An interleukin-6 receptor-dependent molecular switch mediates signal transduction of the IL-27 cytokine subunit p28 (IL-30) via a gp130 protein receptor homodimer

scientific article published on 3 December 2012

An interleukin-6 receptor-dependent molecular switch mediates signal transduction of the IL-27 cytokine subunit p28 (IL-30) via a gp130 protein receptor homodimer is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M112.432955
P932PMC publication ID3567685
P698PubMed publication ID23209286

P50authorJoachim GrötzingerQ28322146
Christoph GarbersQ37838064
Samadhi Aparicio-SiegmundQ47008826
Stefan Rose-JohnQ47812749
Christoph HölscherQ91743109
P2093author name stringGeorg H Waetzig
Joachim Grötzinger
Jürgen Scheller
Björn Spudy
Inken Lorenzen
Jan Sommer
Samadhi Aparicio-Siegmund
P2860cites workSignaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNFQ24297991
WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27Q24307411
Therapeutic strategies for the clinical blockade of IL-6/gp130 signalingQ27002391
IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cellsQ28214882
Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responsesQ28634282
A designer hyper interleukin 11 (H11) is a biologically active cytokine.Q33400335
A role for IL-27p28 as an antagonist of gp130-mediated signalingQ34688139
Viral Interleukin-6: Structure, pathophysiology and strategies of neutralizationQ37822972
The pro- and anti-inflammatory properties of the cytokine interleukin-6.Q37836084
ADAM17: a molecular switch to control inflammation and tissue regenerationQ37900757
New directions in the basic and translational biology of interleukin-27Q37969347
Plasticity and cross-talk of interleukin 6-type cytokinesQ38010926
Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptorQ39459586
The IL-27 p28 subunit binds cytokine-like factor 1 to form a cytokine regulating NK and T cell activities requiring IL-6R for signalingQ39771489
Interleukin 27 induces differentiation of neural C6-precursor cells into astrocytes.Q40062244
No inhibition of IL-27 signaling by soluble gp130.Q40479437
Soluble receptors for cytokines and growth factors: generation and biological functionQ40656511
Unraveling viral interleukin-6 binding to gp130 and activation of STAT-signaling pathways independently of the interleukin-6 receptorQ41839982
Interleukin-30: A novel antiinflammatory cytokine candidate for prevention and treatment of inflammatory cytokine-induced liver injuryQ42007477
Dynamics of the gp130 cytokine complex: a model for assembly on the cellular membraneQ42158045
Complex of soluble human IL-6-receptor/IL-6 up-regulates expression of acute-phase proteinsQ42816476
Structure-guided optimization of the interleukin-6 trans-signaling antagonist sgp130.Q51787521
Processing of tumour necrosis factor-α precursor by metalloproteinasesQ59059630
Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophilsQ62658841
A bioactive designer cytokine for human hematopoietic progenitor cell expansionQ62658923
Interleukin-6 signal transducer gp130 has specific binding sites for different cytokines as determined by antagonistic and agonistic anti-gp130 monoclonal antibodiesQ70911145
Anti-gp130 transducer monoclonal antibodies specifically inhibiting ciliary neurotrophic factor, interleukin-6, interleukin-11, leukemia inhibitory factor or oncostatin MQ71001742
WSX-1 is required for the initiation of Th1 responses and resistance to L. major infectionQ74840049
P433issue6
P407language of work or nameEnglishQ1860
P1104number of pages9
P304page(s)4346-4354
P577publication date2012-12-03
P1433published inJournal of Biological ChemistryQ867727
P1476titleAn interleukin-6 receptor-dependent molecular switch mediates signal transduction of the IL-27 cytokine subunit p28 (IL-30) via a gp130 protein receptor homodimer
P478volume288

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