. | Q35600898 | ||
Role of orphan nuclear receptors in the regulation of drug-metabolising enzymes. | Q35607530 | ||
Transcriptional regulation of cytochrome p450 2B genes by nuclear receptors | Q35610663 | ||
ATP hydrolysis-dependent multidrug efflux transporter: MDR1/P-glycoprotein. | Q35668161 | ||
Nuclear receptors CAR and PXR in the regulation of hepatic metabolism | Q35842802 | ||
Mechanism of the nuclear receptor molecular switch | Q35846738 | ||
Drug interactions with St John's wort : mechanisms and clinical implications | Q35879020 | ||
Induction of phase I, II and III drug metabolism/transport by xenobiotics | Q36099291 | ||
A historical overview of the heterologous expression of mammalian UDP-glucuronosyltransferase isoforms over the past twenty years. | Q36107711 | ||
Regulation of sulfotransferases by xenobiotic receptors | Q36230589 | ||
Regulation of hepatic transporters by xenobiotic receptors | Q36230593 | ||
CAR, the continuously advancing receptor, in drug metabolism and disease | Q36230600 | ||
Orphan nuclear receptors adopted by crystallography | Q36303202 | ||
Coordinate regulation of hepatic bile acid oxidation and conjugation by nuclear receptors | Q36495779 | ||
PXR and CAR: nuclear receptors which play a pivotal role in drug disposition and chemical toxicity | Q36551142 | ||
Structure, function and regulation of carboxylesterases | Q36571225 | ||
Role of the aryl hydrocarbon receptor in drug metabolism | Q36572621 | ||
Nuclear receptors and the regulation of drug-metabolizing enzymes and drug transporters: implications for interindividual variability in response to drugs | Q36795136 | ||
Molecular mechanism of phase I and phase II drug-metabolizing enzymes: implications for detoxification | Q36812605 | ||
The peripheral benzodiazepine receptor ligand 1-(2-chlorophenyl-methylpropyl)-3-isoquinoline-carboxamide is a novel antagonist of human constitutive androstane receptor | Q36925723 | ||
PXR: a xenobiotic receptor of diverse function implicated in pharmacogenetics | Q36995453 | ||
The roles of nuclear receptors CAR and PXR in hepatic energy metabolism | Q37096480 | ||
Identification of pregnane-X receptor target genes and coactivator and corepressor binding to promoter elements in human hepatocytes | Q37118793 | ||
Genetic and molecular analysis of the Ah receptor and of Cyp1a1 gene expression | Q37178974 | ||
P433 | issue | 13 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | metabolic inactivation | Q70681625 |
P304 | page(s) | 1238-1249 | |
P577 | publication date | 2010-08-17 | |
P1433 | published in | Advanced Drug Delivery Reviews | Q2825362 |
P1476 | title | Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR | |
P478 | volume | 62 |
Q64900450 | A current structural perspective on PXR and CAR in drug metabolism. |
Q99588646 | A two-dimensional multiwell cell culture method for the production of CYP3A4-expressing hepatocyte-like cells from HepaRG cells |
Q46419870 | Activating nuclear xenobiotic receptors and triggering ER stress and hepatic cytochromes P450 systems in quails (Coturnix C. coturnix) during atrazine exposure |
Q48233954 | Activation of nuclear receptor CAR by an environmental pollutant perfluorooctanoic acid. |
Q34313944 | Activation of pregnane X receptor by pregnenolone 16 α-carbonitrile prevents high-fat diet-induced obesity in AKR/J mice |
Q38990036 | Activation of the constitutive androstane receptor inhibits gluconeogenesis without affecting lipogenesis or fatty acid synthesis in human hepatocytes |
Q34905038 | Adaptive and specialised transcriptional responses to xenobiotic stress in Caenorhabditis elegans are regulated by nuclear hormone receptors |
Q90814523 | Alflutinib (AST2818), primarily metabolized by CYP3A4, is a potent CYP3A4 inducer |
Q35148413 | An enhanced in vivo stable isotope labeling by amino acids in cell culture (SILAC) model for quantification of drug metabolism enzymes. |
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Q50026342 | Atropisomers of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) exhibit stereoselective effects on activation of nuclear receptors in vitro |
Q38763334 | Bisphenol a induces steatosis in HepaRG cells using a model of perinatal exposure. |
Q90248911 | CYP2B6*6 Genotype Specific Differences in Artemether-Lumefantrine Disposition in Healthy Volunteers |
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Q51016323 | Circadian Clock Is Involved in Regulation of Hepatobiliary Transport Mediated by Multidrug Resistance-Associated Protein 2. |
Q40766725 | Cobicistat versus ritonavir boosting and differences in the drug-drug interaction profiles with co-medications. |
Q41791565 | Constitutive androstane receptor activation promotes bilirubin clearance in a murine model of alcoholic liver disease |
Q47628268 | Constitutive expression and phenobarbital modulation of drug metabolizing enzymes and related nuclear receptors in cattle liver and extra-hepatic tissues |
Q64272623 | Convergent gene losses illuminate metabolic and physiological changes in herbivores and carnivores |
Q28397217 | Cytochrome P450-mediated drug metabolism in the brain |
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Q37079343 | Developmental changes in the transcriptome of the rat choroid plexus in relation to neuroprotection |
Q88626358 | Developmental regulation of kidney and liver solute carrier and ATP-binding cassette drug transporters and drug metabolizing enzymes: the role of remote organ communication |
Q38631590 | Dietary Isoflavones as Modulators of Drug Metabolizing Enzymes and Transporters: Effect on Prescription Medicines |
Q37901060 | Drug interactions in African herbal remedies |
Q50042411 | Effect of Single Nucleotide Polymorphisms in the Xenobiotic-sensing Receptors NR1I2 and NR1I3 on the Pharmacokinetics and Toxicity of Irinotecan in Colorectal Cancer Patients |
Q38307386 | Effect of dietary α-lipoic acid on the mRNA expression of genes involved in drug metabolism and antioxidation system in rat liver |
Q38376011 | Effect of pregnane X receptor expression on drug resistance in breast cancer |
Q57114013 | Effects of Vitamin K₂ on the Expression of Genes Involved in Bile Acid Synthesis and Glucose Homeostasis in Mice with Humanized PXR |
Q36642371 | Effects on gene expression in rat liver after administration of RXR agonists: UAB30, 4-methyl-UAB30, and Targretin (Bexarotene). |
Q92886852 | Emerging roles of bile acids in mucosal immunity and inflammation |
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Q64958249 | Evolutionary Plasticity in Detoxification Gene Modules: The Preservation and Loss of the Pregnane X Receptor in Chondrichthyes Lineages. |
Q33636734 | Evolutionary history and functional characterization of the amphibian xenosensor CAR. |
Q50050787 | Expression and functional regulation of the nuclear receptors AHR, PXR, and CAR, and the transcription factor Nrf2 in rat parotid gland |
Q37249054 | Expression and functional relevance of UGT1A4 in a cohort of human drug-resistant epileptic brains |
Q42283655 | Expression of membrane drug efflux transporters in the sigmoid colon of HIV-infected and uninfected men. |
Q37537458 | Flame retardant BDE-47 effectively activates nuclear receptor CAR in human primary hepatocytes. |
Q33767261 | Fluorometric evaluation of CYP3A4 expression using improved transgenic HepaRG cells carrying a dual-colour reporter for CYP3A4 and CYP3A7. |
Q28486732 | Gene expression variability in human hepatic drug metabolizing enzymes and transporters |
Q47417355 | Hepatic and hippocampal cytochrome P450 enzyme overexpression during spontaneous recurrent seizures. |
Q91523394 | Hepatic transcriptomics analysis reveals that fructose intervention down-regulated xenobiotics-metabolising enzymes through aryl hydrocarbon receptor signalling suppression in C57BL/6N mice |
Q35202603 | High ABCC2 and low ABCG2 gene expression are early events in the colorectal adenoma-carcinoma sequence |
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Q50923092 | High-throughput evaluation method for drug association with pregnane X receptor (PXR) using differential scanning fluorometry. |
Q28468630 | Histone deacetylase inhibitors regulate P-gp expression in colorectal cancer via transcriptional activation and mRNA stabilization |
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Q35575682 | Identification of chemical modulators of the constitutive activated receptor (CAR) in a gene expression compendium |
Q38178585 | Impact of new-generation lipid emulsions on cellular mechanisms of parenteral nutrition-associated liver disease |
Q37189459 | In vitro Effects of Four Native Brazilian Medicinal Plants in CYP3A4 mRNA Gene Expression, Glutathione Levels, and P-Glycoprotein Activity |
Q38057372 | Induction of cytochrome P450 enzymes: a view on human in vivo findings |
Q51137347 | Influence of a critical single nucleotide polymorphism on nuclear receptor PXR-promoter function. |
Q38402177 | Influence of multidrug resistance and drug transport proteins on chemotherapy drug metabolism |
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Q47424488 | Lack of CAR impacts neuronal function and cerebrovascular integrity in vivo. |
Q58612379 | Long-term efavirenz pharmacokinetics is comparable between Tanzanian HIV and HIV/Tuberculosis patients with the same CYP2B6*6 genotype |
Q27022545 | Marine invertebrate xenobiotic-activated nuclear receptors: their application as sensor elements in high-throughput bioassays for marine bioactive compounds |
Q50039756 | Mechanisms of Action Point Towards Combined PBDE/NDL-PCB Risk Assessment |
Q38733688 | Mechanisms of xenobiotic receptor activation: Direct vs. indirect |
Q37553490 | Metformin represses drug-induced expression of CYP2B6 by modulating the constitutive androstane receptor signaling |
Q36618667 | MicroRNA Pharmacoepigenetics: Posttranscriptional Regulation Mechanisms behind Variable Drug Disposition and Strategy to Develop More Effective Therapy |
Q48381016 | Modulation of bilirubin neurotoxicity by the Abcb1 transporter in the Ugt1-/- lethal mouse model of neonatal hyperbilirubinemia. |
Q38820078 | Molecular Basis of Metabolism-Mediated Conversion of PK11195 from an Antagonist to an Agonist of the Constitutive Androstane Receptor |
Q36549795 | Molecular Interactions between NAFLD and Xenobiotic Metabolism. |
Q88788556 | Nonalcoholic Fatty Liver Disease and Diabetes Are Associated with Decreased CYP3A4 Protein Expression and Activity in Human Liver |
Q34946639 | Notoginsenoside R1 attenuates experimental inflammatory bowel disease via pregnane X receptor activation |
Q42198485 | Novel complex of HAT protein TIP60 and nuclear receptor PXR promotes cell migration and adhesion |
Q36245600 | Novel understanding of ABC transporters ABCB1/MDR/P-glycoprotein, ABCC2/MRP2, and ABCG2/BCRP in colorectal pathophysiology |
Q59797226 | Nuclear Receptor Metabolism of Bile Acids and Xenobiotics: A Coordinated Detoxification System with Impact on Health and Diseases |
Q37130938 | Nuclear Receptors in Drug Metabolism, Drug Response and Drug Interactions |
Q37835926 | Nuclear receptor PXR, transcriptional circuits and metabolic relevance |
Q38768048 | Nuclear receptors and nonalcoholic fatty liver disease |
Q35919726 | Nuclear receptors in the multidrug resistance through the regulation of drug-metabolizing enzymes and drug transporters. |
Q91272344 | Nutritional status modifies pregnane X receptor regulated transcriptome |
Q38845179 | Obatoclax as a perpetrator in drug-drug interactions and its efficacy in multidrug resistance cell lines |
Q90704733 | Oleanolic Acid and Ursolic Acid Induce UGT1A1 Expression in HepG2 Cells by Activating PXR Rather Than CAR |
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