Guanylate cyclase and the .NO/cGMP signaling pathway

scientific article (publication date: 5 May 1999)

Guanylate cyclase and the .NO/cGMP signaling pathway is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/S0005-2728(99)00024-9
P3181OpenCitations bibliographic resource ID1798536
P698PubMed publication ID10320667
P5875ResearchGate publication ID12977335

P2093author name stringJ W Denninger
M A Marletta
P2860cites workIsolation of adenosine 3', 5'-monophosphate and guanosine 3', 5'-monophosphate from rat urineQ79568332
Molecular cloning and expression of a new α‐subunit of soluble guanylyl cyclase Interchangeability of the α‐subunits of the enzymeQ24296917
Structure of the adenylyl cyclase catalytic coreQ27735000
Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaSQ27748762
Structure, localization, and regulation of cGMP-inhibited phosphodiesterase (PDE3)Q28115585
Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brainQ28118165
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factorQ28299224
Sensitizing soluble guanylyl cyclase to become a highly CO-sensitive enzymeQ28379416
The cloning and expression of a new guanylyl cyclase orphan receptorQ28509697
The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholineQ29547539
Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxideQ29619956
Kinetics of nitric oxide dissociation from five- and six-coordinate nitrosyl hemes and heme proteins, including soluble guanylate cyclaseQ30427519
Nitric oxide activates guanylate cyclase and increases guanosine 3′:5′-cyclic monophosphate levels in various tissue preparationsQ30449094
Molecular cloning of cDNAs and expression of mRNAs encoding alpha and beta subunits of soluble guanylyl cyclase from medaka fish Oryzias latipesQ32064666
The primary structure of the larger subunit of soluble guanylyl cyclase from bovine lung. Homology between the two subunits of the enzymeQ33500217
Catalytic mechanism of the adenylyl and guanylyl cyclases: modeling and mutational analysisQ33702555
Nitric oxide reversibly inhibits seven members of the caspase family via S-nitrosylationQ34065605
Nitric oxide: a cytotoxic activated macrophage effector moleculeQ34169525
Carbon monoxide: a putative neural messengerQ34305648
Colocalization of the genes coding for the alpha 3 and beta 3 subunits of soluble guanylyl cyclase to human chromosome 4 at q31.3-q33.Q34334853
Assignment of GUCIA2, the gene coding for the alpha 2 subunit of soluble guanylyl cyclase, to position 11q21-q22 on human chromosome 11.Q34383735
Heterogeneity in human soluble guanylate cyclase due to alternative splicingQ34542817
Mutation of His-105 in the beta 1 subunit yields a nitric oxide-insensitive form of soluble guanylyl cyclaseQ35124292
Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cellsQ35372931
Nitrate biosynthesis in manQ36384530
The primary structure of the 70 kDa subunit of bovine soluble guanylate cyclaseQ36416369
Molecular characterization of two Drosophila guanylate cyclases expressed in the nervous systemQ36704498
Targeted gene deletion of heme oxygenase 2 reveals neural role for carbon monoxideQ36832902
Mammalian nitrate biosynthesis: incorporation of 15NH3 into nitrate is enhanced by endotoxin treatmentQ37343268
Two amino acid substitutions convert a guanylyl cyclase, RetGC-1, into an adenylyl cyclase.Q37375937
Haem-dependent activation of guanylate cyclase and cyclic GMP formation by endogenous nitric oxide: a unique transduction mechanism for transcellular signalingQ37598066
Identification of sequences mediating guanylyl cyclase dimerizationQ38296651
Nitric oxide: biosynthesis and biological significanceQ38767971
Activation of cerebral guanylate cyclase by nitric oxideQ39147309
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The beta2 subunit inhibits stimulation of the alpha1/beta1 form of soluble guanylyl cyclase by nitric oxide. Potential relevance to regulation of blood pressureQ39790834
Sodium nitroprusside and other smooth muscle-relaxants increase cyclic GMP levels in rat ductus deferensQ40068123
Nitric oxide: a new paradigm for second messengers.Q40368445
Nitric oxide regulates mitochondrial respiration and cell functions by inhibiting cytochrome oxidase.Q40467971
Soluble guanylyl cyclase and platelet functionQ40623860
Effects of cyclic GMP on smooth muscle relaxation.Q40624466
Chemistry of nitric oxide: biologically relevant aspects.Q40945731
Nitric oxide: a neural messengerQ41020997
Inhibition of NF-kappaB and HIV-1 long terminal repeat transcriptional activation by inducible nitric oxide synthase 2 activityQ41056356
Expression and purification of soluble, active heterodimeric guanylyl cyclase from baculovirusQ41096972
Structure and function of cyclic nucleotide-gated channelsQ41132646
Two Drosophila genes that encode the alph and beta subunits of the brain soluble guanylyl cyclaseQ41333830
Nitric oxide-stimulated guanine nucleotide exchange on p21rasQ41357997
Adenylyl cyclases: structure, regulation and function in an enzyme superfamilyQ41461637
Tailoring cAMP-signalling responses through isoform multiplicityQ41516369
New insights on the functions of the guanylyl cyclase receptorsQ41554016
Distinct and specific functions of cGMP-dependent protein kinasesQ41576484
Cotranslational protein foldingQ41667140
Expression of soluble guanylyl cyclase. Catalytic activity requires two enzyme subunitsQ41718282
Regeneration of the ferrous heme of soluble guanylate cyclase from the nitric oxide complex: acceleration by thiols and oxyhemoglobinQ42059639
Resonance Raman characterization of soluble guanylate cyclase expressed from baculovirusQ42061123
Functional domains of soluble guanylyl cyclaseQ42065567
Functional implications of nitric oxide produced by mitochondria in mitochondrial metabolismQ42990885
Purification of soluble guanylyl cyclase from bovine lung by a new immunoaffinity chromatographic methodQ43913799
High-level expression of biologically active soluble guanylate cyclase using the baculovirus system is strongly heme-dependent.Q44752137
Dissociation of nitric oxide from soluble guanylate cyclaseQ46951812
Synergistic activation of soluble guanylate cyclase by YC-1 and carbon monoxide: implications for the role of cleavage of the iron-histidine bond during activation by nitric oxideQ47910766
Exchange of substrate and inhibitor specificities between adenylyl and guanylyl cyclasesQ47954577
A new form of guanylyl cyclase is preferentially expressed in rat kidneyQ48244925
Molecular cloning of a cDNA coding for 70 kilodalton subunit of soluble guanylate cyclase from rat lungQ48308215
Carbon monoxide: an endogenous modulator of the nitric oxide-cyclic GMP signaling system.Q49047336
Detection of guanyl cyclase in mammalian tissues.Q49111556
The deactivation of soluble guanylyl cyclase by redox-active agents.Q50525208
Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle.Q50773580
Purifieation of a Soluble, Sodium-Nitroprusside-Stimulated Guanylate Cyclase from Bovine LungQ50939098
Isolation of a Drosophila gene encoding a head-specific guanylyl cyclase.Q52542883
Inhibition of endothelial vascular cell adhesion molecule-1 expression by nitric oxide involves the induction and nuclear translocation of IkappaBalpha.Q54350265
Guanyl cyclase. Determination of enzyme activityQ55061849
Soluble guanylate cyclase purified from bovine lung contains heme and copperQ55062277
Reactions between nitric oxide and haemoglobin under physiological conditionsQ57204871
Blood Flow Regulation by S-Nitrosohemoglobin in the Physiological Oxygen GradientQ58641869
A polymerase I palm in adenylyl cyclase?Q58983850
Purification of heme-containing soluble guanylyl cyclaseQ68300418
Cyclic nucleotidesQ70058580
Nitrate synthesis in the germfree and conventional ratQ70542428
Oxidation of nitrogen oxides by bound dioxygen in hemoproteinsQ70913719
Spectral and kinetic studies on the activation of soluble guanylate cyclase by nitric oxideQ70930193
Binding of nitric oxide and carbon monoxide to soluble guanylate cyclase as observed with Resonance raman spectroscopyQ71087376
Heme Stoichiometry of Heterodimeric Soluble Guanylate CyclaseQ71786399
Studies of the heme coordination and ligand binding properties of soluble guanylyl cyclase (sGC): characterization of Fe(II)sGC and Fe(II)sGC(CO) by electronic absorption and magnetic circular dichroism spectroscopies and failure of CO to activate tQ72183771
Activation of purified guanylate cyclase by nitric oxide requires heme. Comparison of heme-deficient, heme-reconstituted and heme-containing forms of soluble enzyme from bovine lungQ72538837
Electron paramagnetic resonance spectral evidence for the formation of a pentacoordinate nitrosyl-heme complex on soluble guanylate cyclaseQ72566480
Soluble guanylate cyclase from bovine lung: activation with nitric oxide and carbon monoxide and spectral characterization of the ferrous and ferric statesQ72677054
Guanylyl cyclases: a family of receptor-linked enzymesQ72791546
Kinetics of the reaction of nitric oxide with oxygen in aqueous solutionsQ72859948
A molecular redox switch on p21(ras). Structural basis for the nitric oxide-p21(ras) interactionQ73039100
Kinetic mechanism of luciferase subunit folding and assemblyQ73106815
Effects of GTP on bound nitric oxide of soluble guanylate cyclase probed by resonance Raman spectroscopyQ73581647
Localization of the heme binding region in soluble guanylate cyclaseQ73940521
Activation of the cardiac calcium release channel (ryanodine receptor) by poly-S-nitrosylationQ74016180
Mechanism of YC-1-induced activation of soluble guanylyl cyclaseQ74095219
Identification of histidine 105 in the beta1 subunit of soluble guanylate cyclase as the heme proximal ligandQ74378137
P433issue2-3
P407language of work or nameEnglishQ1860
P304page(s)334-50
P577publication date1999-05-05
P1433published inBiochimica et Biophysica ActaQ864239
P1476titleGuanylate cyclase and the .NO/cGMP signaling pathway
P478volume1411

Reverse relations

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Q44437870Nitric oxide inhibits spleen cell proliferative response after burn injury by inducing cytostasis, apoptosis, and necrosis of activated T lymphocytes: role of the guanylate cyclase
Q43882345Nitric oxide modulates branching morphogenesis in fetal rat lung explants
Q40801489Nitric oxide regulates actin reorganization through cGMP and Ca(2+)/calmodulin in RAW 264.7 cells
Q46446527Nitric oxide signaling gone awry: nitration of glutamine synthetase and hyperammonemia in sepsis
Q36717720Nitric oxide signaling in the microcirculation
Q41859850Nitric oxide signaling pathway activation inhibits the immune escape of pancreatic carcinoma cells
Q46875435Nitric oxide stimulates growth hormone secretion from human fetal pituitaries and cultured pituitary adenomas
Q43761077Nitric oxide suppresses the expression of Bcl-2 binding protein BNIP3 in hepatocytes
Q43716918Nitric oxide synthase expression and nitric oxide/cyclic GMP pathway in swine granulosa cells
Q92895828Nitric oxide upregulates microglia phagocytosis and increases transient receptor potential vanilloid type 2 channel expression on the plasma membrane
Q35448831Nitric oxide-mediated antioxidative mechanism in yeast through the activation of the transcription factor Mac1.
Q40564009Nitric oxide-mediated regulation of gamma interferon-induced bacteriostasis: inhibition and degradation of human indoleamine 2,3-dioxygenase
Q42254238Nitric oxide/cGMP signalling induces Escherichia coli K1 receptor expression and modulates the permeability in human brain endothelial cell monolayers during invasion
Q37133497Nitrosative stress and redox-cycling agents synergize to cause mitochondrial dysfunction and cell death in endothelial cells
Q37885200Nitrosyl iron complexes--synthesis, structure and biology
Q44712554Nitrosyl-heme complexes are formed in the ischemic heart: evidence of nitrite-derived nitric oxide formation, storage, and signaling in post-ischemic tissues
Q35679460Non-nuclear actions of estrogen: new targets for prevention and treatment of cardiovascular disease
Q42997077Novel application of S-nitrosoglutathione-Sepharose to identify proteins that are potential targets for S-nitrosoglutathione-induced mixed-disulphide formation
Q92518446Novel circular RNAs expressed in brain microvascular endothelial cells after oxygen-glucose deprivation/recovery
Q33258695Occurrence of cGMP/nitric oxide-sensitive store-operated calcium entry in fibroblasts and its effect on matrix metalloproteinase secretion
Q34312682On the regulation of NMDA receptors by nitric oxide
Q43722386Opioids are non-competitive inhibitors of nitric oxide synthase in T47D human breast cancer cells
Q43780908Organic phosphates as a new class of soluble guanylate cyclase inhibitors
Q36743914Oxidant and redox signaling in vascular oxygen sensing: implications for systemic and pulmonary hypertension
Q44055074Oxygen-mediated regulation of tumor cell invasiveness. Involvement of a nitric oxide signaling pathway
Q88393495PDE5 inhibitors - pharmacology and clinical applications 20 years after sildenafil discovery
Q60301404PKG1α oxidation negatively regulates food seeking behaviour and reward
Q94682570Partial inhibition of nitric oxide synthase activity stimulates the nuclear maturation progression of bovine cumulus-oocyte complex in vitro in the presence of hemisections of the follicular walls
Q37167309Perivascular innervation: a multiplicity of roles in vasomotor control and myoendothelial signaling
Q43132159Pharmacological modulators of nitric oxide signaling and contextual fear conditioning in mice
Q47133234Pharmacological preconditioning with gemfibrozil preserves cardiac function after heart transplantation
Q47855780Phenotypic Consequences of a Genetic Predisposition to Enhanced Nitric Oxide Signaling
Q97887377Phosphodiesterase Inhibitors for Alzheimer's Disease: A Systematic Review of Clinical Trials and Epidemiology with a Mechanistic Rationale
Q33552229Pivotal effects of phosphodiesterase inhibitors on myocyte contractility and viability in normal and ischemic hearts
Q88532421Posttranslational regulation of CYP2J2 by nitric oxide
Q31873538Presence of soluble and particulate guanylyl cyclase in the same hippocampal astrocytes
Q41964867Probing domain interactions in soluble guanylate cyclase
Q27652988Probing the Function of Heme Distortion in the H-NOX Family
Q96302505Probing the Structural Dynamics of the Catalytic Domain of Human Soluble Guanylate Cyclase
Q39504233Probing the presence of the ligand-binding haem in cellular nitric oxide receptors
Q74043682Progress report on molecular biometallics (1996-2000), a project of the priority areas for research under the auspices of the Japanese Government
Q35045463Properties of NO-activated guanylyl cyclases expressed in cells
Q33503762Protective effects of remifentanil on septic mice
Q29615001Protein S-nitrosylation: a physiological signal for neuronal nitric oxide
Q42830730Protein kinase G activates the JNK1 pathway via phosphorylation of MEKK1.
Q46890968Pulling NO out of thin air.
Q46807252Purification and characterization of NO-sensitive guanylyl cyclase
Q39253194ROS in Cancer: The Burning Question
Q35084643Rapid desensitization of the nitric oxide receptor, soluble guanylyl cyclase, underlies diversity of cellular cGMP responses
Q39419466Reactive Oxygen and Nitrogen Species in the Development of Pulmonary Hypertension
Q92550186Reactive Vasodilation Predicts Mortality in Primary Systemic Light-Chain Amyloidosis
Q28383441Reactive nitrogen species in cellular signaling
Q36423922Recent Advances in Multinuclear Metal Nitrosyl Complexes
Q34204894Recent advances in heme-protein sensors
Q37940831Reciprocal regulation of cellular nitric oxide formation by nitric oxide synthase and nitrite reductases.
Q45712722Redox regulation of cytosolic glycerol-3-phosphate dehydrogenase: Cys(102) is the target of the redox control and essential for the catalytic activity
Q44111470Reduction of cGMP and nitric oxide has antidepressant-like effects in the forced swimming test in rats
Q30275422Regulation of Transcription Factors by Reactive Oxygen Species and Nitric Oxide in Vascular Physiology and Pathology
Q45037115Regulation of cGMP-dependent protein kinase expression by soluble guanylyl cyclase in vascular smooth muscle cells
Q32139068Regulation of mitochondrial respiration by nitric oxide inhibition of cytochrome c oxidase
Q44886475Regulation of regional lung perfusion by nitric oxide
Q37716393Regulation of the G2/M transition in rodent oocytes
Q36528103Relaxant effect of all-trans-retinoic acid via NO-sGC-cGMP pathway and calcium-activated potassium channels in rat mesenteric artery
Q38410871Researching glutamate - induced cytotoxicity in different cell lines: a comparative/collective analysis/study
Q54551400Resonance Raman and ligand binding studies of the oxygen-sensing signal transducer protein HemAT from Bacillus subtilis.
Q37458498Responses of nitric oxide-cGMP release in acupuncture point to electroacupuncture in human skin in vivo using dermal microdialysis
Q42699608Retrospection on the Role of Soluble Guanylate Cyclase in Parkinson's Disease.
Q27025929Review article: carbon monoxide in gastrointestinal physiology and its potential in therapeutics
Q34155309Revisiting the kinetics of nitric oxide (NO) binding to soluble guanylate cyclase: the simple NO-binding model is incorrect
Q38255515Riociguat as a treatment regime for pulmonary arterial hypertension: a review.
Q37851516Riociguat for the treatment of pulmonary hypertension.
Q45265126Role of arginine 220 in the oxygen sensor FixL from Bradyrhizobium japonicum
Q43823331Role of conformational changes in the heme-dependent regulation of human soluble guanylate cyclase
Q30352944Role of heme iron coordination and protein structure in the dynamics and geminate rebinding of nitric oxide to the H93G myoglobin mutant: implications for nitric oxide sensors.
Q41871145Role of local production of endothelium-derived nitric oxide on cGMP signaling and S-nitrosylation.
Q34465820Role of nitric oxide in the pathogenesis of muscular dystrophies: a "two hit" hypothesis of the cause of muscle necrosis
Q34500513S-nitrosylation Inhibits protein kinase C-mediated contraction in mouse aorta
Q46828457S-nitrosylation of peroxiredoxin II E promotes peroxynitrite-mediated tyrosine nitration.
Q27644723S-nitrosylation-induced conformational change in blackfin tuna myoglobin
Q46836638Sesamol induces nitric oxide release from human umbilical vein endothelial cells
Q36865835Shewanella oneidensis MR-1 H-NOX regulation of a histidine kinase by nitric oxide
Q48254496Sildenafil, a phosphodiesterase type 5 inhibitor, reduces antidepressant-like activity of paroxetine in the forced swim test in mice.
Q35783934Simulation of NO and O2 transport facilitated by polymerized hemoglobin solutions in an arteriole that takes into account wall shear stress-induced NO production
Q36440848Sjogrens syndrome--the non-apoptotic model of glandular hypofunction.
Q33771832Small molecule signaling agents: the integrated chemistry and biochemistry of nitrogen oxides, oxides of carbon, dioxygen, hydrogen sulfide, and their derived species
Q36032937Smoking-gene interaction and disease development: relevance to pancreatic cancer and atherosclerosis
Q43213802Soluble Guanylyl Cyclases in Invertebrates: Targets for NO and O(2).
Q37399819Soluble guanylate cyclase generation of cGMP regulates migration of MGE neurons
Q34599905Soluble guanylate cyclases in the retina
Q35206512Soluble guanylyl cyclase: physiological role as an NO receptor and the potential molecular target for therapeutic application
Q42505728Species differences in the localization of soluble guanylyl cyclase subunits in monkey and rat brain.
Q57052484Spectral characterization of a novel NO sensing protein in bacteria: NosP
Q48609421Structural and functional insights into the heme-binding domain of the human soluble guanylate cyclase α2 subunit and heterodimeric α2β1.
Q27659887Structural insights into the molecular mechanism of H-NOX activation
Q34407649Structural insights into the role of iron-histidine bond cleavage in nitric oxide-induced activation of H-NOX gas sensor proteins
Q27644394Structure-Based Design and Synthesis of N ω -Nitro- l -Arginine-Containing Peptidomimetics as Selective Inhibitors of Neuronal Nitric Oxide Synthase. Displacement of the Heme Structural Water
Q43824637Substance P and nitric oxide signaling in cerebral cortex: anatomical evidence for reciprocal signaling between two classes of interneurons
Q31900687Subunits of the nitric oxide receptor, soluble guanylyl cyclase, expressed in rat brain
Q28573791Synaptic localization of nitric oxide synthase and soluble guanylyl cyclase in the hippocampus
Q90479658Tadalafil: 15 years' journey in male erectile dysfunction and beyond
Q92126516The Effects of Oral l-Arginine and l-Citrulline Supplementation on Blood Pressure
Q41998443The Influence of Nitric Oxide on Soluble Guanylate Cyclase Regulation by Nucleotides: ROLE OF THE PSEUDOSYMMETRIC SITE.
Q37077155The NO-cGMP-PKG signaling pathway regulates synaptic plasticity and fear memory consolidation in the lateral amygdala via activation of ERK/MAP kinase
Q28087418The Ovarian Antral Follicle: Living on the Edge of Hypoxia or Not?
Q92941609The Role of Endothelial Dysfunction in Peripheral Blood Nerve Barrier: Molecular Mechanisms and Pathophysiological Implications
Q41636614The Roles of Hypoxia Signaling in the Pathogenesis of Cardiovascular Diseases
Q44608900The alpha, but not the beta, isoform of the human thromboxane A2 receptor is a target for nitric oxide-mediated desensitization. Independent modulation of Tp alpha signaling by nitric oxide and prostacyclin.
Q43830334The biotin switch method for the detection of S-nitrosylated proteins
Q28364510The case of CO signaling: why the jury is still out
Q36990410The chemistry of cell signaling by reactive oxygen and nitrogen species and 4-hydroxynonenal.
Q27652454The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase
Q36817378The cyclic AMP signaling pathway: Exploring targets for successful drug discovery (Review).
Q44623558The effect of nitric oxide on cyclooxygenase‐2 (COX‐2) overexpression in head and neck cancer cell lines
Q41909315The effects of nitroxyl (HNO) on soluble guanylate cyclase activity: interactions at ferrous heme and cysteine thiols.
Q42526635The expression pattern of nitric oxide-sensitive guanylyl cyclase in the rat heart changes during postnatal development
Q36866594The future of the oral pharmacotherapy of male erectile dysfunction: things to come
Q36917165The grateful dead: calcium and cell death in plant innate immunity
Q40776133The involvement of HAb18G/CD147 in regulation of store-operated calcium entry and metastasis of human hepatoma cells
Q43135819The mechanism of ciliary stimulation by acetylcholine: roles of calcium, PKA, and PKG.
Q34361273The nitric oxide/cyclic GMP system in astroglial cells.
Q35651212The role of carbon monoxide in the gastrointestinal tract.
Q37808293The role of heme oxygenase and carbon monoxide in inflammatory bowel disease
Q27691434The role of the intestinal microcirculation in necrotizing enterocolitis
Q26765101The role of titin and extracellular matrix remodelling in heart failure with preserved ejection fraction
Q45934163The susceptibility of muscle cells to oxidative stress is independent of nitric oxide synthase expression.
Q35880300Thioredoxin is required for S-nitrosation of procaspase-3 and the inhibition of apoptosis in Jurkat cells.
Q35529294Thioredoxin reductase inhibition reduces relaxation by increasing oxidative stress and s-nitrosylation in mouse aorta.
Q56534524Thioredoxin shapes the sensory response to produced nitric oxide
Q33948069Tonic and acute nitric oxide signaling through soluble guanylate cyclase is mediated by nonheme nitric oxide, ATP, and GTP
Q27315925Transcriptional profiling in rat hair follicles following simulated Blast insult: a new diagnostic tool for traumatic brain injury
Q36070963Transcutaneous Electrical Stimulation Increased Nitric Oxide-Cyclic GMP Release Biocaptured Over Skin Surface of Pericardium Meridian and Acupuncture Points in Humans
Q91804312Transforming growth factor-β downregulates sGC subunit expression in pulmonary artery smooth muscle cells via MEK and ERK signaling
Q93180069Treatment with Nitrate, but Not Nitrite, Lowers the Oxygen Cost of Exercise and Decreases Glycolytic Intermediates While Increasing Fatty Acid Metabolites in Exercised Zebrafish
Q48178136Understanding How H-NOX (Heme Nitric Oxide/Oxygen) domain works needs first clarifying how diatomic gases are relocated inside this sensing protein. A molecular-mechanics approach
Q27627805Unprecedented proximal binding of nitric oxide to heme: implications for guanylate cyclase
Q34066200Vascular dysfunction associated with type 2 diabetes and Alzheimer's disease: a potential etiological linkage
Q26779400Vascular nitric oxide: Beyond eNOS
Q90235313Vasopressin V1a Receptors Regulate Cerebral Aquaporin 1 after Traumatic Brain Injury
Q86516868Vasorelaxing effects of the soluble guanylyl cyclase activator BAY 60-2770 in nitrate-tolerant monkey and canine coronary arteries
Q33924184What part of NO don't you understand? Some answers to the cardinal questions in nitric oxide biology.
Q49090028Whole brain spheroid cultures as a model to study the development of nitric oxide synthase-guanylate cyclase signal transduction.
Q33948966YC-1 activation of human soluble guanylyl cyclase has both heme-dependent and heme-independent components
Q44260144YC-1 potentiates the nitric oxide/cyclic GMP pathway in corpus cavernosum and facilitates penile erection in rats
Q35043575Zinc Finger 280B regulates sGCα1 and p53 in prostate cancer cells
Q40829251Zn2+ and Cd2+ increase the cyclic GMP level in PC12 cells by inhibition of the cyclic nucleotide phosphodiesterase
Q37124752pH-dependent mechanism of nitric oxide release in nitrophorins 2 and 4
Q39577603βig-h3 regulates store-operated Ca2+ entry and promotes the invasion of human hepatocellular carcinoma cells

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