Phosphatidylethanolamine N-methyltransferase (PEMT) knockout mice have hepatic steatosis and abnormal hepatic choline metabolite concentrations despite ingesting a recommended dietary intake of choline

scientific article published on March 2003

Phosphatidylethanolamine N-methyltransferase (PEMT) knockout mice have hepatic steatosis and abnormal hepatic choline metabolite concentrations despite ingesting a recommended dietary intake of choline is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1042/BJ20021523
P932PMC publication ID1223223
P698PubMed publication ID12466019

P50authorSteven ZeiselQ7615406
P2093author name stringLloyd J Edwards
Jiannan Song
Xiaonan Zhu
Mei-Heng Mar
P2860cites workA RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATIONQ25939000
Molecular distinction of phosphatidylcholine synthesis between the CDP-choline pathway and phosphatidylethanolamine methylation pathwayQ28145646
An unexpected requirement for phosphatidylethanolamine N-methyltransferase in the secretion of very low density lipoproteinsQ28218853
Phosphatidylethanolamine N-methyltransferase from liverQ28254706
Choline, an essential nutrient for humansQ28271351
Biochemical and evolutionary significance of phospholipid methylationQ28284866
The active synthesis of phosphatidylcholine is required for very low density lipoprotein secretion from rat hepatocytesQ28296454
Maternal choline availability alters the localization of p15Ink4B and p27Kip1 cyclin-dependent kinase inhibitors in the developing fetal rat brain hippocampusQ28565977
Disruption of the murine gene encoding phosphatidylethanolamine N-methyltransferaseQ36710965
Phosphatidylcholine breakdown and signal transductionQ40739122
Opposing regulation of choline deficiency-induced apoptosis by p53 and nuclear factor kappaB.Q40788762
Methyl-group donors cannot prevent apoptotic death of rat hepatocytes induced by choline-deficiencyQ41131132
Reduction in VLDL, but not HDL, in plasma of rats deficient in choline.Q41230740
Phosphorylcholine: a novel second messenger essential for mitogenic activity of growth factors.Q42804770
Choline deficiency causes reversible hepatic abnormalities in patients receiving parenteral nutrition: proof of a human choline requirement: a placebo-controlled trialQ43725242
Disruption of choline methyl group donation for phosphatidylethanolamine methylation in hepatocarcinoma cellsQ43895713
Choline deficiency induces apoptosis in SV40-immortalized CWSV-1 rat hepatocytes in cultureQ44092584
Quantitation of choline and its metabolites in tissues and foods by liquid chromatography/electrospray ionization-isotope dilution mass spectrometryQ44154223
Choline and human nutrition.Q48221812
Variations of phospholipid methyltransferase(s) activity in the rat pituitary: estrous cycle and sex differencesQ48225507
Choline availability alters embryonic development of the hippocampus and septum in the rat.Q48271134
Prenatal dietary choline supplementation decreases the threshold for induction of long-term potentiation in young adult ratsQ48461149
Choline deficiency selects for resistance to p53-independent apoptosis and causes tumorigenic transformation of rat hepatocytes.Q53444558
Phosphatidylethanolamine N-methyltransferase from rat liverQ68005483
Effects of choline deficiency and methotrexate treatment upon liver folate content and distributionQ68183375
Choline deficiency causes translocation of CTP:phosphocholine cytidylyltransferase from cytosol to endoplasmic reticulum in rat liverQ68450198
Liver cell turnover in rats fed a choline-devoid dietQ69018418
Head group specificity in the requirement of phosphatidylcholine biosynthesis for very low density lipoprotein secretion from cultured hepatocytesQ69639634
Pregnancy and lactation are associated with diminished concentrations of choline and its metabolites in rat liverQ71587664
A peroxidase-coupled method for the colorimetric determination of serum triglyceridesQ71662084
Identification of 197 genetic variations in six human methyltranferase genes in the Japanese populationQ74518279
Choline deficiency-induced liver damage is reversible in Pemt(-/-) miceQ77439023
Effects of choline deficiency and methotrexate treatment upon rat liverQ80991181
Characterization of choline transport at maternal and fetal interfaces of the perfused guinea-pig placentaQ93635252
P433issuePt 3
P407language of work or nameEnglishQ1860
P921main subjectknockout mouseQ1364740
steatosisQ1365091
P1104number of pages7
P304page(s)987-993
P577publication date2003-03-01
P1433published inBiochemical JournalQ864221
P1476titlePhosphatidylethanolamine N-methyltransferase (PEMT) knockout mice have hepatic steatosis and abnormal hepatic choline metabolite concentrations despite ingesting a recommended dietary intake of choline
P478volume370

Reverse relations

cites work (P2860)
Q992484002,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) dysregulates hepatic one carbon metabolism during the progression of steatosis to steatohepatitis with fibrosis in mice
Q41869535A novel transgenic mouse model of CBS-deficient homocystinuria does not incur hepatic steatosis or fibrosis and exhibits a hypercoagulative phenotype that is ameliorated by betaine treatment.
Q28297862Aberrant estrogen regulation of PEMT results in choline deficiency-associated liver dysfunction
Q55119909Abnormal liver phosphatidylcholine synthesis revealed in patients with acute respiratory distress syndrome.
Q83916009Adverse hepatic and cardiac responses to rosiglitazone in a new mouse model of type 2 diabetes: relation to dysregulated phosphatidylcholine metabolism
Q49500923AhR and SHP regulate phosphatidylcholine and S-adenosylmethionine levels in the one-carbon cycle
Q35832696Associations of cord blood metabolites with early childhood obesity risk
Q46121050Betaine administration corrects ethanol-induced defective VLDL secretion
Q55060254Betaine alleviates hepatic lipid accumulation via enhancing hepatic lipid export and fatty acid oxidation in rats fed with a high-fat diet.
Q35007696Betaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trial
Q41463752Betaine improves nonalcoholic fatty liver and associated hepatic insulin resistance: a potential mechanism for hepatoprotection by betaine
Q38222126Body composition in gene knockouts of sulfur amino acid-metabolizing enzymes
Q35070302Choline Availability During Embryonic Development Alters Progenitor Cell Mitosis in Developing Mouse Hippocampus
Q37743322Choline and betaine in health and disease
Q46475003Choline and dimethylglycine produce superoxide/hydrogen peroxide from the electron transport chain in liver mitochondria
Q36713205Choline deficiency in mice and humans is associated with increased plasma homocysteine concentration after a methionine load
Q38000739Choline nutrition programs brain development via DNA and histone methylation
Q28279881Choline supplementation promotes hepatic insulin resistance in phosphatidylethanolamine N-methyltransferase-deficient mice via increased glucagon action
Q24649101Choline: critical role during fetal development and dietary requirements in adults
Q36599941Clinical features of nonalcoholic steatohepatitis in Japan: Evidence from the literature
Q38908997Cystathionine beta-synthase deficiency alters hepatic phospholipid and choline metabolism: Post-translational repression of phosphatidylethanolamine N-methyltransferase is a consequence rather than a cause of liver injury in homocystinuria.
Q37510162Developmental programming by maternal insulin resistance: hyperinsulinemia, glucose intolerance, and dysregulated lipid metabolism in male offspring of insulin-resistant mice.
Q36339606Dysregulated cytokine metabolism, altered hepatic methionine metabolism and proteasome dysfunction in alcoholic liver disease
Q36827875Effects of Nonpurified and Choline Supplemented or Nonsupplemented Purified Diets on Hepatic Steatosis and Methionine Metabolism in C3H Mice
Q28566528Ethanol lowers glutathione in rat liver and brain and inhibits methionine synthase in a cobalamin-dependent manner
Q37257271Functional characterization of phospholipid N-methyltransferases from Arabidopsis and soybean
Q36725000Gene response elements, genetic polymorphisms and epigenetics influence the human dietary requirement for choline
Q26780248Genetic background in nonalcoholic fatty liver disease: A comprehensive review
Q36984689Genetic polymorphisms in methyl-group metabolism and epigenetics: lessons from humans and mouse models
Q37362755Genetic predisposition in NAFLD and NASH: impact on severity of liver disease and response to treatment.
Q38131030Immunological and molecular basis of nonalcoholic steatohepatitis and nonalcoholic fatty liver disease
Q37683158Intrahepatic gene expression during chronic hepatitis C virus infection in chimpanzees
Q92784126Metabolomic Evaluation of Scenedesmus sp. as a Feed Ingredient Revealed Dose-Dependent Effects on Redox Balance, Intermediary and Microbial Metabolism in a Mouse Model
Q41094296Metabolomic characteristics of cholesterol-induced non-obese nonalcoholic fatty liver disease in mice
Q24650636Methionine deficiency and hepatic injury in a dietary steatohepatitis model
Q91648864Mtrr hypomorphic mutation alters liver morphology, metabolism and fuel storage in mice
Q45042166Nonalcoholic steatohepatitis is associated with a state of betaine-insufficiency
Q36468143Perinatal choline influences brain structure and function
Q36581975Phosphatidylcholine and the CDP-choline cycle.
Q37074110Phosphatidylethanolamine N-methyltransferase and choline dehydrogenase gene polymorphisms are associated with human sperm concentration
Q24535745Polymorphism of the PEMT gene and susceptibility to nonalcoholic fatty liver disease (NAFLD)
Q90019833Proteolytic Control of Lipid Metabolism
Q44965942Regioisomers of phosphatidylcholine containing DHA and their potential to deliver DHA to the brain: role of phospholipase specificities
Q37375389Rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis
Q36939985Role of transmethylation reactions in alcoholic liver disease
Q50524783Salinity regulates N-methylation of phosphatidylethanolamine in euryhaline crustaceans hepatopancreas and exchange of newly-formed phosphatidylcholine with hemolymph.
Q28308138Sequential synthesis and methylation of phosphatidylethanolamine promote lipid droplet biosynthesis and stability in tissue culture and in vivo
Q37131633Small molecule activators of pre-mRNA 3' cleavage
Q29618044Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice
Q84571700Synthesis of phosphatidylcholine through phosphatidylethanolamine N-methylation in tissues of the mussel Mytilus galloprovincialis
Q43123082TNFalpha-dependent hepatic steatosis and liver degeneration caused by mutation of zebrafish S-adenosylhomocysteine hydrolase
Q36890332The Pediatric Methionine Requirement Should Incorporate Remethylation Potential and Transmethylation Demands.
Q38015454The nutrigenetics and nutrigenomics of the dietary requirement for choline
Q34554574The use of selected nutrition supplements and complementary and alternative medicine in liver disease
Q36379398Transcreener: screening enzymes involved in covalent regulation

Search more.