Small-molecule inhibitors at the PSD-95/nNOS interface have antidepressant-like properties in mice.

scientific article published on 27 February 2013

Small-molecule inhibitors at the PSD-95/nNOS interface have antidepressant-like properties in mice. is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1001793951
P356DOI10.1038/NPP.2013.57
P8608Fatcat IDrelease_p5liqhcxtvcupk4vfgiruejwsm
P932PMC publication ID3682152
P698PubMed publication ID23446451
P5875ResearchGate publication ID235749924

P50authorAndrew HarkinQ43111042
Kumlesh K. DevQ50421348
Terri A LevineQ58888171
P2093author name stringMarika V Doucet
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PSD-95 assembles a ternary complex with the N-methyl-D-aspartic acid receptor and a bivalent neuronal NO synthase PDZ domainQ40928878
Selective inhibitors of neuronal nitric oxide synthase--is no NOS really good NOS for the nervous system?Q41534673
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Treatment of cerebral ischemia by disrupting ischemia-induced interaction of nNOS with PSD-95.Q42794015
Involvement of serotonin receptor subtypes in the antidepressant-like effect of TRIM in the rat forced swimming testQ43156061
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Antidepressant- and anxiolytic-like effects of selective neuronal NOS inhibitor 1-(2-trifluoromethylphenyl)-imidazole in miceQ44366974
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Involvement of NMDA receptors and L-arginine-nitric oxide pathway in the antidepressant-like effects of zinc in mice.Q44567452
Nitric oxide synthase inhibitors augment the effects of serotonin re-uptake inhibitors in the forced swimming testQ44910806
Ketamine treatment reverses behavioral and physiological alterations induced by chronic mild stress in rats.Q46014089
Effects of neuronal and inducible NOS inhibitor 1-[2-(trifluoromethyl) phenyl] imidazole (TRIM) in unpredictable chronic mild stress procedure in miceQ46235950
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Effects of nitric oxide synthase inhibitors 1-(2-trifluoromethylphenyl)--imidazole (TRIM) and 7-nitroindazole (7-NI) on learning and memory in miceQ48137438
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7-Nitroindazole, a neuronal nitric oxide synthase inhibitor, impairs passive-avoidance and elevated plus-maze memory performance in rats.Q50895784
Nitric oxide synthase inhibitors impair reference memory formation in a radial arm maze task in rats.Q52038363
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Antidepressant-like actions of an AMPA receptor potentiator (LY392098).Q53972514
Nitric oxide synthases: structure, function and inhibitionQ55951119
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Evidence for dual effects of nitric oxide in the forced swimming test and in the tail suspension test in miceQ73298429
Nitric oxide synthase inhibitors have antidepressant-like properties in mice. 1. Acute treatments are active in the forced swim testQ77965235
P433issue8
P407language of work or nameEnglishQ1860
P304page(s)1575-1584
P577publication date2013-02-27
P1433published inNeuropsychopharmacologyQ2261280
P1476titleSmall-molecule inhibitors at the PSD-95/nNOS interface have antidepressant-like properties in mice
P478volume38

Reverse relations

cites work (P2860)
Q40733593Biochemical investigations of the mechanism of action of small molecules ZL006 and IC87201 as potential inhibitors of the nNOS-PDZ/PSD-95-PDZ interactions
Q33635613Delineation of molecular pathway activities of the chronic antidepressant treatment response suggests important roles for glutamatergic and ubiquitin-proteasome systems
Q38245421Dissecting the role of polarity regulators in cancer through the use of mouse models.
Q35162554Effect of the fragrance inhalation of essential oil from Asarum heterotropoides on depression-like behaviors in mice.
Q37699516Efficient Binding of the NOS1AP C-Terminus to the nNOS PDZ Pocket Requires the Concerted Action of the PDZ Ligand Motif, the Internal ExF Site and Structural Integrity of an Independent Element
Q40569105Fluorination Effects on NOS Inhibitory Activity of Pyrazoles Related to Curcumin.
Q37559823Ketamine as antidepressant? Current state and future perspectives
Q36010727Mas-Related Gene (Mrg) C Activation Attenuates Bone Cancer Pain via Modulating Gi and NR2B
Q35586357NMDA receptor subunits and associated signaling molecules mediating antidepressant-related effects of NMDA-GluN2B antagonism
Q92102996PDZ Domains as Drug Targets
Q58708002PSD-95-nNOS Coupling Regulates Contextual Fear Extinction in the Dorsal CA3
Q58783067PSD95 and nNOS interaction as a novel molecular target to modulate conditioned fear: relevance to PTSD
Q37330439Purine and pyrimidine metabolism: Convergent evidence on chronic antidepressant treatment response in mice and humans
Q42052984Regional Specific Modulation of Stress-Induced Neuronal Activation Associated with the PSD95/NOS Interaction Inhibitor ZL006 in the Wistar Kyoto Rat.
Q35962657Small molecule inhibitors of PSD95-nNOS protein-protein interactions as novel analgesics
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Q38647566ZL006, a small molecule inhibitor of PSD-95/nNOS interaction, does not induce antidepressant-like effects in two genetically predisposed rat models of depression and control animals.

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