Involvement of heparanase in the pathogenesis of acute kidney injury: nephroprotective effect of PG545.

scientific article published on 25 March 2017

Involvement of heparanase in the pathogenesis of acute kidney injury: nephroprotective effect of PG545. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.18632/ONCOTARGET.16573
P932PMC publication ID5470960
P698PubMed publication ID28388547

P50authorValentina MasolaQ30513702
Gianluigi ZazaQ37635234
Maurizio OnistoQ60966024
P2093author name stringSamuel N Heyman
Antonio Lupo
Israel Vlodavsky
Neta Ilan
Preeti Singh
Edward Hammond
Iyad Khamaysi
Zaid Abassi
Shadi Hamoud
Ahmad Hassan
Gloria Bellin
Omri Nativ
Rabia Shekh Muhammad
Giovani Gambaro
P2860cites workAcute renal failure: definitions, diagnosis, pathogenesis, and therapyQ24563291
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PG545, a heparan sulfate mimetic, reduces heparanase expression in vivo, blocks spontaneous metastases and enhances overall survival in the 4T1 breast carcinoma modelQ27327191
Impact of heparanase on renal fibrosisQ28083753
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Newly generated heparanase knock-out mice unravel co-regulation of heparanase and matrix metalloproteinasesQ28475274
Functions of cell surface heparan sulfate proteoglycansQ29618521
Cathepsin L is responsible for processing and activation of proheparanase through multiple cleavages of a linker segmentQ33331276
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In vivo fragmentation of heparan sulfate by heparanase overexpression renders mice resistant to amyloid protein A amyloidosisQ33772163
Heparanase levels are elevated in the urine and plasma of type 2 diabetes patients and associate with blood glucose levelsQ33834001
Renal response to tissue injury: lessons from heme oxygenase-1 GeneAblation and expressionQ33894514
Heparanase: a key enzyme involved in cell invasionQ34183747
Pathophysiology of ischemic acute renal failureQ34275833
Elevated urine heparanase levels are associated with proteinuria and decreased renal allograft functionQ34426913
PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical modelsQ34627931
Mammalian heparanase: what is the message?Q34652072
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Heparanase: A Potential New Factor Involved in the Renal Epithelial Mesenchymal Transition (EMT) Induced by Ischemia/Reperfusion (I/R) InjuryQ36088435
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Macrophage activation by heparanase is mediated by TLR-2 and TLR-4 and associates with plaque progressionQ36542354
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Heparanase: roles in cell survival, extracellular matrix remodelling and the development of kidney diseaseQ39120713
Role of heparanase-driven inflammatory cascade in pathogenesis of diabetic nephropathyQ39162263
Tubular epithelial syndecan-1 maintains renal function in murine ischemia/reperfusion and human transplantationQ39413604
Acute kidney injury, mortality, length of stay, and costs in hospitalized patientsQ39730814
Heparanase is essential for the development of diabetic nephropathy in mice.Q39782778
Regulation of glomerular heparanase expression by aldosterone, angiotensin II and reactive oxygen species.Q39853500
Endothelin-1 Induces Proteinuria by Heparanase-Mediated Disruption of the Glomerular GlycocalyxQ39879255
Increased expression of heparanase in puromycin aminonucleoside nephrosisQ40778136
Inducible expression of Egr-1-dependent genes. A paradigm of transcriptional activation in vascular endotheliumQ41604083
Mechanisms of heparanase inhibition by the heparan sulfate mimetic PG545 and three structural analoguesQ41817665
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Transgenic expression of mammalian heparanase uncovers physiological functions of heparan sulfate in tissue morphogenesis, vascularization, and feeding behaviorQ44760488
Heparanase-1 gene expression and regulation by high glucose in renal epithelial cells: a potential role in the pathogenesis of proteinuria in diabetic patientsQ46570573
The road from AKI to CKD: the role of endothelinQ46709379
Heparanase is involved in the pathogenesis of proteinuria as a result of glomerulonephritisQ47298666
Experimental ischemia-reperfusion: biases and myths-the proximal vs. distal hypoxic tubular injury debate revisited.Q53060383
Induction of glomerular heparanase expression in rats with adriamycin nephropathy is regulated by reactive oxygen species and the renin-angiotensin system.Q53606143
Acute renal failureQ54139071
Heparanase inhibition reduces proteinuria in a model of accelerated anti-glomerular basement membrane antibody disease.Q54664919
Heparanase Is Essential for the Development of Acute Experimental GlomerulonephritisQ57789449
Gene expression for endothelins and their receptors in glomeruli of diabetic ratsQ72855454
Identification of Neutrophil Gelatinase-Associated Lipocalin as a Novel Early Urinary Biomarker for Ischemic Renal InjuryQ79091417
Increased expression of heparanase in overt diabetic nephropathyQ79272921
A synthetic heparanase inhibitor reduces proteinuria in passive Heymann nephritisQ80907742
Urinary heparanase activity in patients with Type 1 and Type 2 diabetesQ83082153
P433issue21
P407language of work or nameEnglishQ1860
P921main subjectacute kidney injuryQ424337
P304page(s)34191-34204
P577publication date2017-05-01
P1433published inOncotargetQ1573155
P1476titleInvolvement of heparanase in the pathogenesis of acute kidney injury: nephroprotective effect of PG545
P478volume8

Reverse relations

cites work (P2860)
Q92925933Endothelial glycocalyx as a potential theriapeutic target in organ injuries
Q59799492Inhibition of heparanase protects against chronic kidney dysfunction following ischemia/reperfusion injury
Q64237303Ligustrazin increases lung cell autophagy and ameliorates paraquat-induced pulmonary fibrosis by inhibiting PI3K/Akt/mTOR and hedgehog signalling via increasing miR-193a expression
Q47377873Opposing Functions of Heparanase-1 and Heparanase-2 in Cancer Progression
Q89965719The Heparan Sulfate Mimetic PG545 Modulates T Cell Responses and Prevents Delayed-Type Hypersensitivity
Q99712217The Yin and Yang of Alarmins in Regulation of Acute Kidney Injury

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