A VEGF/JAK2/STAT5 axis may partially mediate endothelial cell tolerance to hypoxia

scientific article published on September 2005

A VEGF/JAK2/STAT5 axis may partially mediate endothelial cell tolerance to hypoxia is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1042/BJ20050351
P932PMC publication ID1198922
P698PubMed publication ID15918795
P5875ResearchGate publication ID7822597

P50authorJames Donovan BestQ86690869
David M ThomasQ64605553
P2093author name stringDavid Thomas
Andrew C Dudley
Alicia Jenkins
P2860cites workMacrovascular and microvascular endothelium during long-term hypoxia: alterations in cell growth, monolayer permeability, and cell surface coagulant propertiesQ68187303
Decreased deformability of polymorphonuclear leukocytes in diabetic catsQ71806171
Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlationQ73034285
Aminoguanidine and the effects of modified LDL on cultured retinal capillary cellsQ73640418
Vascular endothelial growth factor activates STAT proteins in aortic endothelial cellsQ74232904
Fas ligand (CD95 ligand) controls angiogenesis beneath the retinaQ74623258
Activation of the Janus kinase/signal transducer and activator of transcription pathway by osmotic shockQ77171959
Vascular permeability factor/vascular endothelial growth factor and the significance of microvascular hyperpermeability in angiogenesisQ77808299
Inverse correlation between apoptotic (Fas ligand, caspase-3) and angiogenic factors (VEGF, microvessel density) in squamous cell lung carcinomasQ78199502
VEGF, VEGFRs expressions and activated STATs in ovarian epithelial carcinomaQ80531924
Modulation of gene expression by hypoxia in human umbilical cord vein endothelial cells: A transcriptomic and proteomic studyQ24294853
The STATs in cell stress-type responsesQ24799716
Signaling through the JAK/STAT pathway, recent advances and future challengesQ28201804
Oxidative stress triggers STAT3 tyrosine phosphorylation and nuclear translocation in human lymphocytesQ28377588
Hypoxia predisposes neonatal rat ventricular myocytes to apoptosis induced by activation of the Fas (CD95/Apo-1) receptor: Fas activation and apoptosis in hypoxic myocytesQ28564545
Constitutive nuclear localization of Janus kinases 1 and 2Q28565323
The STATs of cancer--new molecular targets come of ageQ29614601
Stat3 as an oncogeneQ29614606
Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesisQ29617644
VEGF-TRAP(R1R2) suppresses choroidal neovascularization and VEGF-induced breakdown of the blood-retinal barrierQ33186480
Transcriptional regulation of the heat shock protein genes by STAT family transcription factors.Q33706908
Induction of apoptosis and Fas receptor/Fas ligand expression by ischemia/reperfusion in cardiac myocytes requires serine 727 of the STAT-1 transcription factor but not tyrosine 701.Q33942943
Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disordersQ34292807
Activated STAT-1 pathway in the myocardium as a novel therapeutic target in ischaemia/reperfusion injuryQ35041141
STAT-1: a novel regulator of apoptosisQ35641356
Activation of the STAT signaling pathway can cause expression of caspase 1 and apoptosisQ36571893
Stress-induced phosphorylation of STAT1 at Ser727 requires p38 mitogen-activated protein kinase whereas IFN-gamma uses a different signaling pathwayQ36704173
Inhibition of Bcr-Abl kinase activity by PD180970 blocks constitutive activation of Stat5 and growth of CML cellsQ38359739
Inhibition of the Jak/STAT signaling pathway prevents the high glucose-induced increase in tgf-beta and fibronectin synthesis in mesangial cells.Q38360469
Constitutive activation of Stat3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cellsQ38360859
Vascular endothelial growth factor (VEGF) and ovarian carcinoma cell supernatant activate signal transducers and activators of transcription (STATs) via VEGF receptor-2 (KDR) in human hemopoietic progenitor cellsQ40533870
Janus kinase (Jak) subcellular localization revisited: the exclusive membrane localization of endogenous Janus kinase 1 by cytokine receptor interaction uncovers the Jak.receptor complex to be equivalent to a receptor tyrosine kinaseQ40559879
Inhibition of transcription factor Stat5 induces cell death of human prostate cancer cellsQ40651643
Constitutive activation of Jak2 contributes to proliferation and resistance to apoptosis in NPM/ALK-transformed cellsQ40656057
Inhibition of constitutive STAT3 activity sensitizes resistant non-Hodgkin's lymphoma and multiple myeloma to chemotherapeutic drug-mediated apoptosis.Q40676058
Endothelial cells downregulate expression of the 70 kDa heat shock protein during hypoxia.Q40865932
Human IL-3 stimulates endothelial cell motility and promotes in vivo new vessel formationQ40936743
Oxygen distribution and consumption in the cat retina during normoxia and hypoxemiaQ42976565
The carboxyl-terminal activation domain of the STAT-1 transcription factor enhances ischemia/reperfusion-induced apoptosis in cardiac myocytesQ44132497
Erythropoietin is involved in growth and angiogenesis in malignant tumours of female reproductive organsQ44207698
Increased retinal neovascularization in Fas ligand-deficient miceQ44489879
STAT signaling in ischemic heart: a role of STAT5A in ischemic preconditioningQ44513055
Mechanisms of hypoxia-induced endothelial cell death. Role of p53 in apoptosisQ44557964
Nuclear translocation of phosphorylated STAT3 is essential for vascular endothelial growth factor-induced human dermal microvascular endothelial cell migration and tube formationQ47745076
Regulation of Fas ligand expression by vascular endothelial growth factor in endometrial stromal cells in vitroQ47792995
Cooperation between STAT3 and c-jun suppresses Fas transcription.Q50335898
Opposing actions of STAT-1 and STAT-3 on the Bcl-2 and Bcl-x promoters.Q55033997
P433issuePt 2
P407language of work or nameEnglishQ1860
P921main subjectendotheliumQ111140
hypoxiaQ105688
P304page(s)427-436
P577publication date2005-09-01
P1433published inBiochemical JournalQ864221
P1476titleA VEGF/JAK2/STAT5 axis may partially mediate endothelial cell tolerance to hypoxia
P478volume390