Novel cytotoxic T-lymphocyte escape mutation by a three-amino-acid insertion in the human immunodeficiency virus type 1 p6Pol and p6Gag late domain associated with drug resistance

scientific article published on 17 October 2007

Novel cytotoxic T-lymphocyte escape mutation by a three-amino-acid insertion in the human immunodeficiency virus type 1 p6Pol and p6Gag late domain associated with drug resistance is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.01096-07
P932PMC publication ID2224368
P698PubMed publication ID17942528
P5875ResearchGate publication ID5902162

P50authorJulie McElrathQ22006776
James MullinsQ57555076
P2093author name stringYi Liu
Jianhong Cao
John McNevin
Matthew McSweyn
P2860cites workThe pigtail macaque MHC class I allele Mane-A*10 presents an immundominant SIV Gag epitope: identification, tetramer development and implications of immune escape and reversion.Q54646517
Reversion of CTL escape–variant immunodeficiency viruses in vivoQ56427919
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Clinical and epidemiologic features of primary HIV infectionQ71182378
Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progressionQ71803154
Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDSQ73034306
Gag-p6 Tsg101 binding site duplications in maternal-infant HIV infectionQ81585097
Selection, transmission, and reversion of an antigen-processing cytotoxic T-lymphocyte escape mutation in human immunodeficiency virus type 1 infectionQ24564623
Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infectionQ24564779
Tsg101, a homologue of ubiquitin-conjugating (E2) enzymes, binds the L domain in HIV type 1 Pr55(Gag)Q24633537
CD8+ T lymphocyte responses target functionally important regions of Protease and Integrase in HIV-1 infected subjectsQ24798701
The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cellsQ28139452
HIV-1 and Ebola virus encode small peptide motifs that recruit Tsg101 to sites of particle assembly to facilitate egressQ28207991
Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virusQ28302762
Resistance to nucleoside analog reverse transcriptase inhibitors mediated by human immunodeficiency virus type 1 p6 proteinQ33846417
Selective escape from CD8+ T-cell responses represents a major driving force of human immunodeficiency virus type 1 (HIV-1) sequence diversity and reveals constraints on HIV-1 evolutionQ34092644
Consistent patterns in the development and immunodominance of human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T-cell responses following acute HIV-1 infectionQ34361731
Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I moleculesQ34468033
Charting HIV's remarkable voyage through the cell: Basic science as a passport to future therapyQ34714816
Dual pressure from antiretroviral therapy and cell-mediated immune response on the human immunodeficiency virus type 1 protease geneQ35020128
Comprehensive analysis of human immunodeficiency virus type 1 (HIV-1)-specific gamma interferon-secreting CD8+ T cells in primary HIV-1 infectionQ35020830
Cytotoxic T cell recognition of an HIV-1 reverse transcriptase variant peptide incorporating the K103N drug resistance mutationQ35090710
Selection on the human immunodeficiency virus type 1 proteome following primary infectionQ35101338
Impaired processing and presentation of cytotoxic-T-lymphocyte (CTL) epitopes are major escape mechanisms from CTL immune pressure in human immunodeficiency virus type 1 infectionQ35542741
Rapid reversion of sequence polymorphisms dominates early human immunodeficiency virus type 1 evolutionQ35634318
HIV and SIV CTL escape: implications for vaccine designQ35852284
Evolution of human immunodeficiency virus type 1 cytotoxic T-lymphocyte epitopes: fitness-balanced escapeQ36315529
Immune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infectionQ36399423
HIV-1 protease and reverse transcriptase mutations for drug resistance surveillanceQ36696351
A dominant role for CD8+-T-lymphocyte selection in simian immunodeficiency virus sequence variationQ37683178
Natural variation in HIV-1 protease, Gag p7 and p6, and protease cleavage sites within gag/pol polyproteins: amino acid substitutions in the absence of protease inhibitors in mothers and children infected by human immunodeficiency virus type 1.Q38357781
Immunogenicity of mutations induced by nucleoside reverse transcriptase inhibitors for human immunodeficiency virus type 1-specific cytotoxic T cellsQ39539955
Sequential steps in human immunodeficiency virus particle maturation revealed by alterations of individual Gag polyprotein cleavage sites.Q39579012
Simultaneous positive and purifying selection on overlapping reading frames of the tat and vpr genes of simian immunodeficiency virus.Q39606727
The dimer interfaces of protease and extra-protease domains influence the activation of protease and the specificity of GagPol cleavageQ39698249
Domains upstream of the protease (PR) in human immunodeficiency virus type 1 Gag-Pol influence PR autoprocessingQ39870468
Specific recognition of lamivudine-resistant HIV-1 by cytotoxic T lymphocytesQ40880429
An assay for peptide binding to HLA-Cw*0102.Q40928687
Analysis of insertions and deletions in the gag p6 region of diverse HIV type 1 strains.Q43913441
Error-prone polymerization by HIV-1 reverse transcriptase. Contribution of template-primer misalignment, miscoding, and termination probability to mutational hot spotsQ44332934
Cytotoxic-T-cell responses, viral load, and disease progression in early human immunodeficiency virus type 1 infectionQ44519261
Evolution of CD8+ T cell immunity and viral escape following acute HIV-1 infectionQ44674538
Selection of human immunodeficiency virus type 1 variants with an insertion mutation in the p6(gag) and p6(pol) genes under highly active antiretroviral therapyQ45728754
Characterization of ribosomal frameshifting in HIV-1 gag-pol expressionQ46573916
HIV evolution: CTL escape mutation and reversion after transmissionQ47211742
Antiretroviral drug resistance mutations sustain or enhance CTL recognition of common HIV-1 Pol epitopesQ47578453
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectdrug resistanceQ12147416
P304page(s)495-502
P577publication date2007-10-17
P1433published inJournal of VirologyQ1251128
P1476titleNovel cytotoxic T-lymphocyte escape mutation by a three-amino-acid insertion in the human immunodeficiency virus type 1 p6Pol and p6Gag late domain associated with drug resistance
P478volume82

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cites work (P2860)
Q48061694Accumulation of P(T/S)AP Late Domain Duplications in HIV Type 1 Subtypes B, C, and F Derived from Individuals Failing ARV Therapy and ARV Drug-Naive Patients
Q34053505Analysis of infectious virus clones from two HIV-1 superinfection cases suggests that the primary strains have lower fitness
Q36434250Elucidation of the Molecular Mechanism Driving Duplication of the HIV-1 PTAP Late Domain
Q37033282Functional consequences of human immunodeficiency virus escape from an HLA-B*13-restricted CD8+ T-cell epitope in p1 Gag protein.
Q36845893Genetic characterization of human immunodeficiency virus type 1 in elite controllers: lack of gross genetic defects or common amino acid changes
Q37847620HLA-C as a mediator of natural killer and T-cell activation: spectator or key player?
Q34341384HLA-Cw*0102-restricted HIV-1 p24 epitope variants can modulate the binding of the inhibitory KIR2DL2 receptor and primary NK cell function
Q34190667HLA-Cw*03-restricted CD8+ T-cell responses targeting the HIV-1 gag major homology region drive virus immune escape and fitness constraints compensated for by intracodon variation
Q34489422Human Immunodeficiency Virus Type 1 Protease Inhibitor Drug-Resistant Mutants Give Discordant Results When Compared in Single-Cycle and Multiple-Cycle Fitness Assays
Q33517118Integrating in silico and in vitro analysis of peptide binding affinity to HLA-Cw*0102: a bioinformatic approach to the prediction of new epitopes
Q37246421Near full-length genome analysis of low prevalent human immunodeficiency virus type 1 subclade F1 in São Paulo, Brazil
Q59360836PTAP motif duplication in the p6 Gag protein confers a replication advantage on HIV-1 subtype C