TNFalpha-dependent hepatic steatosis and liver degeneration caused by mutation of zebrafish S-adenosylhomocysteine hydrolase

scientific article published in March 2009

TNFalpha-dependent hepatic steatosis and liver degeneration caused by mutation of zebrafish S-adenosylhomocysteine hydrolase is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1242/DEV.027565
P932PMC publication ID2685951
P698PubMed publication ID19201949
P5875ResearchGate publication ID23989394

P2093author name stringMichael Pack
Ian A Blair
Ian V J Murray
Yuehua Huang
Randolph P Matthews
Kristin Lorent
Rafael Mañoral-Mobias
Weilong Gong
P2860cites workTransport of reduced glutathione in hepatic mitochondria and mitoplasts from ethanol-treated rats: Effect of membrane physical properties andS-adenosyl-L-methionineQ58116845
Tumor necrosis factor alpha in the pathogenesis of human and murine fulminant hepatic failureQ64380562
Plasma tumor necrosis factor alpha predicts decreased long-term survival in severe alcoholic hepatitisQ68515696
Quantitative evaluation and regulation of S-adenosylmethionine-dependent transmethylation in sheep tissuesQ69689186
Effect of adenosine metabolites on methyltransferase reactions in isolated rat liversQ71033672
Transport ofS-Adenosylmethionine in Isolated Rat Liver MitochondriaQ73513594
Evidence of choline depletion and reduced betaine and dimethylglycine with increased homocysteine in plasma of children with cystic fibrosisQ79954768
Comparative kinetics of cofactor association and dissociation for the human and trypanosomal S-adenosylhomocysteine hydrolases. 1. Basic features of the association and dissociation processesQ80190572
TNF-alpha induces hepatic steatosis in mice by enhancing gene expression of sterol regulatory element binding protein-1c (SREBP-1c)Q80226666
Correlation of serum TNF-alpha levels and histologic liver injury scores in pediatric nonalcoholic fatty liver diseaseQ80351620
Lessons from animal models of NASHQ81296801
Identification of the human mitochondrial S-adenosylmethionine transporter: bacterial expression, reconstitution, functional characterization and tissue distributionQ24301845
Crystal structure of S-adenosylhomocysteine hydrolase from rat liverQ27618848
Structure determination of selenomethionyl S-adenosylhomocysteine hydrolase using data at a single wavelengthQ27757575
The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitisQ28238742
UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and developmentQ28241669
A histone H3 lysine 27 demethylase regulates animal posterior developmentQ28248320
Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2Q28280326
The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour necrosis factor alpha in the pathogenesis of non-alcoholic steatohepatitisQ28345942
Infliximab reverses steatosis and improves insulin signal transduction in liver of rats fed a high-fat dietQ28574910
SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuronQ28589681
CDP-choline:1,2-diacylglycerol cholinephosphotransferaseQ28609588
Molecular mediators of hepatic steatosis and liver injuryQ29616709
Erasing the methyl mark: histone demethylases at the center of cellular differentiation and diseaseQ29617086
Defective TNF-alpha-mediated hepatocellular apoptosis and liver damage in acidic sphingomyelinase knockout miceQ30881683
Gnotobiotic zebrafish reveal evolutionarily conserved responses to the gut microbiotaQ33201187
Neonatal hepatic steatosis by disruption of the adenosine kinase geneQ34068093
S-Adenosylmethionine and methylationQ34382111
Distinct signals from the microbiota promote different aspects of zebrafish gut differentiationQ34539345
S-adenosylhomocysteine hydrolase deficiency in a human: a genetic disorder of methionine metabolismQ34546376
Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cellsQ34619655
Ethanol, oxidative stress, and cytokine-induced liver cell injuryQ34683423
Role of abnormal methionine metabolism in alcoholic liver injuryQ34774377
Tumour necrosis factor alpha signalling through activation of Kupffer cells plays an essential role in liver fibrosis of non-alcoholic steatohepatitis in miceQ35760220
The ins and outs of mitochondrial dysfunction in NASH.Q35821156
Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferationQ35885731
Alcohol-induced S-adenosylhomocysteine accumulation in the liver sensitizes to TNF hepatotoxicity: possible involvement of mitochondrial S-adenosylmethionine transportQ36016487
Activation of the innate immune system and alcoholic liver disease: effects of ethanol per se or enhanced intestinal translocation of bacterial toxins induced by ethanol?Q36339597
Mouse models in non-alcoholic fatty liver disease and steatohepatitis research.Q36377266
Mitochondrial glutathione: hepatocellular survival-death switchQ36588190
Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in miceQ36688699
S-adenosylmethionine inhibits lipopolysaccharide-induced gene expression via modulation of histone methylationQ36691639
S-adenosylhomocysteine hydrolase deficiency in a 26-year-old man.Q36726616
S-Adenosylhomocysteine hydrolase deficiency: a second patient, the younger brother of the index patient, and outcomes during therapyQ36740605
Regulation of macrophage activation in alcoholic liver diseaseQ36849050
Role of transmethylation reactions in alcoholic liver diseaseQ36939985
Methionine metabolism and liver diseaseQ37106480
A glycine N-methyltransferase knockout mouse model for humans with deficiency of this enzymeQ37472353
The mouse lethal nonagouti (a(x)) mutation deletes the S-adenosylhomocysteine hydrolase (Ahcy) geneQ37630985
The transition from fatty liver to NASH associates with SAMe depletion in db/db mice fed a methionine choline-deficient dietQ37709683
Mitochondrial free cholesterol loading sensitizes to TNF- and Fas-mediated steatohepatitisQ38310080
Uric acid and anti-TNF antibody improve mitochondrial dysfunction in ob/ob miceQ38310192
The zebrafish onecut gene hnf-6 functions in an evolutionarily conserved genetic pathway that regulates vertebrate biliary developmentQ38336271
Extraretinal and retinal hedgehog signaling sequentially regulate retinal differentiation in zebrafishQ38353767
The mitochondrial permeability transition is required for tumor necrosis factor alpha-mediated apoptosis and cytochrome c releaseQ39576439
Alterations in S-adenosylhomocysteine metabolism decrease O6-methylguanine DNA methyltransferase gene expression without affecting promoter methylationQ39994320
Epigenetic silencing of tumor necrosis factor alpha during endotoxin toleranceQ40103534
Epigenetic regulation of tumor necrosis factor alpha.Q40130072
S-Adenosylmethionine and betaine correct hepatitis C virus induced inhibition of interferon signaling in vitroQ40300400
S-adenosylhomocysteine sensitizes to TNF-alpha hepatotoxicity in mice and liver cells: a possible etiological factor in alcoholic liver diseaseQ40512960
Biological Effects of Inhibitors of S-Adenosylhomocysteine HydrolaseQ41760112
Phosphatidylethanolamine N-methyltransferase (PEMT) knockout mice have hepatic steatosis and abnormal hepatic choline metabolite concentrations despite ingesting a recommended dietary intake of cholineQ41916987
Cellular differentiation, cytidine analogs and DNA methylationQ42242732
Adenosine analogues as substrates and inhibitors of S-adenosylhomocysteine hydrolaseQ42274240
Computational Characterization of Substrate Binding and Catalysis in S-Adenosylhomocysteine HydrolaseQ43816995
Unique and conserved aspects of gut development in zebrafish.Q44346088
Large-scale gene profiling of the liver in a mouse model of chronic, intragastric ethanol infusionQ44738971
Hepatic transmethylation reactions in micropigs with alcoholic liver diseaseQ44880261
Crystal structure of S-adenosyl-L-homocysteine hydrolase from the human malaria parasite Plasmodium falciparumQ45100728
Chronic ethanol feeding and folate deficiency activate hepatic endoplasmic reticulum stress pathway in micropigsQ45261151
Hyperhomocysteinemia and the MTHFR C677T polymorphism promote steatosis and fibrosis in chronic hepatitis C patientsQ46441212
Hepatic gene expression in patients with obesity-related non-alcoholic steatohepatitisQ46515459
Exacerbation of alcoholic liver injury by enteral endotoxin in rats.Q46547608
Differential gene expression profiles in the steatosis/fibrosis model of rat liver by chronic administration of carbon tetrachlorideQ46765721
The treatment with antibody of TNF-alpha reduces the inflammation, necrosis and fibrosis in the non-alcoholic steatohepatitis induced by methionine- and choline-deficient dietQ46860893
Zebrafish vps33b, an ortholog of the gene responsible for human arthrogryposis-renal dysfunction-cholestasis syndrome, regulates biliary development downstream of the onecut transcription factor hnf6.Q47073248
Exocrine pancreas development in zebrafishQ47073643
A genetic screen in zebrafish identifies the mutants vps18, nf2 and foie gras as models of liver diseaseQ47073806
Inhibition of Jagged-mediated Notch signaling disrupts zebrafish biliary development and generates multi-organ defects compatible with an Alagille syndrome phenocopyQ47073959
Functional analysis of human S-adenosylhomocysteine hydrolase isoforms SAHH-2 and SAHH-3.Q50711959
Inhibition of transmethylation down-regulates CD4 T cell activation and curtails development of autoimmunity in a model systemQ53561972
P4510describes a project that usesImageJQ1659584
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectDanio rerioQ169444
steatosisQ1365091
AdenosylhomocysteinaseQ29825451
P1104number of pages11
P304page(s)865-875
P577publication date2009-03-01
P1433published inDevelopmentQ3025404
P1476titleTNFalpha-dependent hepatic steatosis and liver degeneration caused by mutation of zebrafish S-adenosylhomocysteine hydrolase
P478volume136

Reverse relations

cites work (P2860)
Q38407596A genetic screen for zebrafish mutants with hepatic steatosis identifies a locus required for larval growth.
Q35755173A monocarboxylate transporter required for hepatocyte secretion of ketone bodies during fasting
Q37696293A new model system swims into focus: using the zebrafish to visualize intestinal metabolism in vivo
Q34419696Analysis of oxidative stress in zebrafish embryos.
Q52628078Blocking fatty acid-fueled mROS production within macrophages alleviates acute gouty inflammation
Q36597443Cannabinoid receptor signaling regulates liver development and metabolism
Q33755683Characterization of timed changes in hepatic copper concentrations, methionine metabolism, gene expression, and global DNA methylation in the Jackson toxic milk mouse model of Wilson disease.
Q36033608Co-silencing of tomato S-adenosylhomocysteine hydrolase genes confers increased immunity against Pseudomonas syringae pv. tomato DC3000 and enhanced tolerance to drought stress
Q34788574DNA hypomethylation causes bile duct defects in zebrafish and is a distinguishing feature of infantile biliary atresia.
Q28468698Defining Hepatic Dysfunction Parameters in Two Models of Fatty Liver Disease in Zebrafish Larvae
Q59355907Deregulation of methionine metabolism as determinant of progression and prognosis of hepatocellular carcinoma
Q42636809Disruption of planar cell polarity activity leads to developmental biliary defects
Q37834052Drinks Like a Fish: Using Zebrafish to Understand Alcoholic Liver Disease
Q35156930Epigenetic control of intestinal barrier function and inflammation in zebrafish
Q50063376Epigenetically mediated inhibition of S-adenosylhomocysteine hydrolase and the associated dysregulation of 1-carbon metabolism in nonalcoholic steatohepatitis and hepatocellular carcinoma.
Q50465061Fructose leads to hepatic steatosis in zebrafish that is reversed by mechanistic target of rapamycin (mTOR) inhibition
Q41123904Functional Characterization of SlSAHH2 in Tomato Fruit Ripening
Q84786574Functional analysis of anS-adenosylhomocysteine hydrolase homolog of chestnut blight fungus
Q36292759High fat plus high cholesterol diet lead to hepatic steatosis in zebrafish larvae: a novel model for screening anti-hepatic steatosis drugs
Q41232821High-fat Feeding Paradigm for Larval Zebrafish: Feeding, Live Imaging, and Quantification of Food Intake.
Q30499964Histone deacetylase 1 is required for exocrine pancreatic epithelial proliferation in development and cancer
Q42131004Homeostatic generation of reactive oxygen species protects the zebrafish liver from steatosis
Q50134174Homocysteine regulates fatty acid and lipid metabolism in yeast.
Q50588376IBD. Fishing for missing heritability in IBD.
Q41935728Intrahepatic Biliary Anomalies in a Patient With Mowat‐Wilson Syndrome Uncover a Role for the Zinc Finger Homeobox Gene zfhx1b in Vertebrate Biliary Development
Q38806486LITTLE FISH, BIG DATA: ZEBRAFISH AS A MODEL FOR CARDIOVASCULAR AND METABOLIC DISEASE.
Q64252476Lipid Modulating Anti-oxidant Stress Activity of Gastrodin on Nonalcoholic Fatty Liver Disease Larval Zebrafish Model
Q37524738Liver development in zebrafish (Danio rerio).
Q90671645Metformin modulates innate immune-mediated inflammation and early progression of NAFLD-associated hepatocellular carcinoma in zebrafish
Q42056773Mutations in vacuolar H+ -ATPase subunits lead to biliary developmental defects in zebrafish.
Q34998404New school in liver development: lessons from zebrafish
Q45922797Overexpression of gankyrin induces liver steatosis in zebrafish (Danio rerio)
Q50482458S-Adenosyl Homocysteine Hydrolase (SAHH) Accelerates Flagellar Regeneration in Dunaliella salina
Q34306534S-adenosylmethionine in Liver Health, Injury, and Cancer
Q27010291Studying non-alcoholic fatty liver disease with zebrafish: a confluence of optics, genetics, and physiology
Q26996802The emerging use of zebrafish to model metabolic disease
Q36981804The expanding role of fish models in understanding non-alcoholic fatty liver disease
Q28468696Translating Discovery in Zebrafish Pancreatic Development to Human Pancreatic Cancer: Biomarkers, Targets, Pathogenesis, and Therapeutics
Q37087874Tumor necrosis factor-alpha is produced by dying retinal neurons and is required for Muller glia proliferation during zebrafish retinal regeneration
Q43540551Ubiquitous transcription factor YY1 promotes zebrafish liver steatosis and lipotoxicity by inhibiting CHOP-10 expression
Q50425163Using zebrafish to model liver diseases-Where do we stand?
Q36592471Wilson's Disease: Changes in Methionine Metabolism and Inflammation Affect Global DNA Methylation in Early Liver Disease
Q37651410Zebrafish Discoveries in Cancer Epigenetics.
Q36669372Zebrafish Models of Human Liver Development and Disease
Q35144039Zebrafish as a model for apolipoprotein biology: comprehensive expression analysis and a role for ApoA-IV in regulating food intake
Q26796338Zebrafish: an important tool for liver disease research

Search more.