The effects of nitroxyl (HNO) on soluble guanylate cyclase activity: interactions at ferrous heme and cysteine thiols. (scientific article published on 15 June 2009)

Effects of agents that inactivate free radical NO (NO*) on nitroxyl anion-mediated relaxations, and on the detection of NO* released from the nitroxyl anion donor Angeli's salt

Q28361038

Hydrolysis of Acyloxy Nitroso Compounds Yields Nitroxyl (HNO)

Q29397120

Nitroxyl and its anion in aqueous solutions: spin states, protic equilibria, and reactivities toward oxygen and nitric oxide

Q31062804

On the acidity and reactivity of HNO in aqueous solution and biological systems

Q34445763

Nitroxyl gets to the heart of the matter.

Q34981557

Positive inotropic and lusitropic effects of HNO/NO − in failing hearts: Independence from β-adrenergic signaling

Q34983537

Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels

Q35009484

Spectral and ligand-binding properties of an unusual hemoprotein, the ferric form of soluble guanylate cyclase

Q71010153

Nitric oxide (NO), the only nitrogen monoxide redox form capable of activating soluble guanylyl cyclase

Q71209999

Studies of the heme coordination and ligand binding properties of soluble guanylyl cyclase (sGC): characterization of Fe(II)sGC and Fe(II)sGC(CO) by electronic absorption and magnetic circular dichroism spectroscopies and failure of CO to activate t

Q72183771

Reversible inactivation of guanylate cyclase by mixed disulfide formation

Q72457078

Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates

Q72488009

Bioassay discrimination between nitric oxide (NO.) and nitroxyl (NO-) using L-cysteine

Q72488285

Activation of purified guanylate cyclase by nitric oxide requires heme. Comparison of heme-deficient, heme-reconstituted and heme-containing forms of soluble enzyme from bovine lung

Q72538837

Guanylate cyclase from bovine lung. A kinetic analysis of the regulation of the purified soluble enzyme by protoporphyrin IX, heme, and nitrosyl-heme

Q72539436

Requirement for heme in the activation of purified guanylate cyclase by nitric oxide

Q72555070

Electron paramagnetic resonance spectral evidence for the formation of a pentacoordinate nitrosyl-heme complex on soluble guanylate cyclase

Q72566480

Conversion of nitroxyl (HNO) to nitric oxide (NO) in biological systems: the role of physiological oxidants and relevance to the biological activity of HNO

Q72607660

Identification and partial purification of an endogenous inhibitor of soluble guanylyl cyclase from bovine lung

Q72678836

Mechanisms of inhibition of aldehyde dehydrogenase by nitroxyl, the active metabolite of the alcohol deterrent agent cyanamide

Q77134104

Reactions catalyzed by tetrahydrobiopterin-free nitric oxide synthase

Q77501939

The nitroxyl anion (HNO) is a potent dilator of rat coronary vasculature

Q79451723

Nitroxyl anion donor, Angeli's salt, does not develop tolerance in rat isolated aortae

Q79798643

Effect of nitroxyl on human platelets function

Q81438726

Differential actions of L-cysteine on responses to nitric oxide, nitroxyl anions and EDRF in the rat aorta

Q35041842

A biochemical rationale for the discrete behavior of nitroxyl and nitric oxide in the cardiovascular system

Q35234291

Desensitization of soluble guanylyl cyclase, the NO receptor, by S-nitrosylation

Q35925811

Coordination chemistry of the HNO ligand with hemes and synthetic coordination complexes

Q35983739

Activation of purified soluble guanylate cyclase by protoporphyrin IX.

Q36293899

The pharmacology of nitroxyl (HNO) and its therapeutic potential: not just the Janus face of NO

Q36408421

Soluble guanylate cyclase

Q36610123

Side effects of using nitrates to treat heart failure and the acute coronary syndromes, unstable angina and acute myocardial infarction

Q36905844

Activation of hepatic guanylate cyclase by N-methyl-N'-nitro-N-nitrosoguanidine. Effects of thiols, N-ethylmaleimide, and divalent cations

Q39155731

Oxidative-reductive modulation of guinea pig splenic cell guanylate cyclase activity

Q39188716

Effects of thiol inhibitors on hepatic guanylate cylase activity

Q39195101

Persistent susceptibility of cathepsin B to irreversible inhibition by nitroxyl (HNO) in the presence of endogenous nitric oxide

Q39969381

Nitric oxide-cyclic GMP signal transduction system.

Q41100343

Calcium ion downregulates soluble guanylyl cyclase activity: evidence for a two-metal ion catalytic mechanism

Q43614080

Photolysis of the HNO adduct of myoglobin: transient generation of the aminoxyl radical

Q43693272

Comparison of responses to novel nitric oxide donors in the feline pulmonary vascular bed.

Q43800978

Role of catalase in the smooth muscle relaxant actions of sodium azide and cyanamide.

Q43854038

1H NMR structure of the heme pocket of HNO-myoglobin

Q44317568

NO- activates soluble guanylate cyclase and Kv channels to vasodilate resistance arteries

Q44438485

Preparation of heme-free soluble guanylate cyclase

Q44577972

Fast nitroxyl trapping by ferric porphyrins.

Q44685929

Efficient trapping of HNO by deoxymyoglobin

Q44744397

Reaction between S-nitrosothiols and thiols: generation of nitroxyl (HNO) and subsequent chemistry.

Q45946745

Antioxidant actions of nitroxyl (HNO).

Q45996374

Bonding in HNO-myoglobin as characterized by X-ray absorption and resonance raman spectroscopies.

Q46336986

Nitric oxide-related species-induced protein oxidation: reversible, irreversible, and protective effects on enzyme function of papain.

Q46394502

Mass spectrometric analysis of nitroxyl-mediated protein modification: comparison of products formed with free and protein-based cysteines

Q46756652

Mechanisms of HNO and NO production from Angeli's salt: density functional and CBS-QB3 theory predictions

Q46781301

Theoretical reduction potentials for nitrogen oxides from CBS-QB3 energetics and (C)PCM solvation calculations

Q46810248

Characterization of nitrosoalkane binding and activation of soluble guanylate cyclase

Q46838730

Comparison of the NO and HNO donating properties of diazeniumdiolates: primary amine adducts release HNO in Vivo

Q46860343

Chemical oxidation of N-hydroxyguanidine compounds. Release of nitric oxide, nitroxyl and possible relationship to the mechanism of biological nitric oxide generation

Q51696392

Electromagnetic properties of hemoproteins. V. Optical and electron paramagnetic resonance characteristics of nitric oxide derivatives of metalloporphyrin-apohemoprotein complexes.

Q54332403

Complexes of .NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects

Q68064574

Oxidation of dithiothreitol during turnover of nitric oxide reductase: evidence for generation of nitroxyl with the enzyme from Paracoccus denitrificans

Q68099225

Stereochemistry of low-spin cobalt porphyrins. I. Structure and bonding in a nitrosylcobalt porphyrin and their bearing on one rational model for the oxygenated protoheme

Q69645941

Activation of soluble guanylate cyclase by NO-hemoproteins involves NO-heme exchange. Comparison of heme-containing and heme-deficient enzyme forms

Q69878955

The involvement of catalytic site thiol groups in the activation of soluble guanylate cyclase by sodium nitroprusside

Q69892443

P433

issue

P407

language of work or name

English

Q1860

P1104

number of pages

P304

page(s)

21788-21796

P577

publication date

2009-06-15

P1433

published in

Journal of Biological Chemistry

Q867727

P1476

title

The effects of nitroxyl (HNO) on soluble guanylate cyclase activity: interactions at ferrous heme and cysteine thiols

P478

volume

284

Reverse relations

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